The Biosynthetic gene cluster for the antitumor rebeccamycin: Characterization and generation of indolocarbazole derivatives

Chemistry and Biology

Volumn 9, Issue 4, 2002, Pages 519-531

  Sánchez, César ^a   Butovich, Igor A ^b   Braña, Alfredo F ^a   Rohr, Jürgen ^b   Méndez, Carmen ^a   Salas, José A ^a  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LECHEVALIERIA AEROCOLONIGENES; SACCHAROTHRIX; STREPTOMYCES; STREPTOMYCES ALBUS;

AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; CARBAZOLE DERIVATIVE; GLYCOSYLTRANSFERASE; INDOLE DERIVATIVE; INDOLO(3,2 B)CARBAZOLE; INDOLO(3,2-B)CARBAZOLE; REBECCAMYCIN;

ACTINOMYCETALES; ARTICLE; BIOSYNTHESIS; CHROMOSOME MAP; DNA SEQUENCE; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MULTIGENE FAMILY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STREPTOMYCES;

ACTINOMYCETALES; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; CARBAZOLES; CHROMOSOME MAPPING; CLONING, MOLECULAR; GLYCOSYLTRANSFERASES; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; SEQUENCE ANALYSIS, DNA; STREPTOMYCES;

EID: 0036235877     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(02)00126-6     Document Type: Article

References (68)

1. A survey of indolo[2,3-a]carbazoles and related natural products
2. Calories from carbohydrates: Energetic contribution of the carbohydrate moiety of rebeccamycin to DNA binding and the effect of its orientation on topoisomerase I inhibition
3. UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: A new generation of anti-cancer agents for the new century?
4. Isolation and structure of rebeccamycin - A new antitumor antibiotic from Nocardia aerocolonigenes
5. Production and biological activity of rebeccamycin, a novel antitumor agent
6. Recent developments of rebeccamycin analogues as topoisomerase I inhibitors and antitumor agents
7. Microbial biosynthesis of halometabolites
8. Cloning and expression of a gene encoding N-glycosyltransferase (ngt) from Saccharothrix aerocolonigenes ATCC39243
9. A new shuttle cosmid vector, pKC505, for streptomycetes: Its use in the cloning of three different spiramycin-resistance genes from a Streptomyces ambofaciens library
10. Design of PCR-primers for the detection of halogenase-encoding regions in bacteria
11. Antimicrobial activities of indolocarbazole and bis-indole protein kinase C inhibitors
12. The biosynthetic origins of rebeccamycin
13. Biosynthesis of staurosporine. 2. Incorporation of tryptophan
14. Identification of indolepyruvic acid as an intermediate of rebeccamycin biosynthesis
15. Purification and cloning of an apoptosis-inducing protein derived from fish infected with Anisakis simplex, a causative nematode of human anisakiasis
16. Complete genome sequence of Caulobacter crescentus
17. Production, isolation and structure determination of novel fluoroindolocarbazoles from Saccharothrix aerocolonigenes ATCC 39243
18. Sequence analysis and functional characterization of the violacein biosynthetic pathway from Chromobacterium violaceum
19. Biosynthesis of violacein: Intact incorporation of the tryptophan molecule on the oxindole side, with intramolecular rearrangement of the indole ring on the 5-hydroxyindole side
20. A set of ordered cosmids and a detailed genetic and physical map for the 8 Mb Streptomyces coelicolor A3(2) chromosome
21. Origin of nitrogen in the indolocarbazole unit of staurosporine
22. Crystal structure of the reduced form of p-hydroxybenzoate hydroxylase refined at 2.3 Å resolution
23. The mobile flavin of 4-OH benzoate hydroxylase
24. A functional 4-hydroxysalicylate/hydroxyquinol degradative pathway gene cluster is linked to the initial dibenzo-p-dioxin pathway genes in Sphingomonas sp. Strain RW1
25. A hydroxylase-like gene product contributes to synthesis of a polyketide spore pigment in Streptomyces halstedii
26. Molecular evolution of P450 superfamily and P450-containing monooxygenase systems
27. The purification and characterization of a unique cytochrome P-450 enzyme from Berberis stolonifera plant cell cultures
28. Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908
29. A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities
30. Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564
31. Conservation of the pyrrolnitrin biosynthetic gene cluster among six pyrrolnitrin-producing strains
32. Isolation of a bromo analog of rebeccamycin from Saccharothrix aerocolonigenes
33. Functional analysis of the small component of the 4-hydroxyphenylacetate 3-monooxygenase of Escherichia coli W: A prototype of a new flavin:NAD(P)H reductase subfamily
34. The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: Sequence analysis and expression in a heterologous host
35. Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin
36. Identification of a flavin:NADH oxidoreductase involved in the biosynthesis of actinorhodin
37. Sequencing and functional analysis of styrene catabolism genes from Pseudomonas fluorescens ST
38. Comparative molecular analysis of Na+/H+ exchangers: A unified model for Na+/H+ antiport?
39. Biosynthesis of the orthosomycin antibiotic avilamycin A: Deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 and production of new antibiotics
40. Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster
41. A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport
42. Natural metabolic diversity encoded by the enterocin biosynthesis gene cluster
43. A subfamily of MalT-related ATP-dependent regulators in the LuxR family
44. Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: Analysis of the gene cluster and deduction of the biosynthetic pathway
45. Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis
46. AfsR is a pleiotropic but conditionally required regulatory gene for antibiotic production in Streptomyces coelicolor A3(2)
47. Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: Attributes of catalytic efficiency, stereoselectivity and regulation with implications for function
48. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
49. A novel fusidic acid resistance gene from Streptomyces lividans 66 encodes a highly specific esterase
50. The MarR repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli: Prototypic member of a family of bacterial regulatory proteins involved in sensing phenolic compounds
51. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
52. Promoter constructions for efficient secretion expression in Streptomyces lividans
53. Advances in indolo[2,3-a]carbazole chemistry: Design and synthesis of protein kinase C and topoisomerase I inhibitors
54. Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp
55. Indolocarbazoles: Potent, selective inhibitors of human cytomegalovirus replication
56. Synthesis of N-alkyl substituted indolocarbazoles as potent inhibitors of human cytomegalovirus replication
57. Streptomyces albus G mutants defective in the SalGI restriction-modification system
58. XL1-Blue: A high efficiency plasmid transforming recA Escherichia coli strain with β-galactosidase selection
59. Lamboid phages that simplify the recovery of in vitro recombinants
60. Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus)
61. Two glycosyltransferases and a glycosidase are involved in oleandomycin modification during its biosynthesis by Streptomyces antibioticus
62. Identification of two genes from Streptomyces argillaceus encoding two glycosyltransferases involved in the transfer of a disaccharide during the biosynthesis of the antitumor drug mithramycin
63. DNA sequencing with chain terminating inhibitors
64. A comprehensive set of sequence analysis programs for the VAX
65. Basic local alignment search tool