-
1
-
-
0028137580
-
Mechanisms and meaning of cellular oxygen sensing in the organism
-
Acker H. Mechanisms and meaning of cellular oxygen sensing in the organism. Respir Physiol 95: 1-10, 1994.
-
(1994)
Respir Physiol
, vol.95
, pp. 1-10
-
-
Acker, H.1
-
2
-
-
18744373593
-
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia
-
Ang SO, Chen H, Hirota K, Gordeuk VR, Jelinek J, Guan Y, Liu E, Sergueeva AI, Miasnikova GY, Mole D, Maxwell PH, Stockton DW, Semenza GL, and Prchal JT. Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia. Nat Genet 32: 614-621, 2002.
-
(2002)
Nat Genet
, vol.32
, pp. 614-621
-
-
Ang, S.O.1
Chen, H.2
Hirota, K.3
Gordeuk, V.R.4
Jelinek, J.5
Guan, Y.6
Liu, E.7
Sergueeva, A.I.8
Miasnikova, G.Y.9
Mole, D.10
Maxwell, P.H.11
Stockton, D.W.12
Semenza, G.L.13
Prchal, J.T.14
-
3
-
-
0029803552
-
An essential role for p300/CBP in the cellular response to hypoxia
-
Arany Z, Huang LE, Eckner R, Bhattacharya S, Jiang C, Goldberg MA, Bunn HF, and Livingston DM. An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 93: 12969-12973, 1996.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 12969-12973
-
-
Arany, Z.1
Huang, L.E.2
Eckner, R.3
Bhattacharya, S.4
Jiang, C.5
Goldberg, M.A.6
Bunn, H.F.7
Livingston, D.M.8
-
4
-
-
0027410945
-
Co-localization of erythropoietin mRNA and ecto-5′-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin
-
Bachmann S, Le Hir M, and Eckardt KU. Co-localization of erythropoietin mRNA and ecto-5′-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin. J Histochem Cytochem 41: 335-341, 1993.
-
(1993)
J Histochem Cytochem
, vol.41
, pp. 335-341
-
-
Bachmann, S.1
Le Hir, M.2
Eckardt, K.U.3
-
5
-
-
0026049416
-
Enhancer element at the 3′-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene
-
Beck I, Ramirez S, Weinmann R, and Caro J. Enhancer element at the 3′-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene. J Biol Chem 266: 15563-15566, 1991.
-
(1991)
J Biol Chem
, vol.266
, pp. 15563-15566
-
-
Beck, I.1
Ramirez, S.2
Weinmann, R.3
Caro, J.4
-
6
-
-
0034013854
-
Neurons and astrocytes express EPO mRNA: Oxygen-sensing mechanisms that involve the redox-state of the brain
-
Bernaudin M, Bellail A, Marti HH, Yvon A, Vivien D, Duchatelle I, Mackenzie ET, and Petit E. Neurons and astrocytes express EPO mRNA: oxygen-sensing mechanisms that involve the redox-state of the brain. Glia 30: 271-278, 2000.
-
(2000)
Glia
, vol.30
, pp. 271-278
-
-
Bernaudin, M.1
Bellail, A.2
Marti, H.H.3
Yvon, A.4
Vivien, D.5
Duchatelle, I.6
Mackenzie, E.T.7
Petit, E.8
-
7
-
-
0033512017
-
A potential role for erythropoietin in focal permanent cerebral ischemia in mice
-
Bernaudin M, Marti HH, Roussel S, Divoux D, Nouvelot A, Mackenzie ET, and Petit E. A potential role for erythropoietin in focal permanent cerebral ischemia in mice. J Cereb Blood Flow Metab 19: 643-651, 1999.
-
(1999)
J Cereb Blood Flow Metab
, vol.19
, pp. 643-651
-
-
Bernaudin, M.1
Marti, H.H.2
Roussel, S.3
Divoux, D.4
Nouvelot, A.5
Mackenzie, E.T.6
Petit, E.7
-
8
-
-
2442644755
-
Sur la richesse en hémoglobine du sang des animaux vivant sur les hauts lieux
-
Bert P. Sur la richesse en hémoglobine du sang des animaux vivant sur les hauts lieux. C R Acad Sci Paris 94: 805-807, 1882.
-
(1882)
C R Acad Sci Paris
, vol.94
, pp. 805-807
-
-
Bert, P.1
-
9
-
-
0024989764
-
Evidence suggesting negative regulation of the erythropoietin gene by ribonucleoprotein
-
Beru N, Smith D, and Goldwasser E. Evidence suggesting negative regulation of the erythropoietin gene by ribonucleoprotein. J Biol Chem 265: 14100-14104, 1990.
-
(1990)
J Biol Chem
, vol.265
, pp. 14100-14104
-
-
Beru, N.1
Smith, D.2
Goldwasser, E.3
-
10
-
-
0026494916
-
Hypoxic induction of the human erythropoietin gene: Cooperation between the promoter and enhancer, each of which contains steroid receptor response elements
-
Blanchard KL, Acquaviva AM, Galson DL, and Bunn HF. Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements. Mol Cell Biol 12: 5373-5385, 1992.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5373-5385
-
-
Blanchard, K.L.1
Acquaviva, A.M.2
Galson, D.L.3
Bunn, H.F.4
-
11
-
-
0001700756
-
A humoral mechanism in anoxic erythrocytosis
-
Bonsdorff E and Jalavisto E. A humoral mechanism in anoxic erythrocytosis. Acta Physiol Scand 16: 150-170, 1948.
-
(1948)
Acta Physiol Scand
, vol.16
, pp. 150-170
-
-
Bonsdorff, E.1
Jalavisto, E.2
-
12
-
-
0042368882
-
The hypoxia-inducible factors: Key transcriptional regulators of hypoxic responses
-
Bracken CP, Whitelaw ML, and Peet DJ. The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses. Cell Mol Life Sci 60: 1376-1393, 2003.
-
(2003)
Cell Mol Life Sci
, vol.60
, pp. 1376-1393
-
-
Bracken, C.P.1
Whitelaw, M.L.2
Peet, D.J.3
-
13
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick RK and McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294: 1337-1340, 2001.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
14
-
-
0038163900
-
Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury
-
Cai Z, Manalo DJ, Wei G, Rodriguez ER, Fox-Talbot K, Lu H, Zweier JL, and Semenza GL. Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation 108: 79-85, 2003.
-
(2003)
Circulation
, vol.108
, pp. 79-85
-
-
Cai, Z.1
Manalo, D.J.2
Wei, G.3
Rodriguez, E.R.4
Fox-Talbot, K.5
Lu, H.6
Zweier, J.L.7
Semenza, G.L.8
-
15
-
-
0000909936
-
Sur l'activité hémopoiétique du sérum au cours de la régénération du sang
-
Carnot P and Deflandre C. Sur l'activité hémopoié tique du sérum au cours de la régénération du sang. C R Acad Sci Paris 143: 384-386, 1906.
-
(1906)
C R Acad Sci Paris
, vol.143
, pp. 384-386
-
-
Carnot, P.1
Deflandre, C.2
-
16
-
-
0032578458
-
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
-
Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, and Schumacker PT. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 95: 11715-11720, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 11715-11720
-
-
Chandel, N.S.1
Maltepe, E.2
Goldwasser, E.3
Mathieu, C.E.4
Simon, M.C.5
Schumacker, P.T.6
-
17
-
-
0033634937
-
Tissue-specific regulation of erythropoietin production in the murine kidney, brain, and uterus
-
Chikuma M, Masuda S, Kobayashi T, Nagao M, and Sasaki R. Tissue-specific regulation of erythropoietin production in the murine kidney, brain, and uterus. Am J Physiol Endocrinol Metab 279: E1242-E1248, 2000.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.279
-
-
Chikuma, M.1
Masuda, S.2
Kobayashi, T.3
Nagao, M.4
Sasaki, R.5
-
18
-
-
0035983324
-
Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
-
Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, Plaisance S, Dor Y, Keshet E, Lupu F, Nemery B, Dewerchin M, Van Veldhoven P, Plate K, Moons L, Collen D, and Carmeliet P. Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 8: 702-710, 2002.
-
(2002)
Nat Med
, vol.8
, pp. 702-710
-
-
Compernolle, V.1
Brusselmans, K.2
Acker, T.3
Hoet, P.4
Tjwa, M.5
Beck, H.6
Plaisance, S.7
Dor, Y.8
Keshet, E.9
Lupu, F.10
Nemery, B.11
Dewerchin, M.12
Van Veldhoven, P.13
Plate, K.14
Moons, L.15
Collen, D.16
Carmeliet, P.17
-
19
-
-
0029995806
-
Expression of erythropoietin by the human placenta
-
Conrad KP, Benyo DF, Westerhausen-Larsen A, and Miles TM. Expression of erythropoietin by the human placenta. FASEB J 10: 760-768, 1996.
-
(1996)
FASEB J
, vol.10
, pp. 760-768
-
-
Conrad, K.P.1
Benyo, D.F.2
Westerhausen-Larsen, A.3
Miles, T.M.4
-
20
-
-
0033584965
-
EPAS1 trans-activation during hypoxia requires p42/p44 MAPK
-
Conrad PW, Freeman TL, Beitner-Johnson D, and Millhorn DE. EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. J Biol Chem 274: 33709-33713, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 33709-33713
-
-
Conrad, P.W.1
Freeman, T.L.2
Beitner-Johnson, D.3
Millhorn, D.E.4
-
21
-
-
2442659874
-
Molecular biology of the erythropoietin receptor in hematopoietic and non-hematopoietic tissues
-
edited by Molineux G, Foote M, and Elliott SG. Berlin: Birkhäuser Verlag
-
Dame C. Molecular biology of the erythropoietin receptor in hematopoietic and non-hematopoietic tissues. In: Erythropoietin and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology, edited by Molineux G, Foote M, and Elliott SG. Berlin: Birkhäuser Verlag, 2003, p. 35-64.
-
(2003)
Erythropoietin and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology
, pp. 35-64
-
-
Dame, C.1
-
22
-
-
0034731342
-
Erythropoietin gene expression in different areas of the developing human central nervous system
-
Dame C, Bartmann P, Wolber E, Fahnenstich H, Hofmann D, and Fandrey J. Erythropoietin gene expression in different areas of the developing human central nervous system. Brain Res Dev Brain Res 125: 69-74, 2000.
-
(2000)
Brain Res Dev Brain Res
, vol.125
, pp. 69-74
-
-
Dame, C.1
Bartmann, P.2
Wolber, E.3
Fahnenstich, H.4
Hofmann, D.5
Fandrey, J.6
-
23
-
-
0032211174
-
Erythropoietin mRNA expression in human fetal and neonatal tissue
-
Dame C, Fahnenstich H, Freitag P, Hofmann D, Abdul-Nour T, Bartmann P, and Fandrey J. Erythropoietin mRNA expression in human fetal and neonatal tissue. Blood 92: 3218-3225, 1998.
-
(1998)
Blood
, vol.92
, pp. 3218-3225
-
-
Dame, C.1
Fahnenstich, H.2
Freitag, P.3
Hofmann, D.4
Abdul-Nour, T.5
Bartmann, P.6
Fandrey, J.7
-
24
-
-
0035079692
-
The biology of erythropoietin in the central nervous system and its neurotrophic and neuroprotective potential
-
Dame C, Juul SE, and Christensen RD. The biology of erythropoietin in the central nervous system and its neurotrophic and neuroprotective potential. Biol Neonate 79: 228-235, 2001.
-
(2001)
Biol Neonate
, vol.79
, pp. 228-235
-
-
Dame, C.1
Juul, S.E.2
Christensen, R.D.3
-
25
-
-
0036440670
-
Developmental changes in the expression of transcription factors GATA-1, -2 and -3 during the onset of human medullary haematopoiesis
-
Dame C, Sola MC, Fandrey J, Rimsza LM, Freitag P, Knopfle G, Christensen RD, and Bungert J. Developmental changes in the expression of transcription factors GATA-1, -2 and -3 during the onset of human medullary haematopoiesis. Br J Haematol 119: 510-515, 2002.
-
(2002)
Br J Haematol
, vol.119
, pp. 510-515
-
-
Dame, C.1
Sola, M.C.2
Fandrey, J.3
Rimsza, L.M.4
Freitag, P.5
Knopfle, G.6
Christensen, R.D.7
Bungert, J.8
-
26
-
-
1642535393
-
Hepatic erythropoietin gene Regulation by GATA-4
-
Dame C, Sola MC, Lim KC, Leach KM, Fandrey J, Ma Y, Knopfle G, Engel JD, and Bungert J. Hepatic erythropoietin gene Regulation by GATA-4. J Biol Chem 279: 2955-2961, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 2955-2961
-
-
Dame, C.1
Sola, M.C.2
Lim, K.C.3
Leach, K.M.4
Fandrey, J.5
Ma, Y.6
Knopfle, G.7
Engel, J.D.8
Bungert, J.9
-
27
-
-
0030583277
-
Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT)
-
Drutel G, Kathmann M, Heron A, Schwartz JC, and Arrang JM. Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT). Biochem Biophys Res Commun 225: 333-339, 1996.
-
(1996)
Biochem Biophys Res Commun
, vol.225
, pp. 333-339
-
-
Drutel, G.1
Kathmann, M.2
Heron, A.3
Schwartz, J.C.4
Arrang, J.M.5
-
28
-
-
0033118983
-
Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
-
Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, and Fujii-Kuriyama Y. Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J 18: 1905-1914, 1999.
-
(1999)
EMBO J
, vol.18
, pp. 1905-1914
-
-
Ema, M.1
Hirota, K.2
Mimura, J.3
Abe, H.4
Yodoi, J.5
Sogawa, K.6
Poellinger, L.7
Fujii-Kuriyama, Y.8
-
29
-
-
0031000736
-
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development
-
Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, and Fujii-Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 94: 4273-4278, 1997.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4273-4278
-
-
Ema, M.1
Taya, S.2
Yokotani, N.3
Sogawa, K.4
Matsuda, Y.5
Fujii-Kuriyama, Y.6
-
30
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, and Ratcliffe PJ. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107: 43-54, 2001.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
Tian, Y.M.11
Masson, N.12
Hamilton, D.L.13
Jaakkola, P.14
Barstead, R.15
Hodgkin, J.16
Maxwell, P.H.17
Pugh, C.W.18
Schofield, C.J.19
Ratcliffe, P.J.20
more..
-
31
-
-
0000009635
-
Humoral regulation of red cell production
-
Erslev AJ. Humoral regulation of red cell production. Blood 8: 349-357, 1953.
-
(1953)
Blood
, vol.8
, pp. 349-357
-
-
Erslev, A.J.1
-
32
-
-
0023120533
-
Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial
-
Eschbach JW, Egrie JC, Downing MR, Browne JK, and Adamson JW. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial. N Engl J Med 316: 73-78, 1987.
-
(1987)
N Engl J Med
, vol.316
, pp. 73-78
-
-
Eschbach, J.W.1
Egrie, J.C.2
Downing, M.R.3
Browne, J.K.4
Adamson, J.W.5
-
33
-
-
0027458517
-
In vivo and in vitro regulation of erythropoietin mRNA: Measurement by competitive polymerase chain reaction
-
Fandrey J and Bunn HF. In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction. Blood 81: 617-623, 1993.
-
(1993)
Blood
, vol.81
, pp. 617-623
-
-
Fandrey, J.1
Bunn, H.F.2
-
34
-
-
0027970536
-
Role of hydrogen peroxide in hypoxia-induced erythropoietin production
-
Fandrey J, Frede S, and Jelkmann W. Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem J 303: 507-510, 1994.
-
(1994)
Biochem J
, vol.303
, pp. 507-510
-
-
Fandrey, J.1
Frede, S.2
Jelkmann, W.3
-
35
-
-
0025193093
-
Role of cytochrome P450 in the control of the production of erythropoietin
-
Fandrey J, Seydel FP, Siegers CP, and Jelkmann W. Role of cytochrome P450 in the control of the production of erythropoietin. Life Sci 47: 127-134, 1990.
-
(1990)
Life Sci
, vol.47
, pp. 127-134
-
-
Fandrey, J.1
Seydel, F.P.2
Siegers, C.P.3
Jelkmann, W.4
-
36
-
-
0026629718
-
Effect of inflammatory cytokines on hypoxia-induced erythropoietin production
-
Faquin WC, Schneider TJ, and Goldberg MA. Effect of inflammatory cytokines on hypoxia-induced erythropoietin production. Blood 79: 1987-1994, 1992.
-
(1992)
Blood
, vol.79
, pp. 1987-1994
-
-
Faquin, W.C.1
Schneider, T.J.2
Goldberg, M.A.3
-
37
-
-
0036882343
-
NF-κB plays a key role in hypoxia-inducible factor-1-regulated erythropoietin gene expression
-
Figueroa YG, Chan AK, Ibrahim R, Tang Y, Burow ME, Alam J, Scandurro AB, and Beckman BS. NF-κB plays a key role in hypoxia-inducible factor-1-regulated erythropoietin gene expression. Exp Hematol 30: 1419-1427, 2002.
-
(2002)
Exp Hematol
, vol.30
, pp. 1419-1427
-
-
Figueroa, Y.G.1
Chan, A.K.2
Ibrahim, R.3
Tang, Y.4
Burow, M.E.5
Alam, J.6
Scandurro, A.B.7
Beckman, B.S.8
-
38
-
-
0029101515
-
Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements
-
Firth JD, Ebert BL, and Ratcliffe PJ. Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. J Biol Chem 270: 21021-21027, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 21021-21027
-
-
Firth, J.D.1
Ebert, B.L.2
Ratcliffe, P.J.3
-
39
-
-
2442661050
-
From the elusive "Hemopoietine" to the anti-anemic drug rErythropoietin
-
edited by Jelkmann W. Johnson City, TN: Graham
-
Fisher JW. From the elusive "Hemopoietine" to the anti-anemic drug rErythropoietin. In: Erythropoietin: Molecular Biology and Clinical Use, edited by Jelkmann W. Johnson City, TN: Graham, 2003, p. 3-32.
-
(2003)
Erythropoietin: Molecular Biology and Clinical Use
, pp. 3-32
-
-
Fisher, J.W.1
-
40
-
-
0023231231
-
Erythropoietin production by the fetal liver in an adult environment
-
Flake AW, Harrison MR, Adzick NS, and Zanjani ED. Erythropoietin production by the fetal liver in an adult environment. Blood 70: 542-545, 1987.
-
(1987)
Blood
, vol.70
, pp. 542-545
-
-
Flake, A.W.1
Harrison, M.R.2
Adzick, N.S.3
Zanjani, E.D.4
-
41
-
-
0343683375
-
HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 α and developmentally expressed in blood vessels
-
Flamme I, Frohlich T, von Reutern M, Kappel A, Damert A, and Risau W. HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 α and developmentally expressed in blood vessels. Mech Dev 63: 51-60, 1997.
-
(1997)
Mech Dev
, vol.63
, pp. 51-60
-
-
Flamme, I.1
Frohlich, T.2
Von Reutern, M.3
Kappel, A.4
Damert, A.5
Risau, W.6
-
42
-
-
0031227765
-
Erythropoietin gene expression is suppressed after lipopolysaccharide or interleukin-1 beta injections in rats
-
Frede S, Fandrey J, Pagel H, Hellwig T, and Jelkmann W. Erythropoietin gene expression is suppressed after lipopolysaccharide or interleukin-1 beta injections in rats. Am J Physiol Regul Integr Comp Physiol 273: R1067-R1071, 1997.
-
(1997)
Am J Physiol Regul Integr Comp Physiol
, vol.273
-
-
Frede, S.1
Fandrey, J.2
Pagel, H.3
Hellwig, T.4
Jelkmann, W.5
-
43
-
-
0027490299
-
Comparison of the human and mouse erythropoietin genes shows extensive homology in the flanking regions
-
Galson DL, Tan CC, Ratcliffe PJ, and Bunn HF. Comparison of the human and mouse erythropoietin genes shows extensive homology in the flanking regions. Blood 82: 3321-3326, 1993.
-
(1993)
Blood
, vol.82
, pp. 3321-3326
-
-
Galson, D.L.1
Tan, C.C.2
Ratcliffe, P.J.3
Bunn, H.F.4
-
44
-
-
0028967752
-
The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1
-
Galson DL, Tsuchiya T, Tendler DS, Huang LE, Ren Y, Ogura T, and Bunn HF. The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1. Mol Cell Biol 15: 2135-2144, 1995.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 2135-2144
-
-
Galson, D.L.1
Tsuchiya, T.2
Tendler, D.S.3
Huang, L.E.4
Ren, Y.5
Ogura, T.6
Bunn, H.F.7
-
45
-
-
0034665113
-
Nitric oxide affects the production of reactive oxygen species in hepatoma cells: Implications for the process of oxygen sensing
-
Genius J and Fandrey J. Nitric oxide affects the production of reactive oxygen species in hepatoma cells: implications for the process of oxygen sensing. Free Radic Biol Med 29: 515-521, 2000.
-
(2000)
Free Radic Biol Med
, vol.29
, pp. 515-521
-
-
Genius, J.1
Fandrey, J.2
-
46
-
-
0024273450
-
Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
-
Goldberg MA, Dunning SP, and Bunn HF. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 242: 1412-1415, 1988.
-
(1988)
Science
, vol.242
, pp. 1412-1415
-
-
Goldberg, M.A.1
Dunning, S.P.2
Bunn, H.F.3
-
47
-
-
0242408897
-
The regulated expression of erythropoietin by two human hepatoma cell lines
-
Goldberg MA, Glass GA, Cunningham JM, and Bunn HF. The regulated expression of erythropoietin by two human hepatoma cell lines. Proc Natl Acad Sci USA 84: 7972-7976, 1987.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 7972-7976
-
-
Goldberg, M.A.1
Glass, G.A.2
Cunningham, J.M.3
Bunn, H.F.4
-
48
-
-
0027516683
-
Photometric characteristics of haem proteins in erythropoietin-producing hepatoma cells (HepG2)
-
Görlach A, Holtermann G, Jelkmann W, Hancock JT, Jones SA, Jones OTG, and Acker H. Photometric characteristics of haem proteins in erythropoietin-producing hepatoma cells (HepG2). Biochem J 290: 771-776, 1993.
-
(1993)
Biochem J
, vol.290
, pp. 771-776
-
-
Görlach, A.1
Holtermann, G.2
Jelkmann, W.3
Hancock, J.T.4
Jones, S.A.5
Jones, O.T.G.6
Acker, H.7
-
49
-
-
0036064271
-
HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration
-
Grimm C, Wenzel A, Groszer M, Mayser H, Seeliger M, Samardzija M, Bauer C, Gassmann M, and Reme CE. HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration. Nat Med 8: 718-724, 2002.
-
(2002)
Nat Med
, vol.8
, pp. 718-724
-
-
Grimm, C.1
Wenzel, A.2
Groszer, M.3
Mayser, H.4
Seeliger, M.5
Samardzija, M.6
Bauer, C.7
Gassmann, M.8
Reme, C.E.9
-
50
-
-
0034116376
-
The PAS superfamily: Sensors of environmental and developmental signals
-
Gu YZ, Hogenesch JB, and Bradfield CA. The PAS superfamily: sensors of environmental and developmental signals. Annu Rev Pharmacol Toxicol 40: 519-561, 2000.
-
(2000)
Annu Rev Pharmacol Toxicol
, vol.40
, pp. 519-561
-
-
Gu, Y.Z.1
Hogenesch, J.B.2
Bradfield, C.A.3
-
51
-
-
0031733828
-
Molecular characterization and chromosomal localization of a third α-class hypoxia inducible factor subunit, HIF3α
-
Gu YZ, Moran SM, Hogenesch JB, Wartman L, and Bradfield CA. Molecular characterization and chromosomal localization of a third α-class hypoxia inducible factor subunit, HIF3α. Gene Expr 7: 205-213, 1998.
-
(1998)
Gene Expr
, vol.7
, pp. 205-213
-
-
Gu, Y.Z.1
Moran, S.M.2
Hogenesch, J.B.3
Wartman, L.4
Bradfield, C.A.5
-
52
-
-
0034661486
-
A new transacting factor that modulates hypoxia-induced expression of the erythropoietin gene
-
Gupta M, Mungai PT, and Goldwasser E. A new transacting factor that modulates hypoxia-induced expression of the erythropoietin gene. Blood 96: 491-497, 2000.
-
(2000)
Blood
, vol.96
, pp. 491-497
-
-
Gupta, M.1
Mungai, P.T.2
Goldwasser, E.3
-
53
-
-
0348134741
-
Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF1α
-
Hagen T, Taylor CT, Lam F, and Moncada S. Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1α. Science 302: 1975-1978, 2003.
-
(2003)
Science
, vol.302
, pp. 1975-1978
-
-
Hagen, T.1
Taylor, C.T.2
Lam, F.3
Moncada, S.4
-
54
-
-
0033181324
-
Interleukin-1beta and tumor necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1
-
Hellwig-Burgel T, Rutkowski K, Metzen E, Fandrey J, and Jelkmann W. Interleukin-1beta and tumor necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1. Blood 94: 1561-1567, 1999.
-
(1999)
Blood
, vol.94
, pp. 1561-1567
-
-
Hellwig-Burgel, T.1
Rutkowski, K.2
Metzen, E.3
Fandrey, J.4
Jelkmann, W.5
-
55
-
-
18544386401
-
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
-
Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, and Schofield CJ. Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J Biol Chem 277: 26351-26355, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 26351-26355
-
-
Hewitson, K.S.1
McNeill, L.A.2
Riordan, M.V.3
Tian, Y.M.4
Bullock, A.N.5
Welford, R.W.6
Elkins, J.M.7
Oldham, N.J.8
Bhattacharya, S.9
Gleadle, J.M.10
Ratcliffe, P.J.11
Pugh, C.W.12
Schofield, C.J.13
-
56
-
-
0043234538
-
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
-
Hirsila M, Koivunen P, Gunzler V, Kivirikko KI, and Myllyharju J. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem 278: 30772-30780, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 30772-30780
-
-
Hirsila, M.1
Koivunen, P.2
Gunzler, V.3
Kivirikko, K.I.4
Myllyharju, J.5
-
57
-
-
0028900637
-
Use of a marked erythropoietin gene for investigation of its cis-acting elements
-
Ho V, Acquaviva A, Duh E, and Bunn HF. Use of a marked erythropoietin gene for investigation of its cis-acting elements. J Biol Chem 270: 10084-10090, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 10084-10090
-
-
Ho, V.1
Acquaviva, A.2
Duh, E.3
Bunn, H.F.4
-
58
-
-
0030887045
-
Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
-
Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, and Bradfield CA. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem 272: 8581-8593, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 8581-8593
-
-
Hogenesch, J.B.1
Chan, W.K.2
Jackiw, V.H.3
Brown, R.C.4
Gu, Y.Z.5
Pray-Grant, M.6
Perdew, G.H.7
Bradfield, C.A.8
-
59
-
-
0037131159
-
Sequence determinants in hypoxia-inducible factor-1α for hydroxylation by the prolyl hydroxylases PHD1, PHD 2, and PHD3
-
Huang J, Zhao Q, Mooney SM, and Lee FS. Sequence determinants in hypoxia-inducible factor-1α for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3. J Biol Chem 277: 39792-39800, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 39792-39800
-
-
Huang, J.1
Zhao, Q.2
Mooney, S.M.3
Lee, F.S.4
-
60
-
-
0032493368
-
Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
-
Huang LE, Gu J, Schau M, and Bunn HF. Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 95: 7987-7992, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
61
-
-
0029753008
-
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its a subunit
-
Huang LE, Arany Z, Livingston DM, and Bunn HF. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its a subunit. J Biol Chem 271: 32253-32259, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 32253-32259
-
-
Huang, L.E.1
Arany, Z.2
Livingston, D.M.3
Bunn, H.F.4
-
62
-
-
0031043063
-
Negative regulation of the erythropoietin gene expression by the GATA transcription factors
-
Imagawa S, Yamamoto M, and Miura Y. Negative regulation of the erythropoietin gene expression by the GATA transcription factors. Blood 89: 1430-1439, 1997.
-
(1997)
Blood
, vol.89
, pp. 1430-1439
-
-
Imagawa, S.1
Yamamoto, M.2
Miura, Y.3
-
63
-
-
0035917313
-
2 sensing
-
2 sensing. Science 292: 464-468, 2001.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
64
-
-
15444342958
-
2 homeostasis by hypoxia-inducible factor 1 α
-
2 homeostasis by hypoxia-inducible factor 1 α. Genes Dev 12: 149-162, 1998.
-
(1998)
Genes Dev
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
Gassmann, M.7
Gearhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
Semenza, G.L.11
-
65
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science 292: 468-472, 2001.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
66
-
-
0021978919
-
Isolation and characterization of genomic and cDNA clones of human erythropoietin
-
Jacobs K, Shoemaker C, Rudersdorf R, Neill SD, Kaufman RJ, Mufson A, Seehra J, Jones SS, Hewick R, and Fritsch EF. Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature 313: 806-810, 1985.
-
(1985)
Nature
, vol.313
, pp. 806-810
-
-
Jacobs, K.1
Shoemaker, C.2
Rudersdorf, R.3
Neill, S.D.4
Kaufman, R.J.5
Mufson, A.6
Seehra, J.7
Jones, S.S.8
Hewick, R.9
Fritsch, E.F.10
-
67
-
-
0000684716
-
Role of the kidney in erythropoiesis
-
Jacobson LO, Goldwasser E, Fried W, and Plzak L. Role of the kidney in erythropoiesis. Nature 179: 633-634, 1957.
-
(1957)
Nature
, vol.179
, pp. 633-634
-
-
Jacobson, L.O.1
Goldwasser, E.2
Fried, W.3
Plzak, L.4
-
68
-
-
0026526168
-
Erythropoietin: Structure, control of production, and function
-
Jelkmann W. Erythropoietin: structure, control of production, and function. Physiol Rev 72: 449-489, 1992.
-
(1992)
Physiol Rev
, vol.72
, pp. 449-489
-
-
Jelkmann, W.1
-
69
-
-
0031821059
-
Proinflammatory cytokines lowering erythropoietin production
-
Jelkmann W. Proinflammatory cytokines lowering erythropoietin production. J Interferon Cytokine Res 18: 555-559, 1998.
-
(1998)
J Interferon Cytokine Res
, vol.18
, pp. 555-559
-
-
Jelkmann, W.1
-
70
-
-
0026569973
-
Monokines inhibiting erythropoietin production in human hepatoma cultures and in isolated perfused rat kidneys
-
Jelkmann W, Pagel H, Wolff M, and Fandrey J. Monokines inhibiting erythropoietin production in human hepatoma cultures and in isolated perfused rat kidneys. Life Sci 50: 301-308, 1992.
-
(1992)
Life Sci
, vol.50
, pp. 301-308
-
-
Jelkmann, W.1
Pagel, H.2
Wolff, M.3
Fandrey, J.4
-
71
-
-
0023102788
-
Dependence of erythropoietin production on blood oxygen affinity and hemoglobin concentration in rats
-
Jelkmann W and Seidl J. Dependence of erythropoietin production on blood oxygen affinity and hemoglobin concentration in rats. Biomed Biochim Acta 46: S304-S308, 1987.
-
(1987)
Biomed Biochim Acta
, vol.46
-
-
Jelkmann, W.1
Seidl, J.2
-
72
-
-
0035347260
-
Induction of HIF-1α in response to hypoxia is instantaneous
-
Jewell UR, Kvietikova I, Scheid A, Bauer C, Wenger RH, and Gassmann M. Induction of HIF-1α in response to hypoxia is instantaneous. FASEB J 15: 1312-1314, 2001.
-
(2001)
FASEB J
, vol.15
, pp. 1312-1314
-
-
Jewell, U.R.1
Kvietikova, I.2
Scheid, A.3
Bauer, C.4
Wenger, R.H.5
Gassmann, M.6
-
73
-
-
0030787469
-
Transactivation and inhibitory domains of hypoxia-inducible factor 1α. Modulation of transcriptional activity by oxygen tension
-
Jiang BH, Zheng JZ, Leung SW, Roe R, and Semenza GL. Transactivation and inhibitory domains of hypoxia-inducible factor 1α. Modulation of transcriptional activity by oxygen tension. J Biol Chem 272: 19253-19260, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 19253-19260
-
-
Jiang, B.H.1
Zheng, J.Z.2
Leung, S.W.3
Roe, R.4
Semenza, G.L.5
-
74
-
-
0024336445
-
Functional specialization of different hepatocyte populations
-
Jungermann K and Katz N. Functional specialization of different hepatocyte populations. Physiol Rev 69: 708-764, 1989.
-
(1989)
Physiol Rev
, vol.69
, pp. 708-764
-
-
Jungermann, K.1
Katz, N.2
-
75
-
-
0031893945
-
Erythropoietin and erythropoietin receptor in the developing human central nervous system
-
Juul SE, Anderson DK, Li Y, and Christensen RD. Erythropoietin and erythropoietin receptor in the developing human central nervous system. Pediatr Res 43: 40-49, 1998.
-
(1998)
Pediatr Res
, vol.43
, pp. 40-49
-
-
Juul, S.E.1
Anderson, D.K.2
Li, Y.3
Christensen, R.D.4
-
76
-
-
0034742684
-
Erythropoietin acts as a trophic factor in neonatal rat intestine
-
Juul SE, Ledbetter DJ, Joyce AE, Dame C, Christensen RD, Zhao Y, and DeMarco V. Erythropoietin acts as a trophic factor in neonatal rat intestine. Gut 49: 182-189, 2001.
-
(2001)
Gut
, vol.49
, pp. 182-189
-
-
Juul, S.E.1
Ledbetter, D.J.2
Joyce, A.E.3
Dame, C.4
Christensen, R.D.5
Zhao, Y.6
DeMarco, V.7
-
77
-
-
0032538797
-
Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1α
-
Kallio PJ, Okamoto K, O'Brien S, Carrero P, Makino Y, Tanaka H, and Poellinger L. Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1α. EMBO J 17: 6573-6586, 1998.
-
(1998)
EMBO J
, vol.17
, pp. 6573-6586
-
-
Kallio, P.J.1
Okamoto, K.2
O'Brien, S.3
Carrero, P.4
Makino, Y.5
Tanaka, H.6
Poellinger, L.7
-
78
-
-
0032519536
-
Embryonal carcinoma P19 cells produce erythropoietin constitutively but express lactate dehydrogenase in an oxygen-dependent manner
-
Kambe T, Tada J, Chikuma M, Masuda S, Nagao M, Tsuchiya T, Ratcliffe PJ, and Sasaki R. Embryonal carcinoma P19 cells produce erythropoietin constitutively but express lactate dehydrogenase in an oxygen-dependent manner. Blood 91: 1185-1195, 1998.
-
(1998)
Blood
, vol.91
, pp. 1185-1195
-
-
Kambe, T.1
Tada, J.2
Chikuma, M.3
Masuda, S.4
Nagao, M.5
Tsuchiya, T.6
Ratcliffe, P.J.7
Sasaki, R.8
-
79
-
-
0034393799
-
Oxygen radicals as messengers in oxygen-dependent gene expression
-
Kietzmann T, Fandrey J, and Acker H. Oxygen radicals as messengers in oxygen-dependent gene expression. News Physiol Sci 15: 202-208, 2000.
-
(2000)
News Physiol Sci
, vol.15
, pp. 202-208
-
-
Kietzmann, T.1
Fandrey, J.2
Acker, H.3
-
80
-
-
0035217750
-
Expression of erythropoietin mRNA, protein and receptor in ovine fetal membranes
-
Kim MJ, Bogic L, Cheung CY, and Brace RA. Expression of erythropoietin mRNA, protein and receptor in ovine fetal membranes. Placenta 22: 846-851, 2001.
-
(2001)
Placenta
, vol.22
, pp. 846-851
-
-
Kim, M.J.1
Bogic, L.2
Cheung, C.Y.3
Brace, R.A.4
-
81
-
-
0036038271
-
Epididymis is a novel site of erythropoietin production in mouse reproductive organs
-
Kobayashi T, Yanase H, Iwanaga T, Sasaki R, and Nagao M. Epididymis is a novel site of erythropoietin production in mouse reproductive organs. Biochem Biophys Res Commun 296: 145-151, 2002.
-
(2002)
Biochem Biophys Res Commun
, vol.296
, pp. 145-151
-
-
Kobayashi, T.1
Yanase, H.2
Iwanaga, T.3
Sasaki, R.4
Nagao, M.5
-
82
-
-
2542507564
-
Regulation of human erythropoietin gene induction by upstream flanking sequences in transgenic mice
-
Kochling J, Curtin PT, and Madan A. Regulation of human erythropoietin gene induction by upstream flanking sequences in transgenic mice. Br J Haematol 103: 960-968, 1998.
-
(1998)
Br J Haematol
, vol.103
, pp. 960-968
-
-
Kochling, J.1
Curtin, P.T.2
Madan, A.3
-
83
-
-
1642315195
-
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
-
Koivunen P, Hirsila M, Gunzler V, Kivirikko KI, and Myllyharju J. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J Biol Chem 279: 9899-9904, 2003.
-
(2003)
J Biol Chem
, vol.279
, pp. 9899-9904
-
-
Koivunen, P.1
Hirsila, M.2
Gunzler, V.3
Kivirikko, K.I.4
Myllyharju, J.5
-
85
-
-
0023868741
-
Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization
-
Koury ST, Bondurant MC, and Koury MJ. Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood 71: 524-527, 1988.
-
(1988)
Blood
, vol.71
, pp. 524-527
-
-
Koury, S.T.1
Bondurant, M.C.2
Koury, M.J.3
-
86
-
-
0025912710
-
Localization of cells producing erythropoietin in murine liver by in situ hybridization
-
Koury ST, Bondurant MC, Koury MJ, and Semenza GL. Localization of cells producing erythropoietin in murine liver by in situ hybridization. Blood 77: 2497-2503, 1991.
-
(1991)
Blood
, vol.77
, pp. 2497-2503
-
-
Koury, S.T.1
Bondurant, M.C.2
Koury, M.J.3
Semenza, G.L.4
-
87
-
-
0028891906
-
The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site
-
Kvietikova I, Wenger RH, Marti HH, and Gassmann M. The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site. Nucleic Acids Res 23: 4542-4550, 1995.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 4542-4550
-
-
Kvietikova, I.1
Wenger, R.H.2
Marti, H.H.3
Gassmann, M.4
-
88
-
-
0036832772
-
Inhibition of erythropoietin gene expression signaling involves the transcription factors GATA-2 and NF-kappaB
-
La Ferla K, Reimann C, Jelkmann W, and Hellwig-Burgel T. Inhibition of erythropoietin gene expression signaling involves the transcription factors GATA-2 and NF-kappaB. FASEB J 16: 1811-1813, 2002.
-
(2002)
FASEB J
, vol.16
, pp. 1811-1813
-
-
La Ferla, K.1
Reimann, C.2
Jelkmann, W.3
Hellwig-Burgel, T.4
-
89
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, and Bruick RK. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 16: 1466-1471, 2002.
-
(2002)
Genes Dev
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
90
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
-
Lando D, Peet DJ, Whelan DA, Gorman JJ, and Whitelaw ML. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 295: 858-861, 2002.
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
91
-
-
0034681378
-
A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1α and the HIF-like factor
-
Lando D, Pongratz I, Poellinger L, and Whitelaw ML. A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1α and the HIF-like factor. J Biol Chem 275: 4618-4627, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 4618-4627
-
-
Lando, D.1
Pongratz, I.2
Poellinger, L.3
Whitelaw, M.L.4
-
92
-
-
0027241363
-
The human erythropoietin-encoding gene contains a CAAT box, TATA boxes and other transcriptional regulatory elements in its 5′ flanking region
-
Lee-Huang S, Lin JJ, Kung HF, Huang PL, Lee L, and Huang PL. The human erythropoietin-encoding gene contains a CAAT box, TATA boxes and other transcriptional regulatory elements in its 5′ flanking region. Gene 128: 227-236, 1993.
-
(1993)
Gene
, vol.128
, pp. 227-236
-
-
Lee-Huang, S.1
Lin, J.J.2
Kung, H.F.3
Huang, P.L.4
Lee, L.5
Huang, P.L.6
-
93
-
-
0242611254
-
Cloning and expression of the human erythropoietin gene
-
Lin FK, Suggs S, Lin CH, Browne JK, Smalling R, Egrie JC, Chen KK, Fox GM, Martin F, and Stabinsky Z. Cloning and expression of the human erythropoietin gene. Proc Natl Acad Sci USA 82: 7580-7584, 1985.
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 7580-7584
-
-
Lin, F.K.1
Suggs, S.2
Lin, C.H.3
Browne, J.K.4
Smalling, R.5
Egrie, J.C.6
Chen, K.K.7
Fox, G.M.8
Martin, F.9
Stabinsky, Z.10
-
94
-
-
0029002253
-
Regulated basal, inducible, and tissue-specific human erythropoietin gene expression in transgenic mice requires multiple cis DNA sequences
-
Madan A, Lin C, Hatch SL, and Curtin PT. Regulated basal, inducible, and tissue-specific human erythropoietin gene expression in transgenic mice requires multiple cis DNA sequences. Blood 85: 2735-2741, 1995.
-
(1995)
Blood
, vol.85
, pp. 2735-2741
-
-
Madan, A.1
Lin, C.2
Hatch, S.L.3
Curtin, P.T.4
-
95
-
-
0035525744
-
Erythropoietin expression in primary rat Sertoli and peritubular myoid cells
-
Magnanti M, Gandini O, Giuliani L, Gazzaniga P, Marti HH, Gradilone A, Frati L, Agliano AM, and Gassmann M. Erythropoietin expression in primary rat Sertoli and peritubular myoid cells. Blood 98: 2872-2874, 2001.
-
(2001)
Blood
, vol.98
, pp. 2872-2874
-
-
Magnanti, M.1
Gandini, O.2
Giuliani, L.3
Gazzaniga, P.4
Marti, H.H.5
Gradilone, A.6
Frati, L.7
Agliano, A.M.8
Gassmann, M.9
-
96
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon PC, Hirota K, and Semenza GL. FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15: 2675-2686, 2001.
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
97
-
-
0035312526
-
A developmental transition in definitive erythropoiesis: Erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4
-
Makita T, Hernandez-Hoyos G, Chen THP, Wu H, Rothenberg EV, and Sucov HM. A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4. Genes Dev 15: 889-901, 2001.
-
(2001)
Genes Dev
, vol.15
, pp. 889-901
-
-
Makita, T.1
Hernandez-Hoyos, G.2
Chen, T.H.P.3
Wu, H.4
Rothenberg, E.V.5
Sucov, H.M.6
-
98
-
-
0029976021
-
Erythropoietin gene expression in human, monkey and murine brain
-
Marti HH, Wenger RH, Rivas LA, Straumann U, Digicaylioglu M, Henn V, Yonekawa Y, Bauer C, and Gassmann M. Erythropoietin gene expression in human, monkey and murine brain. Eur J Neurosci 8: 666-676, 1996.
-
(1996)
Eur J Neurosci
, vol.8
, pp. 666-676
-
-
Marti, H.H.1
Wenger, R.H.2
Rivas, L.A.3
Straumann, U.4
Digicaylioglu, M.5
Henn, V.6
Yonekawa, Y.7
Bauer, C.8
Gassmann, M.9
-
99
-
-
0012385258
-
Function of erythropoietin in the brain
-
edited by Jelkmann W. Johnson City, TN: Graham
-
Marti HH and Bernaudin M. Function of erythropoietin in the brain. In: Erythropoietin: Molecular Biology and Clinical Use, edited by Jelkmann W. Johnson City, TN: Graham, 2003, p. 195-215.
-
(2003)
Erythropoietin: Molecular Biology and Clinical Use
, pp. 195-215
-
-
Marti, H.H.1
Bernaudin, M.2
-
100
-
-
0036162264
-
Isoform-specific expression of hypoxia-inducible factor-1α during the late stages of mouse spermiogenesis
-
Marti HH, Katschinski DM, Wagner KF, Schaffer L, Stier B, and Wenger RH. Isoform-specific expression of hypoxia-inducible factor-1α during the late stages of mouse spermiogenesis. Mol Endocrinol 16: 234-243, 2002.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 234-243
-
-
Marti, H.H.1
Katschinski, D.M.2
Wagner, K.F.3
Schaffer, L.4
Stier, B.5
Wenger, R.H.6
-
101
-
-
0035903468
-
Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
-
Masson N, Willam C, Maxwell PH, Pugh CW, and Ratcliffe PJ. Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation. EMBO J 20: 5197-5206, 2001.
-
(2001)
EMBO J
, vol.20
, pp. 5197-5206
-
-
Masson, N.1
Willam, C.2
Maxwell, P.H.3
Pugh, C.W.4
Ratcliffe, P.J.5
-
102
-
-
0041885339
-
HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular 02 levels
-
Masson N and Ratcliffe PJ. HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular 02 levels. J Cell Sci 116: 3041-3049, 2003.
-
(2003)
J Cell Sci
, vol.116
, pp. 3041-3049
-
-
Masson, N.1
Ratcliffe, P.J.2
-
103
-
-
0027302375
-
Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells
-
Masuda S, Nagao M, Takahata K, Konishi Y, Gallyas F Jr, Tabira T, and Sasaki R. Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells. J Biol Chem 268: 11208-11216, 1993.
-
(1993)
J Biol Chem
, vol.268
, pp. 11208-11216
-
-
Masuda, S.1
Nagao, M.2
Takahata, K.3
Konishi, Y.4
Gallyas Jr., F.5
Tabira, T.6
Sasaki, R.7
-
104
-
-
0033936178
-
The oviduct produces erythropoietin in an estrogen- and oxygen-dependent manner
-
Masuda S, Kobayashi T, Chikuma M, Nagao M, and Sasaki R. The oviduct produces erythropoietin in an estrogen- and oxygen-dependent manner. Am J Physiol Endocrinol Metab 278: E1038-E1044, 2000.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.278
-
-
Masuda, S.1
Kobayashi, T.2
Chikuma, M.3
Nagao, M.4
Sasaki, R.5
-
105
-
-
0028086474
-
Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: Evidence for erythropoietin production by Ito cells
-
Maxwell PH, Ferguson DJ, Osmond MK, Pugh CW, Heryet A, Doe BG, Johnson MH, and Ratcliffe PJ. Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells. Blood 84: 1823-1830, 1994.
-
(1994)
Blood
, vol.84
, pp. 1823-1830
-
-
Maxwell, P.H.1
Ferguson, D.J.2
Osmond, M.K.3
Pugh, C.W.4
Heryet, A.5
Doe, B.G.6
Johnson, M.H.7
Ratcliffe, P.J.8
-
106
-
-
0027367661
-
Identification of the renal erythropoietin-producing cells using transgenic mice
-
Maxwell PH, Osmond MK, Pugh CW, Heryet A, Nicholls LG, Tan CC, Doe BG, Ferguson DJ, Johnson MH, and Ratcliffe PJ. Identification of the renal erythropoietin-producing cells using transgenic mice. Kidney Int 44: 1149-1162, 1993.
-
(1993)
Kidney Int
, vol.44
, pp. 1149-1162
-
-
Maxwell, P.H.1
Osmond, M.K.2
Pugh, C.W.3
Heryet, A.4
Nicholls, L.G.5
Tan, C.C.6
Doe, B.G.7
Ferguson, D.J.8
Johnson, M.H.9
Ratcliffe, P.J.10
-
107
-
-
0027461553
-
Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: Evidence for a wide-spread oxygen-sensing mechanism
-
Maxwell PH, Pugh CW, and Ratcliffe PJ. Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: evidence for a wide-spread oxygen-sensing mechanism. Proc Natl Acad Sci USA 90: 2423-2427, 1993.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 2423-2427
-
-
Maxwell, P.H.1
Pugh, C.W.2
Ratcliffe, P.J.3
-
108
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, and Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275, 1999.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
109
-
-
0037386143
-
Intracellular localisation of human HIF-1α hydroxylases: Implications for oxygen sensing
-
Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Burgel T, Jelkmann W, Acker H, and Fandrey J. Intracellular localisation of human HIF-1 α hydroxylases: implications for oxygen sensing. J Cell Sci 116: 1319-1326, 2003.
-
(2003)
J Cell Sci
, vol.116
, pp. 1319-1326
-
-
Metzen, E.1
Berchner-Pfannschmidt, U.2
Stengel, P.3
Marxsen, J.H.4
Stolze, I.5
Klinger, M.6
Huang, W.Q.7
Wotzlaw, C.8
Hellwig-Burgel, T.9
Jelkmann, W.10
Acker, H.11
Fandrey, J.12
-
110
-
-
0042469448
-
Nitric oxide impairs normoxic degradation of HIF-1α by inhibition of prolyl hydroxylases
-
Metzen E, Zhou J, Jelkmann W, Fandrey J, and Brune B. Nitric oxide impairs normoxic degradation of HIF-1α by inhibition of prolyl hydroxylases. Mol Biol Cell 14: 3470-3481, 2003.
-
(2003)
Mol Biol Cell
, vol.14
, pp. 3470-3481
-
-
Metzen, E.1
Zhou, J.2
Jelkmann, W.3
Fandrey, J.4
Brune, B.5
-
111
-
-
0017755573
-
Purification of human erythropoietin
-
Miyake T, Kung CK, and Goldwasser E. Purification of human erythropoietin. J Biol Chem 252: 5558-5564, 1977.
-
(1977)
J Biol Chem
, vol.252
, pp. 5558-5564
-
-
Miyake, T.1
Kung, C.K.2
Goldwasser, E.3
-
112
-
-
0037416792
-
HLF/HIF-2α is a key factor in retinopathy of prematurity in association with erythropoietin
-
Morita M, Ohneda O, Yamashita T, Takahashi S, Suzuki N, Nakajima O, Kawauchi S, Ema M, Shibahara S, Udono T, Tomita K, Tamai M, Sogawa K, Yamamoto M, and Fujii-Kuriyama Y. HLF/ HIF-2α is a key factor in retinopathy of prematurity in association with erythropoietin. EMBO J 22: 1134-1146, 2003.
-
(2003)
EMBO J
, vol.22
, pp. 1134-1146
-
-
Morita, M.1
Ohneda, O.2
Yamashita, T.3
Takahashi, S.4
Suzuki, N.5
Nakajima, O.6
Kawauchi, S.7
Ema, M.8
Shibahara, S.9
Udono, T.10
Tomita, K.11
Tamai, M.12
Sogawa, K.13
Yamamoto, M.14
Fujii-Kuriyama, Y.15
-
115
-
-
0023598543
-
Regulation of erythropoietin production in a human hepatoblastoma cell line
-
Nielsen OJ, Schuster SJ, Kaufman R, Erslev AJ, and Caro J. Regulation of erythropoietin production in a human hepatoblastoma cell line. Blood 70: 1904-1909, 1987.
-
(1987)
Blood
, vol.70
, pp. 1904-1909
-
-
Nielsen, O.J.1
Schuster, S.J.2
Kaufman, R.3
Erslev, A.J.4
Caro, J.5
-
116
-
-
0033593219
-
Oxygen-regulated and transactivating domains in endothelial PAS protein 1: Comparison with hypoxia-inducible factor-1α
-
O'Rourke JF, Tian YM, Ratcliffe PJ, and Pugh CW. Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1α. J Biol Chem 274: 2060-2071, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 2060-2071
-
-
O'Rourke, J.F.1
Tian, Y.M.2
Ratcliffe, P.J.3
Pugh, C.W.4
-
117
-
-
0034682513
-
The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling
-
Peng J, Zhang L, Drysdale L, and Fong GH. The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling. Proc Natl Acad Sci USA 97: 8386-8391, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 8386-8391
-
-
Peng, J.1
Zhang, L.2
Drysdale, L.3
Fong, G.H.4
-
118
-
-
0030937718
-
Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit
-
Pugh CW, O'Rourke JF, Nagao M, Gleadle JM, and Ratcliffe PJ. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit. J Biol Chem 272: 11205-11214, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 11205-11214
-
-
Pugh, C.W.1
O'Rourke, J.F.2
Nagao, M.3
Gleadle, J.M.4
Ratcliffe, P.J.5
-
119
-
-
0038037735
-
Regulation of angiogenesis by hypoxia: Role of the HIF system
-
Pugh CW and Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 9: 677-684, 2003.
-
(2003)
Nat Med
, vol.9
, pp. 677-684
-
-
Pugh, C.W.1
Ratcliffe, P.J.2
-
120
-
-
0025885693
-
Functional analysis of an oxygen-regulated transcriptional enhancer lying 3′ to the mouse erythropoietin gene
-
Pugh CW, Tan CC, Jones RW, and Ratcliffe PJ. Functional analysis of an oxygen-regulated transcriptional enhancer lying 3′ to the mouse erythropoietin gene. Proc Natl Acad Sci USA 88: 10553-10557, 1991.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 10553-10557
-
-
Pugh, C.W.1
Tan, C.C.2
Jones, R.W.3
Ratcliffe, P.J.4
-
121
-
-
76549258955
-
Studies on the mechanism of erythropoietic stimulation in parabiotic rats during hypoxia
-
Reissmann KR. Studies on the mechanism of erythropoietic stimulation in parabiotic rats during hypoxia. Blood 5: 372-380, 1950.
-
(1950)
Blood
, vol.5
, pp. 372-380
-
-
Reissmann, K.R.1
-
122
-
-
0032725554
-
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
-
Richard DE, Berra E, Gothie E, Roux D, and Pouyssegur J. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J Biol Chem 274: 32631-32637, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 32631-32637
-
-
Richard, D.E.1
Berra, E.2
Gothie, E.3
Roux, D.4
Pouyssegur, J.5
-
123
-
-
18444380862
-
Expression of hypoxia-inducible factor-1α and -2α in hypoxic and ischemic rat kidneys
-
Rosenberger C, Mandriota S, Jurgensen JS, Wiesener MS, Horstrup JH, Frei U, Ratcliffe PJ, Maxwell PH, Bachmann S, and Eckardt KU. Expression of hypoxia-inducible factor-1α and -2α in hypoxic and ischemic rat kidneys. J Am Soc Nephrol 13: 1721-1732, 2002.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 1721-1732
-
-
Rosenberger, C.1
Mandriota, S.2
Jurgensen, J.S.3
Wiesener, M.S.4
Horstrup, J.H.5
Frei, U.6
Ratcliffe, P.J.7
Maxwell, P.H.8
Bachmann, S.9
Eckardt, K.U.10
-
124
-
-
0007037173
-
Versuche zum nachweis eines spezifischen erythropoetischen hormons
-
Ruhenstroth-Bauer G. Versuche zum Nachweis eines spezifischen erythropoetischen Hormons. Arch Exp Pathol Pharmakol 211: 32-56, 1950.
-
(1950)
Arch Exp Pathol Pharmakol
, vol.211
, pp. 32-56
-
-
Ruhenstroth-Bauer, G.1
-
125
-
-
0032100732
-
HIF-1 α is required for solid tumor formation and embryonic vascularization
-
Ryan HE, Lo J, and Johnson RS. HIF-1 α is required for solid tumor formation and embryonic vascularization. EMBO J 17: 3005-3015, 1998.
-
(1998)
EMBO J
, vol.17
, pp. 3005-3015
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
126
-
-
0032516086
-
In vivo evidence that erythropoietin protects neurons from ischemic damage
-
Sakanaka M, Wen TC, Matsuda S, Masuda S, Morishita E, Nagao M, and Sasaki R. In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA 95: 4635-4640, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 4635-4640
-
-
Sakanaka, M.1
Wen, T.C.2
Matsuda, S.3
Masuda, S.4
Morishita, E.5
Nagao, M.6
Sasaki, R.7
-
127
-
-
0030961006
-
Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
-
Salceda S and Caro J. Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272: 22642-22647, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
128
-
-
0036232662
-
Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1α is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP
-
Sang N, Fang J, Srinivas V, Leshehinsky I, and Caro J. Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1α is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP. Mol Cell Biol 22: 2984-2992, 2002.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2984-2992
-
-
Sang, N.1
Fang, J.2
Srinivas, V.3
Leshehinsky, I.4
Caro, J.5
-
129
-
-
0035354579
-
Pleiotropic functions and tissue-specific expression of erythropoietin
-
Sasaki R, Masuda S, and Nagao M. Pleiotropic functions and tissue-specific expression of erythropoietin. News Physiol Sci 16: 110-113, 2001.
-
(2001)
News Physiol Sci
, vol.16
, pp. 110-113
-
-
Sasaki, R.1
Masuda, S.2
Nagao, M.3
-
130
-
-
0029836805
-
Nitric oxide donors suppress erythropoietin production in vitro
-
Schobersberger W, Hoffmann G, and Fandrey J. Nitric oxide donors suppress erythropoietin production in vitro. Pflügers Arch 432: 980-985, 1996.
-
(1996)
Pflügers Arch
, vol.432
, pp. 980-985
-
-
Schobersberger, W.1
Hoffmann, G.2
Fandrey, J.3
-
131
-
-
0024495050
-
Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure
-
Schuster SJ, Badiavas EV, Costa-Giomi P, Weinmann R, Erslev AJ, and Caro J. Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure. Blood 73: 13-16, 1989.
-
(1989)
Blood
, vol.73
, pp. 13-16
-
-
Schuster, S.J.1
Badiavas, E.V.2
Costa-Giomi, P.3
Weinmann, R.4
Erslev, A.J.5
Caro, J.6
-
133
-
-
0034006016
-
HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
-
Semenza GL. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88: 1474-1480, 2000.
-
(2000)
J Appl Physiol
, vol.88
, pp. 1474-1480
-
-
Semenza, G.L.1
-
134
-
-
0034021690
-
Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
-
Semenza GL. Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit Rev Biochem Mol Biol 35: 71-103, 2000.
-
(2000)
Crit Rev Biochem Mol Biol
, vol.35
, pp. 71-103
-
-
Semenza, G.L.1
-
135
-
-
0025012679
-
Human erythropoietin gene expression in transgenic mice: Multiple transcription initiation sites and cis-acting regulatory elements
-
Semenza GL, Dureza RC, Traystman MD, Gearhart JD, and Antonarakis SE. Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements. Mol Cell Biol 10: 930-938, 1990.
-
(1990)
Mol Cell Biol
, vol.10
, pp. 930-938
-
-
Semenza, G.L.1
Dureza, R.C.2
Traystman, M.D.3
Gearhart, J.D.4
Antonarakis, S.E.5
-
136
-
-
0026072341
-
Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice
-
Semenza GL, Koury ST, Nejfelt MK, Gearhart JD, and Antonarakis SE. Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. Proc Natl Acad Sci USA 88: 8725-8729, 1991.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 8725-8729
-
-
Semenza, G.L.1
Koury, S.T.2
Nejfelt, M.K.3
Gearhart, J.D.4
Antonarakis, S.E.5
-
137
-
-
0024507117
-
Polycythemia in transgenic mice expressing the human erythropoietin gene
-
Semenza GL, Traystman MD, Gearhart JD, and Antonarakis SE. Polycythemia in transgenic mice expressing the human erythropoietin gene. Proc Natl Acad Sci USA 86: 2301-2305, 1989.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 2301-2305
-
-
Semenza, G.L.1
Traystman, M.D.2
Gearhart, J.D.3
Antonarakis, S.E.4
-
138
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza GL and Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12: 5447-5454, 1992.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
139
-
-
0036216692
-
HIF-1 and tumor progression: Pathophysiology and therapeutics
-
Semenza GL. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 8: S62-S67, 2002.
-
(2002)
Trends Mol Med
, vol.8
-
-
Semenza, G.L.1
-
140
-
-
0035957426
-
Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
-
Siren AL, Fratelli M, Brines M, Goemans C, Casagrande S, Lewczuk P, Keenan S, Gleiter C, Pasquali C, Capobianco A, Mennini T, Heumann R, Cerami A, Ehrenreich H, and Ghezzi P. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci USA 98: 4044-4049, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4044-4049
-
-
Siren, A.L.1
Fratelli, M.2
Brines, M.3
Goemans, C.4
Casagrande, S.5
Lewczuk, P.6
Keenan, S.7
Gleiter, C.8
Pasquali, C.9
Capobianco, A.10
Mennini, T.11
Heumann, R.12
Cerami, A.13
Ehrenreich, H.14
Ghezzi, P.15
-
141
-
-
0032560504
-
Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia
-
Sogawa K, Numayama-Tsuruta K, Ema M, Abe M, Abe H, and Fujii-Kuriyama Y. Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia. Proc Natl Acad Sci USA 95: 7368-7373, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7368-7373
-
-
Sogawa, K.1
Numayama-Tsuruta, K.2
Ema, M.3
Abe, M.4
Abe, H.5
Fujii-Kuriyama, Y.6
-
142
-
-
0033574737
-
Structure of the VHL-ElonginC-ElonginB complex: Implications for VHL tumor suppressor function
-
Stebbins CE, Kaelin WG Jr, and Pavletich NP. Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. Science 284: 455-461, 1999.
-
(1999)
Science
, vol.284
, pp. 455-461
-
-
Stebbins, C.E.1
Kaelin Jr., W.G.2
Pavletich, N.P.3
-
143
-
-
0036786965
-
Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells
-
Stolze I, Berchner-Pfannschmidt U, Freitag P, Wotzlaw C, Rossler J, Frede S, Acker H, and Fandrey J. Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells. Blood 100: 2623-2628, 2002.
-
(2002)
Blood
, vol.100
, pp. 2623-2628
-
-
Stolze, I.1
Berchner-Pfannschmidt, U.2
Freitag, P.3
Wotzlaw, C.4
Rossler, J.5
Frede, S.6
Acker, H.7
Fandrey, J.8
-
144
-
-
0035157487
-
Stimulation of GATA-2 as a mechanism of hydrogen peroxide suppression in hypoxia-induced erythropoietin gene expression
-
Tabata M, Tarumoto T, Ohmine K, Furukawa Y, Hatake K, Ozawa K, Hasegawa Y, Mukai H, Yamamoto M, and Imagawa S. Stimulation of GATA-2 as a mechanism of hydrogen peroxide suppression in hypoxia-induced erythropoietin gene expression. J Cell Physiol 186: 260-267, 2001.
-
(2001)
J Cell Physiol
, vol.186
, pp. 260-267
-
-
Tabata, M.1
Tarumoto, T.2
Ohmine, K.3
Furukawa, Y.4
Hatake, K.5
Ozawa, K.6
Hasegawa, Y.7
Mukai, H.8
Yamamoto, M.9
Imagawa, S.10
-
145
-
-
0034697904
-
Requirement for p38α in erythropoietin expression: A role for stress kinases in erythropoiesis
-
Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, and Karin M. Requirement for p38α in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102: 221-231, 2000.
-
(2000)
Cell
, vol.102
, pp. 221-231
-
-
Tamura, K.1
Sudo, T.2
Senftleben, U.3
Dadak, A.M.4
Johnson, R.5
Karin, M.6
-
147
-
-
0031020884
-
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
-
Tian H, McKnight SL, and Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 11: 72-82, 1997.
-
(1997)
Genes Dev
, vol.11
, pp. 72-82
-
-
Tian, H.1
McKnight, S.L.2
Russell, D.W.3
-
148
-
-
0032213236
-
The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
-
Tian H, Hammer RE, Matsumoto AM, Russell DW, and McKnight SL. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 12: 3320-3324, 1998.
-
(1998)
Genes Dev
, vol.12
, pp. 3320-3324
-
-
Tian, H.1
Hammer, R.E.2
Matsumoto, A.M.3
Russell, D.W.4
McKnight, S.L.5
-
149
-
-
0000685312
-
Sur l'augmentation considérable du nombre des globules rouge dans le sang chez les inhabitants des hauts plateaux de l'Amérique du Sud
-
Viault F. Sur l'augmentation considérable du nombre des globules rouge dans le sang chez les inhabitants des hauts plateaux de l'Amérique du Sud. C R Acad Sci Paris 111: 917-918, 1890.
-
(1890)
C R Acad Sci Paris
, vol.111
, pp. 917-918
-
-
Viault, F.1
-
151
-
-
0036320934
-
2-regulated gene expression
-
2-regulated gene expression. FASEB J 16: 1151-1162, 2002.
-
(2002)
FASEB J
, vol.16
, pp. 1151-1162
-
-
Wenger, R.H.1
-
152
-
-
0032079558
-
Oxygen-regulated erythropoietin gene expression is dependent on a CpG methylation-free hypoxia-inducible factor-1 DNA-binding site
-
Wenger RH, Kvietikova I, Rolfs A, Camenisch G, and Gassmann M. Oxygen-regulated erythropoietin gene expression is dependent on a CpG methylation-free hypoxia-inducible factor-1 DNA-binding site. Eur J Biochem 253: 771-777, 1998.
-
(1998)
Eur J Biochem
, vol.253
, pp. 771-777
-
-
Wenger, R.H.1
Kvietikova, I.2
Rolfs, A.3
Camenisch, G.4
Gassmann, M.5
-
153
-
-
0029070559
-
Cytokines in fetal blood and amniotic fluid in Rh-immunized pregnancies
-
Westgren M, Ek S, Remberger M, Ringden O, and Stangenberg M. Cytokines in fetal blood and amniotic fluid in Rh-immunized pregnancies. Obstet Gynecol 86: 209-213, 1995.
-
(1995)
Obstet Gynecol
, vol.86
, pp. 209-213
-
-
Westgren, M.1
Ek, S.2
Remberger, M.3
Ringden, O.4
Stangenberg, M.5
-
154
-
-
0022980521
-
Effect of human erythropoietin derived from recombinant DNA on the anaemia of patients maintained by chronic haemodialysis
-
Winearls CG, Oliver DO, Pippard MJ, Reid C, Downing MR, and Cotes PM. Effect of human erythropoietin derived from recombinant DNA on the anaemia of patients maintained by chronic haemodialysis. Lancet 2: 1175-1178, 1986.
-
(1986)
Lancet
, vol.2
, pp. 1175-1178
-
-
Winearls, C.G.1
Oliver, D.O.2
Pippard, M.J.3
Reid, C.4
Downing, M.R.5
Cotes, P.M.6
-
156
-
-
0029888061
-
The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells
-
Wood SM, Gleadle JM, Pugh CW, Hankinson O, and Ratcliffe PJ. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells. J Biol Chem 271: 15117-15123, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 15117-15123
-
-
Wood, S.M.1
Gleadle, J.M.2
Pugh, C.W.3
Hankinson, O.4
Ratcliffe, P.J.5
-
157
-
-
0032824560
-
Inactivation of erythropoietin leads to defects in cardiac morphogenesis
-
Wu H, Lee SH, Gao J, Liu X, and Iruela-Arispe ML. Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Development 126: 3597-3605, 1999.
-
(1999)
Development
, vol.126
, pp. 3597-3605
-
-
Wu, H.1
Lee, S.H.2
Gao, J.3
Liu, X.4
Iruela-Arispe, M.L.5
-
158
-
-
0028880455
-
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
-
Wu H, Liu X, Jaenisch R, and Lodish HF. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 83: 59-67, 1995.
-
(1995)
Cell
, vol.83
, pp. 59-67
-
-
Wu, H.1
Liu, X.2
Jaenisch, R.3
Lodish, H.F.4
-
159
-
-
0030953740
-
Effects of erythropoietin, bromocryptine and hydralazine on testicular function in rats with chronic renal failure
-
Yamamoto Y, Sofikitis N, and Miyagawa I. Effects of erythropoietin, bromocryptine and hydralazine on testicular function in rats with chronic renal failure. Andrologia 29: 141-144, 1997.
-
(1997)
Andrologia
, vol.29
, pp. 141-144
-
-
Yamamoto, Y.1
Sofikitis, N.2
Miyagawa, I.3
-
160
-
-
0032566597
-
Estrogen-dependent production of erythropoietin in uterus and its implication in uterine angiogenesis
-
Yasuda Y, Masuda S, Chikuma M, Inoue K, Nagao M, and Sasaki R.
-
(1998)
J Biol Chem
, vol.273
, pp. 25381-25387
-
-
Yasuda, Y.1
Masuda, S.2
Chikuma, M.3
Inoue, K.4
Nagao, M.5
Sasaki, R.6
-
161
-
-
0033957513
-
DNA methylation represses the expression of the human erythropoietin gene by two different mechanisms
-
Yin H and Blanchard KL. DNA methylation represses the expression of the human erythropoietin gene by two different mechanisms. Blood 95: 111-119, 2000.
-
(2000)
Blood
, vol.95
, pp. 111-119
-
-
Yin, H.1
Blanchard, K.L.2
-
162
-
-
0036262729
-
Erythropoietin and erythropoietin receptor expression in human endometrium throughout the menstrual cycle
-
Yokomizo R, Matsuzaki S, Uehara S, Murakami T, Yaegashi N, and Okamura K. Erythropoietin and erythropoietin receptor expression in human endometrium throughout the menstrual cycle. Mol Hum Reprod 8: 441-446, 2002.
-
(2002)
Mol Hum Reprod
, vol.8
, pp. 441-446
-
-
Yokomizo, R.1
Matsuzaki, S.2
Uehara, S.3
Murakami, T.4
Yaegashi, N.5
Okamura, K.6
-
163
-
-
0033104847
-
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
-
Yu AY, Shimoda LA, Iyer NV, Huso DL, Sun X, McWilliams R, Beaty T, Sham JS, Wiener CM, Sylvester JT, and Semenza GL. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α. J Clin Invest 103: 691-696, 1999.
-
(1999)
J Clin Invest
, vol.103
, pp. 691-696
-
-
Yu, A.Y.1
Shimoda, L.A.2
Iyer, N.V.3
Huso, D.L.4
Sun, X.5
McWilliams, R.6
Beaty, T.7
Sham, J.S.8
Wiener, C.M.9
Sylvester, J.T.10
Semenza, G.L.11
-
164
-
-
0036333152
-
Erythropoietin receptor signalling is required for normal brain development
-
Yu X, Shacka JJ, Eells JB, Suarez-Quian C, Przygodzki RM, Beleslin-Cokic B, Lin CS, Nikodem VM, Hempstead B, Flanders KC, Costantini F, and Noguchi CT. Erythropoietin receptor signalling is required for normal brain development. Development 129: 505-516, 2002.
-
(2002)
Development
, vol.129
, pp. 505-516
-
-
Yu, X.1
Shacka, J.J.2
Eells, J.B.3
Suarez-Quian, C.4
Przygodzki, R.M.5
Beleslin-Cokic, B.6
Lin, C.S.7
Nikodem, V.M.8
Hempstead, B.9
Flanders, K.C.10
Costantini, F.11
Noguchi, C.T.12
-
165
-
-
0015977919
-
Erythropoietin production in the fetus: Role of the kidney and maternal anemia
-
Zanjani ED, Peterson EN, Gordon AS, and Wasserman LR. Erythropoietin production in the fetus: role of the kidney and maternal anemia. J Lab Clin Med 83: 281-287, 1974.
-
(1974)
J Lab Clin Med
, vol.83
, pp. 281-287
-
-
Zanjani, E.D.1
Peterson, E.N.2
Gordon, A.S.3
Wasserman, L.R.4
|