Enhanced CPT sensitivity of yeast cells and selective relaxation of Gal4 motif-containing DNA by novel Gal4-topoisomerase I fusion proteins

Journal of Molecular Biology

Volumn 337, Issue 2, 2004, Pages 295-305

  Alessandri, Marco ^a   Beretta, Giovanni L ^a,b   Ferretti, Edmondo ^a   Mancia, Annalaura ^a   Khobta, Andriy ^a   Capranico, Giovanni ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

CPT, camptothecin; DNA relaxation; DNA topoisomerase; Drug cell killing; GalTop, Gal4 DNA binding domain; Hybrid DNA binding proteins; SE, standard error; Top1, topoisomerase 1; Wt, wild type; Yeast

Indexed keywords

DNA; DNA TOPOISOMERASE; HYBRID PROTEIN; TRANSCRIPTION FACTOR GAL4;

ARTICLE; BINDING AFFINITY; CHROMATIN; CONTROLLED STUDY; DNA DAMAGE; DRUG SENSITIVITY; ENZYME ACTIVITY; MOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; YEAST CELL;

EID: 1442274748     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.01.032     Document Type: Article

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