Mechanisms of DNA topoisomerase I-induced cell killing in the yeast: Saccharomyces cerevisiae

Annals of the New York Academy of Sciences

Volumn 922, Issue , 2000, Pages 65-75

  Fiorani, Paola ^a   Bjornsti, Mary Ann ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; DNA TOPOISOMERASE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; CELL KILLING; CONFERENCE PAPER; CYTOTOXICITY; DNA DAMAGE; ENZYME ANALYSIS; NONHUMAN; SACCHAROMYCES CEREVISIAE; TEMPERATURE SENSITIVITY;

SACCHAROMYCES CEREVISIAE;

EID: 0034517146     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb07026.x     Document Type: Conference Paper

References (42)

1. Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs
2. Investigating the biological functions of DNA topoisomerases in eukaryotic cells
3. DNA topoisomerases
4. Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme
5. DNA topoisomerases: Essential enzymes and lethal targets
6. Mechanistic aspects of type-I topoisomerases
7. Structural insights into the function of typeIB topoisomerases
8. Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
9. Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells
10. Yeast as a genetic system in the dissection of the mechanism of cell killing by topoisomerase-targeting anticancer drugs
11. Cell death induced by topoisomerase-targeted drugs: More questions than answers
12. Targeted disruption of the mouse topoisomerase I gene by camptothecin selection
13. Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II
14. A novel family of Trf (DNA topoisomerase I-related function) genes required for proper nuclear segregation
15. DNA topoisomerase I is essential in Drosophila melanogaster
16. DNA topoisomerase-targeting antitumor drugs can be studied in yeast
17. Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin
18. Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: Restoration of sensitivity of the cells to the antitumor drug camptothecin
19. A camptothecin-resistant DNA topoisomerase I mutant exhibits altered sensitivities to other DNA topoisomerase poisons
20. Increased camptothecin toxicity in mammalian cells expressing Saccharomyces cerevisiae DNA topoisomerase I
21. Analysis of camptothecin resistance in yeast: Relevance to cancer
22. SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I
23. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA
24. A model for the mechanism of human topoisomerase I
25. Camptothecin resistance from a single mutation changing glycine 363 of human DNA topoisomerase I to cysteine
26. Compendium of DNA topoisomerase sequences
27. Mechanisms of camptothecin resistance in yeast DNA topoisomerase I mutants
28. Cell cycle arrest and lethality produced by alterations in the catalytic activity of yeast DNA topoisomerase I mutants
29. Intragenic suppressors of mutant DNA topoisomerase I-induced lethality diminish enzyme binding of DNA
30. The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I
31. Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity
32. Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin
33. Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent-enzyme DNA intermediate
34. Overexpression of human topoisomerase I in baby hamster kidney cells: Hypersensitivity of clonal isolates to camptothecin
35. Camptothecin sensitivity is mediated by the pleiotropic drug resistance network in yeast
36. CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage
37. Inventory and function of yeast ABC proteins: About sex, stress, pleiotropic drug and heavy metal resistance
38. Probenecid alters topotecan systemic and renal disposition by inhibiting renal tubular secretion
39. Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line
40. CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication
41. Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin
42. Dpb11, which interacts with DNA polymerase II(e) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint