A mutation in yeast topoisomerase II that confers hypersensitivity to multiple classes of topoisomerase II poisons

Journal of Biological Chemistry

Volumn 275, Issue 11, 2000, Pages 7980-7987

  Dong, Jiaowang ^a   Walker, Jerrylaine ^a   Nitiss, John L ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); MUTANT PROTEIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CONTROLLED STUDY; DNA CLEAVAGE; DRUG MECHANISM; GENE MUTATION; HYPERSENSITIVITY; MOLECULAR MODEL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; YEAST;

AMSACRINE; ANTI-INFECTIVE AGENTS; BINDING SITES; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EUKARYOTIC CELLS; FLUOROQUINOLONES; INTERCALATING AGENTS; MODELS, MOLECULAR; MUTATION; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 0034678060     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.11.7980     Document Type: Article

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