메뉴 건너뛰기




Volumn 56, Issue 6, 1999, Pages 1309-1316

Murine transgenic cells lacking DNA topoisomerase IIβ are resistant to acridines and mitoxantrone: Analysis of cytotoxicity and cleavable complex formation

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE DERIVATIVE; AMSACRINE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; MITOXANTRONE;

EID: 0032756225     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.6.1309     Document Type: Article
Times cited : (87)

References (40)
  • 1
    • 0032032797 scopus 로고    scopus 로고
    • Eukaryotic DNA topoisomerase IIβ
    • Austin CA and Marsh KL (1998) Eukaryotic DNA topoisomerase IIβ. Bioessays 20:215-226.
    • (1998) Bioessays , vol.20 , pp. 215-226
    • Austin, C.A.1    Marsh, K.L.2
  • 2
    • 0029072779 scopus 로고
    • Expression, domain structure, and enzymatic properties of an active recombinant human DNA topoisomerase IIβ
    • Austin CA, Marsh KL, Wasserman RA, Willmore E, Sayer PJ, Wang JC and Fisher LM (1995) Expression, domain structure, and enzymatic properties of an active recombinant human DNA topoisomerase IIβ. J Biol Chem 270:15739-15746.
    • (1995) J Biol Chem , vol.270 , pp. 15739-15746
    • Austin, C.A.1    Marsh, K.L.2    Wasserman, R.A.3    Willmore, E.4    Sayer, P.J.5    Wang, J.C.6    Fisher, L.M.7
  • 3
    • 0027516123 scopus 로고
    • Novel Hela topoisomerase II is the IIβ isoform: Complete coding sequence and homology with other type II topoisomerases
    • Austin CA, Sng J, Patel S and Fisher LM (1993) Novel Hela topoisomerase II is the IIβ isoform: Complete coding sequence and homology with other type II topoisomerases. Biochim Biophys Acta 1172:283-291.
    • (1993) Biochim Biophys Acta , vol.1172 , pp. 283-291
    • Austin, C.A.1    Sng, J.2    Patel, S.3    Fisher, L.M.4
  • 4
    • 0030932881 scopus 로고    scopus 로고
    • A carbamate analogue of amsacrine with activity against non-cycling cells stimulates topoisomerase II cleavage at DNA sites distinct from those of amsacrine
    • Baguely BC, Leteurtre F, Riou JF, Finlay GJ and Pommier Y (1997) A carbamate analogue of amsacrine with activity against non-cycling cells stimulates topoisomerase II cleavage at DNA sites distinct from those of amsacrine. Eur J Cancer 33:272-279.
    • (1997) Eur J Cancer , vol.33 , pp. 272-279
    • Baguely, B.C.1    Leteurtre, F.2    Riou, J.F.3    Finlay, G.J.4    Pommier, Y.5
  • 5
    • 0029844281 scopus 로고    scopus 로고
    • Etoposide causes illegitimate V (D) J recombination in human lymphoid leukemic cells
    • Chen C, Fuscoe JC, Liu O and Belling MV (1996) Etoposide causes illegitimate V (D) J recombination in human lymphoid leukemic cells. Blood 86:2210-2218.
    • (1996) Blood , vol.86 , pp. 2210-2218
    • Chen, C.1    Fuscoe, J.C.2    Liu, O.3    Belling, M.V.4
  • 6
    • 0030845812 scopus 로고    scopus 로고
    • Role of topoisomerase IIβ in the resistance of 9-OH-ellipticine-resistant Chinese hamster fibroblasts to topoisomerase II inhibitors
    • Dereuddre S, Delaporte C and Jacquemin-Sablon A (1997) Role of topoisomerase IIβ in the resistance of 9-OH-ellipticine-resistant Chinese hamster fibroblasts to topoisomerase II inhibitors. Cancer Res 57:4301-4308.
    • (1997) Cancer Res , vol.57 , pp. 4301-4308
    • Dereuddre, S.1    Delaporte, C.2    Jacquemin-Sablon, A.3
  • 7
    • 0028973467 scopus 로고
    • Cloning and characterization of full-length cDNAs coding for the DNA topoisomerase IIβ from Chinese hamster lung cells sensitive and resistant to 9-OH-ellipticine
    • Dereuddre S, Frey S, Delaporte C and Jacquemin-Sablon A (1995) Cloning and characterization of full-length cDNAs coding for the DNA topoisomerase IIβ from Chinese hamster lung cells sensitive and resistant to 9-OH-ellipticine. Biochim Biophys Acta 1264:178-182.
    • (1995) Biochim Biophys Acta , vol.1264 , pp. 178-182
    • Dereuddre, S.1    Frey, S.2    Delaporte, C.3    Jacquemin-Sablon, A.4
  • 9
    • 0028091270 scopus 로고
    • Altered subcellular distribution of topoisomerase lia in a drug resistant human small cell lung cancer cell line
    • Feldhoff PW, Mirski SEL, Cole SPC and Sullivan DM (1994) Altered subcellular distribution of topoisomerase lia in a drug resistant human small cell lung cancer cell line. Cancer Res 54:756-762.
    • (1994) Cancer Res , vol.54 , pp. 756-762
    • Feldhoff, P.W.1    Mirski, S.E.L.2    Cole, S.P.C.3    Sullivan, D.M.4
  • 11
    • 0025941508 scopus 로고
    • Mitoxantrone resistance in HL-60 leukemia cells: Reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase IIβ isoform
    • Harker WG, Slade DL, Drake FH and Parr EL (1991) Mitoxantrone resistance in HL-60 leukemia cells: Reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase IIβ isoform. Biochemistry 30:9953-9961.
    • (1991) Biochemistry , vol.30 , pp. 9953-9961
    • Harker, W.G.1    Slade, D.L.2    Drake, F.H.3    Parr, E.L.4
  • 12
    • 0028985942 scopus 로고
    • Alterations in the topoisomerase II α gene, messenger RNA, and subcellular protein distribution as well as reduced expression of the DNA topoisomerase II β enzyme in a mitoxantrone-resistant HL-60 human leukemia cell line
    • Harker WG, Slade DL, Parr RL, Feldoff PW, Sullivan DM and Holguin MH (1995) Alterations in the topoisomerase II α gene, messenger RNA, and subcellular protein distribution as well as reduced expression of the DNA topoisomerase II β enzyme in a mitoxantrone-resistant HL-60 human leukemia cell line. Cancer Res 55:1707-1716.
    • (1995) Cancer Res , vol.55 , pp. 1707-1716
    • Harker, W.G.1    Slade, D.L.2    Parr, R.L.3    Feldoff, P.W.4    Sullivan, D.M.5    Holguin, M.H.6
  • 13
    • 0003448569 scopus 로고
    • Cold Spring Harbor Laboratory Publications, Cold Spring Harbor, New York
    • Harlow E and Lane D (1988) Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory Publications, Cold Spring Harbor, New York.
    • (1988) Antibodies: A Laboratory Manual
    • Harlow, E.1    Lane, D.2
  • 14
    • 0022896243 scopus 로고
    • Topoisomerase II: A specific marker for cell proliferation
    • Heck MMS and Earnshaw WC (1986) Topoisomerase II: A specific marker for cell proliferation. J Cell Biol 103:2569-2581.
    • (1986) J Cell Biol , vol.103 , pp. 2569-2581
    • Heck, M.M.S.1    Earnshaw, W.C.2
  • 15
    • 0000266944 scopus 로고
    • Differential expression of DNA topoisomerase I and II during the eukaryotic cell cycle. Proc
    • Heck MMS, Hittleman WN and Earnshaw WC (1988) Differential expression of DNA topoisomerase I and II during the eukaryotic cell cycle. Proc Natl Acad Sci USA 85:1086-1090.
    • (1988) Natl Acad Sci USA , vol.85 , pp. 1086-1090
    • Heck, M.M.S.1    Hittleman, W.N.2    Earnshaw, W.C.3
  • 16
    • 0032222419 scopus 로고    scopus 로고
    • Absence of topoisomerase II β in an amsacrine-resistant human leukemia cell line with mutant topoisomerase II α
    • Herzog CE, Holmes KA, Tuschong LM, Ganapathi R and Zwelling LA (1998) Absence of topoisomerase II β in an amsacrine-resistant human leukemia cell line with mutant topoisomerase II α. Cancer Res 58:5298-5300.
    • (1998) Cancer Res , vol.58 , pp. 5298-5300
    • Herzog, C.E.1    Holmes, K.A.2    Tuschong, L.M.3    Ganapathi, R.4    Zwelling, L.A.5
  • 17
    • 0026988982 scopus 로고
    • The distribution of immunoreactive topoisomerase protein in human tissues and neoplasms
    • Holden JA, Rolfson DH and Wittwer CT (1992) The distribution of immunoreactive topoisomerase protein in human tissues and neoplasms. Oncol Res 4:157-166.
    • (1992) Oncol Res , vol.4 , pp. 157-166
    • Holden, J.A.1    Rolfson, D.H.2    Wittwer, C.T.3
  • 18
    • 0029563719 scopus 로고
    • Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines
    • Houlbrook S, Addison CM, Davies SL, Carmichael J, Stratford IJ, Harris AL and Hickson ID (1995) Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines. Br J Cancer 72:1454-1461.
    • (1995) Br J Cancer , vol.72 , pp. 1454-1461
    • Houlbrook, S.1    Addison, C.M.2    Davies, S.L.3    Carmichael, J.4    Stratford, I.J.5    Harris, A.L.6    Hickson, I.D.7
  • 19
    • 0026526176 scopus 로고
    • Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II
    • Lee M, Wang JC and Beran M (1992) Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II. J Mol Biol 223:837-843.
    • (1992) J Mol Biol , vol.223 , pp. 837-843
    • Lee, M.1    Wang, J.C.2    Beran, M.3
  • 20
    • 0025997529 scopus 로고
    • Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines
    • Long BH, Wang L, Lorico A, Wang RCC, Brattain MG and Casazza AM (1991) Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines. Cancer Res 51:5275-5284.
    • (1991) Cancer Res , vol.51 , pp. 5275-5284
    • Long, B.H.1    Wang, L.2    Lorico, A.3    Wang, R.C.C.4    Brattain, M.G.5    Casazza, A.M.6
  • 21
    • 0029028957 scopus 로고
    • Increased rate of adenine triphosphate-dependent etoposide (VP-16) efflux in a murine leukemia cell line over expressing the multidrug resistance-associated protein (MRP) gene
    • Lorico A, Rappa G, Srimatkandada S, Catapano CV, Fernandes DJ, Germino JF and Sartorelli AC (1995) Increased rate of adenine triphosphate-dependent etoposide (VP-16) efflux in a murine leukemia cell line over expressing the multidrug resistance-associated protein (MRP) gene. Cancer Res 56:4352-4360.
    • (1995) Cancer Res , vol.56 , pp. 4352-4360
    • Lorico, A.1    Rappa, G.2    Srimatkandada, S.3    Catapano, C.V.4    Fernandes, D.J.5    Germino, J.F.6    Sartorelli, A.C.7
  • 22
    • 0031014248 scopus 로고    scopus 로고
    • Complementation of temperature-sensitive topoisomerase II mutations in Saccharomyces cerevisiae by a human TOP2β construct allows the study of topoisomerase IIβ inhibitors in yeast
    • Meczes EL, Marsh KL, Fisher LM, Rogers MP and Austin CA (1997) Complementation of temperature-sensitive topoisomerase II mutations in Saccharomyces cerevisiae by a human TOP2β construct allows the study of topoisomerase IIβ inhibitors in yeast. Cancer Chemother Pharmacol 39:367-375.
    • (1997) Cancer Chemother Pharmacol , vol.39 , pp. 367-375
    • Meczes, E.L.1    Marsh, K.L.2    Fisher, L.M.3    Rogers, M.P.4    Austin, C.A.5
  • 24
    • 0029006931 scopus 로고
    • Cytoplasmic localisation of a mutant M, 160,000 topoisomerase II α is associated with the loss of putative bipartite nuclear localisation signals in a drug-resistant human lung cancer cell line
    • Mirski SEL and Cole SPC (1995) Cytoplasmic localisation of a mutant M, 160,000 topoisomerase II α is associated with the loss of putative bipartite nuclear localisation signals in a drug-resistant human lung cancer cell line. Cancer Res 55: 2129-2134.
    • (1995) Cancer Res , vol.55 , pp. 2129-2134
    • Mirski, S.E.L.1    Cole, S.P.C.2
  • 25
    • 0027443694 scopus 로고
    • Altered topoisomerase IIα in a drug-resistant small cell lung cancer cell line selected in VP-16
    • Mirski SEL, Evans CD, Almquist KC, Slovak ML and Cole SPC (1993) Altered topoisomerase IIα in a drug-resistant small cell lung cancer cell line selected in VP-16. Cancer Res 53:4866-4873.
    • (1993) Cancer Res , vol.53 , pp. 4866-4873
    • Mirski, S.E.L.1    Evans, C.D.2    Almquist, K.C.3    Slovak, M.L.4    Cole, S.P.C.5
  • 26
    • 0031408940 scopus 로고    scopus 로고
    • Cellular responses to methyl-N-[4-(9-acridinylamino)-2-methoxyphenyl] carbatamate hydrochloride, an analogue of amsacrine active against non-proliferating cells
    • Moreland N, Finlay GJ, Dragunow M, Holdaway KM and Baguley BC (1997) Cellular responses to methyl-N-[4-(9-acridinylamino)-2-methoxyphenyl] carbatamate hydrochloride, an analogue of amsacrine active against non-proliferating cells. Eur J Cancer 33:1668-1676.
    • (1997) Eur J Cancer , vol.33 , pp. 1668-1676
    • Moreland, N.1    Finlay, G.J.2    Dragunow, M.3    Holdaway, K.M.4    Baguley, B.C.5
  • 27
    • 0023748947 scopus 로고
    • Synergistic enhancement of 6-thioguanine cytotoxicity by ADP-ribosyltransferase inhibitors
    • Moses K, Harris AL and Durkacz BW (1988) Synergistic enhancement of 6-thioguanine cytotoxicity by ADP-ribosyltransferase inhibitors. Cancer Res 48:5650-5654.
    • (1988) Cancer Res , vol.48 , pp. 5650-5654
    • Moses, K.1    Harris, A.L.2    Durkacz, B.W.3
  • 28
    • 0024395605 scopus 로고
    • Effect of antineoplastic agents on the DNA cleavage/religation of eukaryotic topoisomerase II: Inhibition of DNA religation by etoposide. Biochem
    • Osheroff N (1989) Effect of antineoplastic agents on the DNA cleavage/religation of eukaryotic topoisomerase II: Inhibition of DNA religation by etoposide. Biochemistry 28:6157-6160.
    • (1989) Istry , vol.28 , pp. 6157-6160
    • Osheroff, N.1
  • 29
    • 0031722207 scopus 로고    scopus 로고
    • Differential sensitivities of recombinant human topoisomerase II α and β to various classes of topoisomerase II-interacting agents
    • Perrin D, Hille B and Hill BT (1998) Differential sensitivities of recombinant human topoisomerase II α and β to various classes of topoisomerase II-interacting agents. Biochem Pharmacol 56:503-507.
    • (1998) Biochem Pharmacol , vol.56 , pp. 503-507
    • Perrin, D.1    Hille, B.2    Hill, B.T.3
  • 30
    • 0000420523 scopus 로고    scopus 로고
    • DNA topoisomerase II inhibitors
    • Teicher BA ed Humana Press, Totowa, New Jersey
    • Pommier Y (1997) DNA topoisomerase II inhibitors, in Cancer Therapeutics: Experimental and Clinical Agents (Teicher BA ed) pp 153-174, Humana Press, Totowa, New Jersey.
    • (1997) Cancer Therapeutics: Experimental and Clinical Agents , pp. 153-174
    • Pommier, Y.1
  • 31
    • 0021792433 scopus 로고
    • Correlations between intercalator-induced DNA strand breaks and sister chromatid exchanges, mutations, and cytotoxicity in Chinese hamster cells
    • Pommier Y, Zwelling LA, Kao-Shan C, Whang-Peng J and Bradley MO (1985a) Correlations between intercalator-induced DNA strand breaks and sister chromatid exchanges, mutations, and cytotoxicity in Chinese hamster cells. Cancer Res 45:3143-3149.
    • (1985) Cancer Res , vol.45 , pp. 3143-3149
    • Pommier, Y.1    Zwelling, L.A.2    Kao-Shan, C.3    Whang-Peng, J.4    Bradley, M.O.5
  • 32
    • 0028258989 scopus 로고
    • Expression of 170kDa and 180kDa isoforms of DNA topoisomerase II in resting and proliferating human lymphocytes
    • Prosperi E, Negri G, Marchese G and Astaldi Ricotti GCB (1994) Expression of 170kDa and 180kDa isoforms of DNA topoisomerase II in resting and proliferating human lymphocytes. Cell Prolif 27:257-267.
    • (1994) Cell Prolif , vol.27 , pp. 257-267
    • Prosperi, E.1    Negri, G.2    Marchese, G.3    Astaldi Ricotti, G.C.B.4
  • 34
    • 0031018456 scopus 로고    scopus 로고
    • Topoisomerase II inhibitors fail to induce chromosome-type aberrations in etoposide-resistant cells: Evidence for essential contribution of the cleavable complex formation to the induction of chromosome-type aberrations
    • Suzuki H, Tarumoto Y and Ohsawa M (1997) Topoisomerase II inhibitors fail to induce chromosome-type aberrations in etoposide-resistant cells: Evidence for essential contribution of the cleavable complex formation to the induction of chromosome-type aberrations. Mutagenesis 12:29-33.
    • (1997) Mutagenesis , vol.12 , pp. 29-33
    • Suzuki, H.1    Tarumoto, Y.2    Ohsawa, M.3
  • 35
    • 0026548825 scopus 로고
    • Topoisomerase IIα and topoisomerase IIβ genes: Characterisation and mapping to human chromosome 17 and 3, respectively
    • Tan KB, Dorman TE, Falls KM, Chung TDY, Mirabelli CK, Crooke ST and Mao J (1992) Topoisomerase IIα and topoisomerase IIβ genes: Characterisation and mapping to human chromosome 17 and 3, respectively. Cancer Res 52:231-234.
    • (1992) Cancer Res , vol.52 , pp. 231-234
    • Tan, K.B.1    Dorman, T.E.2    Falls, K.M.3    Chung, T.D.Y.4    Mirabelli, C.K.5    Crooke, S.T.6    Mao, J.7
  • 36
    • 0030887316 scopus 로고    scopus 로고
    • The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues
    • Turley H, Comley M, Houlbrook S, Nozaki N, Kikuch A, Hickson ID, Gatter K and Harris AL (1997) The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues. Br J Cancer 75:1340-1346.
    • (1997) Br J Cancer , vol.75 , pp. 1340-1346
    • Turley, H.1    Comley, M.2    Houlbrook, S.3    Nozaki, N.4    Kikuch, A.5    Hickson, I.D.6    Gatter, K.7    Harris, A.L.8
  • 37
    • 0030014783 scopus 로고    scopus 로고
    • DNA topoisomerases
    • Wang JC (1996) DNA topoisomerases. Annu Rev Biochem 65:635-692.
    • (1996) Annu Rev Biochem , vol.65 , pp. 635-692
    • Wang, J.C.1
  • 38
    • 0031847082 scopus 로고    scopus 로고
    • Etoposide targets topoisomerase IIα and IIβ in leukemic cells: Isoform-specific cleavable complexes visualised and quantified in situ by a novel immunofluorescence technique
    • Willmore E, Frank AJ, Padget K, Tilby MJ and Austin CA (1998) Etoposide targets topoisomerase IIα and IIβ in leukemic cells: Isoform-specific cleavable complexes visualised and quantified in situ by a novel immunofluorescence technique. Mol Pharmacol 53:78-85.
    • (1998) Mol Pharmacol , vol.53 , pp. 78-85
    • Willmore, E.1    Frank, A.J.2    Padget, K.3    Tilby, M.J.4    Austin, C.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.