Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

Molecular Cell

Volumn 19, Issue 6, 2005, Pages 829-840

  Song, Bao Liang ^a   Sever, Navdar ^a   DeBose Boyd, Russell A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INSIG 1 PROTEIN; PROTEIN; PROTEIN GP78; STEROL; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VALOSIN CONTAINING PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME DEGRADATION; ENZYME REGULATION; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN BINDING; UBIQUITINATION;

ANIMALS; CELL CYCLE PROTEINS; CELL LINE; CRICETINAE; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOKINE; STEROLS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA;

EID: 24944591120     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2005.08.009     Document Type: Article

References (39)

1. M.S. Brown, and J.L. Goldstein Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth J. Lipid Res. 21 1980 505 517
2. M.S. Brown, and J.L. Goldstein A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood Proc. Natl. Acad. Sci. USA 96 1999 11041 11048
3. M.S. Brown, J.R. Faust, and J.L. Goldstein Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase J. Biol. Chem. 253 1978 1121 1128
4. R.A. DeBose-Boyd, M.S. Brown, W.P. Li, A. Nohturfft, J.L. Goldstein, and P.J. Espenshade Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi Cell 99 1999 703 712
5. S. Fang, M. Ferrone, C. Yang, J.P. Jensen, S. Tiwari, and A.M. Weissman The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum Proc. Natl. Acad. Sci. USA 98 2001 14422 14427
6. R.M. Feldman, C.C. Correll, K.B. Kaplan, and R.J. Deshaies A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p Cell 91 1997 221 230
7. R.G. Gardner, A.G. Shearer, and R.Y. Hampton In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation Mol. Cell. Biol. 21 2001 4276 4291
8. G. Gil, J.R. Faust, D.J. Chin, J.L. Goldstein, and M.S. Brown Membrane bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme Cell 41 1985 249 258
9. J.L. Goldstein, and M.S. Brown Regulation of the mevalonate pathway Nature 343 1990 425 430
10. J.L. Goldstein, S.K. Basu, and M.S. Brown Receptor-mediated endocytosis of low-density lipoprotein in cultured cells Methods Enzymol. 98 1983 241 260
11. R.Y. Hampton Proteolysis and sterol regulation Annu. Rev. Cell Dev. Biol. 18 2002 345 378
12. Heart Protection Study Collaborative Group MRC/BHF heart protection study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial Lancet 360 2002 7 22
13. X. Hua, A. Nohturfft, J.L. Goldstein, and M.S. Brown Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein Cell 87 1996 415 426
14. D.R. Illingworth, and J.A. Tobert HMG-CoA reductase inhibitors Adv. Protein Chem. 56 2001 77 114
15. M. Kikkert, R. Doolman, M. Dai, R. Avner, G. Hassink, S. Van Voorden, S. Thanedar, J. Roitelman, V. Chau, and E. Wiertz Human Hrd1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum J. Biol. Chem. 279 2003 3525 3534
16. T. Kita, M.S. Brown, and J.L. Goldstein Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase J. Clin. Invest. 66 1980 1094 1100
17. L.W. Lecureux, and B.W. Wattenberg The regulated degradation of a 3-hydroxy-3-methylglutaryl-coenzyme A reductase reporter construct occurs in the endoplasmic reticulum J. Cell Sci. 107 1994 2635 2642
18. J.N. Lee, and J. Ye Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1 J. Biol. Chem. 279 2004 45257 45265
19. P.C.W. Lee, N. Sever, and R.A. DeBose-Boyd Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2 J. Biol. Chem. 280 2005 25242 25259
20. J.S. Liang, T. Kim, S. Fang, J. Yamaguchi, A.M. Weissman, E.A. Fisher, and H.N. Ginsberg Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells J. Biol. Chem. 278 2003 23984 23988
21. L. Liscum, J. Finer-Moore, R.M. Stroud, K.L. Luskey, M.S. Brown, and J.L. Goldstein Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum J. Biol. Chem. 260 1985 522 530
22. E. Nadav, A. Shmueli, H. Barr, H. Gonen, A. Ciechanover, and Y. Reiss A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1 Biochem. Biophys. Res. Commun. 303 2003 91 97
23. C.M. Pickart Mechanisms underlying ubiquitination Annu. Rev. Biochem. 70 2001 503 533
24. C.P. Ponting Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction Biochem. J. 351 2000 527 535
25. R.B. Rawson, R. DeBose-Boyd, J.L. Goldstein, and M.S. Brown Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein J. Biol. Chem. 274 1999 28549 28556
26. J. Roitelman, E.H. Olender, S. Bar-Nun, W.A. Dunn Jr., and R.D. Simoni Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum J. Cell Biol. 117 1992 959 973
27. Scandinavian Simvastatin Study Group Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) Lancet 344 1994 1383 1389
28. N. Sever, B.L. Song, D. Yabe, J.L. Goldstein, M.S. Brown, and R.A. DeBose-Boyd Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol J. Biol. Chem. 278 2003 52479 52490
29. N. Sever, T. Yang, M.S. Brown, J.L. Goldstein, and R.A. DeBose-Boyd Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain Mol. Cell 11 2003 25 33
30. N. Sever, P.C.W. Lee, B.L. Song, R.B. Rawson, and R.A. DeBose-Boyd Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase J. Biol. Chem. 279 2004 43136 43147
31. K. Shimizu, M. Tani, H. Watanabe, Y. Nagamachi, Y. Niinaka, T. Shiroishi, S. Ohwada, A. Raz, and J. Yokota The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein FEBS Lett. 456 1999 295 300
32. B.L. Song, and R.A. DeBose-Boyd Ubiquitination of 3-hydroxy-3- methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase J. Biol. Chem. 279 2004 28798 28806
33. B.L. Song, N.B. Javitt, and R.A. DeBose-Boyd Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol Cell Metab. 1 2005 179 189
34. H. Watanabe, P. Carmi, V. Hogan, T. Raz, S. Silletti, I.R. Nabi, and A. Raz Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor J. Biol. Chem. 266 1991 13442 13448
35. D. Yabe, M.S. Brown, and J.L. Goldstein Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins Proc. Natl. Acad. Sci. USA 99 2002 12753 12758
36. T. Yamamoto, C.G. Davis, M.S. Brown, W.J. Schneider, M.L. Casey, J.L. Goldstein, and D.W. Russell The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA Cell 39 1984 27 38
37. T. Yang, P.J. Espenshade, M.E. Wright, D. Yabe, Y. Gong, R. Aebersold, J.L. Goldstein, and M.S. Brown Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER Cell 110 2002 489 500
38. Y. Ye, H.H. Meyer, and T.A. Rapoport The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol Nature 414 2001 652 656
39. X. Zhong, Y. Shen, P. Ballar, A. Apostolou, R. Agami, and S. Fang AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation J. Biol. Chem. 279 2004 45676 45684