Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis

Journal of Clinical Investigation

Volumn 113, Issue 8, 2004, Pages 1168-1175

  Engelking, Luke J ^a   Kuriyama, Hiroshi ^a   Hammer, Robert E ^a   Horton, Jay D ^a   Brown, Michael S ^a   Goldstein, Joseph L ^a   Liang, Guosheng ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; FATTY ACID; INSULIN; ISOPROTEIN; LIPID; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN INSIG 1; PROTEIN INSIG 2; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN CLEAVAGE ACTIVATING PROTEIN; TRANSCRIPTION FACTOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE DIET; CELL CULTURE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FATTY ACID SYNTHESIS; GENE OVEREXPRESSION; GOLGI COMPLEX; HORMONE ACTION; IN VIVO STUDY; LIPOGENESIS; MEMBRANE BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROCESSING; TRANSGENIC MOUSE; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 2142751644     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI20978     Document Type: Article

References (23)

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