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Volumn 15, Issue 1, 2000, Pages 43-52

UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: A new generation of anti-cancer agents for the new century?

Author keywords

Apoptosis; Cell cycle checkpoint; Indolocarbazole; Protein kinase; Topoisomerase; UCN 01

Indexed keywords

6 FORMYLAMINO 12,13 DIHYDRO 1,11 DIHYDROXY 5H INDOLO[2,3 A][PYRROLO[3,4 C]CARBAZOLE 5,7(6H) DIONE 13 GLUCOSIDE; 7 HYDROXYSTAUROSPORINE; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; CARBAZOLE DERIVATIVE; CEP 751; MIDOSTAURIN; PROTEIN KINASE INHIBITOR; REBECCAMYCIN; UNCLASSIFIED DRUG;

EID: 0034040974     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (111)

References (76)
  • 1
    • 0026081048 scopus 로고
    • Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases
    • Abe K., Yoshida M., Usui T., Horiuchi S., Beppu T. (1991) Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases. Experimental Cell Research, 192, 122.
    • (1991) Experimental Cell Research , vol.192 , pp. 122
    • Abe, K.1    Yoshida, M.2    Usui, T.3    Horiuchi, S.4    Beppu, T.5
  • 2
    • 0026425587 scopus 로고
    • Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models
    • Akinaga S., Gomi K., Morimoto M., Tamaoki T., Okabe M. (1991) Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models. Cancer Research, 51, 4888.
    • (1991) Cancer Research , vol.51 , pp. 4888
    • Akinaga, S.1    Gomi, K.2    Morimoto, M.3    Tamaoki, T.4    Okabe, M.5
  • 4
    • 0027363666 scopus 로고
    • Diverse effects of indolocarbazole compounds on the cell cycle progression of ras-transformed rat fibroblast cells
    • Akinaga S., Nomura K., Gomi K., Okabe M. (1993a) Diverse effects of indolocarbazole compounds on the cell cycle progression of ras-transformed rat fibroblast cells. Journal of Antibiotics, 46, 1767.
    • (1993) Journal of Antibiotics , vol.46 , pp. 1767
    • Akinaga, S.1    Nomura, K.2    Gomi, K.3    Okabe, M.4
  • 5
    • 0027232037 scopus 로고
    • Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C
    • Akinaga S., Nomura K., Gomi K., Okabe M. (1993b) Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C. Cancer Chemotherapy and Pharmacology, 32, 183.
    • (1993) Cancer Chemotherapy and Pharmacology , vol.32 , pp. 183
    • Akinaga, S.1    Nomura, K.2    Gomi, K.3    Okabe, M.4
  • 6
    • 0028057513 scopus 로고
    • Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells
    • Akinaga S., Nomura K., Gomi K., Okabe M. (1994) Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells. Cancer Chemotherapy and Pharmacology, 33, 273.
    • (1994) Cancer Chemotherapy and Pharmacology , vol.33 , pp. 273
    • Akinaga, S.1    Nomura, K.2    Gomi, K.3    Okabe, M.4
  • 7
    • 0030615323 scopus 로고    scopus 로고
    • 1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdil in p53-mutated human epidermoid carcinoma A431 cells
    • 1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdil in p53-mutated human epidermoid carcinoma A431 cells. Cancer Research, 57, 1495.
    • (1997) Cancer Research , vol.57 , pp. 1495
    • Akiyama, T.1    Yoshida, T.2    Tsujita, T.3    Shimizu, M.4    Mizukami, T.5    Okabe, M.6    Akinaga, S.7
  • 10
    • 0028905348 scopus 로고
    • Novel indolocarbazole compound 6-N-formylamino-12, 13-dihydro-1, 11-dihydroxy-13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo-[3,4-c] carbazole-5,7(6H)-dione (NB-506): Its potent antitumor activities in mice
    • Arakawa H., Iguchi T., Morita M., Yoshinari T., Kojiri K., Suda H., Okura A., Nishimura S. (1995) Novel indolocarbazole compound 6-N-formylamino-12, 13-dihydro-1, 11-dihydroxy-13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo-[3,4-c] carbazole-5,7(6H)-dione (NB-506): its potent antitumor activities in mice. Cancer Research, 55, 1316.
    • (1995) Cancer Research , vol.55 , pp. 1316
    • Arakawa, H.1    Iguchi, T.2    Morita, M.3    Yoshinari, T.4    Kojiri, K.5    Suda, H.6    Okura, A.7    Nishimura, S.8
  • 11
    • 0031012175 scopus 로고    scopus 로고
    • Chemosensitization of cancer cells by the staurosporine derivative CGP 41251 in association with decreased P-glycoprotein phosphorylation
    • Beltran P.J., Fan D., Fidler I.J., O'Brian C.A. (1997) Chemosensitization of cancer cells by the staurosporine derivative CGP 41251 in association with decreased P-glycoprotein phosphorylation. Biochemical Pharmacology, 53, 245.
    • (1997) Biochemical Pharmacology , vol.53 , pp. 245
    • Beltran, P.J.1    Fan, D.2    Fidler, I.J.3    O'Brian, C.A.4
  • 13
    • 0032961049 scopus 로고    scopus 로고
    • Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion
    • Bredel M., Pollack I.F., Freund J.M., Rusnak J., Lazo J.S. (1999) Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion. Journal of Neuro-Oncology, 41, 9.
    • (1999) Journal of Neuro-Oncology , vol.41 , pp. 9
    • Bredel, M.1    Pollack, I.F.2    Freund, J.M.3    Rusnak, J.4    Lazo, J.S.5
  • 14
    • 0026501878 scopus 로고
    • Different effects of staurosporine, an inhibitor of protein kinases, on the cell cycle and chromatin structure of normal and leukemic lymphocytes
    • Bruno S., Ardelt B., Skierski J.S., Traganos F., Darzynkiewicz Z. (1992) Different effects of staurosporine, an inhibitor of protein kinases, on the cell cycle and chromatin structure of normal and leukemic lymphocytes. Cancer Research, 51, 470.
    • (1992) Cancer Research , vol.51 , pp. 470
    • Bruno, S.1    Ardelt, B.2    Skierski, J.S.3    Traganos, F.4    Darzynkiewicz, Z.5
  • 15
    • 0029992520 scopus 로고    scopus 로고
    • Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor
    • Bunch R.T., Eastman A. (1996) Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor. Clinical Cancer Research, 2, 791.
    • (1996) Clinical Cancer Research , vol.2 , pp. 791
    • Bunch, R.T.1    Eastman, A.2
  • 16
    • 0030811613 scopus 로고    scopus 로고
    • 7-Hydroxystaurosporine (UCN-01) causes redistribution of proliferating cell nuclear antigen and abrogates cisplatin-induced S phase arrest in Chinese hamster ovary cells
    • Bunch R.T., Eastman A. (1997) 7-Hydroxystaurosporine (UCN-01) causes redistribution of proliferating cell nuclear antigen and abrogates cisplatin-induced S phase arrest in Chinese hamster ovary cells. Cell Growth and Differentiation, 8, 779.
    • (1997) Cell Growth and Differentiation , vol.8 , pp. 779
    • Bunch, R.T.1    Eastman, A.2
  • 19
    • 0031588369 scopus 로고    scopus 로고
    • Characterisation of novel human lung carcinoma cell lines selected for resistance to antineoplastic analogues of staurosporine
    • Courage C., Bradder S.M., Jones T., Schultze-Mosgau M.H., Gescher A. (1997) Characterisation of novel human lung carcinoma cell lines selected for resistance to antineoplastic analogues of staurosporine. International Journal of Cancer, 73, 763.
    • (1997) International Journal of Cancer , vol.73 , pp. 763
    • Courage, C.1    Bradder, S.M.2    Jones, T.3    Schultze-Mosgau, M.H.4    Gescher, A.5
  • 27
    • 0033563119 scopus 로고    scopus 로고
    • Sustained in vivo regression of Dunning H rat prostate cancers treated with combination of androgen ablation and trk tyrosine kinase inhibitors, CEP-751 (KT6587) or CEP-701 (KT5555)
    • George D.J., Dionne C.A., Jani J., Angeles T., Murakata C., Lamb J., Issacs J.T. (1999) Sustained in vivo regression of Dunning H rat prostate cancers treated with combination of androgen ablation and trk tyrosine kinase inhibitors, CEP-751 (KT6587) or CEP-701 (KT5555). Cancer Research, 59, 2395.
    • (1999) Cancer Research , vol.59 , pp. 2395
    • George, D.J.1    Dionne, C.A.2    Jani, J.3    Angeles, T.4    Murakata, C.5    Lamb, J.6    Issacs, J.T.7
  • 28
    • 0032213794 scopus 로고    scopus 로고
    • Analogs of staurosporine: Potential anticancer drugs?
    • Gescher A. (1998) Analogs of staurosporine: potential anticancer drugs? General Pharmacology, 31, 721.
    • (1998) General Pharmacology , vol.31 , pp. 721
    • Gescher, A.1
  • 31
    • 0031725379 scopus 로고    scopus 로고
    • Modulation of apoptosis in rat thymocytes by analogs of staurosporine: Lack of direct association with inhibition of protein kinase C
    • Harkin S.T., Cohen G.M., Gescher A. (1998) Modulation of apoptosis in rat thymocytes by analogs of staurosporine: lack of direct association with inhibition of protein kinase C. Molecular Pharmacology, 54, 663.
    • (1998) Molecular Pharmacology , vol.54 , pp. 663
    • Harkin, S.T.1    Cohen, G.M.2    Gescher, A.3
  • 32
    • 0031670310 scopus 로고    scopus 로고
    • UCN-01 suppresses thymidylate synthase gene expression and enhances 5-fluorouracil-induced apoptosis in a sequence-dependent manner
    • Hsueh C.T., Kelsen D., Schwartz G.K. (1998) UCN-01 suppresses thymidylate synthase gene expression and enhances 5-fluorouracil-induced apoptosis in a sequence-dependent manner. Clinical Cancer Research, 4, 2201.
    • (1998) Clinical Cancer Research , vol.4 , pp. 2201
    • Hsueh, C.T.1    Kelsen, D.2    Schwartz, G.K.3
  • 33
    • 0030706078 scopus 로고    scopus 로고
    • UCN-01 in ovary cancer cells: Effective as a single agent and in combination with cisdiamminedichloroplatinum(II) independent of p53 status
    • Husain A., Yan X.J., Rosales N., Aghajanian C., Schwartz O.K., Spriggs D.R. (1997) UCN-01 in ovary cancer cells: Effective as a single agent and in combination with cisdiamminedichloroplatinum(II) independent of p53 status. Clinical Cancer Research, 3, 2089.
    • (1997) Clinical Cancer Research , vol.3 , pp. 2089
    • Husain, A.1    Yan, X.J.2    Rosales, N.3    Aghajanian, C.4    Schwartz, O.K.5    Spriggs, D.R.6
  • 34
    • 0029877641 scopus 로고    scopus 로고
    • Effects of the new selective protein kinase C inhibitor 4′-N-benzoyl staurosporine on cell cycle distribution and growth inhibition in human small cell lung cancer cells
    • Ikegami Y., Yano S., Nakano K. (1996) Effects of the new selective protein kinase C inhibitor 4′-N-benzoyl staurosporine on cell cycle distribution and growth inhibition in human small cell lung cancer cells. Arzneimittel-Forschung/Drug Research, 46, 201.
    • (1996) Arzneimittel-Forschung/Drug Research , vol.46 , pp. 201
    • Ikegami, Y.1    Yano, S.2    Nakano, K.3
  • 36
    • 0029871688 scopus 로고    scopus 로고
    • UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line
    • Kawakami K., Futami H., Takahara J., Yamaguchi K. (1996) UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line. Biochemical and Biophysical Research Communications, 219, 778.
    • (1996) Biochemical and Biophysical Research Communications , vol.219 , pp. 778
    • Kawakami, K.1    Futami, H.2    Takahara, J.3    Yamaguchi, K.4
  • 41
    • 0024379951 scopus 로고
    • A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity
    • Meyer T., Regenass U., Fabbro D., Alteri E., Rosel J., Muller M., Caravatti G., Matter A. (1989) A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity. International Journal of Cancer, 43, 851.
    • (1989) International Journal of Cancer , vol.43 , pp. 851
    • Meyer, T.1    Regenass, U.2    Fabbro, D.3    Alteri, E.4    Rosel, J.5    Muller, M.6    Caravatti, G.7    Matter, A.8
  • 44
    • 0032970814 scopus 로고    scopus 로고
    • Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI anticancer drug screen: Multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase pathway
    • Nieves-Neira W, Pommier Y. (1999) Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI anticancer drug screen: multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase pathway. International Journal of Cancer, 82, 396.
    • (1999) International Journal of Cancer , vol.82 , pp. 396
    • Nieves-Neira, W.1    Pommier, Y.2
  • 46
    • 0030694346 scopus 로고    scopus 로고
    • Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-derived sympathetic neurons
    • Park D.S., Levine B., Ferrari G, Greene L.A. (1997) Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-derived sympathetic neurons. Journal of Neuroscience, 17, 8975.
    • (1997) Journal of Neuroscience , vol.17 , pp. 8975
    • Park, D.S.1    Levine, B.2    Ferrari, G.3    Greene, L.A.4
  • 47
    • 0029938768 scopus 로고    scopus 로고
    • Blocking of glioma proliferation in vitro and in vivo and potentiating the effects of BCNU and cisplatin: UCN-01, a selective protein kinase C inhibitor
    • Pollack I.F., Kawecki S., Lazo J.S. (1996) Blocking of glioma proliferation in vitro and in vivo and potentiating the effects of BCNU and cisplatin: UCN-01, a selective protein kinase C inhibitor. Journal of Neurosurgery, 84, 1024.
    • (1996) Journal of Neurosurgery , vol.84 , pp. 1024
    • Pollack, I.F.1    Kawecki, S.2    Lazo, J.S.3
  • 49
  • 51
    • 0028959525 scopus 로고
    • Effects of protein kinase C inhibitor, staurosporine derivative CGP 41251, on cell cycle, DNA synthesis and drug uptake in neoplastic cell lines
    • Sedlak J., Hunakova L., Duraj J., Chorvath B., Novotny L. (1995) Effects of protein kinase C inhibitor, staurosporine derivative CGP 41251, on cell cycle, DNA synthesis and drug uptake in neoplastic cell lines. Anti-Cancer Drugs, 6, 70.
    • (1995) Anti-Cancer Drugs , vol.6 , pp. 70
    • Sedlak, J.1    Hunakova, L.2    Duraj, J.3    Chorvath, B.4    Novotny, L.5
  • 52
    • 0342618467 scopus 로고    scopus 로고
    • Protein kinase inhibitor-induced alterations of drug uptake, cell cycle and surface antigen expression in human multidrug-resistant (PgP and MRP) promyelocytic leukemia HL-60 cells
    • Sedlak J., Hunakova L., Sulikova M., Chorvath B. (1997) Protein kinase inhibitor-induced alterations of drug uptake, cell cycle and surface antigen expression in human multidrug-resistant (PgP and MRP) promyelocytic leukemia HL-60 cells. Leukemia Research, 21, 449.
    • (1997) Leukemia Research , vol.21 , pp. 449
    • Sedlak, J.1    Hunakova, L.2    Sulikova, M.3    Chorvath, B.4
  • 54
    • 0027157590 scopus 로고
    • Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells
    • Seynaeve C.M., Stetler-Stevenson M., Sebers S., Kaur G., Sausville E.A., Worland P.J. (1993) Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells. Cancer Research, 53, 2081.
    • (1993) Cancer Research , vol.53 , pp. 2081
    • Seynaeve, C.M.1    Stetler-Stevenson, M.2    Sebers, S.3    Kaur, G.4    Sausville, E.A.5    Worland, P.J.6
  • 56
    • 0031282980 scopus 로고    scopus 로고
    • Activation of PKCa downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL-60 cells
    • Shao R.G., Cao C.X., Pommier Y. (1997a) Activation of PKCa downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL-60 cells. Journal of Biological Chemistry, 272, 31321.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 31321
    • Shao, R.G.1    Cao, C.X.2    Pommier, Y.3
  • 57
    • 0030870632 scopus 로고    scopus 로고
    • Abrogation of an S phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function
    • Shao R.G., Cao C.X., Shimizu T., O'Connor P.M., Kohn K.W., Pommier Y. (1997b) Abrogation of an S phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function. Cancer Research, 57, 4029.
    • (1997) Cancer Research , vol.57 , pp. 4029
    • Shao, R.G.1    Cao, C.X.2    Shimizu, T.3    O'Connor, P.M.4    Kohn, K.W.5    Pommier, Y.6
  • 58
    • 0031213555 scopus 로고    scopus 로고
    • 7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53
    • Shao R.G., Shimizu T., Pommier Y. (1997e) 7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53. Experimental Cell Research, 234, 388.
    • (1997) Experimental Cell Research , vol.234 , pp. 388
    • Shao, R.G.1    Shimizu, T.2    Pommier, Y.3
  • 59
    • 0033104517 scopus 로고    scopus 로고
    • Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes
    • Shao R.G., Cao C.X., Zhang H., Kohn K.W., Wold M.S., Pommier Y. (1999) Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO Journal, 18, 1397.
    • (1999) EMBO Journal , vol.18 , pp. 1397
    • Shao, R.G.1    Cao, C.X.2    Zhang, H.3    Kohn, K.W.4    Wold, M.S.5    Pommier, Y.6
  • 61
    • 0003355733 scopus 로고    scopus 로고
    • Induction of apoptosis without cell cycle progression by UCN-01 abrogates gemcitabine induced S phase arrest in human myeloid ML-1 cells
    • Shi Z., Plunkett W. (1999) Induction of apoptosis without cell cycle progression by UCN-01 abrogates gemcitabine induced S phase arrest in human myeloid ML-1 cells. Proceedings of the American Association for Cancer Research, 40, 305.
    • (1999) Proceedings of the American Association for Cancer Research , vol.40 , pp. 305
    • Shi, Z.1    Plunkett, W.2
  • 68
    • 0025840518 scopus 로고
    • Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a
    • Usui T., Yoshida M., Abe K., Osada H., Isono K., Beppu T. (1991) Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a. Journal of Cell Biology, 115, 1275.
    • (1991) Journal of Cell Biology , vol.115 , pp. 1275
    • Usui, T.1    Yoshida, M.2    Abe, K.3    Osada, H.4    Isono, K.5    Beppu, T.6
  • 70
    • 0028990479 scopus 로고
    • Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2
    • Wang Q., Worland P.J., Clark J.L., Carlson B.A., Sausville E.A. (1995) Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2. Cell Growth and Differentiation, 6, 927.
    • (1995) Cell Growth and Differentiation , vol.6 , pp. 927
    • Wang, Q.1    Worland, P.J.2    Clark, J.L.3    Carlson, B.A.4    Sausville, E.A.5
  • 72
    • 0031469395 scopus 로고    scopus 로고
    • Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-β-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress bcl-2
    • Wang S., Vrana J.A., Bartimole T.M., Freemerman A.J., Jarvis W.D., Kramer L.B., Krystal G., Dent P., Grant S. (1997) Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-β-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress bcl-2. Molecular Pharmacology, 52, 1000.
    • (1997) Molecular Pharmacology , vol.52 , pp. 1000
    • Wang, S.1    Vrana, J.A.2    Bartimole, T.M.3    Freemerman, A.J.4    Jarvis, W.D.5    Kramer, L.B.6    Krystal, G.7    Dent, P.8    Grant, S.9
  • 74
    • 0026678588 scopus 로고
    • Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives
    • Yamashita Y., Fujii N., Murakata C., Ashizawa T., Okabe M., Nakano H. (1992) Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives. Biochemistry, 31, 12069.
    • (1992) Biochemistry , vol.31 , pp. 12069
    • Yamashita, Y.1    Fujii, N.2    Murakata, C.3    Ashizawa, T.4    Okabe, M.5    Nakano, H.6
  • 75
    • 0028931509 scopus 로고
    • Novel antitumor indolocarbazole compound 6-N-formylamino-12, 13-dihydro-1, 11-dihydroxy-13-(beta-D-glucopyranosyl)-5H-indolo[2, 3-a]pyrrolo[3, 4-c]carbazole-5,7-(6H)-dione (NB-506): Induction of topoisomerase I-mediated DNA cleavage and mechanisms of cell line-selective cytotoxicity
    • Yoshinari T., Matsumoto M., Arakawa H., Okada H., Noguchi K., Suda H., Okura A., Nishimura S. (1995) Novel antitumor indolocarbazole compound 6-N-formylamino-12, 13-dihydro-1, 11-dihydroxy-13-(beta-D-glucopyranosyl)-5H-indolo[2, 3-a]pyrrolo[3, 4-c]carbazole-5,7-(6H)-dione (NB-506): induction of topoisomerase I-mediated DNA cleavage and mechanisms of cell line-selective cytotoxicity. Cancer Research, 55, 1310.
    • (1995) Cancer Research , vol.55 , pp. 1310
    • Yoshinari, T.1    Matsumoto, M.2    Arakawa, H.3    Okada, H.4    Noguchi, K.5    Suda, H.6    Okura, A.7    Nishimura, S.8


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