Mutation of a conserved serine residue in a quinolone-resistant type II topoisomerase alters the enzyme-DNA and drug interactions

Journal of Biological Chemistry

Volumn 274, Issue 11, 1999, Pages 7292-7301

  Strumberg, Dirk ^a   Nitiss, John L ^b   Rose, Angela ^b   Nicklaus, Marc C ^a   Pommier, Yves ^a,c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE; QUINOLONE DERIVATIVE; SERINE;

ARTICLE; CHROMOSOME SEGREGATION; CHROMOSOME STRUCTURE; COMPLEX FORMATION; DNA BINDING; DNA CLEAVAGE; DNA REPLICATION; ENZYME ACTIVITY; GENE MUTATION; GENETIC CONSERVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; STRUCTURAL GENE;

AMINO ACID SUBSTITUTION; BASE SEQUENCE; DNA; DNA PRIMERS; DNA TOPOISOMERASES, TYPE II; ENZYME STABILITY; ETOPOSIDE; HEAT; HYDROLYSIS; PROTEIN CONFORMATION; QUINOLONES; RECOMBINANT PROTEINS; SALTS; SERINE;

EID: 0033548660     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.11.7292     Document Type: Article

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