Proinflammatory cytokines lowering erythropoietin production

Journal of Interferon and Cytokine Research

Volumn 18, Issue 8, 1998, Pages 555-559

  Jelkmann, Wolfgang ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; ERYTHROPOIETIN; INTERLEUKIN 1; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANEMIA; CYTOKINE PRODUCTION; GENE EXPRESSION REGULATION; GENE REPRESSION; HEPATOMA CELL; HUMAN; INFLAMMATION; ISOLATED KIDNEY; KIDNEY PERFUSION; PRIORITY JOURNAL; REVIEW;

EID: 0031821059     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1998.18.555     Document Type: Review

References (61)

1. JELKMANN, W. (1992). Erythropoietin: structure, and control of production, and function. Physiol. Rev. 72, 449-489.
2. FUCHS, D., HAUSEN, A., REIBNEGGER, G., WERNER, E.R., WERNER-FELMAYER, G., DIERICH, M.P., and WACHTER, H. (1991). Immune activation and the anaemia associated with chronic inflammatory disorders. Eur. J. Haematol. 46, 65-70.
3. MEANS, R.T., and KRANTZ, S.B. (1992). Progress in understanding the pathogenesis of the anemia of chronic disease. Blood 80, 1639-1647.
4. JURADO, R.J. (1997). Iron, infections, and anemia of inflammation. Clin. Infect. Dis. 25, 888-895.
5. BAROSI, G. (1994). Inadequate erythropoietin response to anemia: definition and clinical relevance. Ann. Hematol. 68, 215-223.
6. LUKENS, J.N. (1973). Control of erythropoiesis in rats with adjuvant-induced chronic inflammation. Blood 41, 37-44.
7. FREDE, S., FANDREY, J., PAGEL, H., HELLWIG, T., and JELKMANN, W. (1997). Erythropoietin gene expression is suppressed after lipopolysaccharide or interleukin-1β injections in rats. Am. J. Physiol. 273, R1067-R1071.
8. UDUPA, K.B., and LIPSCHITZ, D.A. (1982). Endotoxin-induced suppression of erythropoiesis: the role of erythropoietin and a heme synthesis stimulating factor. Blood 59, 1267-1271.
9. CHUNCHARUNEE, S., CARTER, C.D., STUDTMANN, K.E., CARO, J., COFFEY, R.J., and DESSYPRIS, E.N. (1993). Chronic administration of transforming growth factor-beta suppresses erythropoietin-dependent erythropoiesis and induces tumour necrosis factor in vivo. Br. J. Haematol. 84, 374-380.
10. HUIE, M.L., GORDON, A.S., MIRAND, E.A., LEONG, S., PRETI, R.A., and NAUGHTON, B.A. (1985). The effects of interferon on murine erythropoiesis. Life Sci. 36, 2459-2462.
11. LENG, H.M.J., and FOLB, P.I. (1996). Erythropoiesis and erythropoietin synthesis during aseptic acute inflammation. Inflam. Res. 45, 541-545.
12. PETAKOV, M., BILJANOVIC-PAUNOVIC, L., JOVCIC, G., STOJANOVIC, N., TODOROVIC, V., and JELKMANN, W. (1998). The influence of acute sterile inflammation on erythropoiesis in rats. Exp. Hematol. 26, 222-227.
13. MILLER, K.L., CARLINO, J.A., OGAWA, Y., AVIS, P.D., and CARROLL., K.G. (1992). Alterations in erythropoiesis in TGF-β1-treated mice. Exp. Hematol. 20, 951-956.
14. JOHNSON, R.A., WADDELOW, T.A., CARO, J., OLIFF, A., and ROODMAN, G.D. (1989). Chronic exposure to tumor necrosis factor in vivo preferentially inhibits erythropoiesis in nude mice. Blood 74, 130-138.
15. WARD, H.P., GORDON, B., and PICKETT, J.C. (1969). Serum levels of erythropoietin in rheumatoid arthritis. J. Lab. Clin. Med. 74, 93-97.
16. WARD, H.P., KURNICK, J.E., and PISARCZYK, M.J. (1971). Serum level of erythropoietin in anemias associated with chronic infection, malignancy, and primary hematopoietic disease. J. Clin. Invest. 50, 332-335.
17. BAER, A.N., DESSYPRIS, E.N., GOLDWASSER, E., and KRANTZ, S.B. (1987). Blunted erythropoietin response to anaemia in rheumatoid arthritis. Br. J. Haematol. 66, 559-564.
18. HOCHBERG, M.C., ARNOLD, C.M., HOGANS, B.B., and SPIVAK, J.L. (1988). Serum immunoreactive erythropoietin in rheumatoid arthritis: impaired response to anemia. Arthritis Rheum. 31, 1318-1321.
19. SALVARANI, C., CASALI, B., SALVO, D., BRUNATI, C., MACCHIONI, P.L., MASSAI, G., LASAGNI, D., RIVASI, P., and PORTIOLI, I. (1991). The role of interleukin 1, erythropoietin and red cell bound immunoglobulins in the anaemia of rheumatoid arthritis. Clin. Exp. Rheumatol. 9, 241-246.
20. CAMACHO, J., ARNALICH, F., ZAMORANO, A.F., and VAZQUEZ, J.J. (1991). Serum erythropoietin levels in the anaemia of chronic disorders. J. Intern. Med. 229, 49-54.
21. SCHREIBER, S., HOWALDT, S., SCHNOOR, M., NIKOLAUS, S., BAUDITZ, J., GASCHE, C., LOCHS, H., and RAEDLER, A. (1996). Recombinant erythropoietin for the treatment of anemia in inflammatory bowel disease. N. Engl. J. Med. 334, 619-623.
22. LAPINSKY, S.E., BAYNES, R.D., SCHULZ, E.J., MACPHAIL, A.P., MENDELOW, B., LEWIS, D., and BOTHWELL, T.H. (1992). Anemia, iron-related measurements and erythropoietin levels in untreated patients with active leprosy. J. Intern. Med. 232, 273-278.
23. EBRAHIM, O., FOLB, P.I., ROBSON, S.C., and JACOBS, P. (1995). Blunted erythropoietin response to anaemia in tuberculosis. Eur. J. Haematol. 55, 251-254.
24. EL HASSAN, A.M.A., SAEED, A.M., FANDREY, J., and JELKMANN, W. (1997). Decreased erythropoietin response in Plasmodium falciparum malaria-associated anaemia. Eur. J. Haematol. 59, 299-304.
25. SPIVAK, J.L., BARNES, D.C., FUCHS, E., and QUINN, T.C. (1989). Serum immunoreactive erythropoietin in HIV-infected patients. JAMA 261, 3104-3107.
26. CAMACHO, J., POVEDA, F., ZAMORANO, A.F., VALENCIA, M.E., VAZQUEZ, J.J., and ARNALICH, F. (1992). Serum erythropoietin levels in anaemic patients with advanced human immunodeficiency virus infection. Br. J. Haematol. 82, 608-614.
27. KREUZER, K.-A., ROCKSTROH, J.K., JELKMANN, W., THEISEN, A., SPENGLER, U., and SAUERBRUCH, T. (1997). Inadequate erythropoietin response to anaemia in HIV patients: relationship to serum levels of tumour necrosis factor-alpha, interleukin-6 and their soluble receptors. Br. J. Haematol. 96, 235-239.
28. MILLER, C.B., JONES, R.J., PIANTADOSI, S., ABELOFF, M.D., and SPIVAK, J.L. (1990). Decreased erythropoietin response in patients with the anemia of cancer. N. Engl. J. Med. 322, 1689-1692.
29. DOWLATI, A., R'ZIK, S., FILLET, G., and BEGUIN, Y. (1997). Anaemia of lung cancer is due to impaired erythroid marrow response to erythropoietin stimulation as well as relative inadequacy of erythropoietin production. Br. J. Haematol. 97, 297-299.
30. BLACKBURN, M.E.C., KENDALL, R.G., GIBBS, J.L., DICKINSON, D.F., PARSONS, J.M., and NORFOLK, D.R. (1992). Anaemia in children following cardiac transplantation: treatment with low dose human recombinant erythropoietin. Int. J. Cardiol. 36, 263-266.
31. END, A., STIFT, A., WIESELTHALER, G., GRIESMACHER, A., SCHLECHTA, B., KOPPENSTEINER, R., SCHREINLER, W., GEISSLER, K., STOCKENHUBER, F., and KLEPETKO, W. (1995). Anemia and erythropoietin levels in lung transplant recipients. Transplantation 60, 1245-1251.
32. CLEMENS, J., and SPIVAK, J.L. (1994). Serum immunoreactive erythropoietin during the perioperative period. Surgery 115, 510-515.
33. BEGUIN, Y., LOO, M., R'ZIK, S., SAUTOIS, B., LEJEUNE, F., RORIVE, G., and FILLET, G. (1993). Early prediction of response to recombinant human erythropoietin in patients with the anemia of renal failure by serum transferrin receptor and fibrinogen. Blood 82, 2010-2016.
34. ABEL, J., SPANNBRUCKER, N., FANDREY, J., and JELKMANN, W. (1996). Serum erythropoietin levels in patients with sepsis and septic shock. Eur. J. Haematol. 57, 359-363.
35. PAGEL, H., JELKMANN, W., and WEISS, C. (1991). Isolated serum-free perfused rat kidneys release immunoreactive erythropoietin in response to hypoxia. Endocrinology 128, 2633-2638.
36. JELKMANN, W., PAGEL, H., WOLFF, M., and FANDREY, J. (1992). Monokines inhibiting erythropoietin production in human hepatoma cultures and isolated perfused rat kidneys. Life Sci. 50, 301-308.
37. JELKMANN, W., FANDREY, J., FREDE, S., and PAGEL, H. (1994). Inhibition of erythropoietin production by cytokines. Ann. NY Acad. Sci. 718, 300-309.
38. GOLDBERG, M.A., GLASS, G.A., CUNNINGHAM, J.M., and BUNN, H.F. (1987). The regulated expression of erythropoietin by two human hepatoma cell lines. Proc. Natl. Acad. Sci. USA 84, 7972-7976.
39. 2 in erythropoietin-producing human hepatoma cell cultures. Am. J. Physiol. 265, C1266-C1270.
40. FANDREY, J., FREDE, S., and JELKMANN, W. (1994). Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem. J. 303, 507-510.
41. WANG, G.L., and SEMENZA, G.L. (1995). Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 270, 1230-1237.
42. HUANG, L.E., ARANY, Z., LIVINGSTON, D.M., and BUNN, H.F. (1996). Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit. J. Biol. Chem. 271, 32253-32259.
43. LENG, H.M.J., KIDSON, S.H., KERAAN, M.M., RANDALL, G.W., and FOLB, P.I. (1996). Cytokine-mediated inhibition of erythropoietin synthesis by dexamethasone. J. Pharm. Pharmacol. 48, 971-974.
44. CASSIDY, M.J.D., DE JAGER, C., EBRAHIM, O., CAMACHIO, P., and ROBSON, S. (1994). Peripheral blood mononuclear cells from patients with chronic renal failure release factors which suppress erythropoietin secretion in vitro. Nephrol. Dial. Transplant. 9, 775-779.
45. JELKMANN, W., WOLFF, M., and FANDREY, J. (1990). Modulation of the production of erythropoietin by cytokines: in vitro studies and their clinical relevance. Contrib. Nephrol. 87, 68-77.
46. FAQUIN, W.C., SCHNEIDER, T.J., and GOLDBERG, M.A. (1992). Effect of inflammatory cytokines on hypoxia-induced erythropoietin production. Blood 79, 1987-1994.
47. FANDREY, J., HUWILER, A., FREDE, S., PFEILSCHIFTER, J., and JELKMANN, W. (1994). Distinct signaling pathways mediate phorbol-ester-induced and cytokine-induced inhibition of erythropoietin gene expression. Eur. J. Biochem. 226, 335-340.
48. JELKMANN, W., WOLFF, M., and FANDREY, J. (1994). Inhibition of erythropoietin production by cytokines and chemotherapy may contribute to the anemia in malignant diseases. In: Oxygen Transport to Tissue XV. P. Vaupel, R. Zander, and D.F. Bruley (eds.). New York: Plenum Press, pp. 525-530.
49. FREDE, S., FANDREY, J., and JELKMANN, W. (1996). Interleukin 1β and phorbol ester induce tumour necrosis factor α production in a hepatic cell line (HepG2). Pflügers Arch. Eur. J. Physiol. 431, 923-927.
50. JELKMANN, W., FREDE, S., and FANDREY, J. (1996). Tumor necrosis factor α (TNFα), via its 55 kDa receptor, exerts an autocrine inhibition of hepatic erythropoietin (Epo) synthesis. Exp. Hematol. 24, 1097 (abstract).
51. ROWELL, D.L., ECKMANN, L., DWINELL, M.B., CARPENTER, S.P., RAUCY, J.L., YANG, S.-K., and KAGNOFF, M.F. (1997). Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion. Am. J. Physiol. 273, G322-G332.
52. BIGDELI, N., MARSHALL, R.C., GRABOW, L., and LOH, W.H. (1992). TGF-beta inhibits proliferation of the HepG2 cell line in vitro with concomitant decreases in erythropoietin and alpha-feto-protein production. Proc. Am. Assoc. Cancer Res. 33, 73 (abstract).
53. ERSLEV, A.J., and BESARAB, A. (1997). Erythropoietin in the pathogenesis and treatment of the anemia of chronic renal failure. Kidney Int. 51, 622-630.
54. THAYSEN, J.H., NIELSEN, O.J., BRANDI, L., and SZPIRT, W. (1991). Erythropoietin deficiency in acute crescentic glomerulonephritis and in total bilateral renal cortical necrosis. J. Intern. Med. 229, 363-369.
55. REJMAN, A.S.M., GRIMES, A.J., COTES, P.M., MANSELL, M.A., and JOEKES, A.M. (1985). Correction of anaemia following renal transplantation: serial changes in serum immunoreactive erythropoietin, absolute reticulocyte count and red-cell creatine levels. Br. J. Haematol. 61, 421-431.
56. BESARAB, A., CARO, J., JARRELL, B.E., FRANCOS, G., and ERSLEV, A.J. (1979). Dynamics of erythropoiesis following renal transplantation. Kidney Int. 32, 526-536.
57. CHANDRA, M., CLEMONS, G.K., and McVICAR, M.I. (1988). Relation of serum erythropoietin levels to renal excretory function: evidence for lowered set point for erythropoietin production in chronic renal failure. J. Pediatr. 113, 1015-1021.
58. YOSHIOKA, K., TAKEMURA, T., MURAKAMI, K., OKADA, M., YAGI, K., MIYAZATO, H., MATSUSHIMA, K., and MAKI, S. (1993). In situ expression of cytokines in IgA nephritis. Kidney Int. 44, 825-833.
59. ROVIN, B.H., and SCHREINER, G.F. (1991). Cell-mediated immunity in glomerular disease. Annu. Rev. Med. 42, 25-33.
60. HERBELIN, A., NGUYEN, A.T., ZINGRAFF, J., URENA, P., and DESCAMPS-LATSCHA, B. (1990). Influence of uremia and hemodialysis on circulating interleukin-1 and tumor necrosis factor α. Kidney Int. 37, 116-125.
61. SHAPIRO, L., KING, A.J., FALAGAS, M.E., STROM, J.A., and DINARELLO, C.A. (1994). Plasma levels of IL-1β, TNFα and their specific inhibitors in undialyzed chronic renal failure, CAPD and hemodialysis patients. Kidney Int. 45, 890-896.