Catalytic mechanism of DNA topoisomerase IB

Molecular Cell

Volumn 5, Issue 6, 2000, Pages 1035-1041

  Krogh, Berit O ^a   Shuman, Stewart ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DNA; DNA TOPOISOMERASE; HISTIDINE; LYSINE; TYROSINE;

AMINO ACID COMPOSITION; ARTICLE; BINDING KINETICS; CATALYSIS; CONFORMATIONAL TRANSITION; DNA BINDING; DNA CLEAVAGE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; HUMAN; HUMAN CELL; INTERACTIONS WITH DNA; REGULATORY MECHANISM;

VACCINIA;

EID: 0033634688     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80268-3     Document Type: Article

References (34)

1. A novel suicide substrate for DNA topoisomerases and site-specific recombinases
2. A newly identified, essential catalytic residue in a critical secondary structure element in the integrase family of site-specific recombinases is conserved in a similar element in eucaryotic type IB topoisomerases
3. Mutational analysis of 39 residues of vaccinia DNA topoisomerase identifies Lys-220, Arg-223, and Asn-228 as important for covalent catalysis
4. Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases
5. The covalent eukaryotic topoisomerase I-DNA intermediate catalyzes pH-dependent hydrolysis and alcohololysis
6. Mechanistic basis for catalytic activation of mitogen-activated protein kinase phosphatase 3 by extracellular signal-regulated kinase
7. Structure of the Holliday junction intermediate in Cre-loxP site-specific recombination
8. Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse
9. Asymmetric bending in the Cre-loxP site-specific recombination synapse
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11. Purification and characterization of human topoisomerase I mutants
12. Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B
13. DNA strand transfer catalyzed by vaccinia topoisomerase: Peroxidolysis and hydroxylaminolysis of the covalent protein-DNA intermediate
14. Melanoplus sanguinipes entomopoxvirus DNA topoisomerase: Site-specific DNA transesterification and effects of 5'-bridging phosphorothiolates
15. Flexibility in DNA recombination: Structure of lambda integrase catalytic core
16. Camptothecins inhibit the utilization of hydrogen peroxide in the ligation step of topoisomerase I catalysis
17. Inversion of the phosphate chirality at the target site of Mu DNA strand transfer: Evidence for a one-step transesterification mechanism
18. Histidine-265 is important for covalent catalysis by vaccinia topoisomerase and is conserved in all eukaryotic type I enzymes
19. DNA strand transfer reactions catalyzed by vaccinia topoisomerase: Hydrolysis and glycerololysis of the covalent protein-DNA intermediate
20. Mutations within a conserved region of vaccinia topoisomerase affect the cleavage-religation equilibrium
21. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA
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23. Proteolytic footprinting of vaccinia topoisomerase bound to DNA
24. Identification of contacts between topoisomerase I and its target DNA by site-specific crosslinking
25. Vaccinia virus DNA topoisomerase: A model eukaryotic type IB enzyme
26. A model for the mechanism of human topoisomerase I
27. Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation
28. Vaccinia DNA topoisomerase I: Kinetic evidence for general acid-base catalysis and a conformational step
29. Stereochemical outcome and kinetic effects of Rp and Sp-phosphorothioate substitutions at the cleavage site of vaccinia type I DNA topoisomerase
30. Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate
31. Crystal structure of the site-specific recombinase XerD
32. Synthesis and properties of diuridine phosphate analogues containing thio and amino modifications
33. Mechanism of DNA transesterification by vaccinia topoisomerase: Catalytic contributions of essential residues Arg-130, Gly-132, Tyr-136, and Lys-167
34. Altering the nucleophile specificity of a protein-tyrosine phosphatase-catalyzed reaction