Insig-dependent Ubiquitination and Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-CoA Reductase Stimulated by Sterols and Geranylgeraniol

Journal of Biological Chemistry

Volumn 278, Issue 52, 2003, Pages 52479-52490

  Sever, Navdar ^a   Song, Bao Liang ^a   Yabe, Daisuke ^a   Goldstein, Joseph L ^a   Brown, Michael S ^a   DeBose Boydb, Russell A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DEGRADATION; ENZYMES; METABOLISM; POLYPEPTIDES; RNA; SUBSTITUTION REACTIONS;

TRANSFECTION;

BIOCHEMISTRY;

ALANINE; ARGININE; CARBON; FARNESOL; GERANYLGERANIOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INSIG PROTEIN; ISOPRENOID; LYSINE; MEMBRANE PROTEIN; MEVALONIC ACID; OXIDOREDUCTASE; POLYPEPTIDE; STEROL DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE OVEREXPRESSION; GENETIC TRANSFECTION; MAMMAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; REACTION ANALYSIS; RNA INTERFERENCE; UBIQUITINATION;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CELL MEMBRANE; CHO CELLS; CRICETINAE; DITERPENES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPLASMIC RETICULUM; FARNESOL; HYDROXYMETHYLGLUTARYL COA REDUCTASES; IMMUNOBLOTTING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYSINE; MEMBRANE PROTEINS; MEVALONIC ACID; MOLECULAR SEQUENCE DATA; PEPTIDES; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SEQUENCE HOMOLOGY, AMINO ACID; STEROLS; SUBCELLULAR FRACTIONS; TIME FACTORS; TRANSFECTION; UBIQUITIN;

ANIMALIA; MAMMALIA;

EID: 0346101770     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M310053200     Document Type: Article

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