Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Journal of Biological Chemistry

Volumn 279, Issue 41, 2004, Pages 43136-43147

  Sever, Navdar ^a   Lee, Peter C W ^a   Song, Bao Liang ^a   Rawson, Robert B ^a   DeBose Boyd, Russell A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; COENZYMES; CYTOLOGY; ENZYME INHIBITION; ESTERS; FATTY ACIDS; GAMMA RAYS; GENETIC ENGINEERING; IRRADIATION; LIPIDS; METABOLISM;

ENDOPLASMIC RETICULUM; ENZYME DEGRADATION; LIPID METABOLISM;

CELLS;

BISPHOSPHONIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INSIG 1 PROTEIN; INSIG 2 PROTEIN; LIPID; MEMBRANE PROTEIN; MESSENGER RNA; PLASMID VECTOR; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN CLEAVAGE ACTIVATING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL ISOLATION; CELL MUTANT; CHO 7 CELL; CHO CELL; CHOLESTEROL SYNTHESIS; ENDOPLASMIC RETICULUM; ENZYME DEGRADATION; FATTY ACID SYNTHESIS; FEEDBACK SYSTEM; GAMMA IRRADIATION; GENE DELETION; GENETIC TRANSFECTION; LIPID METABOLISM; LIPOGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROCESSING; SRD 14 CELL; UBIQUITINATION;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE; CELL NUCLEUS; CHO CELLS; CHOLESTEROL; CRICETINAE; DIPHOSPHONATES; DNA; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; FATTY ACIDS; FIBROBLASTS; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; IMMUNOBLOTTING; LIPID METABOLISM; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDES; PLASMIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROLS; SUBCELLULAR FRACTIONS; TEMPERATURE; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION; UBIQUITIN;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 5644244825     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M406406200     Document Type: Article

References (50)

1. Yang, T., Espenshade, P. J., Wright, M. E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J. L., and Brown, M. S. (2002) Cell 110, 489-500
2. Yabe, D., Brown, M. S., and Goldstein, J. L. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 12753-12758
3. Sever, N., Yang, T., Brown, M. S., Goldstein, J. L., and DeBose-Boyd, R. A. (2003) Mol. Cell 11, 25-33
4. Sever, N., Song, B. L., Yabe, D., Goldstein, J. L., Brown, M. S., and DeBose-Boyd, R. A. (2003) J. Biol. Chem. 278, 52479-52490
5. Feramisco, J. D., Goldstein, J. L., and Brown, M. S. (2004) J. Biol. Chem. 279, 8487-8496
6. Yabe, D., Komuro, R., Liang, G., Goldstein, J. L., and Brown, M. S. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 3155-3160
7. Brown, M. S., and Goldstein, J. L. (1997) Cell 89, 331-340
8. Nohturfft, A., Yabe, D., Goldstein, J. L., Brown, M. S., and Espenshade, P. J. (2000) Cell 102, 315-323
9. Yabe, D., Xia, Z. P., Adams, C. M., and Rawson, R. B. (2002) Proc. Natl. Acad. Sci. U. S. A. 89, 16672-16677
10. Nohturfft, A., Brown, M. S., and Goldstein, J. L. (1998) J. Biol. Chem. 273, 17243-17250
11. Roitelman, J., Olender, E. H., Bar-Nun, S., Dunn, W. A., Jr., and Simoni, R. D. (1992) J. Cell Biol. 117, 959-973
12. Hua, X., Nohturfft, A., Goldstein, J. L., and Brown, M. S. (1996) Cell 87, 415-426
13. Brown, M. S., and Goldstein, J. L. (1999) Proc. Natl. Acad. Sci. U. S. A. 86, 11041-11048
14. Kuwabara, P. E., and Labouesse, M. (2002) Trends Genet. 18, 193-201
15. Nohturfft, A., Hua, X., Brown, M. S., and Goldstein, J. L. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 13709-13714
16. Nohturfft, A., Brown, M. S., and Goldstein, J. L. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 12848-12853
17. Goldstein, J. L., and Brown, M. S. (1990) Nature 343, 425-430
18. Brown, M. S., and Goldstein, J. L. (1980) J. Lipid. Res. 21, 505-517
19. Hampton, R. Y. (2002) Annu. Rev. Cell Dev. Biol. 18, 345-378
20. Hampton, R. Y., Gardner, R. G., and Rine, J. (1996) Mol. Biol. Cell 7, 2029-2044
21. Hampton, R. Y. (1998) Curr. Opin. Lipidol. 9, 93-97
22. Gardner, R. G., Shearer, A. G., and Hampton, R. Y. (2001) Mol. Cell. Biol. 21, 4276-4291
23. Bays, N. W., Wilhovsky, S. K., Goradia, A., Hodgkiss-Harlow, K., and Hampton, R. Y. (2001) Mol. Biol. Cell 12, 4114-4128
24. Bays, N. W., and Hampton, R. Y. (2002) Curr. Biol. 12, R366-R371
25. Goldstein, J. L., Rawson, R. B., and Brown, M. S. (2002) Arch. Biochem. Biophys. 397, 139-148
26. Wang, X., Sato, R., Brown, M. S., Hua, X., and Goldstein, J. L. (1994) Cell 77, 53-62
27. Yang, J., Sato, R., Goldstein, J. L., and Brown, M. S. (1994) Genes Dev. 8, 1910-1919
28. Yang, J., Brown, M. S., Ho, Y. K., and Goldstein, J. L. (1995) J. Biol. Chem. 270, 12152-12161
29. Dawson, P. A., Metherall, J. E., Ridgway, N. D., Brown, M. S., and Goldstein, J. L. (1991) J. Biol. Chem. 266, 9128-9134
30. Ylitalo, R. (2000) Gen. Pharmacol. 35, 287-296
31. Berkhout, T. A., Simon, H. M., Jackson, B., Yates, J., Pearce, N., Groot, P. H., Bentzen, C., Niesor, E., Kerns, W. D., and Suckling, K. E. (1997) Atherosclerosis 133, 203-212
32. Berkhout, T. A., Simon, H. M., Patel, D. D., Bentzen, C., Niesor, E., Jackson, B., and Suckling, K. E. (1996) J. Biol. Chem. 271, 14376-14382
33. Roitelman, J., Masson, D., Avner, R., Ammon-Zufferey, C., Perez, A., Guyon-Gellin, Y., Bentzen, C. L., and Niesor, E. J. (2004) J. Biol. Chem. 278, 6465-6473
34. DeBose-Boyd, R. A., Brown, M. S., Li, W. P., Nohturfft, A., Goldstein, J. L., and Espenshade, P. J. (1999) Cell 89, 703-712
35. Goldstein, J. L., Basu, S. K., and Brown, M. S. (1983) Methods Enzymol. 88, 241-260
36. Yamamoto, T., Davis, C. G., Brown, M. S., Schneider, W. J., Casey, M. L., Goldstein, J. L., and Russell, D. W. (1984) Cell 39, 27-38
37. Metherall, J. E., Goldstein, J. L., Luskey, K. L., and Brown, M. S. (1989) J. Biol. Chem. 264, 15634-15641
38. Mosley, S. T., Brown, M. S., Anderson, R. G., and Goldstein, J. L. (1983) J. Biol. Chem. 258, 13875-13881
39. Rawson, R. B., DeBose-Boyd, R., Goldstein, J. L., and Brown, M. S. (1999) J. Biol. Chem. 274, 28549-28556
40. Liscum, L., Luskey, K. L., Chin, D. J., Ho, Y. K., Goldstein, J. L., and Brown, M. S. (1983) J. Biol. Chem. 258, 8450-8455
41. Engelking, L. J., Kuriyama, H., Hammer, R. E., Horton, J. D., Brown, M. S., Goldstein, J. L., and Liang, G. (2004) J. Clin. Invest. 113, 1168-1175
42. Sakai, J., Nohturfft, A., Cheng, D., Ho, Y. K., Brown, M. S., and Goldstein, J. L. (1997) J. Biol. Chem. 272, 20213-20221
43. Sato, R., Goldstein, J. L., and Brown, M. S. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 9261-9265
44. Rawson, R. B., Cheng, D., Brown, M. S., and Goldstein, J. L. (1998) J. Biol. Chem. 273, 28261-28269
45. Liang, G., Yang, J., Horton, J. D., Hammer, R. E., Goldstein, J. L., and Brown, M. S. (2002) J. Biol. Chem. 277, 9520-9528
46. Brown, M. S., Faust, J. R., and Goldstein, J. L. (1978) J. Biol. Chem. 253, 1121-1128
47. Nakanishi, M., Goldstein, J. L., and Brown, M. S. (1988) J. Biol. Chem. 263, 8929-8937
48. Roitelman, J., and Simoni, R. D. (1992) J. Biol. Chem. 267, 25264-25273
49. Gil, G., Faust, J. R., Chin, D. J., Goldstein, J. L., and Brown, M. S. (1985) Cell 41, 249-258
50. Skalnik, D. G., Narita, H., Kent, C., and Simoni, R. D. (1988) J. Biol. Chem. 263, 6836-6841