Allele frequency distribution of the canine dopamine receptor D4 gene exon III and I in 23 breeds

Journal of Veterinary Medical Science

Volumn 66, Issue 7, 2004, Pages 815-820

  Ito, Hideyuki ^a   Nara, Hidetoshi ^a   Inoue Murayama, Miho ^a   Shimada, Makoto K ^a   Koshimura, Akiko ^a   Ueda, Yuko ^a   Kitagawa, Hitoshi ^a   Takeuchi, Yukari ^b   Mori, Yuji ^b   Murayama, Yuichi ^c   Morita, Mitsuo ^d   Iwasaki, Toshiroh ^e   Ôta, Katuaki ^f   Tanabe, Yuichi ^g   Ito, Shin'ichi ^a  

^a GIFU UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL INSTITUTE OF ANIMAL HEALTH   (Japan)

^d Livestock Improvement Association of Japan   (Japan)

^e TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^f SHINSHU UNIVERSITY   (Japan)

^g AZABU UNIVERSITY   (Japan)

Author keywords

Canine; Dopamine receptor D4 gene; Exons III and I; Polymorphism; Variation among breeds

Indexed keywords

ANIMALIA; CANIS FAMILIARIS;

DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR; PRIMER DNA;

AMINO ACID SEQUENCE; ANIMAL; ANIMAL BEHAVIOR; ARTICLE; DOG; EXON; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; MOLECULAR GENETICS; MOUTH MUCOSA; NUCLEOTIDE SEQUENCE; PHENOTYPE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BEHAVIOR, ANIMAL; DNA PRIMERS; DOGS; EXONS; GENE FREQUENCY; GENOTYPE; MOLECULAR SEQUENCE DATA; MOUTH MUCOSA; PHENOTYPE; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4;

EID: 4344579862     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.66.815     Document Type: Article

References (23)

1. Benjamin, J., Li, L., Patterson, C., Greenberg, B. D., Murphy, D. L. and Hamer, D. H. 1996. Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nat. Genet. 12: 81-84.
2. Bradshaw, J. W., Goodwin, D., Lea, A. M. and Whitehead, S. L. 1996. A survey of the behavioural characteristics of pure-bred dogs in the United Kingdom. Vet. Rec. 138: 465-468.
3. Castellanos, F. X., Lau, E., Tayebi, N., Lee, P., Long, R. E., Giedd, J. N., Sharp, W., Marsh, W. L., Walter, J. M., Hamburger, S. D., Ginns, E. I., Rapoport, J. L. and Sidransky, E. 1998. Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/hyperactivity disorder: genetic and brain morphometric analyses. Mol. Psychiatry 3: 431-434.
4. Catalano, M., Nobile, M., Novelli, E., Nöthen, M. M. and Smeraldi, E. 1993. Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients. Biol. Psychiatry 34: 459-464.
5. Chang, F.-M., Kidd, J. R., Livak, K. J., Pakstis, A. J. and Kidd, K. K. 1996. The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus. Hum. Genet. 98: 91-101.
6. Clutton-Block, J. 1995. Origins of the dog: domestication and early history. pp. 7-20. In: The Domestic Dog: Its Evolution, Behavior and Interactions with People (Serpell J. ed.), Cambridge University Press, Cambridge.
7. Dulawa, S. C., Grandy, D. K., Low, M. J., Paulus, M. P. and Geyer, M. A. 1999. Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli. J. Neurosci. 19: 9550-9556.
8. Ebstein, R. P., Segman, R., Benjamin, J., Osher, Y., Nemanov, L. and Belmaker, R. H. 1997. 5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms. Am. J. Med. Genet. 74: 65-72.
9. Hart, B. L. and Hart, L. A. 1985. Selecting pet dogs on the basis of cluster analysis of breed behavior profiles and gender. J. Am. Vet. Med. Assoc. 186: 1181-1185.
10. Inoue-Murayama, M., Matsuura, N., Murayama, Y., Tsubota, T., Iwasaki, T., Kitagawa, H. and Ito, S. 2002. Sequence comparison of the dopamine receptor D4 exon III repetitive region in several species of the order Carnivora. J. Vet. Med. Sci. 64: 747-749.
11. LaHoste, G. J., Swanson, J. M., Wigal, S. B., Glabe, C., Wigal, T., King, N. and Kennedy, J. L. 1996. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Mol. Psychiatry 1: 121-124.
12. Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H. and Murphy, D. L. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527-1531.
13. Nei, M. and Roychoudhury, A. K. 1974. Sampling variances of heterozygosity and genetic distance. Genetics 76: 379-390.
14. Niimi, Y., Inoue-Murayama, M., Murayama, Y., Ito, S. and Iwasaki, T. 1999. Allelic variation of the D4 dopamine receptor polymorphic region in two dog breeds, Golden retriever and Shiba. J. Vet. Med. Sci. 61: 1281-1286.
15. Niimi, Y., Inoue-Murayama, M., Kato, K., Matsuura, N., Murayama, Y., Ito, S., Momoi, Y., Konno, K. and Iwasaki, T. 2001. Breed differences in allele frequency of the dopamine receptor D4 gene in dogs. J. Hered. 92: 433-436.
16. Reynolds, J., Weir, B. S. and Cockerham, C. C. 1983. Estimation of the coancestry coefficient: basis for a short-term genetic distance. Genetics 105: 767-779.
17. Sabol, S. Z., Nelson, M. L., Fisher, C., Gunzerath, L., Brody, C. L., Hu, S., Sirota, L. A., Marcus, S. E., Greenberg, B. D., Lucas, F. R. 4th, Benjamin, J., Murphy, D. L. and Hamer, D. H. 1999. A genetic association for cigarette smoking behavior. Health Psychol. 18: 7-13.
18. Tanabe, Y., Ôta, K., Ito, S., Hashimoto, Y., Sung, Y. Y., Ryu, J. K. and Faruque, M. O. 1991. Biochemical-genetic relationships among Asian and European dogs and ancestry of the Japanese native dog. J. Anim. Breed. Genet. 108: 455-478.
19. Tanabe, Y. and Yamazaki, K. 2001. Difference in behavioral profiles of dog breeds based on the questionnaire survey - with special reference to aptitude as companion dogs -. J. Vet. Med. 54: 9-14 (in Japanese).
20. van den Berg, L., Versteeg, S. A. and van Oost, B. A. 2003. Isolation and characterization of the canine serotonin receptor 1A gene (htrl A). J. Hered. 94: 49-56.
21. Vandenbergh, D. J., Zonderman, A. B., Wang, J, Uhl, G. R. and Costa, P. T. Jr. 1997. No association between novelty seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Aging participants. Mol. Psychiatry 2: 417-419.
22. Wilcox, B. and Walkowicz, C. 1989. Atlas of Dog Breeds of the World, T. F. H. Publications, Inc., New Jersey.
23. Zenner, M.-T., Nobile, M., Henningsen, R., Smeraldi, E., Civelli, O., Hartman, D. S. and Catalano, M. 1998. Expression and characterization of a dopamine D4R variant associated with delusional disorder. FEBS Lett. 422: 146-150.