Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene

Science

Volumn 301, Issue 5631, 2003, Pages 386-389

  Caspi, Avshalom ^a,b   Sugden, Karen ^a   Moffitt, Terrie E ^a,b   Taylor, Alan ^a   Craig, Ian W ^a   Harrington, HonaLee ^b   McClay, Joseph ^a   Mill, Jonathan ^a   Martin, Judy ^c   Braithwaite, Antony ^d   Poulton, Richie ^c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF OTAGO   (New Zealand)

^d UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSIS; EPIDEMIOLOGY;

POLYMORPHISM;

GENES;

EPIDEMIOLOGY; GENE; STRESS;

ADOLESCENT; ADULT; ALLELE; ARTICLE; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DEPRESSION; EPIDEMIOLOGICAL DATA; FEMALE; GENE; GENE ENVIRONMENT INTERACTION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HEREDITY; HOMOZYGOSITY; HUMAN; LIFE EVENT; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MENTAL STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROSPECTIVE STUDY; SEROTONIN TRANSPORTER GENE; SUICIDE ATTEMPT;

ADULT; ALLELES; CARRIER PROTEINS; CHILD; CHILD ABUSE; DEPRESSION; DEPRESSIVE DISORDER; DISEASE SUSCEPTIBILITY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; LONGITUDINAL STUDIES; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MONOAMINE OXIDASE; NERVE TISSUE PROTEINS; POLYMORPHISM, GENETIC; PROBABILITY; PROMOTER REGIONS (GENETICS); SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS, PSYCHOLOGICAL; SUICIDE, ATTEMPTED;

EID: 0037624040     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1083968     Document Type: Article

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31. We thank P. Silva, founder of the Dunedin Multidisciplinary Health and Development Study, Air New Zealand, and the study members, their families, and their friends. Supported by the Health Research Council of New Zealand and the University of Wisconsin Graduate School and by grants from the U.K. Medical Research Council, the William T. Grant Foundation, and the U.S. National Institute of Mental Health (MH49414 and MH45070). T.E.M. is a Royal Society-Wolfson Research Merit Award holder. The study protocol was approved by the institutional review boards of the participating universities.