-
5
-
-
14444281569
-
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/ JNK and p38 signaling pathways
-
(1997)
Science (Washington DC)
, vol.275
, pp. 90-94
-
-
Ichijo, H.1
Nishida, E.2
Irie, K.3
Ten Dijke, P.4
Saitoh, M.5
Moriguchi, T.6
Takagi, M.7
Matsumoto, K.8
Miyazono, K.9
Gotoh, Y.10
-
22
-
-
0027312272
-
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
-
(1993)
Nature (Lond.)
, vol.363
, pp. 85-88
-
-
Li, N.1
Batzer, A.2
Daly, R.3
Yajnik, V.4
Skolnik, E.5
Chardin, P.6
Bar-Sagi, D.7
Margolis, B.8
Schlessinger, J.9
-
23
-
-
0347537940
-
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
-
(1996)
Nature (Lond.)
, vol.380
, pp. 75-79
-
-
Verheij, M.1
Bose, R.2
Lin, X.H.3
Yao, B.4
Jarvis, W.D.5
Grant, S.6
Birrer, M.J.7
Szabo, E.8
Zon, L.I.9
Kyriakis, J.M.10
Haimovitz-Friedman, A.11
Fuks, Z.12
Kolesnick, R.N.13
-
24
-
-
0008290616
-
Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
-
(1999)
Oncogene
, vol.18
, pp. 6158-6162
-
-
Leppa, S.1
Bohmann, D.2
-
29
-
-
0030905826
-
A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin
-
(1997)
Clin. Cancer Res.
, vol.3
, pp. 537-543
-
-
Schwartz, G.K.1
Ward, D.2
Saltz, L.3
Casper, E.S.4
Spiess, T.5
Mullen, E.6
Woodworth, J.7
Venuti, R.8
Zervos, P.9
Storniolo, A.M.10
Kelsen, D.P.11
-
31
-
-
0031469395
-
Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-β-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2
-
(1997)
Mol. Pharmacol.
, vol.52
, pp. 1000-1009
-
-
Wang, S.1
Vrana, J.A.2
Bartimole, T.M.3
Freemerman, A.J.4
Jarvis, W.D.5
Kramer, L.B.6
Krystal, G.7
Dent, P.8
Grant, S.9
-
32
-
-
0031954529
-
Phase Ib trial of bryostatin 1 in patients with refractory malignancies
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 611-618
-
-
Grant, S.1
Roberts, J.2
Poplin, E.3
Tombes, M.B.4
Kyle, B.5
Welch, D.6
Carr, M.7
Bear, H.D.8
-
34
-
-
0031785213
-
Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-β-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling
-
(1998)
Mol. Pharmacol.
, vol.54
, pp. 844-856
-
-
Jarvis, W.D.1
Fornari F.A., Jr.2
Tombes, R.M.3
Erukulla, R.K.4
Bittman, R.5
Schwartz, G.K.6
Dent, P.7
Grant, S.8
-
35
-
-
0034103022
-
12-O-Tetradecanoyl phorbol 13-acetate, protein kinase C (PKC) activator, protects human leukemia HL-60 cells from Taxol-induced apoptosis: Possible role for extracellular signal-regulated kinase
-
(2000)
Immunopharmacol. Immunotoxicol.
, vol.22
, pp. 61-73
-
-
Pae, H.O.1
Yoo, J.C.2
Choi, B.M.3
Lee, E.J.4
Song, Y.S.5
Chung, H.T.6
-
37
-
-
14444279192
-
Identification of a novel inhibitor of mitogen-activated protein kinase kinase
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 18623-18632
-
-
Favata, M.F.1
Horiuchi, K.Y.2
Manos, E.J.3
Daulerio, A.J.4
Stradley, D.A.5
Feeser, W.S.6
Van Dyk, D.E.7
Pitts, W.J.8
Earl, R.A.9
Hobbs, F.10
Copeland, R.A.11
Magolda, R.L.12
Scherle, P.A.13
Tizaskos, J.M.14
-
39
-
-
0032984348
-
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
-
(1999)
Nat. Med.
, vol.5
, pp. 810-816
-
-
Sebolt-Leopold, J.S.1
Dudley, D.T.2
Herrera, R.3
Van Becelaere, K.4
Wiland, A.5
Gowan, R.C.6
Tecle, H.7
Barrett, S.D.8
Bridges, A.9
Przybranowski, S.10
Leopold, W.R.11
Saltiel, A.R.12
-
41
-
-
0031036872
-
Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
-
(1997)
Science (Washington DC)
, vol.275
, pp. 1129-1132
-
-
Yang, J.1
Liu, X.2
Bhalla, K.3
Kim, C.N.4
Ibrado, A.M.5
Cai, J.6
Peng, T.I.7
Jones, D.P.8
Wang, X.9
-
45
-
-
0034607702
-
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
-
(2000)
Science (Washington DC)
, vol.288
, pp. 870-874
-
-
Tournier, C.1
Hess, P.2
Yang, D.D.3
Xu, J.4
Turner, T.K.5
Nimnual, A.6
Bar-Sagi, D.7
Jones, S.N.8
Flavell, R.A.9
Davis, R.J.10
-
46
-
-
15644381250
-
Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Racl
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 25238-25242
-
-
Maundrell, K.1
Antonsson, B.2
Magnenat, E.3
Camps, M.4
Muda, M.5
Chabert, C.6
Gillieron, C.7
Boschert, U.8
Vial-Knecht, E.9
Martinou, J.C.10
Arkinstall, S.11
-
48
-
-
0027987170
-
Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53
-
(1994)
Oncogene
, vol.9
, pp. 3397-3406
-
-
Jiang, H.1
Lin, J.2
Su, Z.Z.3
Collart, F.R.4
Huberman, E.5
Fisher, P.B.6
-
55
-
-
0033605575
-
Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-κB through IκB kinase-α and IκB kinase-β
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8355-8358
-
-
Zhao, Q.1
Lee, F.S.2
-
65
-
-
0032795940
-
The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 6003-6011
-
-
Talarmin, H.1
Rescan, C.2
Cariou, S.3
Glaise, D.4
Zanninelli, G.5
Bilodeau, M.6
Loyer, P.7
Guguen-Guillouzo, C.8
Baffet, G.9
-
74
-
-
0033556356
-
A role for MAPK/ERK in sympathetic neuron survival: Protection against a p53-dependent, JNK-independent induction of apoptosis by 1-β-D-arabinofuranosylcytosine
-
(1999)
J. Neurosci.
, vol.19
, pp. 664-673
-
-
Anderson, C.N.G.1
Tolkovsky, A.M.2
-
80
-
-
0033583321
-
Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8208-8216
-
-
Wang, T.H.1
Popp, D.M.2
Wang, H.S.3
Saitoh, M.4
Mural, J.G.5
Henley, D.C.6
Ichijo, H.7
Wimalasena, J.8
-
83
-
-
0001554639
-
Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells
-
(1999)
Oncogene
, vol.18
, pp. 377-384
-
-
Shtil, A.A.1
Mandlekar, S.2
Yu, R.3
Walter, R.J.4
Hagen, K.5
Tan, T.H.6
Roninson, I.B.7
Kong, A.N.8
-
92
-
-
0033615657
-
Inhibition of extracellular signal-regulated protein kinase or c-Jun N-terminal protein kinase cascade, differentially activated by cisplatin, sensitizes human ovarian cancer cell line
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 31648-31654
-
-
Hayakawa, J.1
Ohmichi, M.2
Kurachi, H.3
Ikegami, H.4
Kimura, A.5
Matsuoka, T.6
Jikihara, H.7
Mercola, D.8
Murata, Y.9
-
94
-
-
0032737882
-
MAPK superfamily plays an important role in daunomycin-induced apoptosis of cardiac myocytes
-
(1999)
Circulation
, vol.100
, pp. 2100-2107
-
-
Zhu, W.1
Zou, Y.2
Aikawa, R.3
Harada, K.4
Kudoh, S.5
Uozumi, H.6
Hayashi, D.7
Gu, Y.8
Yamazaki, T.9
Nagai, R.10
Yazaki, Y.11
Komuro, I.12
-
95
-
-
0034627879
-
Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells
-
(2000)
Exp. Cell Res.
, vol.254
, pp. 110-119
-
-
Stone, A.A.1
Chambers, T.C.2
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