Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and insigs

Journal of Biological Chemistry

Volumn 279, Issue 50, 2004, Pages 52772-52780

  Adams, Christopher M ^a   Reitz, Julian ^a   De Brabander, Jef K ^a   Feramisco, Jamison D ^a   Li, Lu ^a   Brown, Michael S ^a   Goldstein, Joseph L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CONFORMATIONS; CROSSLINKING; DERIVATIVES; PROTEINS; SYNTHESIS (CHEMICAL);

ELEMENT-BINDING PROTEINS; HYDROXULATED DERIVATIVES; STEROL;

CHOLESTEROL;

25 HYDROXYCHOLESTEROL; CELL MEMBRANE PROTEIN; CELL PROTEIN; CHOLESTEROL; METHYL BETA CYCLODEXTRIN; PROTEIN INSIGS; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN CLEAVAGE ACTIVATING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CHEMICAL BOND; CHOLESTEROL SYNTHESIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ENDOPLASMIC RETICULUM; FRAGMENTATION REACTION; GOLGI COMPLEX; NONHUMAN; PHOTOACTIVATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT;

ANIMALS; BASE SEQUENCE; CCAAT-ENHANCER-BINDING PROTEINS; CHO CELLS; CHOLESTEROL; CRICETINAE; DNA-BINDING PROTEINS; HUMANS; HYDROXYCHOLESTEROLS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTORS;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 10644239801     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M410302200     Document Type: Article

References (41)

1. Kandutsch, A. A., and Chen, H. W. (1974) J. Biol. Chem. 249, 6057-6061
2. Brown, M. S., and Goldstein, J. L. (1974) J. Biol. Chem. 249, 7306-7314
3. Goldstein, J. L., Faust, J. R., Brunschede, G. Y., and Brown, M. S. (1975) in Lipids, Lipoproteins, and Drugs (Kritchevsky, D., Paoletti, R., and Holmes, W. L., eds) pp. 77-84, Plenum, New York
4. Kandutsch, A. A., Chen, H. W., and Heiniger, H.-J. (1978) Science 201, 498-501
5. Goldstein, J. L., and Brown, M. S. (1974) J. Biol. Chem. 249, 5153-5162
6. Krieger, M., Goldstein, J. L., and Brown, M. S. (1978) Proc. Natl. Acad. Sci. U. S. A. 75, 5052-5056
7. Brown, M. S., and Goldstein, J. L. (1986) Science 232, 34-47
8. Brown, M. S., and Goldstein, J. L. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11041-11048
9. Goldstein, J. L., Rawson, R. B., and Brown, M. S. (2002) Arch. Biochem. Biophys. 397, 139-148
10. Horton, J. D., Goldstein, J. L., and Brown, M. S. (2002) J. Clin. Invest. 109, 1125-1131
11. Yang, T., Espenshade, P. J., Wright, M. E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J. L., and Brown, M. S. (2002) Cell 110, 489-500
12. Yabe, D., Brown, M. S., and Goldstein, J. L. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 12753-12758
13. Feramisco, J. D., Goldstein, J. L., and Brown, M. S. (2003) J. Biol. Chem. 279, 8487-8496
14. Yabe, D., Xia, Z.-P., Adams, C. M., and Rawson, R. B. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 16672-16677
15. Radhakrishnan, A., Sun, L.-P., Kwon, H. J., Brown, M. S., and Goldstein, J. L. (2004) Mol. Cell 15, 259-268
16. Adams, C. M., Goldstein, J. L., and Brown, M. S. (2003)Proc. Natl. Acad. Sci. U. S. A. 100, 10647-10652
17. Kilsdonk, E. P. C., Yancey, P. G., Stoudt, G. W., Bangerter, F. W., Johnson, W. J., Phillips, M. C., and Rothblat, G. H. (1995) J. Biol. Chem. 270, 17250-17256
18. Sakai, J., Nohturfft, A., Cheng, D., Ho, Y. K., Brown, M. S., and Goldstein, J. L. (1997) J. Biol. Chem. 272, 20213-20221
19. Brown, A. J., Sun, L., Feramisco, J. D., Brown, M. S. and Goldstein, J. L. (2002) Mol. Cell 10, 237-245
20. Goldstein, J. L., Basu, S. K., and Brown, M. S. (1983) Methods Enzymol. 98, 241-260
21. Brown, M. S., Faust, J. R., Goldstein, J. L., Kaneko, I., and Endo, A. (1978) J. Biol. Chem. 253, 1121-1128
22. Thiele, C., Hannah, M. J., Fahrenholz, F., and Huttner, W. B. (2000) Nat. Cell Biol. 2, 42-49
23. Tavares, R., Randoux, T., Braekman, J.-C., and Daloze, D. (1993) Tetrahedron 49, 5079-5090
24. Hua, X., Sakai, J., Brown, M. S., and Goldstein, J. L. (1996) J. Biol. Chem. 271, 10379-10384
25. Nohturfft, A., Brown, M. S., and Goldstein, J. L. (1998) J. Biol. Chem. 273, 17243-17250
26. Rawson, R. B., DeBose-Boyd, R. A., Goldstein, J. L., and Brown, M. S. (1999) J. Biol. Chem. 274, 28549-28556
27. Yamamoto, T., Davis, C. G., Brown, M. S., Schneider, W. J., Casey, M. L., Goldstein, J. L., and Russell, D. W. (1984) Cell 39, 27-38
28. DeBose-Boyd, R. A., Brown, M. S., Li, W.-P., Nohturfft, A., Goldstein, J. L., and Espenshade, P. J. (1999) Cell 99, 703-712
29. Liang, G., Yang, J., Horton, J. D., Hammer, R. E., Goldstein, J. L., and Brown, M. S. (2002) J. Biol. Chem. 277, 9520-9528
30. Yang, J., Brown, M. S., Ho, Y. K., and Goldstein, J. L. (1995) J. Biol. Chem. 270, 12152-12161
31. Shimano, H., Horton, J. D., Hammer, R. E., Shimomura, I., Brown, M. S., and Goldstein, J. L. (1996) J. Clin. Invest. 98, 1575-1584
32. Russell, D. W. (2003) Annu. Rev. Biochem. 72, 137-174
33. Mintzer, E. A., Waarts, B.-L., Wilschut, J., and Bittman, R. (2002) FEBS Lett. 510, 181-184
34. Matyash, V., Geier, C., Henske, A., Mukherjee, S., Hirsh, D., Thiele, C., Grant, B., Maxfield, F. R., and Kurzchalia, T. V. (2001) Mol. Biol. Cell 12, 1725-1736
35. Taylor, F. R., and Kandutsch, A. A. (1985) Chem. Phys. Lipids 38, 187-194
36. Dawson, P. A., Ridgway, N. D., Slaughter, C. A., Brown, M. S., and Goldstein, J. L. (1989) J. Biol. Chem. 264, 16798-16803
37. Dawson, P. A., van der Westhuyzen, D. R., Goldstein, J. L., and Brown, M. S. (1989) J. Biol. Chem. 264, 9046-9052
38. Levanon, D., Hsieh, C.-L., Francke, U., Dawson, P. A., Ridgway, N. D., Brown, M. S., and Goldstein, J. L. (1990) Genomics 7, 65-74
39. Olkkonen, V. M. (2004) Curr. Opin. Lipidol. 15, 321-327
40. Ridgway, N. D., Dawson, P. A., Ho, Y. K., Brown, M. S., and Goldstein, J. L. (1992) J. Cell Biol. 116, 307-319
41. Touhara, K., Inglese, J., Pitcher, J. A., Shaw, G., and Lefkowitz, R. J. (1994) J. Biol. Chem. 269, 10217-10220