Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 19, 2003, Pages 10647-10652

  Adams, Christopher M ^a   Goldstein, Joseph L ^a   Brown, Michael S ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOPHILE; CATION; CHLORPROMAZINE; CHOLESTEROL; IMIPRAMINE; MEMBRANE PROTEIN; PROTEIN INSIG 1; PROTEIN INSIG 2; PROTEIN SCAP; STEROL DERIVATIVE; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR; TRIFLUOPERAZINE; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE ACTIVATION; GOLGI COMPLEX; LIPOGENESIS; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

ANIMALS; CARRIER PROTEINS; CHO CELLS; CHOLESTEROL; CRICETINAE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MOLECULAR MIMICRY; PROTEIN CONFORMATION; PROTEINS;

ANIMALIA;

EID: 0141591549     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1534833100     Document Type: Article

References (29)

1. Horton, J. D., Goldstein, J. L. & Brown, M. S. (2002) J. Clin. Invest. 109, 1125-1131.
2. Brown, M. S. & Goldstein, J. L. (1997) Cell 89, 331-340.
3. Goldstein, J. L., Rawson, R. B. & Brown, M. S. (2002) Arch. Biochem. Biophys. 397, 139-148.
4. Hua, X., Sakai, J., Brown, M. S. & Goldstein, J. L. (1996) J. Biol. Chem. 271, 10379-10384.
5. Nohturfft, A., Brown, M. S. & Goldstein, J. L. (1998) Proc. Natl. Acad. Sci. USA 95, 12848-12853.
6. Yabe, D., Xia, Z.-P., Adams, C. M. & Rawson, R. B. (2002) Proc. Natl. Acad. Sci. USA 99, 16672-16677.
7. Brown, A. J., Sun, L., Feramisco, J. D., Brown, M. S. & Goldstein, J. L. (2002) Mol. Cell 10, 237-245.
8. Yang, T., Espenshade, P. J., Wright, M. E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J. L. & Brown, M. S. (2002) Cell 110, 489-500.
9. Yabe, D., Brown, M. S. & Goldstein, J. L. (2002) Proc. Natl. Acad. Sci. USA 99, 12753-12758.
10. Sheetz, M. P. & Singer, S. J. (1974) Proc. Natl. Acad. Sci. USA 71, 4457-4461.
11. Underwood, K. W., Andemariam, B., McWilliams, G. L. & Liscum, L. (1996) J. Lipid Res. 37, 1556-1568.
12. Lange, Y. & Steck, T. L. (1994) J. Biol. Chem. 269, 29371-29374.
13. Rawson, R. B., DeBose-Boyd, R. A., Goldstein, J. L. & Brown, M. S. (1999) J. Biol. Chem. 274, 28549-28556.
14. Seegmiller, A. C., Dobrosotskaya, I., Goldstein, J. L., Ho, Y. K., Brown, M. S. & Rawson, R. B. (2002) Dev. Cell 2, 229-238.
15. Dobrosotskaya, I., Seegmiller, A. C., Brown, M. S., Goldstein, J. L. & Rawson, R. B. (2002) Science 296, 879-883.
16. Schreier, S., Malheiros, S. V. P. & de Paula, E. (2000) Biochim. Biophys. Acta 1508, 210-234.
17. Zachowski, A. & Durand, P. (1988) Biochim. Biophys. Acta 937, 411-416.
18. Ahyayauch, H., Requero, M. A., Alonso, A. Bennouna, M. & Goni, F. M. (2002) J. Colloid Interface Sci. 256, 284-289.
19. Wang, X., Sato, R., Brown, M. S., Hua, X. & Goldstein, J. L. (1994) Cell 77, 53-62.
20. Brown, M. S., Dana, S. E. & Goldstein, J. L. (1975) Proc. Natl. Acad. Sci. USA 72, 2925-2929.
21. Lange, Y. & Steck, T. L. (1997) J. Biol. Chem. 272, 13103-13108.
22. Reasor, M. J. & Kacew, S. (2001) Exp. Biol. Med. 226, 825-830.
23. Oswald, R. & Changeux, J.-P. (1981) Proc. Natl. Acad. Sci. USA 78, 3925-3929.
24. Prozialeck, W. C. & Weiss, B. (1982) J. Pharmacol. Exp. Ther. 222, 509-516.
25. Gupta, A. K. & Rudney, H. (1991) J. Lipid Res. 32, 125-136.
26. Moebius, F. F., Striessnig, J. & Glossmann, H. (1997) Trends Pharmacol. Sci. 18, 67-70.
27. Bae, S.-H., Seong, J. & Paik, Y.-K. (2001) Biochem. J. 353, 689-699.
28. Hardman, J. G. & Limbird, L. E. (2001) Goodman and Gilman's The Pharmacological Basis of Therapeutics (McGraw-Hill, New York).
29. Rothman, J. E. & Lenard, J. (1977) Science 195, 743-753.