Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancer drug that selectively alkylates DNA in the minor groove

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 13, 1999, Pages 7196-7201

  Takebayashi, Yuji ^a   Pourquier, Philippe ^a   Yoshida, Akira ^a   Kohlhagen, Glenda ^a   Pommier, Yves ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

DNA alkylation; DNA damage; DNA protein crosslink; Minor groove ligand

Indexed keywords

DNA TOPOISOMERASE; TRABECTEDIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; COVALENT BOND; CYTOTOXICITY; DNA ALKYLATION; DNA CROSS LINKING; DNA DENATURATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN PURIFICATION;

ALKYLATION; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; DIOXOLES; DNA; DNA TOPOISOMERASES, TYPE I; HUMANS; ISOQUINOLINES; TETRAHYDROISOQUINOLINES; TUMOR CELLS, CULTURED; UROCHORDATA;

ECTEINASCIDIA TURBINATA;

EID: 0033594881     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.13.7196     Document Type: Article

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