The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 20, 2002, Pages 12675-12680

  Janowski, Bethany A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4ALPHA ALLYL 5ALPHA CHOLESTAN 3ALPHA OL; CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; OXYSTEROL; PROTEIN; PROTEIN INSIG 1; PROTEIN SCAP; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL LEVEL; CONTROLLED STUDY; DRUG EFFECT; HOMEOSTASIS; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; REGULATORY MECHANISM;

ANTICHOLESTEREMIC AGENTS; BLOTTING, NORTHERN; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE; CELL NUCLEUS; CHOLESTANOLS; CHOLESTEROL; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; IMMUNOBLOTTING; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEINS; RNA; SIGNAL TRANSDUCTION; STEROIDS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION; UP-REGULATION;

EID: 0036790994     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.202471599     Document Type: Article

References (27)

1. Lin, H., Rampersaud, A. A., Archer, R. A., Pawlak, J. M., Beavers, L. S., Schmidt, R. J., Kauffman, R. F., Bensch, W. R., Bumol, T. F., Apelgren, L. D., et al. (1995) J. Med. Chem. 38, 277-288.
2. Bensch, W. R., Gadski, R. A., Bean, J. S., Beavers, L. S., Schmidt, R. J., Perry, D. N., Murphy, A. T., McClure, D. B., Eacho, P. I., Breau, A. P., et al. (1999) J. Pharmacol. Exp. Ther. 289, 85-289.
3. Bowling, N., Metter, W. F., Gadski, R. A., McClure, D. B., Schreyer, T., Dawson, P. A. & Vlahos, C. J. (1996) J. Lipid Res. 37, 2586-2598.
4. Janowski, B. A., Shan, B. & Russell, D. W. (2001) J. Biol. Chem. 276, 45408-45416.
5. Brown, M. S. & Goldstein, J. L. (1999) Proc. Natl. Acad. Sci. USA 96, 11041-11048.
6. Rawson, R. B., Zelenski, N. G., Nijhawan, D., Ye, J., Sakai, J., Hasan, M. Z., Chang, T. Y., Brown, M. S. & Goldstein, J. L. (1997) Mol. Cell 1, 47-57.
7. Sakai, S. J., Rawson, R. B., Espenshade, P. J., Cheng, D., Seegmiller, A. C., Goldstein, J. L. & Brown, M. S. (1998) Mol. Cell 2, 505-514.
8. Nohturfft, A., DeBose-Boyd, R. A., Scheek, S., Goldstein, J. L. & Brown, M. S. (1999) Proc. Natl. Acad. Sci. USA 96, 11235-11240.
9. Nohturfft, A., Yabe, D., Goldstein, J. L., Brown, M. S. & Espenshade, P. J. (2000) Cell 102, 315-323.
10. Diamond, R. H., Du, K., Lee, V. M., Mohn, K. L., Haber, B. A., Tewari, D. S. & Taub, R. (1993) J. Biol. Chem. 268, 15185-15192.
11. Peng, Y., Schwarz, E. J., Lazar, M. A., Genin, A., Spinner, N. B. & Taub, R. (1997) Genomics 43, 278-284.
12. Bortoff, K. D., Zhu, C. C., Hrywna, Y. & Messina, J. L. (1997) Endocrine 2, 199-207.
13. Hannah, V. C., Ou, J., Luong, A., Goldstein, J. L. & Brown, M. S. (2001) J. Biol. Chem. 276, 4365-4372.
14. Brown, M. S., Faust, J. R. & Goldstein, J. L. (1978) J. Biol. Chem. 253, 1121-1128.
15. Goldstein, J. L., Basu, S. K. & Brown, M. S. (1983) Methods Enzymol. 98, 241-260.
16. Janowski, B. A., Grogan, M. J., Jones, S. A., Wisely, G. B., Kliewer, S. A., Corey, E. J. & Mangelsdorf, D. J. (1999) Proc. Natl. Acad. Sci. USA 96, 266-271.
17. Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K. & Tuschl, T. (2001) Nature (London) 411, 494-498.
18. Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R. & Mangelsdorf, D. J. (1996) Nature (London) 383, 728-731.
19. Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J. L., Sundeth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A. & Willson, T. M. (1997) J. Biol. Chem. 272, 3137-3140.
20. Repa, J. J., Liang, G., Ou, J., Bashmakov, Y., Lobaccaro, J. M., Shimomura, I., Shan, B., Brown, M. S., Goldstein, J. L. & Mangelsdorf, D. J. (2000) Genes Dev. 14, 2819-2830.
21. Repa, J. J., Turley, S. D., Lobaccaro, J. A., Medina, J., Li, L., Lustig, K., Shan, B., Heyman, R. A., Dietschy, J. M. & Mangelsdorf, D. J. (2000) Science 289, 1524-1529.
22. Yang, T., Goldstein, J. L. & Brown, M. S. (2000) J. Biol. Chem. 275, 29881-29886.
23. Yang, T., Espenshade, P. J., Wright, M. E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J. L. & Brown, M. S. (2002) Cell 110, 489-500.
24. Nohturfft, A., Brown, M. S. & Goldstein, J. L. (1998) Proc. Natl. Acad. Sci. USA 95, 12848-12853.
25. Hua, X., Norhturfft, Goldstein, J. L. & Brown, M. S. (1996) Cell 87, 425-426.
26. Grand-Perret, T., Bouillot, A., Perrot, A., Commans, S., Walker, M. & Issandou, M. (2001) Nat. Med. 7, 1332-1338.
27. Yang, T., Espenshade, P. J., Wright, M. E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J. L. & Brown, M. S. (2002) Cell 110, 489-500.