17β-estradiol decreases hypoxic induction of erythropoietin gene expression

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 283, Issue 2 52-2, 2002, Pages

  Mukundan, Harshini ^a,b   Resta, Thomas C ^a   Kanagy, Nancy L ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

Hypoxia; Nitric oxide; Polycythemia

Indexed keywords

ERYTHROPOIETIN; ESTRADIOL; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ISOENZYME; MESSENGER RNA; NITRITE; NOS3 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; GENE EXPRESSION; HYPOXIA; KIDNEY; NONHUMAN; OVARIECTOMY; POLYCYTHEMIA; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; ANIMAL; ANOXIA; BIOSYNTHESIS; BLOOD; BLOOD GAS ANALYSIS; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HEMATOCRIT; IMMUNOHISTOCHEMISTRY; METABOLISM; ORGAN SIZE; UTERUS;

ANIMALS; ANOXIA; BLOOD GAS ANALYSIS; ERYTHROPOIETIN; ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION; HEMATOCRIT; IMMUNOHISTOCHEMISTRY; ISOENZYMES; KIDNEY; NITRATES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; ORGAN SIZE; OVARIECTOMY; RATS; RNA, MESSENGER; UTERUS;

EID: 0036340721     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00573.2001     Document Type: Article

References (69)

1. Dual influence of nitric oxide on gene regulation during hypoxia
2. Influence of body size and gender on control of ventilation
3. The oxygen sensor that controls EPO production: Facts and fancies
4. Vascular endothelial growth factor is modulated in vascular muscle cells by estradiol, tamoxifen, and hypoxia
5. Plasma concentration of LH, FSH, prolactin, progesterone and estradiol-17β throughout the 4-day estrous cycle of the rat
6. Catecholamines and angiotensinogen gene expression in kidney proximal tubular cells
7. Effects of 17β-estradiol on endothelium-dependent relaxation induced by acetylcholine in female rat aorta
8. Tissue-specific regulation of erythropoietin production in the murine kidney, brain, and uterus
9. Localization of erythropoietin mRNA in the rat kidney by polymerase chain reaction
10. Localization of specific erythropoietin binding sites in defined areas of the mouse brain
11. Estradiol attenuates hypoxia-induced endothelin-1 gene expression
12. The ontogeny of the biological role and production of erythropoietin
13. Distribution of erythropoietin producing cells in rat kidneys during hypoxic hypoxia
14. Reciprocal antagonism between estrogen receptor and NF-κB activity in vivo
15. Differential effects of ventilatory stimulation by sex hormones and almitrine on hypoxic erythrocytosis
16. Erythropoietin production by interstitial cells of hypoxic monkey kidneys
17. Endothelium-independent relaxation of vascular smooth muscle by 17β-estradiol
18. 17β-estradiol increases nitric oxide-dependent dilation in rat pulmonary arteries and thoracic aorta
19. Electron microscopic localization of lacZ expression in the proximal convoluted tubular cells of the kidney in transgenic mice carrying chimeric erythropoietin/lacZ gene constructs
20. Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling
21. Correlation of HO-1 expression with onset and reversal of hypoxia-induced vasoconstrictor hyporeactivity
22. Development of bone marrow erythroblastic islands in hypoxic rats with intact or damaged kidney tubules
23. Modulation of erythropoiesis in rat bone marrow erythroblastic islands by cyclooxygenase inhibition
24. Relationship between absolute and relative hematocrit changes and bone marrow response in rats
25. Retinoic acid stimulates erythropoietin gene transcription in embryonal carcinoma cells through the direct repeat of a steroid/thyroid hormone receptor response element half-site in the hypoxia-response enhancer
26. Cross reactivity between human erythropoietin antibody and horse erythropoietin
27. Nongenomic stimulation of nitric oxide release by estrogen is mediated by estrogen receptor-α localized in caveolae
28. Identification of hypoxia-inducible factor-1 (HIF-1) ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide
29. Effects of hypoxia on growth factor expression in the rat kidney in vivo
30. Role of estrogen as initiator of daily LH surges in the ovariectomized rat
31. Investigation of organophilic montmorillonite clay inclusion in zearalenone-contaminated diets using the mouse uterine weight bioassay
32. Estrogen upregulates endothelial nitric oxide synthase gene expression in fetal pulmonary artery endothelium
33. Distribution characteristics of entrapped recombinant human erythropoietin in liposomes and its intestinal absorption in rats
34. The oviduct produces erythropoietin in an estrogen-regulated manner
35. Effects of sex hormones on cardiovascular and hematologic responses to chronic hypoxia in rats
36. Renal vasodilatory influence of endogenous carbon monoxide in chronically hypoxic rats
37. Protein kinase C-α protein expression is necessary for sustained erythropoietin production in human hepatocellular carcinoma (Hep3B) cells exposed to hypoxia
38. Polycythemic responses to hypoxia: Molecular and genetic mechanisms of chronic mountain sickness
39. The immature mouse is a suitable model for detection of estrogenicity in the uterotropic bioassay
40. The role of estrogen in the regulation of erythropoietin production
41. The effect of estrogens on erythroid stem cells in polycythemic mice
42. Inducible nitric oxide synthase and glomerular hemodynamics in rats with liver cirrhosis
43. Gender differences in the renal nitric oxide (NO) system: Dissociation between expression of endothelial NO synthase and renal hemodynamic response to NO synthase inhibition
44. Maintained upregulation of pulmonary eNOS gene and protein expression during recovery from chronic hypoxia
45. Selective upregulation of arterial endothelial nitric oxide synthase in pulmonary hypertension
46. Estradiol induced attenuation of pulmonary hypertension is not associated with altered eNOS expression
47. Glyceraldehyde-3-phosphate dehydrogenase gene expression in human breast cancer
48. Tamoxifen up-regulates oestrogen receptor-α, c-fos, and glyceraldehyde 3-phosphate-dehydrogenase mRNAs in ovine endometrium
49. Endothelial vasodilator production by uterine and systemic arteries. VII. Estrogen and progesterone effects on eNOS
50. Accumulation of HIF-1α under the influence of nitric oxide
51. Regulation of the hypoxia-inducible factor 1α by the inflammatory mediators nitric oxide and tumor necrosis factor-α in contrast to desferroxamine and phenylarsine oxide
52. Erythropoietin: Multiple physiological functions and regulation of biosynthesis
53. Pleiotropic functions and tissue-specific expression of erythropoietin
54. Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure
55. Localization of erythropoietin gene expression in proximal renal tubular cells detected by digoxigenin-labelled oligonucleotide probes
56. Ontogeny of nitric oxide in the pulmonary vasculature
57. Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia
58. 17β-estradiol increases VEGF receptor-2 and promotes DNA synthesis in retinal microvascular endothelial cells
59. Influences of gender and sex hormones on hypoxic ventilatory response in cats
60. Role of endogenous female hormones in hypoxic chemosensitivity
61. Vitamin D metabolism and phosphate transport in developing kidney: Effect of diet and mutation
62. Endogenous nitric oxide attenuates erythropoietin gene expression in vivo
63. Renal expression of constitutive NOS and DDAH: Separate effects of salt intake and angiotensin
64. Endothelial vasodilator production by uterine and systemic arteries. III. Ovarian and estrogen effects on NO synthase
65. Nitric oxide-dependent pulmonary vasodilation in polycythemic rats
66. Erythropoietin structure-function relationships: High degree of sequence homology among mammals
67. Estrogen-dependent production of erythropoietin in uterus and its implication in uterine angiogenesis
68. Nitric oxide enhancement of erythropoietin production in the isolated perfused rat kidney
69. Direct comparison of GAPDH, β-actin, cyclophilin, and 28S rRNA as internal standards for quantifying RNA levels under hypoxia