How do drug-induced topoisomerase I-DNA lesions signal to the molecular interaction network that regulates cell cycle checkpoints, DNA replication, and DNA repair?

Cell Biochemistry and Biophysics

Volumn 33, Issue 2, 2000, Pages 175-180

  Kohn, Kurt W ^a   Shao, Rhong Guang ^a   Pommier, Yves ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; DNA; DNA TOPOISOMERASE; PROTEIN P53;

APOPTOSIS; CELL CULTURE; CELL CYCLE; CHEMISTRY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA REPLICATION ORIGIN; DRUG EFFECT; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

APOPTOSIS; CAMPTOTHECIN; CELL CYCLE; DNA; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA TOPOISOMERASES, TYPE I; HUMANS; REPLICATION ORIGIN; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034570196     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1385/CBB:33:2:175     Document Type: Conference Paper

References (26)

1. Chen, A. Y. and Liu, L. F. (1994) DNA topoisomerases: essential enzymes and lethal targets. Rev. Pharmacol. Toxicol. 94, 194-218.
2. Pommier, Y., Leteurtre, F., Fesen, M. R., Fujimori, A., Bertrand, R., Solary, E., Kohlhagen, G., and Kohn, K. W. (1994) Cellular determinants of sensitivity and resistance to DNA topoisomerase inhibitors. Cancer Invest. 12, 530-42.
3. Pommier, Y., Pourquier, P., Fan, Y., and Strumberg, D. (1998) Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme. Biochim. Biophys. Acta 1400, 83-105.
4. Holm, C., Covey, J. M., Kerrigan, D., and Pommier, Y. (1989) Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells. Cancer Res. 49, 6365-6368.
5. Hsiang, Y., Liu, L. F., Wall, M. E., Wani, M. C., Nicholas, A. W., Manikumar, G., Kirschenbaum, S., Silber, R., and Potmesil, M. (1989) DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues. Cancer Res. 49, 4385-4389.
6. Wold, M. S. (1997) Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu. Rev. Biochem. 66, 61-92.
7. Shao, R.-G., Cao, C.-X., Zhang, H., Kohn, K. W., Wold, M. S., and Pommier, Y. (1999) Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates DNA-PK/RPA complexes. EMBO J., in press.
8. O'Connor, P. M., Kerrigan, D., Bertrand, R., Kohn, K. W., and Pommier, Y. (1990) 10,11-Methylenedioxycamptothecin, a topoisomerase I inhibitor of increased potency: DNA damage and correlation to cytotoxicity in human colon carcinoma (HT-29) cells. Cancer Commun. 2, 395-400.
9. Morris, E. J. and Geller, H. M. (1996) Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity. J. Cell. Biol. 134, 757-770.
10. Zernik-Kobak, M., Vasunia, K., Connelly, M., Anderson, C. W., and Dixon, K. (1997) Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells. J. Biol. Chem. 272, 23,896-23,904.
11. Henricksen, L. A., Umbricht, C. B., and Wold, M. S. (1994) Recombinant replication protein A: expression, complex formation, and functional characterization. J. Biol. Chem. 269, 11,121-11,132.
12. Gately, D. P., Hittle, J. C., Chan, C. K. T., and Yen, T. J. (1998) Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity. Mol. Biol. Cell 9, 2361-2374.
13. Boubnov, N. V., Weaver, D. T., Someya, A., Take, Y., and Shioda, M. (1995) The Possible involvement of DNA-dependent protein kinase in the phosphorylation of P1 protein in cell-free DNA replication of Xenopus eggs. Mol. Cell. Biol. 15, 5700-5706.
14. Brush, G. S., Anderson, C. W., and Kelly, T. J. (1994) The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication. Proc. Natl. Acad. Sci. USA 91, 12,520-12,524.
15. Niu, H., Erdjumeni-Bromage, H., Pan, Z.-Q., Lee, S.-H., Tempst, P., and Hurwitz, J. (1997) Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and cdc2 kinase in vitro. J. Biol. Chem. 272, 12,634-12,641.
16. Lees-Miller, S. P., Godbout, R., Chan, D. W., Weinfeld, M., Day, R. S. I., Barron, G. M., and Allalunis-Turner, J. (1995) Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science 267, 1183-1185.
17. Lieber, M. R., Grawunder, U., Wu, X., and Yaneva, M. (1997) Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks. Curr. Opin. Genet. Dev. 7, 99-104.
18. West, R. B., Yaneva, M., and Lieber, M. R. (1998) Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini. Mol. Cell. Biol. 18, 5908-5920.
19. Yaneva, M., Kowalewski, R., and Lieber, M. R. (1997) Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies. EMBO J. 16, 5098-5112.
20. Shao, R.-G., Cao, C.-X., Shimizu, T., O'Connor, P., Kohn, K. W., and Pommier, Y. A. (1997) Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53. Cancer Res. 57, 4029-4035.
21. Dutta, A., Ruppert, J. M., Aster, J. C., and Winchester, E. (1993) Inhibition of DNA replication factor RPA by p53. Nature 365, 79-82.
22. Miller, S. D., Moses, K., Jayaraman, L., and Prives, C. (1997) Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by single-stranded DNA. Mol. Cell. Biol. 17, 2194-2201.
23. Abramova, N. A., Russell, J., Botchan, M., and Li, R. (1997) Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner. Proc. Natl. Acad. Sci. USA 94, 7186-7191.
24. deVries, E., van Driel, W., Bergsma, W. G., Arnberg, A. C., and van den Vliet, P. C. (1989) HeEa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex. J. Mol. Biol. 208, 65-78.
25. Blackwell, L. J., Borowiec, J. A., and Mastrangelo, I. A. (1996) Single-stranded-DNA binding alters human replication protein A structure and facilitates interaction with DNA-dependent protein kinase. Mol. Cell. Biol. 16, 4798-4807.
26. Gomes, X. V. and Wold, M. S. (1996) Functional domains of the 70-kilodalton subunit of human replication protein A. Biochemistry 35, 10,558-10,568.