Development of DNA topoisomerase-related therapeutics: A short perspective of new challenges

Current Medicinal Chemistry - Anti-Cancer Agents

Volumn 4, Issue 4, 2004, Pages 335-345

  Capranico, Giovanni ^a,b   Zagotto, Giuseppe ^a,b   Palumbo, Manlio ^a,b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Cancer; Crystal structures; Drug receptor; Protein toxins; Topoisomerase; Topoisomerase directed drugs

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; ALKANNIN; ANTHRACYCLINE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE; BETA LAPACHONE; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; CARBAZOLE DERIVATIVE; CLEROCIDIN; CYTOTOXIC AGENT; DITERPENOID; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; ECTEINASCIDIN; EPIPODOPHYLLOTOXIN; ETOPOSIDE; GEMCITABINE; NATURAL PRODUCT; NUCLEAR PROTEIN; PRODRUG; PSOROSPERMIN; REBECCAMYCIN; SALVICINE; SHIKONIN; STAUROSPORINE DERIVATIVE; TOPOTECAN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER SURVIVAL; CANCER THERAPY; CHROMOSOME CONDENSATION; CHROMOSOME SEGREGATION; DNA RECOMBINATION; DNA REPLICATION; DNA TRANSCRIPTION; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG TARGETING; DRUG TRANSFORMATION; ENZYME ACTIVITY; ENZYME STRUCTURE; HUMAN; NONHUMAN; PROTEIN FAMILY; REGULATORY MECHANISM; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; DNA DAMAGE; DNA REPAIR; DNA TOPOISOMERASES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; NEOPLASMS;

EID: 3142662140     PISSN: 15680118     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568011043352885     Document Type: Review

References (99)

1. Wang, J. C. Nat. Rev. Mol. Cell Biol., 2002, 3, 430-440.
2. Wang, J. C. Annu. Rev. Biochem., 1996, 65, 635-692.
3. Champoux, J. J. Annu. Rev. Biochem., 2001, 70, 369-413.
4. Sharma, A. and Mondragon, A. Curr. Opin. Struct. Biol., 1995, 5, 39-47.
5. Maxwell, A. Biochem. Soc. Trans., 1999, 27, 48-53.
6. Liu, L. F. Annu. Rev. Biochem., 1989, 58, 351-375.
7. Pourquier, P. and Pommier, Y. Adv. Cancer Res., 2001, 80, 189-216.
8. Nitiss, J. L. Biochim. Biophys. Acta, 1998, 1400, 63-81.
9. Capranico, G.; Binaschi, M.; Borgnetto, M. E.; Zunino, F.; and Palumbo, M. Trends Pharmacol. Sci., 1997, 18, 323-329.
10. Li, T. K. and Liu, L. F. Annu. Rev. Pharmacol. Toxicol., 2001, 41, 53-77.
11. Kohn, K. W.; Shao, R. G.; and Pommier, Y. Cell Biochem. Biophys., 2000, 33, 175-180.
12. Walker, J. V. and Nitiss, J. L. Cancer Invest, 2002, 20, 570-589.
13. Fiorani, P. and Bjornsti, M. A. Ann. N. Y. Acad. Sci., 2000, 922, 65-75.
14. Anderson, V. E. and Osheroff, N. Curr. Pharm. Des, 2001, 7, 337-353.
15. Van Melderen, L. Int. J. Med. Microbiol., 2002, 291, 537-544.
16. Saleem, A.; Edwards, T. K.; Rasheed, Z.; and Rubin, E. H. Ann. N. Y. Acad. Sci., 2000, 922, 46-55.
17. Beck, W. T.; Mo, Y. Y.; and Bhat, U. G. Biochem. Soc. Trans., 2001, 29, 702-703.
18. Gatto, B.; Capranico, G.; and Palumbo, M. Current Pharmaceutical Design, 1999, 5, 195-215.
19. Cheng, C.; Kussie, P.; Pavletich, N. and Shuman, S. Cell, 1998, 92, 841-850.
20. Petersen, B. O. and Shuman, S. J. Biol. Chem., 1997, 272, 3891-3896.
21. Krogh, B. O. and Shuman, S. Mol. Cell, 2000, 5, 1035-1041.
22. Redinbo, M. R.; Stewart, L.; Kuhn, P.; Champoux, J. J. and Hol, W. G. Science, 1998, 279, 1504-1513.
23. Krogh, B. O. and Shuman, S. Proc. Natl. Acad. Sci. USA, 2002, 99, 1853-1858.
24. Lesher, D. T.; Pommier, Y.; Stewart, L. and Redinbo, M. R. Proc. Natl. Acad. Sci. USA, 2002, 99, 12102-12107.
25. Belova, G. I.; Prasad, R.; Kozyavkin, S. A.; Lake, J. A.; Wilson, S. H. and Slesarev, A. I. Proc. Natl. Acad. Sci. USA, 2001, 98, 6015-6020.
26. Belova, G. I.; Prasad, R.; Nazimov, I. V.; Wilson, S. H.; and Slesarev, A. I. J. Biol. Chem., 2002, 277, 4959-4965.
27. Changela, A.; DiGate, R. J.; and Mondragon, A. Crystal structure of a complex of a type IA DNA topoisomerase with a single-stranded DNA molecule. Nature, 2001, 411, 1077-1081.
28. Rodriguez, A. C. and Stock, D. EMBO J., 2002, 21, 418-426.
29. Rodriguez, A. C. J. Biol. Chem., 2002, 277, 29865-29873.
30. Davies, D. R.; Interthal, H.; Champoux, J. J. and Hol, W. G. The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1. Structure. (Camb.), 2002, 10, 237-248.
31. Bencharit, S.; Morton, C. L.; Howard-Williams, E. L.; Danks, M. K.; Potter, P. M. and Redinbo, M. R. Nat. Struct. Biol., 2002, 9, 337-342.
32. Staker, B. L.; Hjerrild, K.; Feese, M. D.; Behnke, C. A.; Burgin, A. B. Jr. and Stewart, L. Proc. Natl. Acad. Sci. USA, 2002, 99, 15387-15392.
33. Jaxel, C.; Capranico, G.; Kerrigan, D.; Kohn, K. W. and Pommier, Y. J. Biol. Chem., 1991, 266, 20418-20423.
34. Champoux, J. J. and Aronoff, R. J. Biol. Chem., 1989, 264, 1010-1015.
35. Fan, Y.; Weinstein, J. N.; Kohn, K. W.; Shi, L. M. and Pommier, Y. Journal of Medicinal Chemistry, 1998, 41, 2216-2226.
36. Elsea, S. H.; Westergaard, M.; Burden, D. A.; Lomenick, J. P. and Osheroff, N. Biochemistry, 1997, 36, 2919-2924.
37. Wang, H.; Mao, Y.; Zhou, N.; Hu, T.; Hsieh, T. S. and Liu, L. F. J. Biol. Chem., 2001, 276, 15990-15995.
38. Dong, J.; Walker, J. and Nitiss, J. L. A mutation in yeast topoisomerase II that confers hypersensitivity to multiple classes of topoisomerase II poisons. J. Biol. Chem., 2000, 275, 7980-7987.
39. Strahl-Bolsinger, S.; Hecht, A.; Luo, K. and Grunstein, M. Genes Dev., 1997, 11, 83-93.
40. Strumberg, D.; Nitiss, J. L.; Dong, J.; Kohn, K. W. and Pommier, Y. J. Biol. Chem., 1999, 274, 28246-28255.
41. Strumberg, D.; Nitiss, J. L.; Rose, A.; Nicklaus, M. C. and Pommier, Y. J. Biol. Chem., 1999, 274, 7292-7301.
42. Moro, S.; Beretta, G.L.; Dal Ben, D.; Nitiss, J.; Palumbo, M. and Capranico G. Biochemistty, 2004, in press.
43. Leroy, D.; Kajava, A. V.; Frei, C. and Gasser, S. M. Biochemistry, 2001, 40, 1624-1634.
44. Vilain, N.; Tsai-Pflugfelder, M.; Benoit, A.; Gasser, S. M. and Leroy, D. Nucleic Acids Res., 2003, 31, 5714-5722.
45. Bailly, C. Curr. Med. Chem., 2000, 7, 39-58.
46. Meng, L. H.; Liao, Z. Y. and Pommier, Y. Curr. Top. Med. Chem., 2003, 3, 305-320.
47. Prudhomme, M. Eur. J. Med. Chem., 2003, 38, 123-140.
48. Denny, W. A. and Baguley, B. C. Curr. Top. Med. Chem., 2003, 3, 339-353.
49. Walker, J. V. and Nitiss, J. L. Cancer Invest., 2002, 20, 570-589.
50. Larsen, A. K.; Escargueil, A. E. and Skladanowski, A. Pharmacol. Ther., 2003, 99, 167-181.
51. Wilstermann, A. M. and Osheroff, N. Curr. Top. Med. Chem., 2003, 3, 321-338.
52. Holden, J. A. Curr. Med. Chem. Anti. -Canc. Agents, 2001, 1, 1-25.
53. Li, T. K. and Liu, L. F. Annu. Rev. Pharmacol. Toxicol., 41, 53-77., 2001, 53-77.
54. Kawada, S.; Yamashita, Y.; Fujii, N. and Nakano, H. Cancer Res., 1991, 51, 2922-2925.
55. Aune, G. J.; Furuta, T. and Pommier, Y. Anticancer Drugs, 2002, 13, 545-555.
56. Schwartsmann, G.; Brondani, d. R.; Berlinck, R. G. and Jimeno, J. Lancet Oncol., 2001, 2, 221-225.
57. Kupchan, S. M.; Streelman, D. R. and Sneden, A. T. J. Nat. Prod., 1980, 43, 296-301.
58. Takebayashi, Y.; Pourquier, P.; Yoshida, A.; Kohlhagen, G. and Pommier, Y. Proc. Natl. Acad. Sci. USA, 1999, 96, 7196-7201.
59. Marco, E.; Garcia-Nieto, R.; Mendieta, J.; Manzanares, I.; Cuevas, C. and Gago, F. J. Med. Chem., 2002, 45, 871-880.
60. Jin, S.; Gorfajn, B.; Faircloth, G. and Scotto, K. W. Proc. Natl. Acad. Sci. USA, 2000, 97, 6775-6779.
61. Kwok, Y. and Hurley, L. H. J. Biol. Chem., 1998, 273, 33020-33026.
62. Kwok, Y.; Zeng, Q. and Hurley, L. H. Proc. Natl. Acad. Sci. USA, 95, 1998, 13531-13536.
63. Kawada, S.; Yamashita, Y.; Fujii, N. and Nakano, H. Cancer Res., 1991, 51, 2922-2925.
64. Binaschi, M.; Zagotto, G.; Palumbo, M.; Zunino, F.; Farinosi, R. and Capranico, G. Cancer Res., 1997, 57, 1710-1716.
65. Gatto, B.; Richter, S.; Moro, S.; Capranico, G. and Palumbo, M. Nucleic Acids Res., 2001, 29, 4224-4230.
66. Richter, S.; Gatto, B.; Fabris, D.; Takao, K.; Kobayashi, S. and Palumbo, M. Nucleic Acids Res., 2003, 31, 5149-5156.
67. Meng, L. H.; Zhang, J. S. and Ding, J. Biochem. Pharmocol., 2001, 62, 733-741.
68. Kim, M. Y.; Na, Y.; Vankayalapati, H.; Gleason-Guzman, M. and Hurley, L. H. J. Med. Chem., 2003, 46, 2958-2972.
69. Klemm, M.; Cheng, C.; Cassell, G.; Shuman, S. and Segall, A. M. J. Mol. Biol., 2000, 299, 1203-1216.
70. Pourquier, P.; Gioffre, C.; Kohlhagen, G.; Urasaki, Y.; Goldwasser, F.; Hertel, L. W.; Yu, S.; Pon, R. T.; Gmeiner, W. H. and Pommier, Y. Clin. Cancer Res., 2002, 8, 2499-2504.
71. Sanchez, C.; Butovich, I. A.; Brana, A. F.; Rohr, J.; Mendez, C. and Salas, J. A. Chem. Biol., 2002, 9, 519-531.
72. Akinaga, S.; Sugiyama, K. and Akiyama, T. Anticancer Drug Des, 2000, 15, 43-52.
73. Marminon, C.; Pierre, A.; Pfeiffer, B.; Perez, V.; Leonce, S. Joubert, A.; Bailly, C.; Renard, P.; Hickman, J. and Prudhomme, M. Journal of Medicinal Chemistry, 2003, 46, 609-622.
74. Arimondo, P. B.; Boutorine, A.; Baldeyrou, B.; Bailly, C.; Kuwahara, M.; Hecht, S. M.; Sun, J. S.; Garestier, T. and Helene, C. J. Biol. Chem., 2002, 277, 3132-3140.
75. Arimondo, P. B.; Bailly, C.; Boutorine, A. S.; Moreau, P.; Prudhomme, M.; Sun, J. S.; Garestier, T. and Helene, C. Bioconjug. Chem., 2001, 12, 501-509.
76. Wang, C. C. C. and Dervan, P. B. Journal of the American Chemical Society, 2001, 123, 8657-8661.
77. Dudouet, B.; Burnett, R.; Dickinson, L. A.; Wood, M. R.; Melander, C.; Belitsky, J. M.; Edelson, B.; Wurtz, N.; Briehn, C.; Dervan, P. B. and Gottesfeld, J. M. Chem. Biol., 2003, 10, 859-867.
78. Samata, K.; Yamagishi, T.; Ichihara, T.; Nanaumi, K.; Ikeda, T.; Ikeya, H.; Kuraishi, A.; Nakaike, S.; Kashiwagi, K. and Igarashi, K. Cancer Chemother. Pharmacol., 2002, 50, 367-372.
79. Papageorgiou, V. P.; Assimopoulou, A. N.; Couladouros, E. A.; Hepworth, D. and Nicolaou, K. C. Angewandte Chemie International Edition, 1999, 38, 271-300.
80. Song, G. Y.; Kim, Y.; You, Y. J.; Cho, H.; Kim, S. H.; Sok, D. E. and Ahn, B. Z. Archiv Der Pharmazie, 2000, 333, 87-92.
81. Ting, C. Y.; Hsu, C. T.; Hsu, H. T.; Su, J. S.; Chen, T. Y.; Tarn, W. Y.; Kuo, Y. H.; Whang-Peng, J.; Liu, L. F. and Hwang, J. Biochem. Pharmacol., 2003, 66, 1981-1991.
82. Vicker, N.; Burgess, L.; Chuckowree, I. S.; Dodd, R.; Folkes, A. J.; Hardick, D. J.; Hancox, T. C.; Miller, W.; Milton, J.; Sohal, S.; Wang, S.; Wren, S. P.; Charlton, P. A.; Dangerfield, W.; Liddle, C.; Mistry, P.; Stewart, A. J. and Denny, W. A. J. Med. Chem., 2002, 45, 721-739.
83. Renodon-Corniere, A.; Jensen, L. H.; Nitiss, J. L.; Jensen, P. B. and Sehested, M. Biochemistry, 2002, 41, 13395-13402.
84. Pavlov, A. R.; Belova, G. I.; Kozyavkin, S. A. and Slesarev, A. I. Proc. Natl. Acad. Sci. USA, 2002, 99, 13510-13515.
85. Singh, S. K.; Ruchelman, A. L.; Li, T. K.; Liu, A.; Liu, L. F. and LaVoie, E. J. Journal of Medicinal Chemistry, 2003, 46, 2254-2257.
86. Vicker, N.; Burgess, L.; Chuckowree, I. S.; Dodd, R.; Folkes, A. J.; Hardick, D. J.; Hancox, T. C.; Miller, W.; Milton, J.; Sohal, S.; Wang, S. M.; Wren, S. P.; Charlton, P. A.; Dangerfield, W.; Liddle, C.; Mistry, P.; Stewart, A. J. and Denny, W. A. Journal of Medicinal Chemistry, 2002, 45, 721-739.
87. Peters, K. B. and Brown, J. M. Cancer Res., 2002, 62, 5248-5253.
88. Yakisich, J. S.; Siden, A.; Encroth, P. and Cruz, M. Biochem. Biophys. Res. Commun., 2001, 289, 586-590.
89. Gao, H.; Huang, K. C.; Yamasaki, E. F.; Chan, K. K.; Chohan, L. and Snapka, R. M. Proc. Natl. Acad. Sci. USA, 1999, 96, 12168-12173.
90. Barthelmes, H. U.; Niederberger, E.; Roth, T.; Schulte, K.; Tang, W. C.; Boege, F.; Fiebig, H. H.; Eisenbrand, G. and Marko, D. Br. J. Cancer, 2001, 85, 1585-1591.
91. Errington, F.; Willmore, E.; Tilby, M. J.; Li, L.; Li, G.; Li, W.; Baguley, B. C. and Austin, C. A. Mol. Pharmacol., 1999, 56, 1309-1316.
92. Binaschi, M.; Farinosi, R.; Borgnetto, M. E. and Capranico, G. Cancer Res., 2000, 60, 3770-3776.
93. Levin, N. A.; Bjornsti, M. -A. and Fink, G. R. Genetics, 1993, 133, 799-814.
94. Hann, C. L.; Carlberg, A. L. and Bjornsti, M. A. Journal of Biological Chemistry, 1998, 273, 31519-31527.
95. Madden, K. R. and Champoux, J. J. Cancer Res., 1992, 52, 525-532.
96. Scaldaferro, S.; Tinelli, S.; Borgnetto, M. E.; Azzini, A. and Capranico, G. Chem. Biol., 2001, 8, 871-881.
97. Stewart, L.; Redinbo, M. R.; Qiu, X.; Hol, W. G. and Champoux, J. J. Science, 1998, 279, 1534-1541.
98. Beretta, G. L.; Binaschi, M.; Zagni, E.; Capuani, L. and Capranico, G. Cancer Res., 1999, 59. 3689-3697.
99. Alessandri, M.; Beretta, G. L.; Ferretti, E.; Mancia, A.; Khobta, A. and Capranico, G. J. Mol. Biol., 2004, 337, 295-305.