Meta-Analysis of the Association between a Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Anxiety-Related Personality Traits

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 127 B, Issue 1, 2004, Pages 85-89

  Sen, Srijan ^a,d   Burmeister, Margit ^a,b   Ghosh, Debashis ^c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d MHRI   (United States)

Author keywords

Depression; Harm avoidance; Neuroticism; Personality; Polymorphism; Variant

Indexed keywords

SEROTONIN TRANSPORTER;

ANXIETY DISORDER; ANXIETY RELATED PERSONALITY TRAIT; ARTICLE; CLINICAL FEATURE; DEPRESSION; DNA POLYMORPHISM; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; META ANALYSIS; NEUROSIS; PERSONALITY DISORDER; PRIORITY JOURNAL; PROMOTER REGION; PUBLICATION; SCORING SYSTEM;

EID: 2142817209     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.20158     Document Type: Article

References (38)

1. Altshuler D, Hirschhorn JN, Klannemark M, et al. 2000. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26:76-80.
2. Ball D, Hill L, Freeman B, et al. 1997. The serotonin transporter gene and peer-rated neuroticism. Neuroreport 8:1301-1304.
3. Costa PT Jr, McCrae RR. 1997. Stability and change in personality assessment: The revised NEO personality inventory in the year 2000. J Pers Assess 68:86-94.
4. De Fruyt F, Van De Wiele L, Van Heerigan C. 2000. Cloninger's psychobiological model of temperament and character and the five-factor model of personality. Pers Individual Differences 29:441-452.
5. Deary IJ, Battersby S, Whiteman MC, Connor JM, Fowkes FG, Harmar A. 1999. Neuroticism and polymorphisms in the serotonin transporter gene. Psychol Med 29:735-739.
6. Du L, Bakish D, Hrdina PD. 2000. Gender differences in association between serotonin transporter gene polymorphism and personality traits. Psychiatr Genet 10:159-164.
7. Ebstein RP, Gritsenko I, Nemanov L, Frisch A, Osher Y, Belmaker RH. 1997. No association between the serotonin transporter gene regulatory region polymorphism and the tridimensional personality questionnaire (TPQ) temperament of harm avoidance. Mol Psychiatry 2:224-226.
8. Egger M, Davey Smith G, Schneider M, Minder C. 1997. Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629-634.
9. Faraone SV, Doyle AE, Mick E, Biederman J. 2001. Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder. Am J Psychiatry 158:1052-1057.
10. Flory JD, Manuck SB, Ferrell RE, Dent KM, Peters DG, Muldoon MF. 1999. Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism. Mol Psychiatry 4:93-96.
11. Gelernter J, Kranzler H, Coccaro EF, Siever LJ, New AS. 1998. Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects. Am J Psychiatry 155:1332-1338.
12. Greenberg BD, Li Q, Lucas FR, et al. 2000. Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet 96:202-216.
13. Gustavsson JP, Nothen MM, Jonsson EG, et al. 1999. No association between serotonin transporter gene polymorphisms and personality traits. Am J Med Genet 88:430-436.
14. Hamer DH, Greenberg BD, Sabol SZ, Murphy DL. 1999. Role of the serotonin transporter gene in temperament and character. J Personal Disord 13:312-327.
15. Hanna GL, Himle JA, Curtis GC, et al. 1998. Serotonin transporter and seasonal variation in blood serotonin in families with obsessive-compulsive disorder [see comments]. Neuropsychopharmacology 18: 102-111.
16. Heils A, Teufel A, Petri S, et al. 1995. Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene. J Neural Transm Gen Sect 102:247-254.
17. Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K. 2002. A comprehensive review of genetic association studies. Genet Med 4:45-61.
18. Jorm AF, Henderson AS, Jacomb PA, et al. 1998. An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms. Mol Psychiatry 3:449-451.
19. Katsuragi S, Kunugi H, Sano A, et al. 1999. Association between serotonin transporter gene polymorphism and anxiety-related traits. Biol Psychiatry 45:368-370.
20. Kluger AN, Siegfried Z, Ebstein RP. 2002. A meta-analysis of the association between DRD4 polymorphism and novelty seeking. Mol Psychiatry 7:712-717.
21. Kumakiri C, Kodama K, Shimizu E, et al. 1999. Study of the association between the serotonin transporter gene regulatory region polymorphism and personality traits in a Japanese population. Neurosci Lett 263: 205-207.
22. Lalovic A, Turecki G. 2002. Meta-analysis of the association between tryptophan hydroxylase and suicidal behavior. Am J Med Genet 114: 533-540.
23. Lesch KP, Bengel D, Heils A, et al. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region [see comments]. Science 274:1527-1531.
24. Loehlin JC. 1993. Nature, nurture, and conservatism in the Australian twin study. Behav Genet 23:287-290.
25. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN. 2003. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33: 177-182.
26. Mazzanti CM, Lappalainen J, Long JC, et al. 1998. Role of the serotonin transporter promoter polymorphism in anxiety-related traits. Arch Gen Psychiatry 55:936-940.
27. Melke J, Landen M, Baghei F, et al. 2001. Serotonin transporter gene polymorphisms are associated with anxiety-related personality traits in women. Am J Med Genet 105:458-463.
28. Murakami F, Shimomura T, Kotani K, Ikawa S, Nanba E, Adachi K. 1999. Anxiety traits associated with a polymorphism in the serotonin transporter gene regulatory region in the Japanese. J Hum Genet 44: 15-17.
29. Nakamura T, Muramatsu T, Ono Y, et al. 1997. Serotonin transporter gene regulatory region polymorphism and anxiety-related traits in the Japanese. Am J Med Genet 74:544-545.
30. Nakamura M, Ueno S, Sano A, Tanabe H. 2000. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry 5:32-38.
31. Osher Y, Hamer D, Benjamin J. 2000. Association and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs. Mol Psychiatry 5:216-219.
32. Ricketts MH, Hamer RM, Sage JI, Manowitz P, Feng F, Menza MA. 1998. Association of a serotonin transporter gene promoter polymorphism with harm avoidance behaviour in an elderly population. Psychiatr Genet 8:41-44.
33. Samochowiec J, Rybakowski F, Czerski P, et al. 2001. Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the temperament and character inventory in healthy volunteers. Neuropsychobiology 43:248-253.
34. Sen S, Villafuerte S, Nesse R, Stoltenberg SF, Hopcian J, Gleiberman L, Weder A, Burmeister M. 2003. Serotonin transporter and GABA (A) alpha6 receptor variants are associated with neuroticism: Suggestion of an interaction. Biol Psychiatry (in press).
35. Stoltenberg SF, Twitchell GR, Hanna GL, et al. 2002. Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism. Am J Med Genet 114:230-234.
36. Tsai SJ, Hong CJ, Cheng CY. 2002. Serotonin transporter genetic polymorphisms and harm avoidance in the Chinese. Psychiatr Genet 12:165-168.
37. Umekage T, Tochigi M, Marui T, et al. 2003. Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population. Neurosci Lett 337:13-16.
38. Zohar AH, Dina C, Rosolio N, Osher Y, Gritsenko I, Bachner-Melman R, Benjamin J, Belmaker RH, Ebstein RP. 2003. Tridimensional personality questionnaire trait of harm avoidance (anxiety proneness) is linked to a locus on chromosome 8p21. Am J Med Genet 117B(1):66-69.