8-Oxoguanine rearranges the active site of human topoisomerase I

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 19, 2002, Pages 12102-12107

  Lesher, Diem Thu Thieu ^a   Pommier, Yves ^c   Stewart, Lance ^d   Redinbo, Matthew R ^a,b  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d Emerald BioStructures   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE; DNA TOPOISOMERASE; INTEGRASE; OLIGONUCLEOTIDE; RECOMBINASE;

ARTICLE; CRYSTAL STRUCTURE; DNA CLEAVAGE; DNA DAMAGE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME MECHANISM; HUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FAMILY; REGULATORY MECHANISM;

BASE SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DNA; DNA TOPOISOMERASES, TYPE I; ELECTROSTATICS; ENZYME STABILITY; GUANINE; HUMANS; MODELS, MOLECULAR; PHENYLALANINE; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; TYROSINE;

EID: 0037125992     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.192282699     Document Type: Article

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