메뉴 건너뛰기




Volumn 23, Issue 2, 2002, Pages 89-95

Mechanisms of inverse agonism at G-protein-coupled receptors

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; RECEPTOR BLOCKING AGENT;

EID: 0036468505     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(02)01993-4     Document Type: Review
Times cited : (117)

References (45)
  • 2
    • 0035083109 scopus 로고    scopus 로고
    • Inverse, protean and ligand-selective agonism: Matters of receptor conformation
    • (2001) FASEB J. , vol.15 , pp. 598-611
    • Kenakin, T.1
  • 5
    • 0034016295 scopus 로고    scopus 로고
    • Inverse agonism at G protein coupled receptors: (patho)Physiological relevance and implications for drug discovery
    • (2000) Br. J. Pharmacol. , vol.130 , pp. 1-12
    • De Ligt, R.A.F.1
  • 6
    • 0031794526 scopus 로고    scopus 로고
    • Agonist independent regulation of constitutively active G protein coupled receptors
    • (1998) Trends Biochem. Sci. , vol.23 , pp. 418-422
    • Leurs, R.1
  • 10
    • 0031468622 scopus 로고    scopus 로고
    • Agonist-independent activation of Gz by the 5-hydroxytryptamine1A receptor co-expressed in Spodoptera frugiperda cells
    • (1997) J. Biol. Chem. , vol.272 , pp. 32979-32987
    • Barr, A.J.1    Manning, D.R.2
  • 11
    • 0029948346 scopus 로고    scopus 로고
    • Inverse agonism of histamine H2 antagonists accounts for up-regulation of spontaneously active histamine H2 receptors
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 6802-6807
    • Smit, M.J.1
  • 14
    • 0034649481 scopus 로고    scopus 로고
    • 3 receptors regulates histamine neurones in brain
    • (2000) Nature , vol.408 , pp. 860-864
    • Morisset, S.1
  • 15
    • 0031784970 scopus 로고    scopus 로고
    • Constitutive activity and structural instability of the wild-type human H2 receptor
    • (1998) J. Neurochem. , vol.71 , pp. 799-807
    • Alewijnse, A.E.1
  • 17
    • 0027513982 scopus 로고
    • A mutation-induced activated state of the β-adrenergic receptor. Extending the ternary complex model
    • (1993) J. Biol. Chem. , vol.268 , pp. 4625-4636
    • Samama, P.1
  • 21
    • 0035049091 scopus 로고    scopus 로고
    • Selective and non selective inverse agonists for constitutively active type 1 PTH receptors: Evidence for altered receptor conformations
    • (2001) Endocrinology , vol.142 , pp. 1534-1545
    • Carter, P.H.1
  • 23
    • 0023858575 scopus 로고
    • Beta adrenergic receptor kinase: Activity of partial agonists for stimulation of adenylyl cyclase correlates with ability to promote receptor phosphorylation
    • (1988) J. Biol. Chem. , vol.263 , pp. 3893-3897
    • Benovic, J.L.1
  • 25
    • 0025238655 scopus 로고
    • Spontaneous association between opioid receptors and GTP binding regulatory proteins in native membranes: Specific regulation by antagonists and sodium ions
    • (1990) Mol. Pharmacol. , vol.37 , pp. 383-394
    • Costa, T.1
  • 26
    • 0026608113 scopus 로고
    • Drug efficacy at guanine nucleotide binding regulatory protein linked receptors: Thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand
    • (1992) Mol. Pharmacol. , vol.41 , pp. 549-560
    • Costa, T.1
  • 30
    • 0030826705 scopus 로고    scopus 로고
    • A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin like growth factor receptor 1. Evidence for a new model of receptor/ligand interactions
    • (1997) J. Biol. Chem. , vol.272 , pp. 22330-22339
    • Bouaboula, M.1
  • 31
    • 0025802682 scopus 로고
    • Interaction of purified bovine brain A1 adenosine receptor with G proteins
    • (1991) Biochem. J. , vol.275 , pp. 651-656
    • Freissmuth, M.1
  • 32
    • 0019940309 scopus 로고
    • Dopamine receptors of the porcine anterior pituitary gland. Evidence for two affinity states discriminated by both agonists and antagonists
    • (1982) Mol. Pharmacol. , vol.22 , pp. 290-297
    • De Lean, A.1
  • 39
    • 0020315926 scopus 로고
    • Anterior pituitary dopamine receptors. Demonstration of interconvertible high and low affinity states of the D2 dopamine receptor
    • (1982) J. Biol. Chem. , vol.257 , pp. 6351-6361
    • Sibley, D.R.1
  • 42
    • 0001765878 scopus 로고
    • Porcine M2 muscarinic acetylcholine receptor effector coupling in CHO cells
    • (1995) J. Biol. Chem. , vol.270 , pp. 15484-15493
    • Vogel, M.K.1
  • 45
    • 0035051547 scopus 로고    scopus 로고
    • 2 dopamine receptor that adopts the activated conformation
    • (2001) J. Neurochem. , vol.77 , pp. 493-504
    • Wilson, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.