Role of the alpha2B-Adrenergic Receptor in the Development of Salt-Induced Hypertension

Hypertension

Volumn 33, Issue 1, 1999, Pages 14-17

  Makaritsis, Konstantinos P ^a   Handy, Diane E ^a   Johns, Conrado ^a   Kobilka, Brian ^a   Gavras, Irene ^a   Gavras, Haralambos ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CREATININE; RECEPTOR SUBTYPE;

AGING; ANIMAL; ARTICLE; BLOOD; BLOOD PRESSURE MEASUREMENT; BODY WEIGHT; COMPARATIVE STUDY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HYPERTENSION; MALE; MOLECULAR GENETICS; MONITORING; MOUSE; NEPHRECTOMY; NUCLEOTIDE SEQUENCE; ORGAN SIZE; PATHOPHYSIOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SALT INTAKE; STATISTICAL ANALYSIS; TIME; ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD PRESSURE REGULATION; ESSENTIAL HYPERTENSION; KNOCKOUT MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; SALT LOADING; SYMPATHETIC INNERVATION; SYMPATHETIC TONE;

AGING; ANIMALS; BASE SEQUENCE; BLOOD PRESSURE DETERMINATION; BODY WEIGHT; CREATININE; DATA INTERPRETATION, STATISTICAL; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HYPERTENSION; MALE; MICE; MOLECULAR SEQUENCE DATA; MONITORING, PHYSIOLOGIC; NEPHRECTOMY; ORGAN SIZE; POLYMERASE CHAIN REACTION; RECEPTORS, ADRENERGIC, ALPHA-2; SODIUM CHLORIDE, DIETARY; TIME FACTORS;

EID: 0032587021     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/01.HYP.33.1.14     Document Type: Article

References (27)

1. Weinberger MH, Miller JZ, Luft FC, Grim CE, Fineberg NS. Definitions and characteristics of sodium sensitivity and blood pressure resistance. Hypertension. 1986;8(suppl II):II-127-II-134.
2. Oparil S, Meng QC, Chen YF, Yang RH, Jin H, Wyss JM. Genetic basis of NaCl-sensitive hypertension. J Cardiovasc Pharmacol. 1988;12(suppl 3):S56-S69.
3. Gavras H, Gavras I. Salt-induced hypertension: the interactive role of vasopressin and of the sympathetic nervous system. J Hypertens. 1989;7:601-606.
4. Bresnahan MR, Gavras I, Hatinoglou S, Muller RE, Gavras H. Central alpha-adrenoceptors during the development of hypertension in rats in high and low salt intake. J Hypertens. 1986;4:719-726.
5. 2-adrenergic) receptors in spontaneously hypertensive rats. Hypertension. 1988;11:326-333.
6. 2-adrenoceptors in SHR. Brain Res. 1988;451:77-84.
7. Gavras H. How does salt raise blood pressure? A hypothesis. Hypertension. 1986;8:83-88.
8. Tsai BS, Lefkowitz J. Agonist-specific effects of monovalent and divalent cations on adenylate cyclase-coupled alpha adrenergic receptors in rabbit platelets. Mol Pharmacol. 1978;14:540.
9. Kohlmann O Jr, Gavras I, Biollaz J, Biollaz B, Gavras H. Sodium chloride-induced partial inhibition in vivo of alpha2-adrenoceptor agonist function. J Hypertens. 1985;3:269-274.
10. Link RE, Stevens MS, Kulatunga M, Scheinin M, Barsh GS, Kobilka BK. Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homology. Mol Pharmacol. 1995;48:48-55.
11. 2-adrenergic receptor subtypes b and c. Science. 1996;273:803-805.
12. Johns C, Gavras I, Handy DE, Salomao A, Gavras H. Models of experimental hypertension in mice. Hypertension. 1996;28:1064-1069.
13. Koletsky S, Goodsitt AM. Natural history and pathogenesis of renal ablation hypertension. Arch Pathol. 1960;69:654-662.
14. Dipette D, Waeber B, Volicer L, Chao P, Gavras I, Gavras H, Brunner HR. Salt-induced hypertension in chronic renal failure: evidence for a neurogenic mechanism. Life Sci. 1983;32:733-740.
15. Oparil S, Chen YF, Meng QC, Yang RH, Jin H, Wyss JM. The neural basis of salt sensitivity in the rat: altered hypothalamic function. Am J Med Sci. 1988;295:360-369.
16. 2a-adrenergic receptor subtype. Science. 1996;273:801-803.
17. 2B-adrenergic receptor subtypes in brain. Hypertension. 1996;27:449-455.
18. MacDonald E, Kobilka BK, Scheinin M. Gene targeting-homing in on alpha 2-adrenoceptor-subtype function. Trends Pharmacol Sci. 1997;18:211-219.
19. Gavras H, Handy D, Gavras I. Alpha-adrenergic receptors in hypertension. In: Laragh JH, Brenner BM, eds. Hypertension Pathophysiology, Diagnosis, and Management. 2nd ed. New York: Raven Press; 1995:853-861.
20. 2-adrenergic receptors and hypertension. Hypertension. 1987;9:3-6.
21. Bylund DB, Ray-Prenger C, Murphy TJ. Alpha-2A and alpha-2B adrenergic receptor subtypes: antagonist binding in tissues and cell lines containing only one subtype. J Pharmacol Exp Ther. 1988;245:600-607.
22. Pettinger WA, Gandler T, Sanchez A, Saavedra JM. Dietary sodium and renal alpha 2-adrenergic receptors in Dahl hypertensive rat. Clin Exp Hypertens A. 1982;4:819-828.
23. 2-adrenergic receptors in salt-related and genetic hypertension. Pharmacology. 1987;34:131-142.
24. 2-adrenoceptors in renal cortex and medulla of NaCl-sensitive spontaneously hypertensive rats. Eur J Pharmacol. 1989;167:355-365.
25. Lockette W, Ghosh S, Farrow S, MacKenzie S, Baker S, Miles P, Schork A, Cadaret L. Alpha 2-adrenergic receptor gene polymorphism and hypertension in blacks. Am J Hypertens. 1995;8:390-394.
26. 2C10-adrenergic receptor genotype. Hypertension. 1996;27:1210-1215.
27. Bursztyn M, Bresnahan M, Gavras I, Gavras H. Pressor hormones in elderly hypertensive persons. Racial differences. Hypertension. 1990;5(suppl I):I-88-I-92.