Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 26, 2002, Pages 16672-16677

  Yabe, Daisuke ^a   Xia, Zong Ping ^a   Adams, Christopher M ^a   Rawson, Robert B ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE; MEMBRANE PROTEIN; PHENYLALANINE; PROTEIN; PROTEIN INSIG 1; PROTEIN INSIG 2; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN CLEAVAGE ACTIVATING PROTEIN; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; MOLECULAR CLONING; MUTAGENESIS; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CCAAT-ENHANCER-BINDING PROTEINS; CHO CELLS; CRICETINAE; DNA-BINDING PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROLS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; MAMMALIA;

EID: 0037168533     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.262669399     Document Type: Article

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