Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 22, 1998, Pages 12848-12853

  Nohturfft, Axel ^a   Brown, Michael S ^a   Goldstein, Joseph L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cholesterol; Endoplasmic reticulum; Golgi apparatus; Sterol regulatory element binding protein; Sterol sensing domain

Indexed keywords

25 HYDROXYCHOLESTEROL; BINDING PROTEIN; CARBOHYDRATE; CHOLESTEROL; ENDOGLYCOSIDASE H; GLYCOSIDASE; SREBP CLEAVAGE ACTIVATING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOHYDRATE METABOLISM; CELL NUCLEUS; CHO CELL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENETIC TRANSCRIPTION; GOLGI COMPLEX; HUMAN; HUMAN CELL; LIPOGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; CHO CELLS; CLONE CELLS; CRICETINAE; DNA-BINDING PROTEINS; DRUG RESISTANCE; ETHYLNITROSOUREA; HUMANS; HYDROXYCHOLESTEROLS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NUCLEAR PROTEINS; POINT MUTATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROLS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0032573056     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.22.12848     Document Type: Article

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