Type-specific regulation of adenylyl cyclase: Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms

Journal of Biological Chemistry

Volumn 276, Issue 51, 2001, Pages 47785-47793

  Onda, Takeshi ^a,b   Hashimoto, Yoko ^b   Nagai, Masashi ^a   Kuramochi, Hiroshi ^a   Saito, Seiichi ^a   Yamazaki, Hiroko ^a   Toya, Yoshiyuki ^b   Sakai, Ikuko ^b   Homcy, Charles J ^c   Nishikawa, Kiyohiro ^a   Ishikawa, Yoshihiro ^b,d  

^a NIPPON KAYAKU CO LTD   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

^d RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MODIFICATION; CRYSTALLOGRAPHY; DERIVATIVES; ENZYME INHIBITION; SYNTHESIS (CHEMICAL);

PHARMACOPHORE ANALYSIS;

ENZYMES;

2 AMINO 7 (2 FURANYL) 7,8 DIHYDRO 5(6H) QUINAZOLINE; 6 (3 DIMETHYLAMINOPROPIONYL)FORSKOLIN; 9 (CYCLOPENTYL)ADENINE; 9 (TETRAHYDRO 2 FURYL)ADENINE; ADENOSINE 3' PHOSPHATE; ADENYLATE CYCLASE; ADENYLATE CYCLASE INHIBITOR; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; DEOXYADENOSINE PHOSPHATE; ENZYME INHIBITOR; FORSKOLIN; FORSKOLIN DERIVATIVE; N (2 PHENYLCYCLOPENTYL)AZACYCLOTRIDECAN 2 IMINE; NKY 80; UNCLASSIFIED DRUG; CYCLIC AMP; ENZYME ACTIVATOR; ISOENZYME; LIGAND;

ANIMAL TISSUE; ARTICLE; COMPUTER AIDED DESIGN; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG SCREENING; DRUG SELECTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME REGULATION; MALE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RAT; ANIMAL; ENZYME ACTIVATION; METABOLISM; RAT STRAIN;

ANIMALIA;

ADENYLATE CYCLASE; ANIMAL; CYCLIC AMP; ENZYME ACTIVATION; ENZYME ACTIVATORS; ENZYME INHIBITORS; FORSKOLIN; ISOENZYMES; LIGANDS; MALE; RATS; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0035930583     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M107233200     Document Type: Article

References (42)

1. Ishikawa, Y., and Homcy, C. J. (1997) Circ. Res. 80, 297-304
2. Tang, W. J., and Hurley, J. H. (1998) Mol. Pharmacol. 54, 231-240
3. Hurley, J. H. (1999) J. Biol. Chem. 274, 7599-7602
4. Ishikawa, Y., Sorota, S., Kiuchi, K., Shannon, R. P., Komamura, K., Katsushika, S., Vatner, D. E., Vatner, S. F., and Homcy, C. J. (1994) J. Clin. Invest. 93, 2224-2229
5. Feinstein, P. G., Schrader, K. A., Bakalyar, H. A., Tang, W. J., Krupinski, J., Gilman, A. G., and Reed, R. R. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 10173-10177
6. Cali, J. J., Zwaagstra, J. C., Mons, N., Cooper, D. M., and Krupinski, J. (1994) J. Biol. Chem. 269, 12190-12195
7. Bakalyar, H. A., and Reed, R. R. (1990) Science 250, 1403-1406
8. Defer, N., Marinx, O., Poyard, M., Lienard, M. O., Jegou, B., and Hanoune, J. (1998) FEBS Lett. 424, 216-220
9. Ishikawa, Y., Grant, B. S., Okumura, S., Schwencke, C., and Yamamoto, M. (2000) Mol. Cell. Endocrinol. 162, 107-112
10. Xia, Z., Choi, E. J., Wang, F., and Storm, D. R. (1992) Neurosci. Lett. 144, 169-173
11. Chaudhry, A., and Granneman, J. G. (1997) Am. J. Physiol. 273, R762-R767
12. Gao, B. N., and Gilman, A. G. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 10178-10182
13. Watson, P. A., Krupinski, J., Kempinski, A. M., and Frankenfield, C. D. (1994) J. Biol. Chem. 269, 28893-28898
14. Seamon, K. B., Padgett, W., and Daly, J. W. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 3363-3367
15. Zhang, G., Liu, Y., Ruoho, A. E., and Hurley, J. H. (1997) Nature 386, 247-253
16. Bristow, M. R., Ginsburg, R., Strosberg, A., Montgomery, W., and Minobe, W. (1984) J. Clin. Invest. 74, 212-223
17. Feldman, M. D., Copelas, L., Gwathmey, J. K., Phillips, P., Warren, S. E., Schoen, F. J., Grossman, W., and Morgan, J. P. (1987) Circulation 75, 331-339
18. Shafiq, J., Suzuki, S., Itoh, T., and Kuriyama, H. (1992) Circ. Res. 71, 70-81
19. Sanbe, A., and Takeo, S. (1995) J. Pharmacol. Exp. Ther. 274, 120-126
20. Toya, Y., Schwencke, C., and Ishikawa, Y. (1998) J. Mol. Cell. Cardiol. 30, 97-108
21. Tesmer, J. J., Sunahara, R. K., Gilman, A. G., and Sprang, S. R. (1997) Science 278, 1907-1916
22. Londos, C., and Wolff, J. (1977) Proc. Natl. Acad. Sci. U. S. A. 74, 5482-5486
23. Tesmer, J. J., Dessauer, C. W., Sunahara, R. K., Murray, L. D., Johnson, R. A., Gilman, A. G., and Sprang, S. R. (2000) Biochemistry 39, 14464-14471
24. Johnson, R. A., and Shoshani, I. (1990) J. Biol. Chem. 265, 11595-11600
25. Florio, V. A., and Ross, E. M. (1983) Mol. Pharmacol. 24, 195-202
26. Dessauer, C. W., and Gilman, A. G. (1997) J. Biol. Chem. 272, 27787-27795
27. Johnson, R. A., Desaubry, L., Bianchi, G., Shoshani, I., Lyons, E. J., Taussig, R., Watson, P. A., Cali, J. J., Krupinski, J., Pieroni, J. P., and Iyengar, R. (1997) J. Biol. Chem. 272, 8962-8966
28. Shoshani, I., Laux, W. H., Perigaud, C., Gosselin, G., and Johnson, R. A. (1999) J. Biol. Chem. 274, 34742-34744
29. Kawabe, J., Ebina, T., Ismail, S., Kitchen, D. B., Homcy, C. J., and Ishikawa, Y. (1994) J. Biol. Chem. 269, 24906-24911
30. Alvarez, R., and Daniels, D. V. (1992) Anal. Biochem. 203, 76-82
31. Salomon, Y. (1979) Adv. Cyclic Nucleotide Res. 10, 35-55
32. Seamon, K. B., Daly, J. W., Metzger, H., De Souza, N. J., and Reden, J. (1983) J. Med. Chem. 26, 436-439
33. Robbins, J. D., Boring, D. L., Tang, W. J., Shank, R., and Seamon, K. B. (1996) J. Med. Chem. 39, 2745-2752
34. Ho, R. J., and Shi, Q. H. (1984) J. Biol. Chem. 259, 7630-7636
35. Sutkowski, E. M., Robbins, J. D., Tang, W. J., and Seamon, K. B. (1996) Mol. Pharmacol. 50, 299-305
36. Hosono, M., Takahira, T., Fujita, A., Fujihara, R., Ishizuka, O., Tatee, T., and Nakamura, K. (1992) J. Cardiovasc. Pharmacol. 19, 625-634
37. Lippe, C., and Ardizzone, C. (1991) Comp. Biochem. Physiol. 99, 209-211
38. Hoshi, T., Garber, S. S., and Aldrich, R. W. (1988) Science 240, 1652-1655
39. Asai, T., Pelzer, S., and Mcdonald, T. F. (1996) Mol. Pharmacol. 50, 1262-1272
40. Robbins, J. D., Appel, N. M., Laurenza, A., Simpson, I. A., De Souza, E. B., and Seamon, K. B. (1992) Brain Res. 581, 148-152
41. Haslam, R. J., Davidson, M. M., and Desjardins, J. V. (1978) Biochem. J. 176, 83-95
42. Stubner, D., and Johnson, R. A. (1989) FEBS Lett. 248, 155-161