Allosteric modulation of β2-adrenergic receptor by Zn2+

Molecular Pharmacology

Volumn 61, Issue 1, 2002, Pages 65-72

  Swaminath, Gayathri ^a   Steenhuis, Jacqueline ^a   Kobilka, Brian ^a,b   Lee, Tae Weon ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; ION CHANNEL; ISOPRENALINE; ZINC; ADRENERGIC BETA AGONISTS; ADRENERGIC BETA ANTAGONISTS; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; COBALT; NICKEL; RECEPTORS, ADRENERGIC, BETA 2;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; LIGAND BINDING; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; SYNAPSE; SYNAPSE VESICLE; ANIMAL; CELL CULTURE; DRUG EFFECT; DRUG INTERACTION; GENETIC TRANSFECTION; GENETICS; HUMAN; INSECT; METABOLISM;

ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ALLOSTERIC REGULATION; ANIMAL; CELLS, CULTURED; COBALT; CYCLIC AMP; DRUG INTERACTIONS; HUMAN; INSECTS; ISOPROTERENOL; NICKEL; RECEPTORS, ADRENERGIC, BETA-2; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; ZINC;

EID: 0036006695     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.1.65     Document Type: Article

References (31)

1. Zinc inhibits miniature GABAergic currents by allosteric modulation of GABAA receptor gating
2. 1 adenosine receptor coupling to G proteins
3. Interaction of Zn2+ with phospholipid membranes
4. Signal transduction by G proteins: 1994 Edition
5. Differential sensitivity of recombinant N-methyl-D-aspartate receptor subtypes to zinc inhibition
6. 2+ sensing receptor
7. 2+-sensing receptor
8. Modulation of glycine-induced currents by zinc and other metal cations in neurons acutely dissociated from the dorsal motor nucleus of the vagus of the rat
9. 2-adrenergic receptor
10. An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium
11. Metal ions and synaptic transmission: Think zinc
12. 2+ enhancement of the recombinant 5-HT(3) receptor is modulated by divalent cations
13. Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors
14. Amino and carboxyl terminal modifications to facilitate the production and purification of a G protein-coupled receptor
15. Restricting the mobility of Gs alpha: Impact on receptor and effector coupling
16. Selective inactivation of guanine-nucleotide-binding regulatory protein (G-protein) α and βγ subunits by urea
17. + modulate receptor-adenyl cyclase coupling and receptor-mediated function
18. A network of conserved intramolecular contacts defines the off-state of the transmembrane switch mechanism in a seven-transmembrane receptor
19. 2-adrenergic receptor system of human platelets. Role for intraplatelet sodium in receptor binding
20. Adenosine A1 receptor-dependent and -independent effects of the allosteric enhancer PD 81,723
21. Regulation of dopamine D2 receptors by sodium and pH
22. Delineation of an endogenous zinc-binding site in the human dopamine transporter
23. Zinc modulates antagonist interactions with D2-like dopamine receptors through distinct molecular mechanisms
24. Zinc allosterically modulates antagonist binding to cloned D1 and D2 dopamine receptors
25. The binding-site crevice of the D(4) dopamine receptor is coupled to three distinct sites of allosteric modulation
26. Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation
27. Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F
28. Two-metal-ion catalysis in adenylyl cyclase
29. Construction of a high affinity zinc switch in the kappa-opioid receptor
30. Allosteric modulation of muscarinic acetylcholine receptors
31. 2+ a novel ionic mediator of neural injury in brain disease