Oxysterol binding protein and its homologues: New regulatory factors involved in lipid metabolism

Current Opinion in Lipidology

Volumn 15, Issue 3, 2004, Pages 321-327

  Olkkonen, Vesa M ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Lipid transport; Membrane contact sites; Osh; Oxysterol binding protein; Oxysterol binding protein related protein; Sterol metabolism

Indexed keywords

LIVER X RECEPTOR; OXYSTEROL;

AMINO TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL ORGANELLE; ENDOPLASMIC RETICULUM; EUKARYOTE; EUKARYOTE EVOLUTION; HUMAN; LIPID METABOLISM; MACROPHAGE; METABOLIC REGULATION; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; REVIEW; SEQUENCE HOMOLOGY; TRANSCRIPTION INITIATION; YEAST;

ANIMALS; BIOLOGICAL TRANSPORT; CELL DIFFERENTIATION; CELL MEMBRANE; ENDOPLASMIC RETICULUM; HUMANS; LIPID METABOLISM; MAMMALS; NEOPLASMS; RECEPTORS, STEROID; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

EUKARYOTA;

EID: 2642558199     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200406000-00013     Document Type: Review

References (71)

1. Schroepfer GJ Jr. Oxysterols: modulators of cholesterol metabolism and other processes. Physiol Rev 2000; 80:361-554.
2. Russell DW. Oxysterol biosynthetic enzymes. Biochim Biophys Acta 2000; 1529:126-135.
3. Björkhem I. Do oxysterols control cholesterol homeostasis? J Clin Invest 2002; 110:725-730.
4. Brown AJ, Jessup W. Oxysterols and atherosclerosis. Atherosclerosis 1999; 142:1-28.
5. Brown MS, Goldstein JL. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci U S A 1999; 96:11041-11048.
6. Brown AJ, Sun L, Feramisco JD, et al. Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism. Mol Cell 2002; 10:237-245.
7. Yang T, Espenshade PJ, Wright ME, et al. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 2002; 110:489-500.
8. Repa JJ, Mangelsdorf DJ. The liver X receptor gene team: potential new players in atherosclerosis. Nat Med 2002; 8:1243-1248.
9. Edwards PA, Kast HR, Anisfeld AM. BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. J Lipid Res 2002; 43:2-12.
10. Babiker A, Andersson O, Lund E, et al. Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism: comparison with high-density lipoprotein-mediated reverse cholesterol transport. J Biol Chem 1997; 272:26253-26261.
11. Lütjohann D, Breuer O, Ahlborg G, et al. Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc Natl Acad Sci U S A 1996; 93:9799-9804.
12. Taylor FR, Saucier SE, Shown EP, et al. Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase. J Biol Chem 1984; 259:12382-12387.
13. Taylor FR, Kandutsch AA. Oxysterol binding protein. Chem Phys Lipids 1985; 38:187-194.
14. Dawson PA, Ridgway ND, Slaughter CA, et al. cDNA cloning and expression of oxysterol-binding protein, an oligomer with a potential leucine zipper. J Biol Chem 1989; 264:16798-16803.
15. Levanon D, Hsieh CL, Francke U, et al. cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19. Genomics 1990; 7:65-74.
16. Ridgway ND, Dawson PA, Ho YK, et al. Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding. J Cell Biol 1992; 116:307-319.
17. Lagace TA, Byers DM, Cook HW, Ridgway ND. Altered regulation of cholesterol and cholesteryl ester synthesis in Chinese-hamster ovary cells overexpressing the oxysterol-binding protein is dependent on the pleckstrin homology domain. Biochem J 1997; 326:205-213.
18. Lagace TA, Byers DM, Cook HW, Ridgway ND. Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol. J Lipid Res 1999; 40:109-116.
19. Beh CT, Cool L, Phillips J, Rine J. Overlapping functions of the yeast oxysterol-binding protein homologues. Genetics 2001; 157:1117-1140.
20. Lehto M, Laitinen S, Chinetti G, et al. The OSBP-related protein family in humans. J Lipid Res 2001; 42:1203-1213.
21. Jaworski CJ, Moreira E, Li A, et al. A family of 12 human genes containing oxysterol-binding domains. Genomics 2001; 78:185-196.
22. Anniss AM, Apostolopoulos J, Dworkin S, et al. An oxysterol-binding protein family identified in mouse. DNA Cell Biol 2002; 21:571-580.
23. Collier FM, Gregorio-King CC, Apostolopoulos J, et al. ORP3 splice variants and their expression in human tissues and hematopoietic cells. DNA Cell Biol 2003; 22:1-9. This work reports that ORP3 undergoes extensive tissue-specific splice variation, suggesting that the gene family encodes an unexpectedly large number of structurally (and probably functionally) distinct protein products.
24. Lehto M, Olkkonen VM. The OSBP-related proteins: a novel protein family involved in vesicle transport, cellular lipid metabolism, and cell signalling. Biochim Biophys Acta 2003; 1631:1-11. A comprehensive review article that discusses extensively the literature on ORP function and interaction partners.
25. Fang M, Kearns BG, Gedvilaite A, et al. Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis. EMBO J 1996; 15:6447-6459.
26. Li X, Xie Z, Bankaitis VA. Phosphatidylinositol/phosphatidylcholine transfer proteins in yeast. Biochim Biophys Acta 2000; 1486:55-71.
27. Li X, Rivas MP, Fang M, et al. Analysis of oxysterol binding protein homologue Kes1p function in regulation of Sec14p-dependent protein transport from the yeast Golgi complex. J Cell Biol 2002; 157:63-77.
28. Donaldson JG, Jackson CL. Regulators and effectors of the ARF GTPases. Curr Opin Cell Biol 2000; 12:475-482.
29. Bigay J, Gounon P, Robineau S, Antonny B. Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvature. Nature 2003; 426:563-566.
30. Jiang B, Brown JL, Sheraton J, et al. A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein. Yeast 1994; 10:341-353.
31. Daum G, Tuller G, Nemec T, et al. Systematic analysis of yeast strains with possible defects in lipid metabolism. Yeast 1999; 15:601-614.
32. Levine TP, Munro S. The pleckstrin homology domain of oxysterol-binding protein recognises a determinant specific to Golgi membranes. Curr Biol 1998; 8:729-739.
33. Levine TP, Munro S. Targeting of Golgi-specific pleckstrin homology domains involves both Ptdlns 4-kinase-dependent and -independent components. Curr Biol 2002; 12:695-704.
34. Gardner RG, Shan H, Matsuda SPT, et al. An oxysterol-derived positive signal for 3-hydroxy-3-methylglutaryl-CoA reductase degradation in yeast. J Biol Chem 2001; 276:8681-8694.
35. Fu X, Menke JG, Chen Y, et al. 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J Biol Chem 2001; 276:38378-38387.
36. Lund EG, Xie C, Kotti T, et al. Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J Biol Chem 2003; 278:22980-22988.
37. Rowe AH, Argmann CA, Edwards JY, et al. Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation. Circ Res 2003; 93:717-725.
38. Ridgway ND, Lagace TA, Cook HW, Byers DM. Differential effects of sphingomyelin hydrolysis and cholesterol transport on oxysterol-binding protein phosphorylation and Golgi localization. J Biol Chem 1998; 273:31621-31628.
39. Storey MK, Byers DM, Cook HW, Ridgway ND. Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol. Biochem J 1998; 336:247-256.
40. Mohammadi A, Perry RJ, Storey MK, et al. Golgi localization and phosphorylation of oxysterol binding protein in Niemann-Pick C and U18666A-treated cells. J Lipid Res 2001; 42:1062-1071.
41. Ridgway ND, Badiani K, Byers DM, Cook HW. Inhibition of phosphorylation of the oxysterol binding protein by brefeldin A. Biochim Biophys Acta 1998; 1390:37-51.
42. Wang C, JeBailey L, Ridgway ND. Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments. Biochem J 2002; 361:461-472.
43. Laitinen S, Lehto M, Lehtonen S, et al. ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism. J Lipid Res 2002; 43:245-255.
44. Johansson M, Bocher V, Lehto M, et al. The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct. Mol Biol Cell 2003; 14:903-915. This paper reports the tissue expression patterns and intracellular localization of the two major variants of ORP1, and delineates determinants of the late endosomal targeting of the ORP1 long (L) variant. Especially ORP1L, but also certain other ORPs are shown to be upregulated during monocyte differentiation into macrophages, and ORP1L is found to enhance the action of liver X receptors. The data suggest a distinct function of ORPs in macrophage sterol metabolism.
45. Lehto M, Tienari J, Lehtonen S, et al. Subfamily III of mammalian oxysterol binding protein (OSBP) homologues: the expression and intracellular localisation of ORP3, ORP6, and ORP7. Cell Tissue Res 2004; 351:39-57. This work reports that the closely related ORP3, 6, and 7 have distinct tissue expression patterns and carry determinants for endoplasmic reticulum and plasma membrane localization, bringing about the hypothesis that their function may involve communication between these two membrane systems.
46. Wyles JP, McMaster CR, Ridgway ND. Vesicle-associated membrane protein-associated protein-A (VAP-A) interacts with the oxysterol-binding protein to modify export from the endoplasmic reticulum. J Biol Chem 2002; 277:29908-29918
47. Fukusawa M, Nishijima M, Hanada K. Genetic evidence for ATP-dependent endoplasmic reticulum-to-Golgi apparatus trafficking of ceramide for sphingomyelin synthesis in Chinese hamster ovary cells. J Cell Biol 1999; 144:673-685.
48. Funato K, Riezman H. Vesicular and nonvesicular transport of ceramide from ER to the Golgi apparatus in yeast. J Cell Biol 2001; 155:949-959.
49. Hanada K, Kumagai K, Yasuda S, et al. Molecular machinery for non-vesicular trafficking of ceramide. Nature 2003; 426:803-809. The ceramide transport and sphingomyelin synthesis defect in a mammalian cell line is reported to be caused by a mutation in the CERT/GPBP gene, which encodes a protein highly similar to ORPs in domain structure. This protein has a Golgi-targeting pleckstrin homology domain closely related to that of OSBP and an endoplasmic reticulum-targeting FFAT motif, but instead of a carboxy-terminal ORD it has a START domain that is shown to bind ceramide. The CERT-mediated ceramide transport is suggested to occur at endoplasmic reticulum-Golgi membrane contact sites.
50. Loewen CJR, Roy A, Levine TP. A conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAP. EMBO J 2003; 22:2025-2035. A novel short motif called FFAT is identified in a number of ORPs and other lipid binding proteins that is shown to target proteins to the endoplasmic reticulum. This occurs via a highly conserved direct interaction with homologues of VAMP-associated proteins, resident trans-membrane proteins of the endoplasmic reticulum. The authors suggest that the function of the FFAT motif may be to facilitate nonvesicular transport of newly synthesized lipids from the endoplasmic reticulum to other organelles.
51. Levine T, Munro S. Dual targeting of Osh1p, a yeast homologue of oxysterol-binding protein, to both the Golgi and the nucleus-vacuole junction. Mol Biol Cell 2001; 12:1633-1644.
52. Olkkonen VM, Levine TP. Oxysterol binding proteins: in more than one place at one time? Biochem Cell Biol 2004; 82:87-98. In this review article the hypothesis on ORP function at membrane contact sites is introduced.
53. Daum G, Vance JE. Import of lipids into mitochondria. Prog Lipid Res 1997; 36:103-130.
54. Whatmore J, Wiedemann C, Somerharju P, et al. Resynthesis of phosphatidylinositol in permeabilized neutrophils following phospholipase Cβ activation: transport of the intermediate, phosphatidic acid, from the plasma membrane to the endoplasmic reticulum for phosphatidylinositol synthesis is not dependent on soluble lipid carriers or vesicular transport. Biochem J 1999; 341:435-444.
55. Pichler H, Gaigg B, Hrastnik C, et al. A subfraction of the yeast endoplasmic reticulum associates with the plasma membrane and has a high capacity to synthesize lipids. Eur J Biochem 2001; 268:2351-2361.
56. Alphey L, Jimenez J, Glover D. A Drosophila homologue of oxysterol binding protein (OSBP): implications for the role of OSBP. Biochim Biophys Acta 1998; 1395:159-164.
57. Sugawara K, Morita K, Ueno N, Shibuya H. BIP, a BRAM-interacting protein involved in TGF-beta signalling, regulates body length in Caenorhabditis elegans. Genes Cells 2001; 6:599-606.
58. Fournier MV, Guimaraes da Costa F, Paschoal ME, et al. Identification of a gene encoding a human oxysterol-binding protein-homologue: a potential general molecular marker for blood dissemination of solid tumors. Cancer Res 1999; 59:3748-3753.
59. Silva NH, Pimenta G, Pulchen WA, et al. Detection of messenger RNA in leukocytes or plasma of patients with chronic myeloid leukemia. Oncol Rep 2001; 8:693-696.
60. Silva NH, Fournier MV, Pimenta G, et al. HLM/OSBP2 is expressed in chronic myeloid leukemia. Int J Mol Med 2003; 12:663-666.
61. Henshall SM, Afar DEH, Hiller J, et al. Survival analysis of genome-wide expression profiles of prostate cancers identifies new prognostic targets of disease relapse. Cancer Res 2003; 63:4196-4203.
62. Difilippantonio S, Chen Y, Pietas A, et al. Gene expression profiles in human non-small and small-cell lung cancers. Eur J Cancer 2003; 39:1936-1947.
63. Jelinek DF, Tschumper RC, Stolovitzky GA, et al. Identification of a global gene expression signature of B-chronic lymphocytic leukemia. Mol Cancer Res 2003; 1:346-361.
64. Silva J, Beckedorf A, Bieberich E. Osteoblast-derived oxysterol is a migration-inducing factor for human breast cancer cells. J Biol Chem 2003; 278:25376-25385. ORP7 is found to be one of the major proteins upregulated in insulin-like growth factor-1 stimulated migrating breast cancer MCF-7 cells, implicating a role of ORP7 in breast cancer metastasis.
65. Gregorio-King CC, Collier GR, McMillan JS, et al. ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells. Blood 2001; 98:2279-2281.
66. Simons K, Ikonen E. How cells handle cholesterol. Science 2000; 290:1721-1726.
67. Fielding CJ, Fielding PE. Relationship between cholesterol trafficking and signaling in rafts and caveolae. Biochim Biophys Acta 2003; 1610:219-228.
68. Mills GB, Moolenaar WH. The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer 2003; 3:582-591.
69. Martelli AM, Manzoli L, Faenza I, et al. Nuclear inositol lipid signaling and its potential involvement in malignant transformation. Biochim Biophys Acta 2002; 1603:11-17.
70. Cuvillier O, Levade T. Enzymes of sphingosine metabolism as potential pharmacological targets for therapeutic intervention in cancer. Pharm Res 2003; 47:439-445.
71. Panini SR, Sinensky MS. Mechanisms of oxysterol-induced apoptosis. Curr Opin Lipidol 2001; 12:529-533.