Toward understanding the biology of a complex phenotype: Rat strain and substrain differences in the sensorimotor gating-disruptive effects of dopamine agonists

Journal of Neuroscience

Volumn 20, Issue 11, 2000, Pages 4325-4336

  Swerdlow, Neal R ^a   Martinez, Zoe A ^a   Hanlon, Faith M ^a   Platten, Amanda ^a   Farid, Marjan ^a   Auerbach, Pamela ^a   Braff, David L ^a   Geyer, Mark A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apomorphine; Dopamine; Prepulse inhibition; Schizophrenia; Startle; Strain

Indexed keywords

DOPAMINE RECEPTOR STIMULATING AGENT;

ANIMAL EXPERIMENT; ARTICLE; CHANNEL GATING; NEUROPSYCHIATRY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; SENSORIMOTOR FUNCTION; STARTLE REFLEX;

EID: 0034212912     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-11-04325.2000     Document Type: Article

References (55)

1. Bolino F, Di Michele V, Di Cicco L, Manna V, Daneluzzo E, Casacchia M (1994) Sensorimotor gating and habituation evoked by electrocutaneous stimulation in schizophrenia. Biol Psychiatry 36:670-679.
2. Braff D, Stone C, Callaway E, Geyer MA, Glick ID, Bali L (1978) Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 15:339-343.
3. Braff D, Grillon C, Geyer M (1992) Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen Psychiatry 49:206-215.
4. Bullock AE, Slobe BS, Vazquez V, Collins AC (1997) Inbred mouse strains differ in the regulation of startle and prepulse inhibition of the startle response. Behav Neurosci 111:1353-1360.
5. Cadenhead KS, Geyer MA, Braff DL (1993) Impaired startle prepulse inhibition and habituation in schizotypal personality disordered patients. Am J Psychiatry 150:1862-1867.
6. Cadenhead KS, Geyer MA, Swerdlow NR, Shafer K, Diaz M, Clementz BA, Braff DL (1998) Sensorimotor gating deficits in schizophrenic patients and their relatives. Biol Psychiatry Abstr 43:10S.
7. Caine SB, Geyer MA, Swerdlow NR (1991) Carbachol infusion into the dentate gyrus disrupts sensorimotor gating of the startle reflex in rats. Psychopharmacology (Berl) 105:347-354.
8. Caine SB, Geyer M A, Swerdlow N R (1995) Effects of D3/D2 dopamine receptor agonists and antagonists on prepulse inhibition of acoustic startle in the rat. Neuropsychopharmacology 12:139-145.
9. Carter RJ, Lione LA, Humby T, Mangiarini L, Mahal A, Bates GP, Dunnett SB, Morton AJ (1999) Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. J Neurosci 19:3248-3257.
10. Castellanos FX, Fine EJ, Kaysen DL, Kozuch PL, Hamburger SD, Rapoport JL, Hallett M (1996) Sensorimotor gating in boys with Tourette's syndrome and ADHD: preliminary results. Biol Psychiatry 39:33-41.
11. Davis M, Mansbach RS, Swerdlow NR, Braff DL, Geyer MA (1990) Apomorphine disrupts prepulse inhibition of acoustic startle in rats. Psychopharmacology (Berl) 102:1-4.
12. Ellenbrock BA, Cools AR (1998) The neurodevelopment hypothesis of schizophrenia: clinical evidence and animal models. Neurosci Res Commun 22:127-136.
13. Ellenbroek BA, Geyer MA, Cools MA (1995) The behavior of APOSUS rats in animal models with construct validity for schizophrenia. J Neurosci 15:7604-7611.
14. Geyer MA, Braff DL (1987) Startle habituation and sensorimotor gating in schizophrenia and related animal models. Schizophr Bull 13:643-668.
15. Geyer MA, Swerdlow N R (1998) Measurement of startle response, prepulse inhibition, and habituation. In: Current protocols in neuroscience (Crawley JN, Skolnick P, eds), pp 8.7.1-8.7.15. New York: Wiley.
16. Geyer MA, Krebs-Thomson K, Varty GB (1999) The effects of M100907 in pharmacological and developmental animal models of prepulse inhibition deficits in schizophrenia. Neuropsychopharmacology 21:S134-S142.
17. Gleason TC, Dreiling JL, Crawley JN (1999) Rat strain differences in response to galanin on the Morris water task. Neuropeptides 33:265-270.
18. Graham F (1975) The more or less startling effects of weak prestimuli. Psychophysiology 12:238-248.
19. Hart S, Zreik M, Carper R, Swerdlow N R (1998) Localizing haloperidol effects on sensorimotor gating in a predictive model of antipsychotic potency. Pharmacol Biochem Behav 61:113-119.
20. Hitchcock JM, Selk DE, Wettstein JG, Rush DK (1999) Intrastrain differences in the disruption of prepulse inhibition in rats by PCP, DOI, and 7-OH-DPAT. Schizophr Res 36:115.
21. Hoffman DC, Donovan H (1994) D1 and D2 dopamine receptor antagonists reverse prepulse inhibition deficits in an animal model of schizophrenia. Psychopharmacology (Berl) 115:447-453.
22. Kinney GG, Wilkinson LO, Saywell KL, Tricklebank MD (1999) Rat strain differences in ability to disrupt sensorimotor gating are limited to the dopaminergic system, specific to prepulse inhibition, and unrelated to changes in startle amplitude or nucleus accumbens dopamine receptor sensitivity. J Neurosci 19:5644-5653.
23. Koch M (1998) Sensorimotor gating changes across the estrous cycle in female rats. Physiol Behav 64:625-628.
24. Koch M, Schnitzler HU (1997) The acoustic startle response in rats -circuits mediating evocation, inhibition and potentiation. Behav Brain Res 89:35-49.
25. Kodsi MH, Swerdlow NR (1997) Regulation of sensorimotor gating by pallidal efferent projections. Brain Res Bull 43:219-228.
26. Kumari V, Soni W, Sharma T (1999) Normalization of information processing deficits in schizophrenia with clozapine. Am J Psychiatry 156:1046-1051.
27. Lipska BK, Swerdlow N R, Geyer MA, Jaskiw GE, Braff DL, Weinberger DR (1995) Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine. Psychopharmacology (Berl) 122:35-43.
28. Loscher W, Cramer S, Ebert U (1998) Differences in kindling development in seven outbred and inbred rat strains. Exp Neurol 154:551-559.
29. Luedtke RR, Artymyshyn RP, Monks BR, Molinoff PB (1992) Comparison of the expression, transcription and genomic organization of D2 dopamine receptors in outbred and inbred strains of rat. Brain Res 584:45-54.
30. Mansbach RS, Geyer MA, Braff DL (1988) Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology (Berl) 94:507-514.
31. Martinez Z, Oostwegel J, Geyer M, Swerdlow NR (2000) Ontogeny of pheneyclidine and apomorphine effects on prepulse inhibition (PPI). Pharmacol Biochcm Behav 65:449-457.
32. McIoni EG, Davis M (1999) Enhancement of the acoustic startle response in rats by the dopamine D1 receptor agonist SKF 82958. Psychopharmacology (Berl) 144:373-380.
33. Oliff HS, Marek P, Miyazaki B, Weber E (1996) The neuroprotective efficacy of MK-801 in focal cerebral ischemia varies with rat strain and vendor. Brain Res 731:208-212.
34. Oliff HS, Coyle P, Weber E (1997) Rat strain and vendor differences in collateral anastomoses. J Cereb Blood Flow Metab 17:571-576.
35. Peng RY, Mansbach RS, Braff DL, Geyer MA (1990) A D2 dopamine receptor agonist disrupts sensorimotor gating in rats. Implications for dopaminergic abnormalities in schizophrenia. Neuropsychopharmacology 3:211-218.
36. Rigdon G (1990) Differential effects of apomorphine on prepulse inhibition of acoustic startle reflex in two rat strains. Psychopharmacology (Berl) 102:419-421.
37. Swerdlow NR, Geyer MA (1993) Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia. Pharmacol Biochem Behav 44:741-744.
38. Swerdlow N R, Geyer MA (1998) Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia. Schizophr Bull 24:285-302.
39. Swerdlow N R, Geyer MA (1999) Neurophysiology and neuropharmacology of short lead interval startle modification. In: Startle modification: implications for neuroscience, cognitive science, and clinical science (Dawson ME, Schell A, Boehmelt A, eds), pp 114-133. Cambridge, UK: Cambridge UP.
40. Swerdlow N R, Caine B, Geyer MA (1991a) Opiate-dopamine interactions in the neural substrates of acoustic startle gating in the rat. Prog Neuropsychopharmacol Biol Psychiatry 15:415-426.
41. Swerdlow NR, Keith VA, Braff DL, Geyer MA (1991b) Effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat. J Pharmacol Exp Ther 256:530-536.
42. Swerdlow NR, Braff DL, Taaid N, Geyer MA (1994a) Assessing the validity of an animal model of deficient sensorimotor gating in schizo-phrenic patients. Arch Gen Psychiatry 51:139-154.
43. Swerdlow NR, Zisook D, Taaid N (1994b) Seroquel (ICI 204,636) restores prepulse inhibition of acoustic startle in apomorphine-treated rats: similarities to clozapine. Psychopharmacology (Berl) 114:675-678.
44. Swerdlow NR, Lipska BK, Weinberger DR, Braff DL, Jaskiw GE, Geyer MA (1995a) Increased sensitivity to the gating-disruptive effects of apomorphine after lesions of the medial prefrontal cortex or ventral hippocampus in adult rats. Psychopharmacology (Berl) 122:27-34.
45. Swerdlow N R, Paulsen J, Braff DL, Butters N, Geyer MA, Swenson MR (1995b) Impaired propulse inhibition of acoustic and tactile startle in patients with Huntington's disease. J Neurol Neurosurg Psychiatry 58:192-200.
46. Swerdlow N R, Bakshi V, Geyer MA (1996) Seroquel restores sensorimotor gating in phencyclidine (PCP)-treated rats. J Pharmacol Exp Ther 279:1290-1299.
47. Swerdlow N R, Varty GB, Geyer MA (1997) Discrepant findings of clozapine effects on prepulse inhibition of startle: is it the route or the rat? Neuropsychopharmacology 18:50-56.
48. Swerdlow N R, Martinez ZA, Hanlon FM, Auerbach P, Platten A, Braff DL, Geyer MA (2000) Towards the genetics of a complex phenotype: strain analyses of drug effects on startle gating. Biol Psychiatry, in press.
49. Turnbull AV, Rivier CL (1999) Sprague-Dawley rats obtained from different vendors exhibit distinct adrenocorticotropin responses to inflammatory stimuli. Neuroendocrinology 70:186-195.
50. Varty GB, Higgins GA (1994) Differences between three rat strains in sensitivity to prepulse inhibition of acoustic startle response: influence of apomorphine and phencyclidine pretreatment. J Psychopharmacol (Oxf) 8:148-156.
51. Wan FJ, Swerdlow NR (1993) Intra-accumbens infusion of quinpirole impairs sensorimotor gating of acoustic startle in rats. Psychopharmacology (Berl) 113:103-109.
52. Wan FJ, Swerdlow N R (1996) The basolateral amygdala regulates sensorimotor gating of acoustic startle in rats. Neuroscience 76:715-724.
53. Wan FJ, Caine SB, Swerdlow NR (1996a) The ventral subiculum modulation of prepulse inhibition is not mediated via D2 dopamine or nucleus accumbens non-NMDA glutamate activity. Eur J Pharmacol 314:9-18.
54. Wan FJ, Taaid N, Swerdlow NR (1996b) Do D1/D2 interactions regulate prepulse inhibition in rats? Neuropsychopharmacology 14:265-274.
55. Weiss IC, Feldon J, Domeney A (1999) Circadian time does not modify the prepulse inhibition response or its attenuation by apomorphine. Pharmacol Biochem Behav 64:501-505.