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Volumn 9, Issue 25, 2003, Pages 2060-2066

Novel protein targeted therapy of metastatic melanoma

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2B INTERFERON; ANTHRAX TOXIN; ANTINEOPLASTIC AGENT; BACTERIAL ANTIGEN; DACARBAZINE; GANGLIOSIDE GM2; INTERFERON; INTERLEUKIN 2; MELANOMA VACCINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; RAF PROTEIN; RAS PROTEIN; TEMOZOLOMIDE;

EID: 0141761371     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612033454162     Document Type: Review
Times cited : (20)

References (64)
  • 2
    • 0031704432 scopus 로고    scopus 로고
    • Incidence, risk factors and prevention of melanoma
    • MacKie RM. Incidence, risk factors and prevention of melanoma. Eur J Cancer 1998; 34 Suppl 3: S3-S6.
    • (1998) Eur. J. Cancer , vol.34 , Issue.SUPPL. 3
    • MacKie, R.M.1
  • 3
    • 0035169350 scopus 로고    scopus 로고
    • Genetic epidemiology of cutaneous melanoma: A global perspective
    • Goldstein AM, Tucker MA. Genetic epidemiology of cutaneous melanoma: a global perspective. Arch Dermatol 2001; 137: 1493-1496.
    • (2001) Arch. Dermatol. , vol.137 , pp. 1493-1496
    • Goldstein, A.M.1    Tucker, M.A.2
  • 4
    • 0034090124 scopus 로고    scopus 로고
    • Update on familial cancer syndromes and the skin
    • Tsao H. Update on familial cancer syndromes and the skin. J Am Acad Dermatol 2000; 42: 939-969.
    • (2000) J. Am. Acad. Dermatol. , vol.42 , pp. 939-969
    • Tsao, H.1
  • 5
    • 17544401946 scopus 로고    scopus 로고
    • A new American Joint Committee on Cancer staging system for cutaneous melanoma
    • Balch CM, Buzaid A, Atkins MB. A new American Joint Committee on Cancer staging system for cutaneous melanoma. Cancer 2000; 88: 1484-1491.
    • (2000) Cancer , vol.88 , pp. 1484-1491
    • Balch, C.M.1    Buzaid, A.2    Atkins, M.B.3
  • 6
    • 0034007555 scopus 로고    scopus 로고
    • Duration of survival for disseminated malignant melanoma: Results of a meta-analysis
    • Lee ML, Tomsu K, Von Eschen KB. Duration of survival for disseminated malignant melanoma: results of a meta-analysis. Melanoma Research 2000; 10: 81-100.
    • (2000) Melanoma Research , vol.10 , pp. 81-100
    • Lee, M.L.1    Tomsu, K.2    Von Eschen, K.B.3
  • 7
    • 0033233190 scopus 로고    scopus 로고
    • Evaluation of S-100beta assays for the prediction of recurrence and prognosis in patients with AJCC stage I-III melanoma
    • Curry BJ, Farrelly M, Hersey P. Evaluation of S-100beta assays for the prediction of recurrence and prognosis in patients with AJCC stage I-III melanoma. Melanoma Research 1999; 9: 557-571.
    • (1999) Melanoma Research , vol.9 , pp. 557-571
    • Curry, B.J.1    Farrelly, M.2    Hersey, P.3
  • 8
    • 0023886429 scopus 로고
    • Thin stage I primary cutaneous melanoma. Comparison of excision with margins of 1 cm or 3 cm
    • Veronesi U, Cascinelli N, Adamus J. Thin stage I primary cutaneous melanoma. Comparison of excision with margins of 1 cm or 3 cm. New England J Med 1988; 318: 1159-1162.
    • (1988) New England J. Med. , vol.318 , pp. 1159-1162
    • Veronesi, U.1    Cascinelli, N.2    Adamus, J.3
  • 9
    • 0027169738 scopus 로고
    • Efficacy of 2-cm surgical margins for intermediate-thickness melanomas (1 to 4 mm): Results of a multi-institutional randomized surgical trial
    • Balch CM, Smith TJ, Jewell WR, Barnihill R. Efficacy of 2-cm surgical margins for intermediate-thickness melanomas (1 to 4 mm): results of a multi-institutional randomized surgical trial. Ann Surg 1993; 218: 262-269.
    • (1993) Ann. Surg. , vol.218 , pp. 262-269
    • Balch, C.M.1    Smith, T.J.2    Jewell, W.R.3    Barnihill, R.4
  • 10
    • 0031744752 scopus 로고    scopus 로고
    • Surgical margins and prognostic factors in patients with thick (>4 mm) primary melanoma
    • Heaton KM, Sussman JJ, Gershenwald JE. Surgical margins and prognostic factors in patients with thick (>4 mm) primary melanoma. Ann Surg Oncol 1998; 4: 322-328.
    • (1998) Ann. Surg. Oncol. , vol.4 , pp. 322-328
    • Heaton, K.M.1    Sussman, J.J.2    Gershenwald, J.E.3
  • 11
    • 0027976461 scopus 로고
    • Surgical management of regional lymph nodes in patients with melanoma. Experience with 4682 patients
    • Slingluff CF, Stidham KR, Ricci WM, Stanley WE, Seigler HF. Surgical management of regional lymph nodes in patients with melanoma. Experience with 4682 patients. Ann Surg 1994; 219: 120-130.
    • (1994) Ann. Surg. , vol.219 , pp. 120-130
    • Slingluff, C.F.1    Stidham, K.R.2    Ricci, W.M.3    Stanley, W.E.4    Seigler, H.F.5
  • 12
    • 0019461784 scopus 로고
    • A multifactorial analysis of melanoma: III. Prognostic factors in melanoma patients with lymph node metastases (stage II)
    • Balch CM, Soong SJ, Murad TM, Ingalls AL, Maddox WA. A multifactorial analysis of melanoma: III. Prognostic factors in melanoma patients with lymph node metastases (stage II). Ann Surg 1981; 193: 377-383.
    • (1981) Ann. Surg. , vol.193 , pp. 377-383
    • Balch, C.M.1    Soong, S.J.2    Murad, T.M.3    Ingalls, A.L.4    Maddox, W.A.5
  • 13
    • 0036128239 scopus 로고    scopus 로고
    • European approach to the treatment of malignant melanoma
    • Eggermont AMM. European approach to the treatment of malignant melanoma. Curr Opin Oncol 2002; 14: 205-211.
    • (2002) Curr. Opin. Oncol. , vol.14 , pp. 205-211
    • Eggermont, A.M.M.1
  • 14
    • 0031800249 scopus 로고    scopus 로고
    • Patterns of recurrence following a negative sentinel lymph node biopsy in 243 patients with stage I or II melanoma
    • Gershenwald JE, Colome MI, Lee JE. Patterns of recurrence following a negative sentinel lymph node biopsy in 243 patients with stage I or II melanoma. J Clin Oncol 1998; 16: 2253-2264.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2253-2264
    • Gershenwald, J.E.1    Colome, M.I.2    Lee, J.E.3
  • 15
    • 0033951677 scopus 로고    scopus 로고
    • Sentinel node biopsies in melanoma patients: A protocol for accurate, efficient, and cost-effective analysis by preselection for immunohistochemistry on the basis of Tyr-PCR
    • van der Velde-Zimmerman D, Schipper ME, De Weger RA, Hennipman A, Borel B, Rinkes IH. Sentinel node biopsies in melanoma patients: a protocol for accurate, efficient, and cost-effective analysis by preselection for immunohistochemistry on the basis of Tyr-PCR. Ann Surg Oncol 2000; 7: 51-58.
    • (2000) Ann. Surg. Oncol. , vol.7 , pp. 51-58
    • van der Velde-Zimmerman, D.1    Schipper, M.E.2    De Weger, R.A.3    Hennipman, A.4    Borel, B.5    Rinkes, I.H.6
  • 16
    • 0031888751 scopus 로고    scopus 로고
    • Safety and efficacy of isolated perfusion of extremities for recurrent tumor in elderly patients
    • Ariyan S, Poo, WJ. Safety and efficacy of isolated perfusion of extremities for recurrent tumor in elderly patients. Surgery 1998; 123: 335-340.
    • (1998) Surgery , vol.123 , pp. 335-340
    • Ariyan, S.1    Poo, W.J.2
  • 17
    • 9244224085 scopus 로고    scopus 로고
    • Use of the carbon dioxide laser to manage cutaneous metastases from malignant melanoma
    • Hill S, Thomas JM. Use of the carbon dioxide laser to manage cutaneous metastases from malignant melanoma. Br J Surg 1996; 83: 509-514.
    • (1996) Br. J. Surg. , vol.83 , pp. 509-514
    • Hill, S.1    Thomas, J.M.2
  • 18
    • 0033001373 scopus 로고    scopus 로고
    • Palliative radiotherapy for recurrent and metastatic malignant melanoma: Prognostic factors for tumor response and long-term outcome: A 20-year experience
    • Seegenschmiedt MH, Keilholz L, Altendorf-Hofmann A. Palliative radiotherapy for recurrent and metastatic malignant melanoma: prognostic factors for tumor response and long-term outcome: a 20-year experience. Intl J Radiat Oncol Biol Phys 1999; 44: 607-621.
    • (1999) Intl. J. Radiat. Oncol. Biol. Phys. , vol.44 , pp. 607-621
    • Seegenschmiedt, M.H.1    Keilholz, L.2    Altendorf-Hofmann, A.3
  • 19
    • 0036534376 scopus 로고    scopus 로고
    • Interferon alpha therapy for malignant melanoma: A systematic review of randomized controlled trials
    • Lens MB, Dawes M. Interferon alpha therapy for malignant melanoma: a systematic review of randomized controlled trials. J Clin Oncol 2002; 20: 1818-1825.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1818-1825
    • Lens, M.B.1    Dawes, M.2
  • 20
    • 0034777045 scopus 로고    scopus 로고
    • Role of interferon-alpha in malignant melanoma remains to be determined
    • Eggermont AMM. Role of interferon-alpha in malignant melanoma remains to be determined. Eur J Cancer 2001; 37: 2147-2153.
    • (2001) Eur. J. Cancer , vol.37 , pp. 2147-2153
    • Eggermont, A.M.M.1
  • 21
    • 0000979050 scopus 로고    scopus 로고
    • Significant impact of HLA class I alleles on outcome in T3N0M0 melanoma patients treated with Melacine (MEL): An allogeneic cell lysate vaccine: Prospective analysis of Southwest Oncology Group (SWOG)-9035
    • Sosman JA, Unger JM, Liu PY. Significant impact of HLA class I alleles on outcome in T3N0M0 melanoma patients treated with Melacine (MEL): an allogeneic cell lysate vaccine: prospective analysis of Southwest Oncology Group (SWOG)-9035. Proc ASCO 2001; 20: 351.
    • (2001) Proc. ASCO , vol.20 , pp. 351
    • Sosman, J.A.1    Unger, J.M.2    Liu, P.Y.3
  • 22
    • 0022580729 scopus 로고
    • Adjuvant immunotherapy of malignant melanoma: Status of clinical trials at UCLA
    • Morton DL. Adjuvant immunotherapy of malignant melanoma: status of clinical trials at UCLA. Int J Immunother 1986; 2: 31-36.
    • (1986) Int. J. Immunother. , vol.2 , pp. 31-36
    • Morton, D.L.1
  • 23
    • 0028205790 scopus 로고
    • Improved survival in stage III melanoma patients with GM2 antibodies: A randomised trial of adjuvant vaccination with GM2 ganglioside
    • Livingstone PO, Wong GYC, Adluri S. Improved survival in stage III melanoma patients with GM2 antibodies: a randomised trial of adjuvant vaccination with GM2 ganglioside. J Clin Oncol 1994; 12: 1036-1044.
    • (1994) J. Clin. Oncol. , vol.12 , pp. 1036-1044
    • Livingstone, P.O.1    Wong, G.Y.C.2    Adluri, S.3
  • 24
    • 0027312394 scopus 로고
    • Prognostic factors in metastatic melanoma
    • Ryan L, Kramer A, Borden EC. Prognostic factors in metastatic melanoma. Cancer 1993; 71: 2995-3005.
    • (1993) Cancer , vol.71 , pp. 2995-3005
    • Ryan, L.1    Kramer, A.2    Borden, E.C.3
  • 26
    • 0031941423 scopus 로고    scopus 로고
    • Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells
    • Nestle FO, Alijagic S, Gilliet M, Sun Y, Grabbe S, Dummer R, et al. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nature Medicine 1998; 4: 328-332.
    • (1998) Nature Medicine , vol.4 , pp. 328-332
    • Nestle, F.O.1    Alijagic, S.2    Gilliet, M.3    Sun, Y.4    Grabbe, S.5    Dummer, R.6
  • 27
    • 0037089687 scopus 로고    scopus 로고
    • Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: Overall results of a randomized trial of the Southwest Oncology Group
    • Sondak VK, Liu PY, Tuthill RJ, Kempf RA, Unger JM, Sosman JA, et al. Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: overall results of a randomized trial of the Southwest Oncology Group. J Clin Oncol 2002; 20: 2058-2066.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 2058-2066
    • Sondak, V.K.1    Liu, P.Y.2    Tuthill, R.J.3    Kempf, R.A.4    Unger, J.M.5    Sosman, J.A.6
  • 28
    • 0035339880 scopus 로고    scopus 로고
    • High-dose interferon alpha-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIb-III melanoma: Results of intergroup trial E1694/S9512/C509801
    • Kirkwood JM, Ibrahim JG, Sosman JA. High-dose interferon alpha-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIb-III melanoma: results of intergroup trial E1694/S9512/C509801. J Clin Oncol 2001; 19: 2370-2380.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2370-2380
    • Kirkwood, J.M.1    Ibrahim, J.G.2    Sosman, J.A.3
  • 29
    • 0037089672 scopus 로고    scopus 로고
    • Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: Impact of HLA class I antigen expression on outcome
    • Sosman JA, Unger JM, Liu PY, Flaherty LE, Park MS, Kempf RA, et al. Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: impact of HLA class I antigen expression on outcome. J Clin Oncol 2002; 20: 2067-2075.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 2067-2075
    • Sosman, J.A.1    Unger, J.M.2    Liu, P.Y.3    Flaherty, L.E.4    Park, M.S.5    Kempf, R.A.6
  • 30
    • 0036605973 scopus 로고    scopus 로고
    • The Waardenburg Syndrome type 4 gene, SOX10, is a novel tumor-associated antigen identified in a patient with a dramatic response to immunotherapy
    • Khong HT, Rosenberg SA. The Waardenburg Syndrome type 4 gene, SOX10, is a novel tumor-associated antigen identified in a patient with a dramatic response to immunotherapy. Cancer Research 2002; 62: 3020-3023.
    • (2002) Cancer Research , vol.62 , pp. 3020-3023
    • Khong, H.T.1    Rosenberg, S.A.2
  • 31
    • 0037080226 scopus 로고    scopus 로고
    • Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy
    • Khong HT, Rosenberg SA. Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy. J Immunol 2002; 168: 951-956.
    • (2002) J. Immunol. , vol.168 , pp. 951-956
    • Khong, H.T.1    Rosenberg, S.A.2
  • 32
    • 0036128896 scopus 로고    scopus 로고
    • Shedding light on proteins, nucleic acids, cells, human and fish
    • Setlow RB. Shedding light on proteins, nucleic acids, cells, human and fish. Mutation Research 2002; 511: 1-14.
    • (2002) Mutation Research , vol.511 , pp. 1-14
    • Setlow, R.B.1
  • 34
    • 0035819040 scopus 로고    scopus 로고
    • Downregulation of E-cadherin and desmoglein 1 by autocrine hepatocyte growth factor during melanoma development
    • Li G, Schaider H, Satyamoorthy K, Hanakawa Y, Hashimoto K, Herlyn M. Downregulation of E-cadherin and desmoglein 1 by autocrine hepatocyte growth factor during melanoma development. Oncogene 2001; 20: 8125-8135.
    • (2001) Oncogene , vol.20 , pp. 8125-8135
    • Li, G.1    Schaider, H.2    Satyamoorthy, K.3    Hanakawa, Y.4    Hashimoto, K.5    Herlyn, M.6
  • 35
    • 0029839525 scopus 로고    scopus 로고
    • The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma
    • Valverde P, Healy E, Sikkink S. The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma. Hum Mol Genet 1996; 5: 1663-1666.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1663-1666
    • Valverde, P.1    Healy, E.2    Sikkink, S.3
  • 38
    • 0037022666 scopus 로고    scopus 로고
    • Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase
    • Koo HM, VanBrocklin M, McWilliams MJ, Leppla SH, Duesbery NS, Vande Woude GF. Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase. Proc Natl Acad Sci USA 2002; 99: 3052-3057.
    • (2002) Proc. Natl. Acad Sci. USA , vol.99 , pp. 3052-3057
    • Koo, H.M.1    VanBrocklin, M.2    McWilliams, M.J.3    Leppla, S.H.4    Duesbery, N.S.5    Vande Woude, G.F.6
  • 43
    • 0033064418 scopus 로고    scopus 로고
    • Identification of a receptor-binding region within domain 4 of the protective antigen component of anthrax toxin
    • Varughese M, Teixerira AV, Liu S, Leppla SH. Identification of a receptor-binding region within domain 4 of the protective antigen component of anthrax toxin. Infect Immun 1999; 67: 1860-1865.
    • (1999) Infect. Immun. , vol.67 , pp. 1860-1865
    • Varughese, M.1    Teixerira, A.V.2    Liu, S.3    Leppla, S.H.4
  • 45
    • 0035097284 scopus 로고    scopus 로고
    • Involvement of domain 3 in oligomerization by the protective antigen moiety of anthrax toxin
    • Mogridge J, Mourez M, Collier RJ. Involvement of domain 3 in oligomerization by the protective antigen moiety of anthrax toxin. J Bacteriol 2001; 183: 2111-2116.
    • (2001) J. Bacteriol. , vol.183 , pp. 2111-2116
    • Mogridge, J.1    Mourez, M.2    Collier, R.J.3
  • 46
    • 0037076304 scopus 로고    scopus 로고
    • Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen
    • Cunningham K, Lacy DB, Mogridge J, Collier RJ. Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen. Proc Natl Acad Sci USA 2002; 99: 7049-7053.
    • (2002) Proc. Natl. Acad Sci. USA , vol.99 , pp. 7049-7053
    • Cunningham, K.1    Lacy, D.B.2    Mogridge, J.3    Collier, R.J.4
  • 47
    • 0037076364 scopus 로고    scopus 로고
    • The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen
    • Mogridge J, Cunningham K, Lacy DB, Mourez M, Collier RJ. The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen. Proc Natl Acad Sci USA 2002; 99: 7045-7048.
    • (2002) Proc. Natl. Acad Sci. USA , vol.99 , pp. 7045-7048
    • Mogridge, J.1    Cunningham, K.2    Lacy, D.B.3    Mourez, M.4    Collier, R.J.5
  • 49
    • 0028072074 scopus 로고
    • Fusions of anthrax toxin lethal factor with shiga toxin and diphtheria toxin enzymatic domains are toxic to mammalian cells
    • Arora N, Leppla SH. Fusions of anthrax toxin lethal factor with shiga toxin and diphtheria toxin enzymatic domains are toxic to mammalian cells. Infect Immun 1994; 62: 4955-4961.
    • (1994) Infect. Immun. , vol.62 , pp. 4955-4961
    • Arora, N.1    Leppla, S.H.2
  • 50
    • 0033868243 scopus 로고    scopus 로고
    • Proteolytic activation of receptor-bound anthrax protective antigen on macrophages promotes its internalization
    • Beauregard KE, Collier RJ, Swanson JA. Proteolytic activation of receptor-bound anthrax protective antigen on macrophages promotes its internalization. Cell Microbiol 2000; 2: 251-258.
    • (2000) Cell Microbiol. , vol.2 , pp. 251-258
    • Beauregard, K.E.1    Collier, R.J.2    Swanson, J.A.3
  • 51
    • 0035957753 scopus 로고    scopus 로고
    • Dominant-negative mutants of a toxin subunit: An approach to therapy of anthrax
    • Sellman BR, Mourez M, Collier RJ. Dominant-negative mutants of a toxin subunit: an approach to therapy of anthrax. Science 2001; 292: 695-697.
    • (2001) Science , vol.292 , pp. 695-697
    • Sellman, B.R.1    Mourez, M.2    Collier, R.J.3
  • 52
    • 0034815440 scopus 로고    scopus 로고
    • Trp 346 and Leu 352 residues in protective antigen are required for the expression of anthrax lethal toxin activity
    • Batra S, Gupta P, Chauhan V, Singh A, Bhatnagar R. Trp 346 and Leu 352 residues in protective antigen are required for the expression of anthrax lethal toxin activity. Biochem Biophys Res Commun 2001; 281: 186-192.
    • (2001) Biochem. Biophys. Res. Commun. , vol.281 , pp. 186-192
    • Batra, S.1    Gupta, P.2    Chauhan, V.3    Singh, A.4    Bhatnagar, R.5
  • 53
    • 0033543208 scopus 로고    scopus 로고
    • Anthrax protective antigen: Prepore-to-pore conversion
    • Miller CJ, Elliott JL, Collier RJ. Anthrax protective antigen: prepore-to-pore conversion. Biochemistry 1999; 38: 10432-10441.
    • (1999) Biochemistry , vol.38 , pp. 10432-10441
    • Miller, C.J.1    Elliott, J.L.2    Collier, R.J.3
  • 54
    • 0028088404 scopus 로고
    • Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity
    • Klimpel KR, Arora N, Leppla SH. Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity. Mol Microbiol 1994; 13: 1093-1100.
    • (1994) Mol. Microbiol. , vol.13 , pp. 1093-1100
    • Klimpel, K.R.1    Arora, N.2    Leppla, S.H.3
  • 55
    • 0024214705 scopus 로고
    • Production and purification of anthrax toxin
    • Leppla SH. Production and purification of anthrax toxin. Methods Enzymol 1988; 165: 103-116.
    • (1988) Methods Enzymol. , vol.165 , pp. 103-116
    • Leppla, S.H.1
  • 56
    • 0034049623 scopus 로고    scopus 로고
    • Optimized production and purification of Bacillus anthracis lethal factor
    • Park S, Leppla SH. Optimized production and purification of Bacillus anthracis lethal factor. Protein Expression and Purification 2000; 18: 293-302.
    • (2000) Protein Expression and Purification , vol.18 , pp. 293-302
    • Park, S.1    Leppla, S.H.2
  • 57
    • 0035957358 scopus 로고    scopus 로고
    • Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways
    • Duesbery NS, Resau J, Webb CP, Koochekpour S, Koo HM, Leppla SH. et al. Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways. Proc Natl Acad Sci USA 2001; 98: 4089-4094.
    • (2001) Proc. Natl. Acad Sci. USA , vol.98 , pp. 4089-4094
    • Duesbery, N.S.1    Resau, J.2    Webb, C.P.3    Koochekpour, S.4    Koo, H.M.5    Leppla, S.H.6
  • 58
    • 0021285324 scopus 로고
    • Immunoelectrophoretic analysis, toxicity, and kinetics of in vitro production of the protective antigen and lethal factor components of Bacillus anthracis toxin
    • Ezzell JW, Ivins BE, Leppla SH. Immunoelectrophoretic analysis, toxicity, and kinetics of in vitro production of the protective antigen and lethal factor components of Bacillus anthracis toxin. Infect Immun 1984; 45: 761-767.
    • (1984) Infect. Immun. , vol.45 , pp. 761-767
    • Ezzell, J.W.1    Ivins, B.E.2    Leppla, S.H.3
  • 59
    • 0022599644 scopus 로고
    • Differences in susceptibility of inbred mice to Bacillus anthracis
    • Welkos SL, Keener TJ, Gibbs PH. Differences in susceptibility of inbred mice to Bacillus anthracis. Infect Immun 1986; 51: 795-800.
    • (1986) Infect. Immun. , vol.51 , pp. 795-800
    • Welkos, S.L.1    Keener, T.J.2    Gibbs, P.H.3
  • 60
    • 0034326255 scopus 로고    scopus 로고
    • Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin
    • Liu S, Netzel-Arnett S, Birkedal-Hansen H, Leppla SH. Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin. Cancer Research 2000; 60: 6061-6067.
    • (2000) Cancer Research , vol.60 , pp. 6061-6067
    • Liu, S.1    Netzel-Arnett, S.2    Birkedal-Hansen, H.3    Leppla, S.H.4
  • 61
    • 0035201401 scopus 로고    scopus 로고
    • Neutrophil collagenase (MMP-8) is expressed during early development in neural crest cells as well as in adult melanoma cells
    • Giambernardi TA, Sakaguchi AY, Gluhak J, Pavlin D, Troyer DA, Das G. et al. Neutrophil collagenase (MMP-8) is expressed during early development in neural crest cells as well as in adult melanoma cells. Matrix Biol 2001; 20: 577-587.
    • (2001) Matrix Biol. , vol.20 , pp. 577-587
    • Giambernardi, T.A.1    Sakaguchi, A.Y.2    Gluhak, J.3    Pavlin, D.4    Troyer, D.A.5    Das, G.6
  • 62
    • 0036403184 scopus 로고    scopus 로고
    • Rationale for Ras and raf-kinase as a target for cancer therapeutics
    • Nottage M, Siu LL. Rationale for Ras and raf-kinase as a target for cancer therapeutics. Curr Pharm Des 2002; 8(25): 2231-42.
    • (2002) Curr. Pharm. Des. , vol.8 , Issue.25 , pp. 2231-2242
    • Nottage, M.1    Siu, L.L.2
  • 63
    • 0035988616 scopus 로고    scopus 로고
    • Anti-cancer drugs of today and tomorrow: Are we close to making the turn from treating to curing cancer?
    • Pervaiz S. Anti-cancer drugs of today and tomorrow: are we close to making the turn from treating to curing cancer? Curr Pharm Des 2002; 8(19): 1723-34.
    • (2002) Curr. Pharm. Des. , vol.8 , Issue.19 , pp. 1723-1734
    • Pervaiz, S.1
  • 64
    • 0036401105 scopus 로고    scopus 로고
    • BAY 43-9006: Preclinical data
    • Wilhelm S, Chien DS. BAY 43-9006: preclinical data. Curr Pharm Des 2002; 8(25): 2255-7.
    • (2002) Curr. Pharm. Des. , vol.8 , Issue.25 , pp. 2255-2257
    • Wilhelm, S.1    Chien, D.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.