Novel angular benzophenazines: Dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents

Journal of Medicinal Chemistry

Volumn 45, Issue 3, 2002, Pages 721-739

  Vicker, Nigel ^a   Burgess, Luke ^a   Chuckowree, Irina S ^a   Dodd, Rory ^a   Folkes, Adrian J ^a   Hardick, David J ^a   Hancox, Timothy C ^a   Miller, Warren ^a   Milton, John ^a   Sohal, Sukhjit ^a   Wang, Shouming ^a   Wren, Stephen P ^a   Charlton, Peter A ^a   Dangerfield, Wendy ^a   Liddle, Chris ^a   Mistry, Prakash ^a   Stewart, Alistair J ^a   Denny, William A ^b  

^a Cantab Pharmaceuticals Ltd   (United Kingdom)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 NAPHTHOQUINONE DERIVATIVE; 4 METHOXYBENZO[A]PHENAZINE 11 CARBOXYLIC ACID [2 (DIMETHYLAMINO) 1 METHYLETHYL]AMIDE; 6 [2 (DIMETHYLAMINO)ETHYLAMINO] 3 HYDROXY 7H INDENO[2,1 C]QUINOLIN 7 ONE; AMIDE; AMINOBENZOIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; BENZOPHENAZINE DERIVATIVE; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; GLYCOPROTEIN P; GYRASE INHIBITOR; MULTIDRUG RESISTANCE PROTEIN; PHENAZINE DERIVATIVE; TOPOTECAN; UNCLASSIFIED DRUG; XR 11576;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE; CHIRALITY; CONTROLLED STUDY; CYTOTOXICITY; DNA STRUCTURE; DRUG BLOOD LEVEL; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; POLYMERIZATION; STEREOCHEMISTRY;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL AVAILABILITY; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; PHENAZINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0037204017     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010329a     Document Type: Article

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