Use of unlinked genetic markers to detect population stratification in association studies

American Journal of Human Genetics

Volumn 65, Issue 1, 1999, Pages 220-228

  Pritchard, Jonathan K ^a,b   Rosenberg, Noah A ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CASE CONTROL STUDY; DISEASE PREDISPOSITION; ETHNOLOGY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC MARKER; HUMAN; PHENOTYPE; POPULATION GENETICS; PRIORITY JOURNAL; PROBABILITY; SAMPLING;

EID: 0033358548     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302449     Document Type: Article

References (24)

1. Beaumont MA, Nichols RA (1996) Evaluating loci for use in the genetic analysis of population structure. Proc R Soc Lond B Biol Sci 263:1619-1626
2. Boehnkc M, Langefeld CD (1998) Genetic association mapping based on discordant sib pairs: the discordant-alleles test. Am J Hum Genet 62:950-961
3. Bowcock AM, Hebert JM, Mountain JL, Kidd JR, Kidd KK, Cavalli-Sforza LL (1991) Drift, admixture, and selection in human evolution: a study with DNA polymorphisms. Proc Natl Acad Sci USA 88:839-843
4. Cavalli-Sforza LL, Menozzi P, Piazza A (1994) The history and geography of human genes. Princeton University Press, Princeton
5. Ewens WJ, Spielman RS (1995) The transmission/disequilibrium test: history, subdivision, and admixture. Am J Hum Genet 57:455-464
6. Falk CT, Rubinstein P (1987) Haplotype relative risks: an easy way to construct a proper control sample for risk calculations. Ann Hum Genet 51:227-233
7. Feldman MW, Kumm J, Pritchard JK (1999) Mutation and migration in models of microsatellite evolution. In: Goldstein D, Schlotterer C (eds) Microsatellites: evolution and applications. Oxford University Press, Oxford
8. Goldstein DB, Linares AR, Cavalli-Sforza LL, Feldman MW (1995) Genetic absolute dating based on microsatellites and the origin of modern humans. Proc Natl Acad Sci USA 92: 6723-6727
9. Hudson RR (1990) Gene genealogies and the coalescent process. In: Futuyma D, Antonovics J (eds) Oxford surveys in evolutionary biology. Vol 7. Oxford University Press, Oxford, pp 1-44
10. Jorde LB, Bamshad MJ, Watkins WS, Zenger R, Fraley AE, Krakowiak PA, Carpenter KD, et al (1995) Origins and affinities of modern humans: a comparison of mitochondrial and nuclear genetic data. Am J Hum Genet 57:523-538
11. Jorde, LB, Rogers AR, Bamshad M, Watkins WS, Krakowiak R, Sung S, Kere J, et al (1997) Microsatellite diversity and the demographic history of modern humans. Proc Natl Acad Sci USA 94:3100-3103
12. Lander ES, Schork NJ (1994) Genetic dissection of complex traits. Science 265:2037-2048
13. Lazzeroni LC, Lange K (1998) A conditional inference framework for extending the transmission/disequilibrium test. Hum Hered 48:67-81
14. McKeigue PM (1997) Mapping genes underlying ethnic differences in disease risk by linkage disequilibrium in recently admixed populations. Am J Hum Genet 60:188-196
15. Risch N, Merikangas K (1996) The future of genetic studies of complex human diseases. Science 273:1516-1517
16. Rohlf FJ, Sokal RR (1995) Statistical tables, 3d ed. WH Freeman, New York
17. Shriver MD, Smith MW, Jin L, Marcini A, Akey JM, Deka R, Ferrell RE (1997) Ethnic-affiliation estimation by use of population-specific DNA markers. Am J Hum Genet 60: 957-964
18. Slatkin M (1991) Inbreeding coefficients and coalescence times. Genet Res 58:167-175
19. Sokal RR, Rohlf FJ (1995) Biometry, 3d ed. WH Freeman, New York
20. Spielman RS, Ewens WJ (1998) A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. Am J Hum Genet 62:450-458
21. Spielman RS, McGinnis RE, Ewens WJ (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-513
22. Thomson G, Robinson WP, Kuhner MK, Joe S (1989) HLA, insulin gene, and Gm associations with IDDM. Genet Epidemiol 6:155-160
23. Wang DG, Fan J-B, Siao C-J, Berno A, Young P, Sapolsky R, Ghandour G, et al (1998) Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science 280:1077-1082
24. Wright S (1951) The genetical structure of populations. Ann Eugenics 15:323-354