-
2
-
-
0029593456
-
1γ2
-
1γ2. Cell 1995, 83:1047-1058. See annotation [2••].
-
(1995)
Cell
, vol.83
, pp. 1047-1058
-
-
Wall, M.A.1
Coleman, D.E.2
Lee, E.3
Iñiguez-Lluhi, J.A.4
Posner, B.A.5
Gilman, A.G.6
Sprang, S.R.7
-
3
-
-
0029664589
-
The 2.0 Ȧ crystal structure of a heterotrimeric G protein
-
Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB: The 2.0 Ȧ crystal structure of a heterotrimeric G protein. Nature 1996, 379:311-319. These papers [2••,3••] present very similar 3D structures of two different Gα-βγ trimers, revealing the structure of Gβγ and defining the Gα-βγ binding interface. In addition, the structures define a probable membrane-oriented face of the trimer by identifying the likely locations of lipid modifications of Gα and Gγ, as well as the carboxyl terminus of Gα.
-
(1996)
Nature
, vol.379
, pp. 311-319
-
-
Lambright, D.G.1
Sondek, J.2
Bohm, A.3
Skiba, N.P.4
Hamm, H.E.5
Sigler, P.B.6
-
4
-
-
0029664921
-
Evolutionarily conserved Gαβγ binding surfaces support a model of the G protein-receptor complex
-
Lichtarge O, Bourne HR, Cohen FE: Evolutionarily conserved Gαβγ binding surfaces support a model of the G protein-receptor complex. Proc Natl Acad Sci USA 1996, 93:7507-7511. Patterns of conserved residues on the surface of Gα point to sites of two surfaces for interaction with other proteins. One of these surfaces interacts with βγ, as shown in the Gαβγ trimer structures. The other, presumably, interacts with serpentine receptors.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 7507-7511
-
-
Lichtarge, O.1
Bourne, H.R.2
Cohen, F.E.3
-
5
-
-
0027318238
-
Structural elements of Gα subunits that interact with Gβγ, receptors, and effectors
-
Conklin BR, Bourne HR: Structural elements of Gα subunits that interact with Gβγ, receptors, and effectors. Cell 1993, 73:631-641.
-
(1993)
Cell
, vol.73
, pp. 631-641
-
-
Conklin, B.R.1
Bourne, H.R.2
-
6
-
-
0029113832
-
Transducin-α C-terminal mutations prevent activation by rhodopsin: A new assay using recombinant proteins expressed in cultured cells
-
Garcia PD, Onrust R, Bell SM, Sakmar TP, Bourne HR: Transducin-α C-terminal mutations prevent activation by rhodopsin: a new assay using recombinant proteins expressed in cultured cells. EMBO J 1995, 14:4460-4469.
-
(1995)
EMBO J
, vol.14
, pp. 4460-4469
-
-
Garcia, P.D.1
Onrust, R.2
Bell, S.M.3
Sakmar, T.P.4
Bourne, H.R.5
-
7
-
-
0029032496
-
The family of G-protein-coupled receptors
-
Strader CD, Fong TM, Graziano MP, Tota MR: The family of G-protein-coupled receptors. FASEB J 1995, 9:745-754.
-
(1995)
FASEB J
, vol.9
, pp. 745-754
-
-
Strader, C.D.1
Fong, T.M.2
Graziano, M.P.3
Tota, M.R.4
-
8
-
-
0026669569
-
Sequence alignment of the G-protein coupled receptor superfamily
-
Probst WC, Snyder LA, Schuster DI, Brosius J, Sealfon SC: Sequence alignment of the G-protein coupled receptor superfamily. DNA Cell Biol 1992, 11:1-20.
-
(1992)
DNA Cell Biol
, vol.11
, pp. 1-20
-
-
Probst, W.C.1
Snyder, L.A.2
Schuster, D.I.3
Brosius, J.4
Sealfon, S.C.5
-
10
-
-
0029556994
-
Projection structure of frog rhodopsin in two crystal forms
-
Schertler GF, Hargrave PA: Projection structure of frog rhodopsin in two crystal forms. Proc Natl Acad Sci USA 1995, 92:11578-11582. At somewhat higher resolution, this structure confirms the seven-helix bundle model inferred from the projection structure of cow rhodopsin [9]. Together, these structures powerfully constrain possible models of mechanisms of receptor activation by ligands and of G-protein activation by receptors.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 11578-11582
-
-
Schertler, G.F.1
Hargrave, P.A.2
-
11
-
-
0027506471
-
The probable arrangement of the helices in G protein-coupled receptors
-
Baldwin JM: The probable arrangement of the helices in G protein-coupled receptors. EMBO J 1993, 12:1693-1703.
-
(1993)
EMBO J
, vol.12
, pp. 1693-1703
-
-
Baldwin, J.M.1
-
13
-
-
0030606345
-
Structure determination of the fourth cytoplasmic loop and carboxyl terminal domain of bovine rhodopsin
-
Yeagle PL, Alderfer JL, Albert AD: Structure determination of the fourth cytoplasmic loop and carboxyl terminal domain of bovine rhodopsin. Mol Vision 1996, 2:12. On World Wide Web URL: http://www.emory.edu/molvis/v2/yeagle.
-
(1996)
Mol Vision
, vol.2
, pp. 12
-
-
Yeagle, P.L.1
Alderfer, J.L.2
Albert, A.D.3
-
14
-
-
0028230817
-
Expanding horizons for receptors coupled to G proteins: Diversity and disease
-
Coughlin SR: Expanding horizons for receptors coupled to G proteins: diversity and disease. Curr Opin Cell Biol 1994, 6:191-197.
-
(1994)
Curr Opin Cell Biol
, vol.6
, pp. 191-197
-
-
Coughlin, S.R.1
-
15
-
-
0028840683
-
Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway
-
Price LA, Kajkowski EM, Hadcock JR, Ozenberger BA, Pausch MH: Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway. Mol Cell Biol 1995, 15:6188-6195.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 6188-6195
-
-
Price, L.A.1
Kajkowski, E.M.2
Hadcock, J.R.3
Ozenberger, B.A.4
Pausch, M.H.5
-
16
-
-
0028920298
-
Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method
-
Javitch JA, Fu D, Chen J, Karlin A: Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method. Neuron 1995, 14:825-831. See annotation [17•].
-
(1995)
Neuron
, vol.14
, pp. 825-831
-
-
Javitch, J.A.1
Fu, D.2
Chen, J.3
Karlin, A.4
-
17
-
-
0029757635
-
Residues in the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice
-
2R) the potential crevice is bordered by at least three helices (TMs 3, 5, and 7) and extends all the way from extracellular fluid to cytoplasm.
-
(1996)
Biochemistry
, vol.35
, pp. 11278-11285
-
-
Fu, D.1
Ballesteros, J.A.2
Weinstein, H.3
Chen, J.4
Javitch, J.A.5
-
18
-
-
0026661978
-
Constitutively active mutants of rhodopsin
-
Robinson PR, Cohen GB, Zhukovsky EA, Oprian DD: Constitutively active mutants of rhodopsin. Neuron 1992, 9:1-7.
-
(1992)
Neuron
, vol.9
, pp. 1-7
-
-
Robinson, P.R.1
Cohen, G.B.2
Zhukovsky, E.A.3
Oprian, D.D.4
-
19
-
-
0028300554
-
Active site-directed inactivation of constitutively active mutants of rhodopsin
-
Govardhan CP, Oprian DD: Active site-directed inactivation of constitutively active mutants of rhodopsin. J Biol Chem 1994, 269:6524-6527.
-
(1994)
J Biol Chem
, vol.269
, pp. 6524-6527
-
-
Govardhan, C.P.1
Oprian, D.D.2
-
20
-
-
0029085550
-
Photoactivated state of rhodopsin and how it can form
-
Fahmy K, Siebert F, Sakmar TP: Photoactivated state of rhodopsin and how it can form. Biophys Chem 1995, 56:171-181.
-
(1995)
Biophys Chem
, vol.56
, pp. 171-181
-
-
Fahmy, K.1
Siebert, F.2
Sakmar, T.P.3
-
21
-
-
0027716597
-
Photoactivated conformational changes in rhodopsin: A time-resolved spin label study
-
Farahbakhsh ZT, Hideg K,Hubbell WL: Photoactivated conformational changes in rhodopsin: a time-resolved spin label study. Science 1993, 262:1416-1419.
-
(1993)
Science
, vol.262
, pp. 1416-1419
-
-
Farahbakhsh, Z.T.1
Hideg, K.2
Hubbell, W.L.3
-
22
-
-
0029035661
-
Mapping light-dependent structural changes in the cytoplasmic loop connecting helices C and D in rhodopsin: A site-directed spin labeling study
-
Farahbakhsh ZT, Ridge KD, Khorana HG, Hubbell WL: Mapping light-dependent structural changes in the cytoplasmic loop connecting helices C and D in rhodopsin: a site-directed spin labeling study. Biochemistry 1995, 34:8812-8819. See annotation [24••].
-
(1995)
Biochemistry
, vol.34
, pp. 8812-8819
-
-
Farahbakhsh, Z.T.1
Ridge, K.D.2
Khorana, H.G.3
Hubbell, W.L.4
-
23
-
-
0029818551
-
Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: A site-directed spin labeling study
-
Altenbach C, Yang K, Farrens DL, Khorana HG, Hubbell WL: Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: a site-directed spin labeling study. Biochemistry 1996, 35:12470-12478. See annotation [24••].
-
(1996)
Biochemistry
, vol.35
, pp. 12470-12478
-
-
Altenbach, C.1
Yang, K.2
Farrens, D.L.3
Khorana, H.G.4
Hubbell, W.L.5
-
24
-
-
0029907599
-
A light-activated conformational switch in rhodopsin
-
Farrens DL, Altenbach C, Yang K, Hubbell WL, Khorana HG: A light-activated conformational switch in rhodopsin. Science 1996, 274:768-770. These (and other) papers [22•,23•,24••] from a collaboration between the Khorana and Hubbell laboratories present evidence that the activation of rhodopsin causes TMs 3 and 6 to move, as rigid bodies, relative to the rest of the seven-helix bundle; in addition, activation is associated with movement of these two TMs away from one another.
-
(1996)
Science
, vol.274
, pp. 768-770
-
-
Farrens, D.L.1
Altenbach, C.2
Yang, K.3
Hubbell, W.L.4
Khorana, H.G.5
-
25
-
-
0028108981
-
Investigation of structure and dynamics in membrane proteins using site-directed spin labeling
-
Hubbell WL, Altenbach C: Investigation of structure and dynamics in membrane proteins using site-directed spin labeling. Curr Opin Struct Biol 1994, 4:566-573.
-
(1994)
Curr Opin Struct Biol
, vol.4
, pp. 566-573
-
-
Hubbell, W.L.1
Altenbach, C.2
-
26
-
-
0029756165
-
Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state
-
Lin SW, Sakmar TP: Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state. Biochemistry 1996, 35:11149-11159.
-
(1996)
Biochemistry
, vol.35
, pp. 11149-11159
-
-
Lin, S.W.1
Sakmar, T.P.2
-
27
-
-
0029778268
-
Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F
-
Sheikh SP, Zvyaga TA, Lichtarge O, Sakmar TP, Bourne HR: Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature 1996, 383:347-350.
-
(1996)
Nature
, vol.383
, pp. 347-350
-
-
Sheikh, S.P.1
Zvyaga, T.A.2
Lichtarge, O.3
Sakmar, T.P.4
Bourne, H.R.5
-
28
-
-
0028946950
-
Characterization of rhodopsin mutants that bind transducin but fail to induce GTP nucleotide uptake. Classification of mutant pigments by fluorescence, nucleotide release, and flash-induced light-scattering assays
-
Ernst OP, Hofmann KP, Sakmar TP: Characterization of rhodopsin mutants that bind transducin but fail to induce GTP nucleotide uptake. Classification of mutant pigments by fluorescence, nucleotide release, and flash-induced light-scattering assays. J Biol Chem 1995, 270:10580-10586. Using a variety of biophysical and biochemical techniques, the authors of this paper show that receptor-promoted release of GDP from the G-protein trimer requires more than just association of the trimer with a serpentine receptor. Although the mechanism by which the receptor induces GDP release is unknown, it probably requires the ERY (single-letter code for amino acids) sequence located at the junction of ic2 and TM3.
-
(1995)
J Biol Chem
, vol.270
, pp. 10580-10586
-
-
Ernst, O.P.1
Hofmann, K.P.2
Sakmar, T.P.3
-
30
-
-
0028061193
-
A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin
-
Amis S, Fahmy K, Hofmann KP, Sakmar TP: A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin. J Biol Chem 1994, 269:23879-23881.
-
(1994)
J Biol Chem
, vol.269
, pp. 23879-23881
-
-
Amis, S.1
Fahmy, K.2
Hofmann, K.P.3
Sakmar, T.P.4
-
31
-
-
0026780339
-
Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin
-
Franke RR, Sakmar TP, Graham RM, Khorana HG: Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin. J Biol Chem 1992, 267:14767-14774.
-
(1992)
J Biol Chem
, vol.267
, pp. 14767-14774
-
-
Franke, R.R.1
Sakmar, T.P.2
Graham, R.M.3
Khorana, H.G.4
-
32
-
-
0027270898
-
Regulation of the rhodopsin-transducin interaction by a highly conserved carboxylic acid group
-
Fahmy K, Sakmar TP: Regulation of the rhodopsin-transducin interaction by a highly conserved carboxylic acid group. Biochemistry 1993, 32:7229-7236.
-
(1993)
Biochemistry
, vol.32
, pp. 7229-7236
-
-
Fahmy, K.1
Sakmar, T.P.2
-
33
-
-
0026592357
-
1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation
-
1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. J Biol Chem 1992, 267:1430-1433.
-
(1992)
J Biol Chem
, vol.267
, pp. 1430-1433
-
-
Kjelsberg, M.A.1
Cotecchia, S.2
Ostrowski, J.3
Caron, M.G.4
Lefkowitz, R.J.5
-
35
-
-
12044260162
-
Mutations that alter the third cytoplasmic loop of the α-factor receptor lead to a constitutive and hypersensitive phenotype
-
Boone C, Davis NG, Sprague GF Jr: Mutations that alter the third cytoplasmic loop of the α-factor receptor lead to a constitutive and hypersensitive phenotype. Proc Natl Acad Sci USA 1993, 90:9921-9925.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 9921-9925
-
-
Boone, C.1
Davis, N.G.2
Sprague G.F., Jr.3
-
36
-
-
0029832901
-
Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop
-
Kudo M, Osuga Y, Kobilka BK, Hsueh AJW: Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop. J Biol Chem 1996, 271:22470-22478.
-
(1996)
J Biol Chem
, vol.271
, pp. 22470-22478
-
-
Kudo, M.1
Osuga, Y.2
Kobilka, B.K.3
Hsueh, A.J.W.4
-
37
-
-
0026752495
-
Different β-subunits determine G-protein interaction with transmembrane receptors
-
Kleuss C, Scherübl H, Hescheler J, Schultz G, Wittig B: Different β-subunits determine G-protein interaction with transmembrane receptors. Nature 1992, 358:424-426.
-
(1992)
Nature
, vol.358
, pp. 424-426
-
-
Kleuss, C.1
Scherübl, H.2
Hescheler, J.3
Schultz, G.4
Wittig, B.5
-
38
-
-
0027530916
-
Selectivity in signal transduction determined by y subunits of heterotrimeric G proteins
-
Kleuss C, Scherübl H, Hescheler J, Schultz G, Wittig B: Selectivity in signal transduction determined by y subunits of heterotrimeric G proteins. Science 1993, 259:832-834.
-
(1993)
Science
, vol.259
, pp. 832-834
-
-
Kleuss, C.1
Scherübl, H.2
Hescheler, J.3
Schultz, G.4
Wittig, B.5
-
39
-
-
0023716027
-
Site of G protein binding to rhodopsin mapped with synthetic peptides from the a subunit
-
Hamm HE, Deretic D, Arendt A, Hargrave PA, Koenig B, Hofmann KP: Site of G protein binding to rhodopsin mapped with synthetic peptides from the a subunit Science 1988, 241:832-835.
-
(1988)
Science
, vol.241
, pp. 832-835
-
-
Hamm, H.E.1
Deretic, D.2
Arendt, A.3
Hargrave, P.A.4
Koenig, B.5
Hofmann, K.P.6
-
40
-
-
0027196532
-
NMR structure of a receptor-bound G-protein peptide
-
Dratz EA, Furstenau JE, Lambert CG, Thireault DL, Rarick H, Schepers T, Pakhlevaniants S, Hamm HE: NMR structure of a receptor-bound G-protein peptide. Nature 1993, 363:276-280.
-
(1993)
Nature
, vol.363
, pp. 276-280
-
-
Dratz, E.A.1
Furstenau, J.E.2
Lambert, C.G.3
Thireault, D.L.4
Rarick, H.5
Schepers, T.6
Pakhlevaniants, S.7
Hamm, H.E.8
-
43
-
-
0028289513
-
Structure and function of G protein-coupled receptors
-
Strader CD, Fong TM, Tota MR, Underwood D, Dixon RAF: Structure and function of G protein-coupled receptors. Annu Rev Biochem 1994, 63:101-132.
-
(1994)
Annu Rev Biochem
, vol.63
, pp. 101-132
-
-
Strader, C.D.1
Fong, T.M.2
Tota, M.R.3
Underwood, D.4
Dixon, R.A.F.5
-
44
-
-
0027258001
-
Alternative splicing of C-terminal tail of prostaglandin e receptor subtype EP3 determines G-protein specificity
-
Namba T, Sugimoto Y, Negishi M, Irie A, Ushikubi F, Kakizuka A, Ito S, Ichikawa A, Narumiya S: Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Nature 1993, 365:166-170.
-
(1993)
Nature
, vol.365
, pp. 166-170
-
-
Namba, T.1
Sugimoto, Y.2
Negishi, M.3
Irie, A.4
Ushikubi, F.5
Kakizuka, A.6
Ito, S.7
Ichikawa, A.8
Narumiya, S.9
-
45
-
-
0028361809
-
Chimeric muscarinic cholinergic:beta-adrenergic receptors that are functionally promiscuous among G proteins
-
Wong SK, Ross EM: Chimeric muscarinic cholinergic:beta-adrenergic receptors that are functionally promiscuous among G proteins. J Biol Chem 1994, 269:18968-18976.
-
(1994)
J Biol Chem
, vol.269
, pp. 18968-18976
-
-
Wong, S.K.1
Ross, E.M.2
-
46
-
-
0029784196
-
The luteinizing hormone/ chorionic gonadotropin receptor has distinct transmembrane conductors for cAMP and inositol phosphate signals
-
Gilchrrst RL, Ryu K, Ji I, Ji TH: The luteinizing hormone/ chorionic gonadotropin receptor has distinct transmembrane conductors for cAMP and inositol phosphate signals. J Biol Chem 1996, 271:19283-19287.
-
(1996)
J Biol Chem
, vol.271
, pp. 19283-19287
-
-
Gilchrrst, R.L.1
Ryu, K.2
Ji, I.3
Ji, T.H.4
-
47
-
-
0030049488
-
Constitutive activation of a single effector pathway: Evidence for multiple activation states of a G protein-coupled receptor
-
Perez DM, Hwa J, Gaivin R, Mathur M, Brown F, Graham RM: Constitutive activation of a single effector pathway: evidence for multiple activation states of a G protein-coupled receptor. Mol Pharmacol 1996, 49:112-122.
-
(1996)
Mol Pharmacol
, vol.49
, pp. 112-122
-
-
Perez, D.M.1
Hwa, J.2
Gaivin, R.3
Mathur, M.4
Brown, F.5
Graham, R.M.6
-
49
-
-
0029589916
-
Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation
-
Liu J, Conklin BR, Blin N, Yun J, Wess J: Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation. Prac Natl Acad Sci USA 1995, 92:11642-11646. Experiments with interfering peptides and site-directed mutations identify regions of receptor and G-protein subunits that are important for receptor-G-protein coupling. To understand receptor-mediated activation of G proteins, however, we must identify specific residues of the two proteins that interact directly with one another. As noted in Table 3, this paper identifies one such contact by showing functional complementation between an amino acid sequence substituted in the carboxy-terminal tail of a Gα and a separate sequence substituted at the junction of ic3 and TM6 in a receptor.
-
(1995)
Prac Natl Acad Sci USA
, vol.92
, pp. 11642-11646
-
-
Liu, J.1
Conklin, B.R.2
Blin, N.3
Yun, J.4
Wess, J.5
-
50
-
-
0029096818
-
Mutational analysis of the relative orientation of transmembrane helices I and VII in G protein-coupled receptors
-
Liu J, Schoneberg T, Van Rhee M, Wess J: Mutational analysis of the relative orientation of transmembrane helices I and VII in G protein-coupled receptors. J Biol Chem 1995, 270:19532-19539.
-
(1995)
J Biol Chem
, vol.270
, pp. 19532-19539
-
-
Liu, J.1
Schoneberg, T.2
Van Rhee, M.3
Wess, J.4
-
51
-
-
0028031727
-
A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor
-
Zhou W, Flanagan C, Ballesteros JA, Konvicka K, Davidson JS, Weinstein H, Millar RP, Sealfon SC: A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor. Mol Pharmacol 1994, 45:165-170.
-
(1994)
Mol Pharmacol
, vol.45
, pp. 165-170
-
-
Zhou, W.1
Flanagan, C.2
Ballesteros, J.A.3
Konvicka, K.4
Davidson, J.S.5
Weinstein, H.6
Millar, R.P.7
Sealfon, S.C.8
-
52
-
-
0028822684
-
A general method for mapping tertiary contacts between amino acid residues in membrane-embedded proteins
-
Yu H, Kono M, McKee TD, Oprian DD: A general method for mapping tertiary contacts between amino acid residues in membrane-embedded proteins. Biochemistry 1995, 34:14963-14969.
-
(1995)
Biochemistry
, vol.34
, pp. 14963-14969
-
-
Yu, H.1
Kono, M.2
McKee, T.D.3
Oprian, D.D.4
-
53
-
-
0029680797
-
Structure and function in rhodopsin. Cysteines 65 and 316 are in proximity in a rhodopsin mutant as indicated by disulfide formation and interactions between attached spin labels
-
Yang K, Farrens DL, Altenbach C, Farahbakhsh ZT, Hubbell WL, Khorana HG: Structure and function in rhodopsin. Cysteines 65 and 316 are in proximity in a rhodopsin mutant as indicated by disulfide formation and interactions between attached spin labels. Biochemistry 1996, 35:14040-14046.
-
(1996)
Biochemistry
, vol.35
, pp. 14040-14046
-
-
Yang, K.1
Farrens, D.L.2
Altenbach, C.3
Farahbakhsh, Z.T.4
Hubbell, W.L.5
Khorana, H.G.6
-
54
-
-
0028800729
-
Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor
-
Elling CE, Nielsen SM, Schwartz TW: Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor. Nature 1995, 374:74-77.
-
(1995)
Nature
, vol.374
, pp. 74-77
-
-
Elling, C.E.1
Nielsen, S.M.2
Schwartz, T.W.3
-
55
-
-
0029957956
-
Connectivity and orientation of the seven helical bundle in the tachykinin NK-1 receptor probed by zinc site engineering
-
Elling CE, Schwartz TW: Connectivity and orientation of the seven helical bundle in the tachykinin NK-1 receptor probed by zinc site engineering. EMBO J 1996, 15:6213-6219.
-
(1996)
EMBO J
, vol.15
, pp. 6213-6219
-
-
Elling, C.E.1
Schwartz, T.W.2
-
56
-
-
0030028517
-
Arrangement of transmembrane domains in adrenergic receptors. Similarity to bacteriorhodopsin
-
Mizobe T, Maze M, Lam V, Suryanarayana S, Kobilka BK: Arrangement of transmembrane domains in adrenergic receptors. Similarity to bacteriorhodopsin. J Biol Chem 1996, 271:2387-2389.
-
(1996)
J Biol Chem
, vol.271
, pp. 2387-2389
-
-
Mizobe, T.1
Maze, M.2
Lam, V.3
Suryanarayana, S.4
Kobilka, B.K.5
-
57
-
-
0027964847
-
Insertion mutagenesis as a tool to predict the secondary structure of a muscarinic receptor domain determining specificity of G-protein coupling
-
Bluml K, Mutschler E, Wess J: Insertion mutagenesis as a tool to predict the secondary structure of a muscarinic receptor domain determining specificity of G-protein coupling. Proc Natl Acad Sci USA 1994, 91:7980-7984.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 7980-7984
-
-
Bluml, K.1
Mutschler, E.2
Wess, J.3
-
58
-
-
0030039837
-
Structure of a G-protein-coupling domain of a muscarinic receptor predicted by random saturation mutagenesis
-
Hill-Eubanks D, Burstein ES, Spalding TA, Brauner-Osborne H, Brann MR: Structure of a G-protein-coupling domain of a muscarinic receptor predicted by random saturation mutagenesis. J Biol Chem 1996, 271:3058-3065.
-
(1996)
J Biol Chem
, vol.271
, pp. 3058-3065
-
-
Hill-Eubanks, D.1
Burstein, E.S.2
Spalding, T.A.3
Brauner-Osborne, H.4
Brann, M.R.5
-
59
-
-
0029818639
-
Structure and function in rhodopsin. Single cysteine substitution mutants in the cytoplasmic interhelical E-F loop region show position-specific effects in transducin activation
-
Yang K, Farrens D, Hubbell WL, Khorana HG: Structure and function in rhodopsin. Single cysteine substitution mutants in the cytoplasmic interhelical E-F loop region show position-specific effects in transducin activation. Biochemistry 1996, 35:12464-12469.
-
(1996)
Biochemistry
, vol.35
, pp. 12464-12469
-
-
Yang, K.1
Farrens, D.2
Hubbell, W.L.3
Khorana, H.G.4
-
60
-
-
0028812838
-
Structure of the third cytoplasmic loop of bovine rhodopsin
-
Yeagle PL, Alderfer JL, Albert AD: Structure of the third cytoplasmic loop of bovine rhodopsin. Biochemistry 1995, 34:14621-14625.
-
(1995)
Biochemistry
, vol.34
, pp. 14621-14625
-
-
Yeagle, P.L.1
Alderfer, J.L.2
Albert, A.D.3
-
61
-
-
0029848323
-
Peptide mimetic of the third cytoplasmic loop of the PTH/PTHrP receptor
-
Mierke DF, Royo M, Pellegrini M, Sun H, Corev M: Peptide mimetic of the third cytoplasmic loop of the PTH/PTHrP receptor. J Am Chem Soc 1996, 118:8998-9004.
-
(1996)
J Am Chem Soc
, vol.118
, pp. 8998-9004
-
-
Mierke, D.F.1
Royo, M.2
Pellegrini, M.3
Sun, H.4
Corev, M.5
-
62
-
-
0028814543
-
Structure-function of muscarinic receptor coupling to G proteins. Random saturation mutagenesis identifies a critical determinant of receptor affinity for G proteins
-
Burstein ES, Spalding TA, Hill-Eubanks D, Brann MR: Structure-function of muscarinic receptor coupling to G proteins. Random saturation mutagenesis identifies a critical determinant of receptor affinity for G proteins. J Biol Chem 1995, 270:3141-3146.
-
(1995)
J Biol Chem
, vol.270
, pp. 3141-3146
-
-
Burstein, E.S.1
Spalding, T.A.2
Hill-Eubanks, D.3
Brann, M.R.4
-
63
-
-
0028172426
-
Binding of an alpha 2 adrenergic receptor third intracellular loop peptide to G beta and the amino terminus of G alpha
-
Taylor JM, Jacob-Mosier GG, Lawton RG, Remmers AE, Neubig RR: Binding of an alpha 2 adrenergic receptor third intracellular loop peptide to G beta and the amino terminus of G alpha. J Biol Chem 1994, 269:27618-27624.
-
(1994)
J Biol Chem
, vol.269
, pp. 27618-27624
-
-
Taylor, J.M.1
Jacob-Mosier, G.G.2
Lawton, R.G.3
Remmers, A.E.4
Neubig, R.R.5
-
64
-
-
0030064529
-
Receptor and membrane interaction sites on Gβ. A receptor-derived peptide binds to the carboxyl terminus
-
Taylor JM, Jacob-Mosier GG, Lawton RG, Van Dort M, Neubig RR: Receptor and membrane interaction sites on Gβ. A receptor-derived peptide binds to the carboxyl terminus. J Biol Chem 1996, 271:3336-3339.
-
(1996)
J Biol Chem
, vol.271
, pp. 3336-3339
-
-
Taylor, J.M.1
Jacob-Mosier, G.G.2
Lawton, R.G.3
Van Dort, M.4
Neubig, R.R.5
-
65
-
-
0026786080
-
Rhodopsin/transducin interactions. I. Characterization of the binding of the transducin-beta gamma subunit complex to rhodopsin using fluorescence spectroscopy
-
Phillips WJ, Cerione RA: Rhodopsin/transducin interactions. I. Characterization of the binding of the transducin-beta gamma subunit complex to rhodopsin using fluorescence spectroscopy. J Biol Chem 1992, 267:17032-17039.
-
(1992)
J Biol Chem
, vol.267
, pp. 17032-17039
-
-
Phillips, W.J.1
Cerione, R.A.2
-
66
-
-
0028296886
-
A C-terminal peptide of bovine rhodopsin binds to the transducin alpha-subunit and facilitates its activation
-
Phillips WJ, Cerione RA: A C-terminal peptide of bovine rhodopsin binds to the transducin alpha-subunit and facilitates its activation. Biochem J 1994, 299:351-357.
-
(1994)
Biochem J
, vol.299
, pp. 351-357
-
-
Phillips, W.J.1
Cerione, R.A.2
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