Orphan G protein-coupled receptors: From DNA to drug targets

Current Opinion in Drug Discovery and Development

Volumn 4, Issue 5, 2001, Pages 535-547

  Shaaban, S ^a   Benton, B ^a  

^a OSI PHARMACEUTICALS INC   (United States)

Author keywords

Bioinformatics; Leukotriene receptors; MCH receptors; Metastin; Neuromedin U; Urotensin II

Indexed keywords

ADENOSINE DIPHOSPHATE; DNA; G PROTEIN COUPLED RECEPTOR; HISTAMINE; LEUKOTRIENE B4; LEUKOTRIENE C4; LEUKOTRIENE D4; LEUKOTRIENE RECEPTOR; LIGAND; LYSOPHOSPHATIDYLCHOLINE; MELANIN CONCENTRATING HORMONE; MONTELUKAST; NEUROMEDIN U; NEUROPEPTIDE FF; POBILUKAST; PRANLUKAST; PROSTAGLANDIN D2; PSYCHOSINE; TYRAMINE; UROTENSIN II; ZAFIRLUKAST; GTP BINDING PROTEINS; GUANINE NUCLEOTIDE BINDING PROTEIN;

CANCER; CARDIOVASCULAR DISEASE; DISEASE MODEL; DRUG TARGETING; HUMAN; INFLAMMATION; OBESITY; PHYSIOLOGY; REVIEW; ANIMAL; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG DESIGN; GENETICS; METABOLISM; PHARMACOLOGY;

ANIMAL; COMPUTATIONAL BIOLOGY; DNA; DRUG DELIVERY SYSTEMS; DRUG DESIGN; GTP-BINDING PROTEINS; HUMAN; LIGANDS; MODELS, MOLECULAR; PHARMACOLOGY;

EID: 0034812699     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (100)

1. Initial sequencing and analysis of the human genome
2. The sequence of the human genome
3. Drug discovery: A historical perspective
4. G-protein-coupled receptors and signaling networks: Emerging paradigms
5. Heptahelical receptor signaling: Beyond the G protein paradigm
6. Evaluation of gene-finding programs on mammalian sequences
7. Hidden Markov models
8. Genetic approaches to the determination of structure-function relationships of G protein-coupled receptors
9. Cutting edge: The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)
10. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)
11. Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors
12. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor
13. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals
14. Ghrelin is a growth-hormone-releasing acylated peptide from stomach
15. Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties
16. Identification of receptors for neuromedin U and its role in feeding
17. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R
18. Cloning, expression, and pharmacological characterization of a novel human histamine receptor
19. Correlation between protein and mRNA abundance in yeast
20. Autoantibodies against neonatal heart M1 muscarinic acetylcholine receptor in children with congenital heart block
21. Agonist-like activity of anti-peptide antibodies directed against an autoimmune epitope on the heart muscarinic acetylcholine receptor
22. Inhibitory activity of antibodies against the human atrial 5-HT4 receptor
23. DNA antisense therapy for asthma in an animal model
24. The renin-angiotensin system and experimental heart failure
25. Obesity and the regulation of energy balance
26. Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice
27. Adenosine, mast cells and asthma
28. Insight into adenosine receptor function using antisense and gene-knockout approaches
29. Molecular cloning and functional characterization of MCH2, a novel human MCH receptor
30. Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor
31. Identification and characterization of a melanin-concentrating hormone receptor
32. ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999
33. Identification of the platelet ADP receptor targeted by antithrombotic drugs
34. Prostaglandin D2 selectively induces chemotaxis in T-helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
35. Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor
36. Identification and characterization of two G protein-coupled receptors for neuropeptide FF
37. Functional characterization of a human receptor for neuropeptide FF and related peptides
38. Identification of a molecular target of psychosine and its role in globoid cell formation
39. Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes
40. Discovery of a novel member of the histamine receptor family
41. Molecular cloning and characterization of a new human histamine receptor, HH4R
42. Cloning and characterization of a novel human histamine receptor
43. Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow
44. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein- coupled receptor
45. AXOR12: A novel human G protein-coupled receptor, activated by the peptide KiSS-1
46. Characterization of the human cysteinyl leukotriene 2 receptor
47. Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: Discovery of a subtype selective agonist
48. The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor
49. Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3
50. Identification of a human gastrointestinal tract and immune system receptor for the peptide neuromedin U
51. Identification and functional characterization of a novel subtype of neuromedin U receptor
52. Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system
53. Identification of a novel neuromedin U receptor subtype expressed in the central nervous system
54. A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization
55. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2
56. Molecular cloning and characterization of another leukotriene B4 receptor
57. Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A
58. Trace amines: Identification of a family of mammalian G protein-coupled receptors
59. Use of constitutive G protein-coupled receptor activity for drug discovery
60. Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast
61. A G protein-coupled receptor for UDP-glucose
62. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
63. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene
64. 3 receptors regulates histamine neurons in brain
65. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer
66. A novel parathyroid hormone (PTH)/PTH-related peptide receptor mutation in Jansen's metaphyseal chondrodysplasia
67. Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty
68. 2-adrenoceptor
69. Constitutive activity of the histamine H, receptor reveals inverse agonism of histamine H, receptor antagonists
70. Paramagnetic proteoliposomes containing a pure, native, and oriented seven-transmembrane segment protein, CCR5
71. Phage display selection on whole cells yields a peptide specific for melanocortin receptor 1
72. Constrained peptide libraries as a tool for finding mimotopes
73. The structural basis for 14-3-3: Phosphopeptide binding specificity
74. Crystal structure of rhodopsin: A G protein-coupled receptor
75. Structural mimicry in G protein-coupled receptors: Implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors
76. Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14
77. Differential vasoconstrictor activity of human urotensin-II in vascular tissue isolated from the rat, mouse, dog, pig, marmoset and cynomolgus monkey
78. Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries
79. Thrombotic thrombocytopenic purpura associated with clopidogrel
80. Mice lacking melanin-concentrating hormone are hypophagic and lean
81. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance
82. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis
83. A second cysteinyl leukotriene receptor in human lung
84. Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells
85. Neuropeptide FF reduces food intake in rats
86. Centrally administered neuropeptide FF inhibits arginine vasopressin release in conscious rats
87. Antinociceptive effects of intrathecally administered F8Famide and FMRFamide in the rat
88. Effects of neuropeptide FF analogs on morphine analgesia in the nucleus raphe dorsalis
89. Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: A co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding
90. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility
91. Oligomerization of G-protein-coupled transmitter receptors
92. G-protein-coupled receptor heterodimerization modulates receptor function
93. Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer. The human δ-opioid receptor displays constitutive oligomerization at the cell surface, which is not regulated by receptor occupancy
94. The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx
95. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
96. Heterodimerization is required for the formation of a functional GABA(B) receptor
97. GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2
98. Protein-protein interaction maps: A lead towards cellular functions
99. Proteomics on full-length membrane proteins using mass spectrometry
100. 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness