Association study of Catechol-O-Methyltransferase gene and Dopamine D 4 Receptor gene polymorphisms and personality traits in healthy young Chinese females

Neuropsychobiology

Volumn 50, Issue 2, 2004, Pages 153-156

  Tsai, Shih Jen ^a,b   Hong, Chen Jee ^a,b   Yu, Younger W Y ^c   Chen, Tai Jui ^c,d  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c E DA HOSPITAL   (Taiwan)

^d KAI SUAN PSYCHIATRIC HOSPITAL   (Taiwan)

Author keywords

Association study; Catechol O methyltransferase; Dopamine D4 receptor; Personality trait; Polymorphism

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE 4 RECEPTOR;

ADULT; ARTICLE; CATECHOL O METHYLTRANSFERASE GENE; CHINESE; DOPAMINE D4 RECEPTOR GENE; FEMALE; GENE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; NORMAL HUMAN; PERSONALITY; POPULATION RESEARCH; PRIORITY JOURNAL; REWARD; SAMPLE; SCORING SYSTEM;

ADULT; CATECHOL O-METHYLTRANSFERASE; CHINA; EXONS; EXPLORATORY BEHAVIOR; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; PERSONALITY; PERSONALITY TESTS; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; REWARD;

EID: 4043060901     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000079107     Document Type: Article

References (22)

1. Cloninger CR: A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry 1987;44:573-588.
2. Bouchard TJ Jr: Genes, environment, and personality. Science 1994;264:1700-1701.
3. 4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nat Genet 1996;12:78-80.
4. Kluger AN, Siegfried Z, Ebstein RP: A metaanalysis of the association between DRD4 polymorphism and novelty seeking. Mol Psychiatry 2002;7:712-717.
5. Munafo MR, Clark TG, Moore LR, Payne E, Walton R, Flint J: Genetic polymorphisms and personality in healthy adults: A systematic review and meta-analysis. Mol Psychiatry 2003;8471-8484.
6. Chayer C, Freedman M: Frontal lobe functions. Curr Neurol Neurosci Rep 2001;1:547-552.
7. Sesack SR, Hawrylak VA, Matus C, Guido MA, Levey AI: Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. J Neurosci 1998;18:2697-2708.
8. Lotta T, Vidgren J, Tilgmann C, Umanen I, Melen K, Julkunen I, Taskinen J: Kinetics of human soluble and membrane bound catechol-O-methyltransferase: A revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 1995;34:4202-4210.
9. Rujescu D, Giegling I, Gietl A, Hartmann AM, Moller HJ: A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits. Biol Psychiatry 2003;54:34-39.
10. Eley TC, Tahir E, Angleitner A, Harriss K, McClay J, Plomin R, Riemann R, Spinath F, Craig I: Association analysis of MAOA and COMT with neuroticism assessed by peers. Am J Med Genet 2003;120B:90-96.
11. Avramopoulos D, Stefanis NC, Hantoumi I, Smyrnis N, Evdokimidis I, Stefanis CN: Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele. Mol Psychiatry 2002;7:706-711.
12. Tsai SJ, Yu YW, Chen TJ, Chen JY, Liou YJ, Chen MC, Hong CJ: Association study of a functional catechol-O-methyltransferase gene polymorphism and cognitive function in healthy females. Neurosci Lett 2003;338:123-126.
13. Tsai SJ, Yu YW, Hong CJ: Personality traits in young female apolipoprotein E (apoE) epsilon4 and non-epsilon4 carriers. Am J Med Genet 2004;124B:58-60.
14. Chen WJ, Chen HM, Chen CC, Chen CC, Yu WY, Cheng AT: Cloninger's Tridimensional Personality Questionnaire: Psychometric properties and construct validity in Taiwanese adults. Compr Psychiatry 2002;43:158-166.
15. Lachman HM, Papolos DF, Satio T, Yu YM, Szumlanski CL, Weinshilboum RM: Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 1996;6:243-250.
16. 4 receptor subtypes and response to clozapine. Lancet 1993;341:116.
17. Tomitaka M, Tomitaka S, Otuka Y, Kim K, Matuki H, Sakamoto K, Tanaka A: Association between novelty seeking and dopamine receptor D4 (DRD4) exon III polymorphism in Japanese subjects. Am J Med Genet 1999;88:469-471.
18. Menza MA, Golbe LI, Cody RA, Forman NE: Dopamine-related personality traits in Parkinson's disease. Neurology 1993;43:505-508.
19. Deutch AY: Prefrontal cortical dopamine systems and the elaboration of functional corticostriatal circuits: Implications for schizophrenia and Parkinson's disease. J Neural Transm Gen Sect 1993;91:197-221.
20. Benjamin J, Osher Y, Lichtenberg P, Bachner-Melman R, Gritsenko I, Kotler M, Belmaker RH, Valsky V, Drendel M, Ebstein RP: An interaction between the catechol O-methyltransferase and serotonin transporter promoter region polymorphisms contributes to tridimensional personality questionnaire persistence scores in normal subjects. Neuropsychobiology 2000;41:48-53.
21. Keltikangas-Jarvinen L, Raikkonen K, Ekelund J, Peltonen L: Nature and nurture in novelty seeking. Mol Psychiatry 2004;9:308-311.
22. 4 polymorphism correlate with personality traits in young Korean female population. Am J Med Genet 2003;118B:76-80.