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Volumn 85, Issue 10, 2001, Pages 1585-1591

Lycobetaine acts as a selective topoisomerase IIβ poison and inhibits the growth of human tumour cells

(9) Barthelmes, H U b Niederberger, E a Roth, T d Schulte, K a Tang, W C a Boege, F b Fiebig, H H c,d Eisenbrand, G a Marko, D a

a Rheinland Pfälzische Technische Universität Kaiserslautern Landau (Germany)

b UNIVERSITY OF WÜRZBURG (Germany)

c UNIVERSITY OF FREIBURG (Germany)

d CHARLES RIVER LABORATORIES (United States)

Author keywords

Cleavable complex; Clonogenic assay; Gastric carcinoma; Lycobetaine; Topoisomerase II ; Ungeremine

Indexed keywords

GYRASE INHIBITOR; LYCOBETAINE; PHENANTHRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DNA CLEAVAGE; DRUG STRUCTURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; TUMOR XENOGRAFT;

ALKALOIDS; AMARYLLIDACEAE ALKALOIDS; ANIMALS; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, WESTERN; CELL CYCLE; CELL DIVISION; COMET ASSAY; DNA; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; INDOLIZINES; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035900807 PISSN: 00070920 EISSN: None Source Type: Journal
DOI: 10.1054/bjoc.2001.2142 Document Type: Article

Times cited : (48)

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