Dopamine D4 receptor exon III genotype influence on the auditory evoked novelty P3

NeuroReport

Volumn 15, Issue 15, 2004, Pages 2411-2415

  Strobel, Alexander ^a   Debener, Stefan ^b   Anacker, Kristin ^a   Müller, Johannes ^a   Lesch, Klaus Peter ^c   Brocke, Burkhard ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Anterior cingulate cortex; Dopamine; DRD4 exon III; Event related potential; Eye blink rate; Novelty P3; Polymorphism

Indexed keywords

DOPAMINE 4 RECEPTOR;

ADULT; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; EVENT RELATED POTENTIAL; EVOKED AUDITORY RESPONSE; EXON; EYELID REFLEX; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; VOLUNTEER;

ACOUSTIC STIMULATION; ADULT; ANALYSIS OF VARIANCE; AZIDES; BLINKING; BRAIN MAPPING; CEREBRAL CORTEX; CHI-SQUARE DISTRIBUTION; EVOKED POTENTIALS, AUDITORY; EXONS; FEMALE; FUNCTIONAL LATERALITY; GENOTYPE; HUMANS; MALE; OCTREOTIDE; POLYMORPHISM, GENETIC; REACTION TIME; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4;

EID: 8444239334     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001756-200410250-00022     Document Type: Article

References (25)

1. Oak JN, Oldenhof J and Van Tol HHM. The dopamine D receptor: one decade of research. Eur J Pharmacol 2000; 405:303-327.
2. Wedzony K, Chocyk A, Mackowiak M, Fijal K and Czyrak A. Cortical localization of dopamine D4 receptors in the rat brain - immunocytochemical study. J Physiol Pharmacol 2000; 51:205-221.
3. Rubinstein M, Cepeda C, Hurst RS, Flores-Hernandez J, Ariano MA et al. Dopamine D4 receptor-deficient mice display cortical hyperexcitability. J Neurosci 2001; 21:3756-3763.
4. Wang X, Zhong P and Yan Z. Dopamine D4 receptors modulate GABAergic signaling in pyramidal neurons of prefrontal cortex. J Neurosci 2002; 22:9185-9193.
5. Dulawa SC, Grandy DK, Low MJ, Paulus MP and Geyer MA. Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli. J Neurosci 1999; 19:9550-9556.
6. Friedman D, Cycowicz YM and Gaeta H. The novelty P3: an event-related brain potential (ERP) sign of the brain's evaluation of novelty. Neurosci Biobehav Rev 2001; 25:355-373.
7. Escera C, Alho K, Winkler I and Näätänen R. Neural mechanisms of involuntary attention to acoustic novelty and change. J Cogn Neurosci 1998; 10:590-604.
8. Debener S, Kranczioch C, Herrmann CS and Engel AK. Auditory novelty oddball allows reliable distinction of top-down and bottom-up processes of attention. Int J Psychophysiol 2002; 46:77-84.
9. Daffner KR, Mesulam MM, Scinto LFM, Acar D, Calvo V et al. The central role of the prefrontal cortex in directing attention to novel events. Brain 2000; 123:927-939.
10. Dien J, Spencer KM and Donchin E. Localization of the event-related potential novelty response as defined by principal components analysis. Brain Res Cogn Brain Res 2003; 17:637-650.
11. Debener S, Makeig S, Delorme A and Engel AK. What is novel in the novelty oddball paradigm? Functional significance of the novelty P3 event-related potential as revealed by independent component analysis. (in press).
12. Botvinick MM, Braver TS, Barch DM, Carter CS and Cohen JD. Conflict monitoring and cognitive control. Psychol Rev 2001; 108:624-652.
13. Allman JM, Hakeem A, Erwin JM, Nimchinsky E and Hof P. The anterior cingulate cortex. The evolution of an interface between emotion and cognition. Ann NY Acad Sci 2001; 935:107-117.
14. Karson CN. Spontaneous eye-blink rates and dopaminergic systems. Brain 1983; 106:643-653.
15. Taylor JR, Elsworth JD, Lawrence MS, Sladek JR Jr, Roth RH et al. Spontaneous blink rates correlate with dopamine levels in the caudate nucleus of MPTP-treated monkeys. Exp Neurol 1999; 158:214-220.
16. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971; 9:97-113.
17. Dreisbach G, Müller J, Goschke T, Strobel A, Schulze K et al. Dopamine and Cognitive Control: the influence of spontaneous eye-blink rate and dopamine gene polymorphisms on perseveration and distractibility. (submitted).
18. Fabiani M and Friedman D. Changes in brain activity patterns and aging: the novelty oddball. Psychophysiology 1995; 32:579-594.
19. Delorme A and Makeig S. EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J Neurosci Methods 2004; 134:9-21.
20. Kayser J and Tenke CE. Optimizing PCA methodology for ERP component identification and measurement: theoretical rationale and empirical evaluation. Clin Neurophysiol 2003; 114:2307-2325.
21. Beauducel A and Debener S. Misallocation of variance in event-related potentials: simulation studies on the effects of test power, topography, and baseline-to-peak vs principal component quantifications. J Neurosci Methods 2003; 124:103-112.
22. Beauducel A, Debener S, Brocke B and Kayser J. On the reliability of augmenting/reducing: peak amplitudes and principal component analysis of auditory evoked potentials. J Psychophysiol 2000; 14: 226-240.
23. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y et al. Dopamin D4 receptor (D4DR) exon III polymorphism associated with the personality trait of novelty seeking. Nature Genet 1996; 12: 78-80.
24. Cohen J. Statistical Power Analysis for the Behavioral Sciences. New York: Academic Press, 1988.
25. Grace AA. The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving. Addiction 2000; 95 (Suppl 2):S119-S128.