The essential role of RIα in the maintenance of regulated PKA activity

Annals of the New York Academy of Sciences

Volumn 968, Issue , 2002, Pages 75-95

  Amieux, Paul S ^a   McKnight, G Stanley ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiac morphogenesis; Gastrulation; Mesoderm formation; PKA holoenzyme assembly

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; HOLOENZYME;

CARNEY COMPLEX; CONFERENCE PAPER; CYTOSKELETON; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SUBUNIT; GASTRULATION; GENE ACTIVATION; GENE MUTATION; HEART DEVELOPMENT; HUMAN; KNOCKOUT MOUSE; MESODERM; MORPHOGENESIS; NONHUMAN; OOCYTE MATURATION; PHENOTYPE; PROTEIN ASSEMBLY; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION;

EID: 0036293582     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04328.x     Document Type: Conference Paper

References (145)

1. Expression of cDNAs for two isoforms of the catalytic subunit of cAMP-dependent protein kinase
2. Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase
3. Compensatory regulation of RIalpha? Protein levels in protein kinase A mutant mice
4. The S49 Kin- cell line transcribes and translates a functional mRNA coding for the catalytic subunit of cAMP-dependent protein kinase
5. Turnover of regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells. Regulation by catalytic subunit and analogs of cyclic AMP
6. Overexpression of the type II regulatory subunit of the cAMP-dependent protein kinase eliminates the type I holoenzyme in mouse cells
7. Hormonal activation of gene transcription in ras-transformed NIH3T3 cells overexpressing RII alpha and RII beta subunits of the cAMP-dependent protein kinase
8. Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase
9. A mutation in the catalytic subunit of protein kinase A prevents myristylation but does not inhibit biological activity
10. Defective motor behavior and neural gene expression in RIIbeta-protein kinase A mutant mice
11. Comparison of plasticity in vivo and in vitro in the developing visual cortex of normal and protein kinase A RIbeta-deficient mice
12. Holoenzymes of cAMP-dependent protein kinase containing the neural form of type I regulatory subunit have an increased sensitivity to cyclic nucleotides
13. Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A
14. Type II regulatory subunits are not required for the anchoring-dependent modulation of Ca2+ channel activity by cAMP-dependent protein kinase
15. Deletion of type IIalpha regulatory subunit delocalizes protein kinase A in mouse sperm without affecting motility or fertilization
16. The biological functions of A-kinase anchor proteins
17. D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain
18. Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits
19. Alternative 5′-exons of the mouse cAMP-dependent protein kinase subunit RIalpha gene are conserved and expressed in both a ubiquitous and tissue-restricted fashion
20. Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha
21. Type I protein kinase A is localized to interphase microtubules and strongly associated with the mitotic spindle
22. Molecular characterization of an anchor protein (AKAPCE) that binds the RI subunit (RCE) of type I protein kinase A from Caenorhabditis elegans
23. Characterization of structural features that mediate the tethering of Caenorhabditis elegans protein kinase A to a novel A kinase anchor protein. Insights into the anchoring of PKAI isoforms
24. Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3′,5′-cyclic adenosine monophosphate on cell replication in human T lymphocytes
25. Location of cAMP-dependent protein kinase type I with the TCR-CD3 complex
26. PKAI as a potential target for therapeutic intervention
27. Protein kinase A RI beta subunit deficiency in lupus T lymphocytes: Bypassing a block in RI beta translation reconstitutes protein kinase A activity and augments IL-2 production
28. mRNA mutations of type I protein kinase A regulatory subunit alpha in T lymphocytes of a subject with systemic lupus erythematosus
29. Cyclic nucleotide-dependent protein kinases. IV. Widespread occurrence of adenosine 3′,5′-monophosphate-dependent protein kinase in various tissues and phyla of the animal kingdom
30. Phosphorylation-dephosphorylation of enzymes
31. Protein kinases
32. Protein kinases in brown adipose tissue of developing rats. Electrophoretic separation and assay of soluble protein kinases on polyacrylamide gels and a study of their properties and changes during development
33. Progesterone-stimulated meiotic cell division in Xenopus oocytes. Induction by regulatory subunit and inhibition by catalytic subunit of adenosine 3′:5′-monophosphate-dependent protein kinase
34. Letter: Protein phosphorylation during oocyte maturation
35. Early effect of progesterone on levels of cyclic adenosine 3′:5′-monophosphate in Xenopus oocytes
36. Regulation of oocyte maturation
37. Protein kinase A acts at multiple points to inhibit Xenopus oocyte maturation
38. Two distinct mechanisms control the accumulation of cyclin B1 and Mos in Xenopus oocytes in response to progesterone
39. Involvement of cAMP-dependent protein kinase and protein phosphorylation in regulation of mouse oocyte maturation
40. Differential regulation of oocyte maturation and cumulus expansion in the mouse oocyte-cumulus cell complex by site-selective analogs of cyclic adenosine monophosphate
41. Role for cyclin-dependent kinase 2 in mitosis exit
42. Requirement for cAMP-PKA pathway activation by M phase-promoting factor in the transition from mitosis to interphase
43. The effect of the nucleocytoplasmic ratio on protein synthesis and expression of a stage-specific antigen in early cleaving mouse embryos
44. Differential effects of activators of cAMP-dependent protein kinase and protein kinase C on cleavage of one-cell mouse embryos and protein synthesis and phosphorylation in one- and two-cell embryos
45. Activation of a two-cell stage-specific gene following transfer of heterologous nuclei into enucleated mouse embryos
46. Acquisition of a transcriptionally permissive state during the 1-cell stage of mouse embryogenesis
47. Regulation of mouse preimplantation development: Inhibition of synthesis of proteins in the two-cell embryo that require transcription by inhibitors of cAMP-dependent protein kinase
48. Regulation of mouse pre-implantation development: Differential effects of CZB medium and Whitten's medium on rates and patterns of protein synthesis in 2-cell embryos
49. Isolation and characterization of Drosophila cAMP-dependent protein kinase genes
50. Genetic investigation of cAMP-dependent protein kinase function in Drosophila development
51. Protein kinase A and hedgehog signaling in Drosophila limb development
52. Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning
53. Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development
54. cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs
55. Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A
56. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
57. A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
58. Sonic hedgehog mediates the polarizing activity of the ZPA
59. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
60. The hedgehog gene family in Drosophila and vertebrate development
61. Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit
62. Mutations in the catalytic subunit of cAMP-dependent protein kinase result in unregulated biological activity
63. Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning
64. Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo
65. Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite
66. Induction of midbrain dopaminergic neurons by Sonic hedgehog
67. Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway
68. Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway
69. Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
70. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
71. Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities
72. Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
73. Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus
74. Sonic hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
75. Gli proteins encode context-dependent positive and negative functions: Implications for development and disease
76. GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization
77. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
78. Protein kinase A is required for chromosomal DNA replication
79. A role for cAMP-dependent protein kinase in early embryonic divisions
80. FGF signaling in mouse gastrulation and anteroposterior patterning
81. Fibroblast growth factors in mammalian development
82. FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak
83. Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: A role for FGFR1 in morphogenetic movement through the primitive streak
84. Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo
85. Fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation
86. Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways
87. Abnormal mesodermal patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2
88. Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2
89. The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak
90. Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK
91. Mesodermal development in mouse embryos mutant for fibronectin
92. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
93. Regulation of actin microfilament integrity in living nonmuscle cells by the cAMP-dependent protein kinase and the myosin light chain kinase
94. Regulation of cytoskeleton organization and paxillin dephosphorylation by cAMP. Studies on murine Y1 adrenal cells
95. Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility
96. Adrenocorticotrophic hormone stimulates phosphotyrosine phosphatase SHP2 in bovine adrenocortical cells: Phosphorylation and activation by cAMP-dependent protein kinase
97. Cell adhesion regulates the interaction between Nck and p21-activated kinase
98. Cell anchorage permits efficient signal transduction between ras and its downstream kinases
99. Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase
100. Protein-tyrosinephosphatase Shp-2 regulates cell spreading, migration, and focal adhesion
101. Regulation of tyrosine kinase cascades by G-protein-coupled receptors
102. Expression of the G protein-coupled receptor kinase 2 during early mouse embryogenesis
103. Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and Carney complex
104. Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex
105. Clinical and molecular features of the Carney complex: Diagnostic criteria and recommendations for patient evaluation
106. Rap1 signalling: Adhering to new models
107. Regulation of Ras-mediated signalling: More than one way to skin a cat
108. Insulin, growth factors, and cAMP
109. The role of cyclic amp in cell proliferation: A critical assessment of the evidence
110. The role of cAMP in regulating tumour cell growth
111. Biphasic effect of ACTH on growth of rat adrenocortical cells in primary culture
112. The ERK-dependent signalling is stage-specifically modulated by FSH, during primary Sertoli cell maturation
113. cAMP-dependent protein kinase A is required for Schwann cell growth: Interactions between the cAMP and neuregulin/tyrosine kinase pathways
114. Regulation of thyroid cell proliferation by tsh and other factors: A critical evaluation of in vitro models
115. Growth hormone-releasing hormone stimulates mitogen-activated protein kinase
116. Tyrosine levels regulate the melanogenic response to alpha-melanocyte-stimulating hormone in human melanocytes: Implications for pigmentation and proliferation
117. Cyclic AMP a key messenger in the regulation of skin pigmentation
118. Mesoderm insufficiency results in failed heart tube formation in RI alpha knockout mice
119. Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells
120. Increasing cAMP attenuates activation of mitogen-activated protein kinase
121. Activation of the COOH-terminal Src kinase (Csk) by caMP-dependent protein kinase inhibits signaling through the T cell receptor
122. Role of adenylate cyclase-cyclic AMP-dependent signal transduction in the ACTH-induced biphasic growth effect of rat adrenocortical cells in primary culture
123. Retroviral inhibition of caMP-dependent protein kinase inhibits myelination but not Schwann cell mitosis stimulated by interaction with neurons
124. Schwann cell proliferative responses to cAMP and Nfl are mediated by cyclin D1
125. Protein kinase A regulates expression of p27(kip1) and cyclin D3 to suppress proliferation of leukemic T cell lines
126. The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of caMP-dependent protein kinase
127. The localization and activity of caMP-dependent protein kinase affect cell cycle progression in thyroid cells
128. The v-Ki-Ras oncogene alters cAMP nuclear signaling by regulating the location and the expression of cAMP-dependent protein kinase IIbeta
129. Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A
130. Syndrome of myxomas, spotty skin pigmentation, and endocrine overactivity (Carney complex)
131. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin
132. Mesodermal development in mouse embryos mutant for fibronectin
133. Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells
134. Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration
135. FAK integrates growth-factor and integrin signals to promote cell migration
136. Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover
137. Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK)
138. Src family kinases are required for integrin but not PDGFR signal transduction
139. Src is required for cell migration and shape changes induced by fibroblast growth factor 1
140. Identification of integrin-stimulated sites of serine phosphorylation in FRNK, the separately expressed C-terminal domain of focal adhesion kinase: A potential role for protein kinase A