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Volumn 91, Issue 4, 1998, Pages 1185-1195

Embryonal carcinoma P19 cells produce erythropoietin constitutively but express lactate dehydrogenase in an oxygen-dependent manner

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; LACTATE DEHYDROGENASE;

EID: 0032519536     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.4.1185     Document Type: Article
Times cited : (19)

References (56)
  • 1
    • 0029842459 scopus 로고    scopus 로고
    • Oxygen sensing and molecular adaptation to hypoxia
    • Bunn HF, Poyton RO: Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 76:839, 1996
    • (1996) Physiol Rev , vol.76 , pp. 839
    • Bunn, H.F.1    Poyton, R.O.2
  • 2
    • 0026019106 scopus 로고
    • Erythropoietin
    • Krantz SB: Erythropoietin. Blood 77:419, 1991
    • (1991) Blood , vol.77 , pp. 419
    • Krantz, S.B.1
  • 3
    • 0026526168 scopus 로고
    • Erythropoietin: Structure, control of production, and function
    • Jelkmann W: Erythropoietin: Structure, control of production, and function. Physiol Rev 72:449, 1992
    • (1992) Physiol Rev , vol.72 , pp. 449
    • Jelkmann, W.1
  • 4
    • 0027956115 scopus 로고
    • A novel site of erythropoietin production: Oxygen-dependent production in cultured rat astrocytes
    • Masuda S, Okano M, Yamagishi K, Nagao M, Ueda M, Sasaki R: A novel site of erythropoietin production: Oxygen-dependent production in cultured rat astrocytes. J Biol Chem 269:19488, 1994
    • (1994) J Biol Chem , vol.269 , pp. 19488
    • Masuda, S.1    Okano, M.2    Yamagishi, K.3    Nagao, M.4    Ueda, M.5    Sasaki, R.6
  • 6
    • 0025912710 scopus 로고
    • Localization of cells propducing erythropoietin in murine liver by in situ hybridization
    • Koury ST, Bondurant MC, Koury MJ, Semenza GL: Localization of cells propducing erythropoietin in murine liver by in situ hybridization. Blood 77:2497, 1991
    • (1991) Blood , vol.77 , pp. 2497
    • Koury, S.T.1    Bondurant, M.C.2    Koury, M.J.3    Semenza, G.L.4
  • 7
    • 0028086474 scopus 로고
    • Expression of a homologously recombined erythropoietin-SV40 T antigen fusion gene in mouse liver: Evidence for erythropoietin production by Ito cells
    • Maxwell PH, Ferguson DJP, Osmond MK, Pugh CW, Heryet A, Doe BG, Johnson MH, Ratcliffe PJ: Expression of a homologously recombined erythropoietin-SV40 T antigen fusion gene in mouse liver: Evidence for erythropoietin production by Ito cells. Blood 84:1823, 1994
    • (1994) Blood , vol.84 , pp. 1823
    • Maxwell, P.H.1    Ferguson, D.J.P.2    Osmond, M.K.3    Pugh, C.W.4    Heryet, A.5    Doe, B.G.6    Johnson, M.H.7    Ratcliffe, P.J.8
  • 8
    • 0030636320 scopus 로고    scopus 로고
    • Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death
    • Morishita E, Masuda S, Nagao M, Yasuda Y, Sasaki R: Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 76:105, 1997
    • (1997) Neuroscience , vol.76 , pp. 105
    • Morishita, E.1    Masuda, S.2    Nagao, M.3    Yasuda, Y.4    Sasaki, R.5
  • 9
    • 0026075610 scopus 로고
    • Hypoxiainducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene
    • Semenza GL, Nejfelt MK, Chi SM, Antonarakis SE: Hypoxiainducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene. Proc Natl Acad Sci USA 88:5680, 1991
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 5680
    • Semenza, G.L.1    Nejfelt, M.K.2    Chi, S.M.3    Antonarakis, S.E.4
  • 10
    • 0026049416 scopus 로고
    • Enhancer element at the 3′-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene
    • Beck I, Ramirez S, Weinmann R, Caro J: Enhancer element at the 3′-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene. J Biol Chem 266:15563, 1991
    • (1991) J Biol Chem , vol.266 , pp. 15563
    • Beck, I.1    Ramirez, S.2    Weinmann, R.3    Caro, J.4
  • 11
    • 0025885693 scopus 로고
    • Functional analysis of an oxygen-regulated transcriptional enhancer lying 3′ to the mouse erythropoietin gene
    • Pugh CW, Tan CC, Jones RW, Ratcliffe PJ: Functional analysis of an oxygen-regulated transcriptional enhancer lying 3′ to the mouse erythropoietin gene. Proc Natl Acad Sci USA 88:10553, 1991
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10553
    • Pugh, C.W.1    Tan, C.C.2    Jones, R.W.3    Ratcliffe, P.J.4
  • 12
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza GL, Wang GL: A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12:5447, 1992
    • (1992) Mol Cell Biol , vol.12 , pp. 5447
    • Semenza, G.L.1    Wang, G.L.2
  • 13
    • 0027461553 scopus 로고
    • Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: Evidence for a widespread oxygen-sensing mechanism
    • Maxwell PH, Pugh CW, Ratcliffe PJ: Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: Evidence for a widespread oxygen-sensing mechanism. Proc Natl Acad Sci USA 90:2423, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2423
    • Maxwell, P.H.1    Pugh, C.W.2    Ratcliffe, P.J.3
  • 14
    • 0027230099 scopus 로고
    • A 24-base-pair sequence 3′ to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer
    • Madan A, Curtin PT: A 24-base-pair sequence 3′ to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer. Proc Natl Acad Sci USA 90:3928, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3928
    • Madan, A.1    Curtin, P.T.2
  • 15
    • 0027172514 scopus 로고
    • Characterization of hypoxiaresponsive enhancer in the human erythropoietin gene shows presence of hypoxia-inducible 120-Kd nuclear DNA-binding protein in erythropoietin-producing and nonproducing cells
    • Beck I, Weinmann R, Caro J: Characterization of hypoxiaresponsive enhancer in the human erythropoietin gene shows presence of hypoxia-inducible 120-Kd nuclear DNA-binding protein in erythropoietin-producing and nonproducing cells. Blood 82:704, 1993
    • (1993) Blood , vol.82 , pp. 704
    • Beck, I.1    Weinmann, R.2    Caro, J.3
  • 16
    • 0027427588 scopus 로고
    • Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia
    • Wang GL, Semenza GL: Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia, J Biol Chem 268:21513, 1993
    • (1993) J Biol Chem , vol.268 , pp. 21513
    • Wang, G.L.1    Semenza, G.L.2
  • 17
    • 0027210562 scopus 로고
    • General involvement of hypoxiainducible factor 1 in transcriptional response to hypoxia
    • Wang GL, Semenza GL: General involvement of hypoxiainducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA 90:4304, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4304
    • Wang, G.L.1    Semenza, G.L.2
  • 18
    • 0028279870 scopus 로고
    • Characterization of functional domains within the mouse erythropoietin 3′ enhancer conveying oxygen-regulated responses in different cell lines
    • Pugh CW, Ebert BL, Ebrahim O, Ratcliffe PJ: Characterization of functional domains within the mouse erythropoietin 3′ enhancer conveying oxygen-regulated responses in different cell lines. Biochim Biophys Acta 1217:297, 1994
    • (1994) Biochim Biophys Acta , vol.1217 , pp. 297
    • Pugh, C.W.1    Ebert, B.L.2    Ebrahim, O.3    Ratcliffe, P.J.4
  • 19
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang GL, Semenza GL: Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270:1230, 1995
    • (1995) J Biol Chem , vol.270 , pp. 1230
    • Wang, G.L.1    Semenza, G.L.2
  • 21
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
    • Jiang BH, Rue E, Wang GL, Roe R, Semenza GL: Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 271:17771, 1996
    • (1996) J Biol Chem , vol.271 , pp. 17771
    • Jiang, B.H.1    Rue, E.2    Wang, G.L.3    Roe, R.4    Semenza, G.L.5
  • 22
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza GL, Roth PH, Fang HM, Wang GL: Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 269:23757, 1994
    • (1994) J Biol Chem , vol.269 , pp. 23757
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3    Wang, G.L.4
  • 23
    • 0028359320 scopus 로고
    • Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase a genes: Similarities with the erythropoietin 3′ enhancer
    • Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ: Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3′ enhancer. Proc Natl Acad Sci USA 91:6496, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6496
    • Firth, J.D.1    Ebert, B.L.2    Pugh, C.W.3    Ratcliffe, P.J.4
  • 24
    • 0029101515 scopus 로고
    • Hypoxic regulation of lactate dehydrogenase A
    • Firth JD, Ebert BL, Ratcliffe PJ: Hypoxic regulation of lactate dehydrogenase A. J Biol Chem 270:21021, 1995
    • (1995) J Biol Chem , vol.270 , pp. 21021
    • Firth, J.D.1    Ebert, B.L.2    Ratcliffe, P.J.3
  • 25
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase a gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, Giallongo A: Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 271:32529, 1996
    • (1996) J Biol Chem , vol.271 , pp. 32529
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4    Concordet, J.P.5    Maire, P.6    Giallongo, A.7
  • 26
    • 0029039195 scopus 로고
    • Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
    • Levy AP, Levy NS, Wegner S, Goldberg MA: Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 270:13333, 1995
    • (1995) J Biol Chem , vol.270 , pp. 13333
    • Levy, A.P.1    Levy, N.S.2    Wegner, S.3    Goldberg, M.A.4
  • 28
    • 0029891739 scopus 로고    scopus 로고
    • Drosophila melanogaster SL2 cells contain a hypoxically inducible DNa binding complex which recognises mammalian HIF-1 binding sites
    • Nagao M, Ebert BL, Ratcliffe PJ, Pugh CW: Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF-1 binding sites. FEBS Lett 387:161, 1996
    • (1996) FEBS Lett , vol.387 , pp. 161
    • Nagao, M.1    Ebert, B.L.2    Ratcliffe, P.J.3    Pugh, C.W.4
  • 29
    • 0030045543 scopus 로고    scopus 로고
    • Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: Similarities with the regulation of erythropoietin
    • Ebert BL, Gleadle JM, O'Rourke JF, Bartlett SM, Poulton J, Ratcliffe PJ: Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: Similarities with the regulation of erythropoietin. Biochem J 313:809, 1996
    • (1996) Biochem J , vol.313 , pp. 809
    • Ebert, B.L.1    Gleadle, J.M.2    O'Rourke, J.F.3    Bartlett, S.M.4    Poulton, J.5    Ratcliffe, P.J.6
  • 31
    • 0024273450 scopus 로고
    • Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
    • Goldberg MA, Dunning SP, Bunn HF: Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein. Science 242:1412, 1988
    • (1988) Science , vol.242 , pp. 1412
    • Goldberg, M.A.1    Dunning, S.P.2    Bunn, H.F.3
  • 32
    • 0026494916 scopus 로고
    • Hypoxic induction of the human erythropoietin gene: Cooperation between the promoter and enhancer, each of which contains steroid receptor response elements
    • Blanchard KL, Acquaviva AM, Galson DL, Bunn HF: Hypoxic induction of the human erythropoietin gene: Cooperation between the promoter and enhancer, each of which contains steroid receptor response elements. Mol Cell Biol 12:5373, 1992
    • (1992) Mol Cell Biol , vol.12 , pp. 5373
    • Blanchard, K.L.1    Acquaviva, A.M.2    Galson, D.L.3    Bunn, H.F.4
  • 33
    • 0028967752 scopus 로고
    • The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1
    • Galson DL, Tsuchiya T, Tendler DS, Huang LE, Ren Y, Ogura T, Bunn HF: The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1. Mol Cell Biol 15:2135, 1995
    • (1995) Mol Cell Biol , vol.15 , pp. 2135
    • Galson, D.L.1    Tsuchiya, T.2    Tendler, D.S.3    Huang, L.E.4    Ren, Y.5    Ogura, T.6    Bunn, H.F.7
  • 34
    • 0025732077 scopus 로고
    • Hematopoietic development of embryonic stem cell in vitro: Cytokine and receptor gene expression
    • Schmitt RM, Bruyns E, Snodgrass HR: Hematopoietic development of embryonic stem cell in vitro: Cytokine and receptor gene expression. Genes Dev 5:728, 1991
    • (1991) Genes Dev , vol.5 , pp. 728
    • Schmitt, R.M.1    Bruyns, E.2    Snodgrass, H.R.3
  • 35
    • 0019947366 scopus 로고
    • Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line
    • McBurney MW, Jones-Villeneuve EMV, Edwards MKS, Anderson PJ: Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line. Nature 299:165, 1982
    • (1982) Nature , vol.299 , pp. 165
    • McBurney, M.W.1    Jones-Villeneuve, E.M.V.2    Mks, E.3    Anderson, P.J.4
  • 36
    • 0024419155 scopus 로고
    • Characterization and use of monoclonal antibodies directed against human erythropoietin that recognize different antigenic determinants
    • Goto M, Murakami A, Akai K, Kawanishi G, Ueda M, Chiba H, Sasaki R: Characterization and use of monoclonal antibodies directed against human erythropoietin that recognize different antigenic determinants. Blood 74:1415, 1989
    • (1989) Blood , vol.74 , pp. 1415
    • Goto, M.1    Murakami, A.2    Akai, K.3    Kawanishi, G.4    Ueda, M.5    Chiba, H.6    Sasaki, R.7
  • 39
    • 85007784564 scopus 로고
    • Characterization of erythropoietin isolated from rat serum: Biochemical comparison of rat and human erythropoietin
    • Okano M, Suga H, Masuda S, Nagao M, Narita H, Ikura K, Sasaki R: Characterization of erythropoietin isolated from rat serum: Biochemical comparison of rat and human erythropoietin. Biosci Biotech Biochem 57:1882, 1993
    • (1993) Biosci Biotech Biochem , vol.57 , pp. 1882
    • Okano, M.1    Suga, H.2    Masuda, S.3    Nagao, M.4    Narita, H.5    Ikura, K.6    Sasaki, R.7
  • 40
    • 0025723987 scopus 로고
    • Effects of site-directed removal of N-glycosylation sites in human erythropoietin on its production and biological properties
    • Yamaguchi K, Akai K, Kawanishi G, Ueda M, Masuda S, Sasaki R: Effects of site-directed removal of N-glycosylation sites in human erythropoietin on its production and biological properties. J Biol Chem 266:20434, 1991
    • (1991) J Biol Chem , vol.266 , pp. 20434
    • Yamaguchi, K.1    Akai, K.2    Kawanishi, G.3    Ueda, M.4    Masuda, S.5    Sasaki, R.6
  • 41
    • 0031018353 scopus 로고    scopus 로고
    • Insulin-like growth factors and insulin stimulate erythropoietin production in primary cultured astrocytes
    • Masuda S, Chikuma M, Sasaki R: Insulin-like growth factors and insulin stimulate erythropoietin production in primary cultured astrocytes. Brain Res 746:63, 1997
    • (1997) Brain Res , vol.746 , pp. 63
    • Masuda, S.1    Chikuma, M.2    Sasaki, R.3
  • 43
    • 0021140101 scopus 로고
    • Expression and regulation of chicken actin genes introduced into mouse myogenic and nonmyogenic cells
    • Seiler-Tuyns A, Eldridge JD, Paterson BM: Expression and regulation of chicken actin genes introduced into mouse myogenic and nonmyogenic cells. Proc Natl Acid Sci USA 81:2980, 1984
    • (1984) Proc Natl Acid Sci USA , vol.81 , pp. 2980
    • Seiler-Tuyns, A.1    Eldridge, J.D.2    Paterson, B.M.3
  • 45
    • 0027490299 scopus 로고
    • Comparison of the human and mouse erythropoietin genes shows extensive homology in the flanking regions
    • Galson DL, Tan CC, Ratcliffe PJ, Bunn HF: Comparison of the human and mouse erythropoietin genes shows extensive homology in the flanking regions. Blood 82:3321, 1993
    • (1993) Blood , vol.82 , pp. 3321
    • Galson, D.L.1    Tan, C.C.2    Ratcliffe, P.J.3    Bunn, H.F.4
  • 46
    • 85086810804 scopus 로고    scopus 로고
    • Erythropoietin enhancer stimulates production of a recombinant protein by Chinese hamster ovary (CHO) cells under hypoxic condition
    • in press
    • Moon SK, Takeuchi S, Kambe T, Tsuchiya T, Masuda S, Nagao M, Sasaki R: Erythropoietin enhancer stimulates production of a recombinant protein by Chinese hamster ovary (CHO) cells under hypoxic condition. Cytotechnology (in press)
    • Cytotechnology
    • Moon, S.K.1    Takeuchi, S.2    Kambe, T.3    Tsuchiya, T.4    Masuda, S.5    Nagao, M.6    Sasaki, R.7
  • 47
    • 0026442116 scopus 로고
    • Production and ligand-binding characteristics of the soluble form of murine erythropoietin receptor
    • Nagao M, Masuda S, Abe S, Ueda M, Sasaki R: Production and ligand-binding characteristics of the soluble form of murine erythropoietin receptor. Biochem Biophys Res Commun 188:888, 1992
    • (1992) Biochem Biophys Res Commun , vol.188 , pp. 888
    • Nagao, M.1    Masuda, S.2    Abe, S.3    Ueda, M.4    Sasaki, R.5
  • 48
    • 0022654783 scopus 로고
    • Murine erythropoietin gene: Cloning, expression, and human gene homolgy
    • Shoemaker CB, Mitsock LD: Murine erythropoietin gene: Cloning, expression, and human gene homolgy. Mol Cell Biol 6:849, 1986
    • (1986) Mol Cell Biol , vol.6 , pp. 849
    • Shoemaker, C.B.1    Mitsock, L.D.2
  • 50
    • 0029851153 scopus 로고    scopus 로고
    • The role of the near upstream sequence in hypoxia-induced expression of the erythropoietin gene
    • Gupta M, Goldwasser E: The role of the near upstream sequence in hypoxia-induced expression of the erythropoietin gene. Nucleic Acid Res 24:4768, 1996
    • (1996) Nucleic Acid Res , vol.24 , pp. 4768
    • Gupta, M.1    Goldwasser, E.2
  • 51
    • 0027302375 scopus 로고
    • Functional erythropoietin receptor of the cells with neural characteristics: Comparison with receptor properties of erythroid cells
    • Masuda S, Nagao M, Takahata K, Konishi Y, Gallyas F Jr, Tabira T, Sasaki R: Functional erythropoietin receptor of the cells with neural characteristics: Comparison with receptor properties of erythroid cells. J Biol Chem 268:11208, 1993
    • (1993) J Biol Chem , vol.268 , pp. 11208
    • Masuda, S.1    Nagao, M.2    Takahata, K.3    Konishi, Y.4    Gallyas Jr., F.5    Tabira, T.6    Sasaki, R.7
  • 52
    • 0029978536 scopus 로고    scopus 로고
    • Anti-erythropoietin receptor monoclonal antibody: Epitope mapping, quantification of the soluble receptor, and detection of the solubilized transmembrane receptor and the receptor-expressing cells
    • Morishita E, Narita H, Nishida M, Kawashima N, Yamagishi K, Masuda S, Nagao M, Hatta H, Sasaki R: Anti-erythropoietin receptor monoclonal antibody: Epitope mapping, quantification of the soluble receptor, and detection of the solubilized transmembrane receptor and the receptor-expressing cells. Blood 88:465, 1996
    • (1996) Blood , vol.88 , pp. 465
    • Morishita, E.1    Narita, H.2    Nishida, M.3    Kawashima, N.4    Yamagishi, K.5    Masuda, S.6    Nagao, M.7    Hatta, H.8    Sasaki, R.9
  • 53
    • 2642627066 scopus 로고
    • Erythropoietin processing in erythropoietic system and central nervous system
    • Nagao M, Masuda S, Ueda M, Sasaki R: Erythropoietin processing in erythropoietic system and central nervous system. Cytotechnology 18:83, 1995
    • (1995) Cytotechnology , vol.18 , pp. 83
    • Nagao, M.1    Masuda, S.2    Ueda, M.3    Sasaki, R.4
  • 56
    • 0026768685 scopus 로고
    • Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia
    • Tan CC, Eckardt KU, Firth JD, Ratcliffe PJ: Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia. Am J Physiol 263:F474,1992
    • (1992) Am J Physiol , vol.263
    • Tan, C.C.1    Eckardt, K.U.2    Firth, J.D.3    Ratcliffe, P.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.