Nitric oxide donors suppress erythropoietin production in vitro

Pflugers Archiv European Journal of Physiology

Volumn 432, Issue 6, 1996, Pages 980-985

  Schobersberger, Wolfgang ^a   Hoffmann, Georg ^b   Fandrey, Joachim ^b  

^a Universitatsklinik fur Anaesthesie und Allgemeine Intensivmedizin   (Austria)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Anaemia; Erythropoietin; HepG2; Nitric oxide; NO donor; Reactive oxygen species

Indexed keywords

8 BROMO CYCLIC GMP; BUTHIONINE SULFOXIMINE; ERYTHROPOIETIN; HYDROGEN PEROXIDE; LINSIDOMINE; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; PYROGALLOL;

ANEMIA; ANIMAL CELL; ARTICLE; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; INFLAMMATORY DISEASE; LIVER CELL CARCINOMA; NONHUMAN; PRIORITY JOURNAL;

CARCINOMA, HEPATOCELLULAR; CYCLIC GMP; CYTOKINES; ERYTHROPOIETIN; HUMANS; HYDROGEN PEROXIDE; LIVER NEOPLASMS; MOLSIDOMINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE; PENICILLAMINE; REACTIVE OXYGEN SPECIES; S-NITROSO-N-ACETYLPENICILLAMINE; TUMOR CELLS, CULTURED;

EID: 0029836805     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050225     Document Type: Article

References (36)

1. Asahi M, Fujii J, Suzuki K, Seo HG, Kuzuya T, Hori M, Tada M, Fujii S, Taniguchi N (1995) Inactivation of glutathione peroxidase by nitric oxide. J Biol Chem 270:21035-21039
2. Barosi G (1994) Inadequate erythropoietin response to anemia: definition and clinical relevance. Ann Hematol 68:215-223
3. Brezis M, Heyman SN, Dinour D, Epstein FH, Rosen S (1991) Role of nitric oxide in renal medullary oxygenation: studies in the isolated and intact rat kidney. J Clin Invest 88:390-395
4. Brown G (1995) Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase. FEBS Lett 369:136-139
5. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
6. Denz H, Huber P, Landmann R, Orth B, Wachter H, Fuchs D (1992) Association between the activation of macrophages, changes of iron metabolism and the degree of anaemia in patients with malignant disorders. Eur J Haematol 48:244-248
7. Fandrey J, Bunn HF (1993) In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction. Blood 81:617-623
8. Fandrey J, Frede S, Jelkmann W (1994) Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem J 303:507-510
9. Faquin WC, Schneider TJ, Goldberg MA (1992) Effect of inflammatory cytokines on hypoxia-induced erythropoietin production. Blood 79:1987-1994
10. Feelisch M, Noack EA (1987) Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase. Eur J Pharmacol 139:19-30
11. Fuchs D, Hausen A, Reibnegger G, Werner ER, Werner-Felmayer G, Dierich P, Wachter H (1991) Immune activation and the anaemia associated with chronic inflammatory disorders. Eur J Haematol 46:65-70
12. Fuchs D, Weiss G, Wachter H (1993) Neopterin, biochemistry and clinical use as a marker for cellular immune reactions. Int Arch Allergy Immunol 101:1-6
13. Gergel D, Misik V, Ondrias K, Cederbaum AI (1995) Increased cytotoxicity of 3-morpholinosydnonimine to HepG2 cells in the presence of Superoxide dismutase. J Biol Chem 270:20922-20929
14. Goldberg MA, Dunning SP, Bunn HF (1988) Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 242:412-415
15. 15N] nitrate in biological fluids. Anal Biochem 126:131-138
16. Jelkmann W (1992) Erythropoietin: structure, control of production and function. Physiol Rev 72:449-489
17. Jelkmann W, Pagel H, Wolff M, Fandrey J (1991) Monokines inhibit erythropoietin production in human hepatoma cultures and in isolated perfused rat kidneys. Life Sci 50:301-308
18. Kinnula VL, Whorton AR, Chang L-Y, Crapo JD (1992) Regulation of hydrogen peroxide generation in cultured endothelial cells. Am J Respir Cell Mol Biol 6:175-182
19. Lee GR (1983) The anemia of chronic disease. Semin Hematol 20:61-80
20. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
21. Maciejewski JP, Selleri C, Sato T, Cho HJ, Keefer LK, Nathan CF, Young NS (1995) Nitric oxide suppression of human hematopoiesis in vitro. J Clin Invest 96:1085-1092
22. Means RT, Krantz SB (1992) Progress in understanding the pathogenesis of the anemia of chronic disease. Blood 80:1639-1647
23. Morris SM, Billiar TR (1994) New insights into the regulation of inducible nitric oxide synthase. Am J Physiol 266:E829-E839
24. Murr C, Fuchs D, Gössler W, Hausen A, Reibnegger G, Werner ER, Werner-Felmeyer G, Esterbauer H, Wachter H (1994) Enhancement of hydrogen peroxide-induced luminol-dependent chemiluminescence by neopterin depends on the presence of iron chelator complexes. FEBS Lett 338:223-226
25. Ohigashi T, Brookins J, Fisher JW (1993) Interaction of nitric oxide and cyclic 3′,5′-monophosphate in erythropoietin production. J Clin Invest 92:1587-1591
26. Schobersberger W, Jelkmann W, Fandrey J, Frede S, Wachter H, Fuchs D (1995) Neopterin-induced suppression of erythropoietin production in vitro. Pteridines 6:12-16
27. Schobersberger W, Hoffmann G, Grote J, Wachter H, Fuchs D (1995) Induction of inducible nitric oxide synthase expression by neopterin in vascular smooth muscle cells. FEBS Lett 377:461-464
28. Schooley JC, Kullgren B, Allison AC (1987) Inhibition by interleukin-1 of the action of erythropoietin on erythroid precursors and its possible role in the pathogenesis of hypoplastic anaemias. Br J Haematol 67:11-17
29. Tan CC, PJ Ratcliffe (1991) Effect of inhibitors of oxidative phosphorylation on erythropoietin mRNA in isolated perfused rat kidneys. Am J Physiol 261:F982-F987
30. Van der Vliet A, O'Neill CA, Halliwell B, Cross CE, Kaur H (1994) Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite. Evidence for hydroxyl radical production from peroxynitrite. FEBS Lett 339:89-92
31. Wachter H, Artner-Dworzak E, Fuchs D, Fuith LC, Hausen A, Reibnegger G, Werner ER, Werner-Felmayer G, Dierich MP (1990) Association between neopterin and iron metabolism in cancer patients. Tumordiagn Ther 11:229-232
32. Weiss G, Fuchs D, Hausen A, Reibnegger G, Werner ER, Werner-Felmeyer G, Semenitz E, Dierich MP, Wachter H (1993) Neopterin modulates toxicity by reactive oxygen and chloride species. FEBS Lett 321:89-92
33. Williams DHL (1983) S-Nitrosation and reactions of S-nitroso-compounds. Chem Soc Rev 14:171-196
34. Wolff M, Jelkmann W (1993) Effects of chemotherapeutic and immunosuppressive drugs on the production of erythropoietin in human hepatoma cultures. Ann Hematol 66:27-31
35. 2 in erythropoietin-producing human hepatoma cell cultures. Am J Physiol 265:C1266-C1270
36. Yoshioka K, Fisher JW (1995) Nitric oxide enhancement of erythropoietin production in the isolated perfused rat kidney. Am J Physiol 69:C917-C922