Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)2,3-methylenedioxy-5H-dibenzo[c,h][1,6] naphthyridin-6-ones: Effect on topoisomerase-I targeting activity and cytotoxicity

Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2003, Pages 2254-2257

  Singh, Sudhir K ^a   Ruchelman, Alexander L ^a   Li, Tsai Kun ^b   Liu, Angela ^b   Liu, Leroy F ^b,c   LaVoie, Edmond J ^a,c  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5H 2,3 METHYLENEDIOXY 5 (2 N,N DIMETHYLAMINOETHYL)DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; 5H 8,9 DIMETHOXY 5 (2 N,N DIMETHYLAMINOETHYL) 2,3 METHYLENEDIOXY 5H DIBENZO[C,H][1,6]NAPHTHYRIDIN 6 ONE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DNA TOPOISOMERASE; IRINOTECAN; NAPHTHYRIDINE DERIVATIVE; TENIPOSIDE; TOPOTECAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVITY; HUMAN; HUMAN CELL;

AMINES; ANTINEOPLASTIC AGENTS; DNA TOPOISOMERASES, TYPE I, EUKARYOTIC; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NAPHTHYRIDINES; NITRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0038247973     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020498a     Document Type: Article

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