Crystal structure of the catalytic portion of human HMG-CoA reductase: Insights into regulation of activity and catalysis

EMBO Journal

Volumn 19, Issue 5, 2000, Pages 819-830

  Istvan, Eva S ^a   Palnitkar, Maya ^a   Buchanan, Susan K ^a,b   Deisenhofer, Johann ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Catalysis; Cholesterol biosynthesis; HMG CoA binding; NADPH binding; Statins

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; CHOLESTEROL; COENZYME A; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OLIGOMER;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME REGULATION; ENZYME SUBSTRATE COMPLEX; HUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

BACTERIA (MICROORGANISMS);

EID: 0034161543     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.5.819     Document Type: Article

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