Orexin receptors and G-protein coupling: Evidence for another "promiscuous" seven transmembrane domain receptor

Journal of Pharmacological Sciences

Volumn 93, Issue 1, 2003, Pages 126-128

  Karteris, Emmanouil ^a   Randeva, Harpal S ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

G protein; Orexin; Signaling

Indexed keywords

CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; OREXIN; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; OREXIN A; OREXIN B; OREXIN RECEPTOR; PERTUSSIS TOXIN; PHOSPHOLIPASE C INHIBITOR; PROTEIN SUBUNIT; RECEPTOR; SEVEN TRANSMEMBRANE DOMAIN RECEPTOR; UNCLASSIFIED DRUG;

CELL STIMULATION; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG RESPONSE; DRUG SPECIFICITY; HUMAN; LETTER; NONHUMAN; NUCLEIC ACID SYNTHESIS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR DENSITY; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; GTP-BINDING PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEUROPEPTIDES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE;

EID: 0141920775     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.93.126     Document Type: Letter

References (11)

1. Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92:573-585.
2. Zhu Y, Miwa Y, Yamanaka A, et al. Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. J Pharmacol Sci. 2003;92:259-266.
3. Karteris E, Randeva HS, Grammatopoulos DK, Jaffe RB, Hillhouse EW. Expression and coupling characteristics of the corticotropin-releasing hormone (CRH) and orexin type-2 (OX2R) receptors in human fetal adrenals. J Clin Endocrinol Metab. 2001;86:4512-4519.
4. Malendowicz LK, Tortorella C, Nussdorfer GG. Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade. J Steroid Biochem Mol Biol. 1999;70:185-188.
5. Mazzocchi G, Malendowicz LK, Gottardo L, Aragona F, Nussdorfer GG. Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade. J Clin Endocrinol Metab. 2001;86:778-782.
6. Randeva HS, Karteris E, Grammatopoulos D, Hillhouse EW. Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: Implications for adrenal function and energy homeostasis. J Clin Endocrinol Metab. 2001;86:4808-4813.
7. Lucaites VL, Nelson DL, Wainscott DB, Baez M. Receptor subtype and density determine the coupling repertoire of the 5-HT2 receptor subfamily. Life Sci. 1996;59:1081-1095.
8. Nanmoku T, Isobe K, Sakurai T, et al. Orexins suppress catecholamine synthesis and secretion in cultured PC12 cells. Biochem Biophys Res Commun. 2000;274:310-315.
9. Karteris E, Chen J, Hillhouse EW, Randeva HS. Differential expression and signaling characteristics of orexin receptors in fed and food deprived rats at the hypothalamic level. 85th Annual Endocrine Meeting; 2003. Poster P1-452.
10. Hilairet S, Bouaboula M, Carriere D, Le Fur G, Casellas P. Hypersensitization of the Orexin 1 receptor by the CB1 receptor: Evidence for cross-talk blocked by the specific CB1 antagonist, SR141716. J Biol Chem. 2003;78:23731-23737.
11. Dalrymple MB, Kroeger KM, Seeber RM, Edine KA. Use of BRET analysis to determine arrestin interactions, homo- and hetero-dimerisation between G protein-coupled receptors orexin type I and II. 85th Annual Endocrine Meeting; 2003. Poster P1-66.