Cytokines and the regulation of hypoxia-inducible factor (HIF)-1α

International Immunopharmacology

Volumn 5, Issue 3, 2005, Pages 461-483

  Haddad, John J ^a,b,c   Harb, Hisham L ^b  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^b LEBANESE INTERNATIONAL UNIVERSITY   (Lebanon)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cytokines; Gene regulation; HIF; Hypoxia; Kinase; MAPK; Sensor; Transcription factors

Indexed keywords

CYTOKINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; OXYGEN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR;

BIOCHEMISTRY; GENE EXPRESSION; HUMAN; HYPOXIA; IMMUNITY; IMMUNOREGULATION; INFLAMMATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN MODIFICATION; REGULATORY MECHANISM; REVIEW;

EID: 15944397647     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2004.11.009     Document Type: Review

References (192)

1. P.T. Schumacker Current paradigms in cellular oxygen sensing Adv. Exp. Med. Biol. 543 2003 57 71
2. J.J. Haddad Oxygen sensing and oxidant/redox-related pathways Biochem. Biophys. Res. Commun. 316 2004 969 977
3. T. Acker, and H. Acker Cellular oxygen sensing need in CNS function: physiological and pathological implications J. Exp. Biol. 207 2004 3171 3188
4. C. Peers, and P.J. Kemp Ion channel regulation by chronic hypoxia in models of acute oxygen sensing Cell Calcium 36 2004 341 348
5. A.J. Giaccia, M.C. Simon, and R. Johnson The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease Genes Dev. 18 2004 2183 2194
6. 2-regulated gene expression FASEB J. 16 2002 1151 1162
7. G. Hopfl, O. Ogunshola, and M. Gassmann Hypoxia and high altitude: the molecular response Adv. Exp. Med. Biol. 543 2003 89 115
8. K.A. Seta, and D.E. Millhorn Functional genomics approach to hypoxia signaling J. Appl. Physiol. 96 2004 765 773
9. J.J. Haddad Hypoxia and the regulation of mitogen-activated protein kinases: gene transcription and the assessment of potential pharmacologic therapeutic interventions Int. Immunopharmacol. 4 2004 1249 1285
10. A.O. Fedele, M.L. Whitelaw, and D.J. Peet Regulation of gene expression by the hypoxia-inducible factors Mol. Interv. 2 2002 229 243
11. C. Michiels, E. Minet, D. Mottet, and M. Raes Regulation of gene expression by oxygen: NF-κB and HIF-1, two extremes Free Radic. Biol. Med. 33 2002 1231 1242
12. P.H. Maxwell HIF-1's relationship to oxygen: simple yet sophisticated Cell Cycle 3 2004 156 159
13. P. Maxwell, and K. Salnikow HIF-1: an oxygen and metal responsive transcription factor Cancer Biol. Ther. 3 2004 29 35
14. J.W. Lee, S.H. Bae, J.W. Jeong, S.H. Kim, and K.W. Kim Hypoxia-inducible factor (HIF-1)α: its protein stability and biological functions Exp. Mol. Med. 36 2004 1 12
15. C.P. Bracken, M.L. Whitelaw, and D.J. Peet The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses Cell. Mol. Life Sci. 60 2003 1376 1393
16. 2-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm EMBO Rep. 2 2001 615 620
17. B.H. Jiang, E. Rue, G.L. Wang, R. Roe, and G.L. Semenza Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1 J. Biol. Chem. 271 1996 17771 17778
18. C.M. Wiener, G. Booth, and G.L. Semenza In vivo expression of mRNAs encoding hypoxia-inducible factor 1 Biochem. Biophys. Res. Commun. 225 1996 485 488
19. D. Mukhopadhyay, and K. Datta Multiple regulatory pathways of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in tumors Semin. Cancer Biol. 14 2004 123 130
20. P.B. Freeburg, and D.R. Abrahamson Hypoxia-inducible factors and kidney vascular development J. Am. Soc. Nephrol. 14 2003 2723 2730
21. V.R. Gordeuk, A.I. Sergueeva, G.Y. Miasnikova, D. Okhotin, Y. Voloshin, and P.L. Choyke Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors Blood 103 2004 3924 3932
22. G.L. Semenza Angiogenesis in ischemic and neoplastic disorders Annu. Rev. Med. 54 2003 17 28
23. G.L. Semenza HIF-1: mediator of physiological and pathophysiological responses to hypoxia J. Appl. Physiol. 88 2000 1474 1480
24. 2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1 J. Appl. Physiol. 96 2004 1173 1177
25. M.L. Fung Hypoxia-inducible factor-1: a molecular hint of physiological changes in the carotid body during long-term hypoxemia? Curr. Drug Targets Cardiovasc. Haematol. Disord. 3 2003 254 259
26. M.C. Simon Siah proteins, HIF prolyl hydroxylases, and the physiological response to hypoxia Cell 117 2004 851 853
27. K. Seta, H.W. Kim, T. Ferguson, R. Kim, P. Pathrose, and Y. Yuan Genomic and physiological analysis of oxygen sensitivity and hypoxia tolerance in PC12 cells Ann. N. Y. Acad. Sci. 971 2002 379 388
28. G. Hopfl, O. Ogunshola, and M. Gassmann HIFs and tumors: causes and consequences Am. J. Physiol. Regul. Integr. Comp. Physiol. 286 2004 R608 R623
29. G.S. Ralph, S. Parham, S.R. Lee, G.L. Beard, M.H. Craigon, and N. Ward Identification of potential stroke targets by lentiviral vector mediated overexpression of HIF-1α and HIF-2α in a primary neuronal model of hypoxia J. Cereb. Blood Flow. Metab. 24 2004 245 258
30. J.H. Distler, R.H. Wenger, M. Gassmann, M. Kurowska, A. Hirth, and S. Gay Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis Arthritis Rheum. 50 2004 10 23
31. C. Rosenberger, W. Griethe, G. Gruber, M. Wiesener, U. Frei, and S. Bachmann Cellular responses to hypoxia after renal segmental infarction Kidney Int. 64 2003 874 886
32. Z. Cai, D.J. Manalo, G. Wei, E.R. Rodriguez, K. Fox-Talbot, and H. Lu Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury Circulation 108 2003 79 85
33. N.G. Bazan, R. Palacios-Pelaez, and W.J. Lukiw Hypoxia signaling to genes: significance in Alzheimer's disease Mol. Neurobiol. 26 2002 283 298
34. T. Acker, and K.H. Plate A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology J. Mol. Med. 80 2002 562 575
35. J.J. Haddad Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors Cell. Signal. 14 2002 879 897
36. 2 tension Proc. Natl. Acad. Sci. U. S. A. 92 1995 5510 5514
37. R.J. Kewley, M.L. Whitelaw, and A. Chapman-Smith The mammalian basic helix-loop-helix/PAS family of transcriptional regulators Int. J. Biochem. Cell. Biol. 36 2004 189 204
38. M.S. Wiesener, H. Turley, W.E. Allen, C. Willam, K.U. Eckardt, and K.L. Talks Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1α Blood 92 1998 2260 2268
39. N.C. Bacon, P. Wappner, J.F. O'Rourke, S.M. Bartlett, B. Shilo, and C.W. Pugh Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1α Biochem. Biophys. Res. Commun. 249 1998 811 816
40. G.L. Semenza, F. Agani, G. Booth, J. Forsythe, N. Iyer, and B.H. Jiang Structural and functional analysis of hypoxia-inducible factor 1 Kidney Int. 51 1997 553 555
41. M. Gassmann, D. Chilov, and R.H. Wenger Regulation of the hypoxia-inducible factor-1α. ARNT is not necessary for hypoxic induction of HIF-1α in the nucleus Adv. Exp. Med. Biol. 475 2000 87 99
42. G. Drutel, M. Kathmann, A. Heron, C. Gros, S. Mace, and J.C. Schwartz Two splice variants of the hypoxia-inducible factor HIF-1α as potential dimerization partners of ARNT2 in neurons Eur. J. Neurosci. 12 2000 3701 3708
43. J.S. Isaacs, Y.J. Jung, and L. Neckers Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1α by modulating an Hsp90-dependent regulatory pathway J. Biol. Chem. 279 2004 16128 16135
44. D. Chilov, G. Camenisch, I. Kvietikova, U. Ziegler, M. Gassmann, and R.H. Wenger Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1α J. Cell Sci. 112 1999 1203 1212
45. T. Hofer, I. Desbaillets, G. Hopfl, R.H. Wenger, and M. Gassmann Characterization of HIF-1α overexpressing HeLa cells and implications for gene therapy Comp. Biochem. Physiol. C Toxicol. Pharmacol. 133 2002 475 481
46. O. Aprelikova, G.V. Chandramouli, M. Wood, J.R. Vasselli, J. Riss, and J.K. Maranchie Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors J. Cell. Biochem. 92 2004 491 501
47. H.M. Sowter, R.R. Raval, J.W. Moore, P.J. Ratcliffe, and A.L. Harris Predominant role of hypoxia-inducible transcription factor (HIF)-1α versus HIF-2α in regulation of the transcriptional response to hypoxia Cancer Res. 63 2003 6130 6134
48. P.H. Maxwell, and P.J. Ratcliffe Oxygen sensors and angiogenesis Semin. Cell Dev. Biol. 13 2002 29 37
49. M.A. Maynard, H. Qi, J. Chung, E.H. Lee, Y. Kondo, and S. Hara Multiple splice variants of the human HIF-3α locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex J. Biol. Chem. 278 2003 11032 11040
50. R.H. Wenger, A. Rolfs, H.H. Marti, J.L. Guenet, and M. Gassmann Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1α Biochem. Biophys. Res. Commun. 223 1996 54 59
51. G. Luo, Y.Z. Gu, S. Jain, W.K. Chan, K.M. Carr, and J.B. Hogenesch Molecular characterization of the murine HIF-1α locus Gene Exp. 6 1997 287 299
52. A. Madan, S. Varma, and H.J. Cohen Developmental stage-specific expression of the α and β subunits of the HIF-1 protein in the mouse and human fetus Mol. Genet. Metab. 75 2002 244 249
53. K.F. Wagner, A.K. Hellberg, S. Balenger, R. Depping, J. Dodd-O, and R.A. Johns Hypoxia-induced mitogenic factor has antiapoptotic action and is upregulated in the developing lung: coexpression with hypoxia-inducible factor-2α Am. J. Respir. Cell Mol. Biol. 31 2004 276 282
54. G.S. Ralph, S. Parham, S.R. Lee, G.L. Beard, M.H. Craigon, and N. Ward Identification of potential stroke targets by lentiviral vector mediated overexpression of HIF-1α and HIF-2α in a primary neuronal model of hypoxia J. Cereb. Blood Flow. Metab. 24 2004 245 258
55. P.B. Freeburg, B. Robert, P.L. St John, and D.R. Abrahamson Podocyte expression of hypoxia-inducible factor (HIF)-1 and HIF-2 during glomerular development J. Am. Soc. Nephrol. 14 2003 927 938
56. M.S. Wiesener, J.S. Jurgensen, C. Rosenberger, C.K. Scholze, J.H. Horstrup, and C. Warnecke Widespread hypoxia-inducible expression of HIF-2α in distinct cell populations of different organs FASEB J. 17 2003 271 273
57. M.A. Maynard, H. Qi, J. Chung, E.H. Lee, Y. Kondo, and S. Hara Multiple splice variants of the human HIF-3α locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex J. Biol. Chem. 278 2003 11032 11040
58. S. Takahata, K. Sogawa, A. Kobayashi, M. Ema, J. Mimura, and N. Ozaki Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1α, HLF, and clock Biochem. Biophys. Res. Commun. 248 1998 789 794
59. M. Korkalainen, J. Tuomisto, and R. Pohjanvirta Identification of novel splice variants of ARNT and ARNT2 in the rat Biochem. Biophys. Res. Commun. 303 2003 1095 1100
60. M.H. Aitola, and M.T. Pelto-Huikko Expression of Arnt and Arnt2 mRNA in developing murine tissues J. Histochem. Cytochem. 51 2003 41 54
61. G.L. Semenza Oxygen-regulated transcription factors and their role in pulmonary disease. Oxygen-regulated transcription factors and their role in pulmonary disease Respir. Res. 1 2000 159 162
62. G.L. Semenza HIF-1 and tumor progression: pathophysiology and therapeutics Trends Mol. Med. 8 2002 S62 S67
63. M.S. Wiesener, J.S. Jurgensen, C. Rosenberger, C.K. Scholze, J.H. Horstrup, and C. Warnecke Widespread hypoxia-inducible expression of HIF-2α in distinct cell populations of different organs FASEB J. 17 2003 271 273
64. 2-evoked regulation of HIF-1α and NF-κB in perinatal lung epithelium requires glutathione biosynthesis Am. J. Physiol. Lung Cell. Mol. Physiol. 278 2000 L492 L503
65. J.J. Haddad, R.E. Olver, and S.C. Land Antioxidant/pro-oxidant equilibrium regulates HIF-1α and NF-κB redox sensitivity: evidence for inhibition by glutathione oxidation in alveolar epithelial cells J. Biol. Chem. 275 2000 21130 21139
66. J.H. Marxsen, P. Stengel, K. Doege, P. Heikkinen, T. Jokilehto, and T. Wagner Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4-hydroxylases Biochem. J. 381 2004 761 767
67. Y. Kageyama, M. Koshiji, K.K. To, Y.M. Tian, P.J. Ratcliffe, and L.E. Huang Leu-574 of human HIF-1α is a molecular determinant of prolyl hydroxylation FASEB J. 18 2004 1028 1030
68. P. Koivunen, M. Hirsila, V. Gunzler, K.I. Kivirikko, and J. Myllyharju Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases J. Biol. Chem. 279 2004 9899 9904
69. K. Mekhail, L. Gunaratnam, M.E. Bonicalzi, and S. Lee HIF activation by pH-dependent nucleolar sequestration of VHL Nat. Cell Biol. 6 2004 642 647
70. M.F. Czyzyk-Krzeska, and J. Meller von Hippel-Lindau tumor suppressor: not only HIF's executioner Trends Mol. Med. 10 2004 146 149
71. S. Turcotte, R.R. Desrosiers, and R. Beliveau Hypoxia upregulates von Hippel-Lindau tumor-suppressor protein through RhoA-dependent activity in renal cell carcinoma Am. J. Physiol. Renal. Physiol. 286 2004 F338 F348
72. E. Metzen, J. Zhou, W. Jelkmann, J. Fandrey, and B. Brune Nitric oxide impairs normoxic degradation of HIF-1α by inhibition of prolyl hydroxylases Mol. Biol. Cell 14 2003 3470 3481
73. E. Berra, E. Benizri, A. Ginouves, V. Volmat, D. Roux, and J. Pouyssegur HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia EMBO J. 22 2003 4082 4090
74. G. D'Angelo, E. Duplan, N. Boyer, P. Vigne, and C. Frelin Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation J. Biol. Chem. 278 2003 38183 38187
75. 2 levels J. Cell Sci. 116 2003 3041 3049
76. Z. Li, D. Wang, X. Na, S.R. Schoen, E.M. Messing, and G. Wu The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1α transcriptional activity EMBO J. 22 2003 1857 1867
77. P.O. Schnell, M.L. Ignacak, A.L. Bauer, J.B. Striet, W.R. Paulding, and M.F. Czyzyk-Krzeska Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors J. Neurochem. 85 2003 483 491
78. A.V. Kuznetsova, J. Meller, P.O. Schnell, J.A. Nash, M.L. Ignacak, and Y. Sanchez von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination Proc. Natl. Acad. Sci. U. S. A. 100 2003 2706 2711
79. C.W. Pugh, and P.J. Ratcliffe The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis Semin. Cancer Biol. 13 2003 83 89
80. W. Kim, and W.G. Kaelin Jr. The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer Curr. Opin. Genet. Dev. 13 2003 55 60
81. G. D'Angelo, E. Duplan, P. Vigne, and C. Frelin Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1α Pro-564 hydroxylation J. Biol. Chem. 278 2003 15406 15411
82. M. Ivan, T. Haberberger, D.C. Gervasi, K.S. Michelson, V. Gunzler, and K. Kondo Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor Proc. Natl. Acad. Sci. U. S. A. 99 2002 13459 13464
83. S.M. Baby, A. Roy, A.M. Mokashi, and S. Lahiri Effects of hypoxia and intracellular iron chelation on hypoxia-inducible factor-1α and -1β in the rat carotid body and glomus cells Histochem. Cell Biol. 120 2003 343 352
84. D.I. Yang, S.D. Chen, Y.T. Yang, T.C. Ju, J.M. Xu, and C.Y. Hsu Carbamoylating chemoresistance induced by cobalt pretreatment in C6 glioma cells: putative roles of hypoxia-inducible factor-1 Br. J. Pharmacol. 141 2004 988 996
85. Y. Yuan, D. Beitner-Johnson, and D.E. Millhorn Hypoxia-inducible factor 2α binds to cobalt in vitro Biochem. Biophys. Res. Commun. 288 2001 849 854
86. J. Zhao, H. Chen, T. Davidson, T. Kluz, Q. Zhang, and M. Costa Nickel-induced 1,4-α-glucan branching enzyme 1 up-regulation via the hypoxic signaling pathway Toxicol. Appl. Pharmacol. 196 2004 404 409
87. G.L. Semenza, B.H. Jiang, S.W. Leung, R. Passantino, J.P. Concordet, and P. Maire Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1 J. Biol. Chem. 271 1996 32529 32537
88. G. Ambrosini, A.K. Nath, M.R. Sierra-Honigmann, and J. Flores-Riveros Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1 J. Biol. Chem. 277 2002 34601 34609
89. C. Peyssonaux, and R.S. Johnson An unexpected role for hypoxic response: oxygenation and inflammation Cell Cycle 3 2 2004 (Feb) 168 171
90. T. Kong, H.K. Eltzschig, J. Karhausen, S.P. Colgan, and C.S. Shelley Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of β2 integrin gene expression Proc. Natl. Acad. Sci. U. S. A. 101 2004 10440 10445
91. D.E. Komatsu, and M. Hadjiargyrou Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair Bone 34 2004 680 688
92. J.W. Park, Y.S. Chun, and M.S. Kim Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools J. Pharmacol. Sci. 94 2004 221 232
93. Q. Liu, U. Berchner-Pfannschmidt, U. Moller, M. Brecht, C. Wotzlaw, and H. Acker A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression Proc. Natl. Acad. Sci. U. S. A. 101 2004 4302 4307
94. C.J. Hu, L.Y. Wang, L.A. Chodosh, B. Keith, and M.C. Simon Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation Mol. Cell. Biol. 23 2003 9361 9374
95. T. Cramer, and R.S. Johnson A novel role for the hypoxia inducible transcription factor HIF-1α: critical regulation of inflammatory cell function Cell Cycle 2 2003 192 193
96. H. Kojima, M.V. Sitkovsky, and M. Cascalho HIF-1α deficiency perturbs T and B cell functions Curr. Pharm. Des. 9 2003 1827 1832
97. Y. Makino, H. Nakamura, E. Ikeda, K. Ohnuma, K. Yamauchi, and Y. Yabe Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells J. Immunol. 171 2003 6534 6540
98. J.J. Haddad Science review: redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for hypoxia-inducible factor-1α Crit. Care 7 2003 47 54
99. C. Madjdpour, U.R. Jewell, S. Kneller, U. Ziegler, R. Schwendener, and C. Booy Decreased alveolar oxygen induces lung inflammation Am. J. Physiol. Lung Cell. Mol. Physiol. 284 2003 L360 L367
100. H.J. Kim, K.J. Jung, B.P. Yu, C.G. Cho, J.S. Choi, and H.Y. Chung Modulation of redox-sensitive transcription factors by calorie restriction during aging Mech. Ageing Dev. 123 2002 1589 1595
101. Y. Jung, J.S. Isaacs, S. Lee, J. Trepel, Z.G. Liu, and L. Neckers Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor-κB activation Biochem. J. 370 2003 1011 1017
102. Y.J. Jung, J.S. Isaacs, S. Lee, J. Trepel, and L. Neckers IL-1β-mediated up-regulation of HIF-1α via an NF-κB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis FASEB J. 17 2003 2115 2117
103. D.W. Gilroy, T. Lawrence, M. Perretti, and A.G. Rossi Inflammatory resolution: new opportunities for drug discovery Nat. Rev. Drug Discov. 3 2004 401 416
104. W. Vanden Berghe, L. Vermeulen, P. Delerive, K. De Bosscher, B. Staels, and G. Haegeman A paradigm for gene regulation: inflammation, NF-κB and PPAR Adv. Exp. Med. Biol. 544 2003 181 196
105. T. Hellwig-Burgel, K. Rutkowski, E. Metzen, J. Fandrey, and W. Jelkmann Interleukin-1β and tumor necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1 Blood 94 1999 1561 1567
106. R.D. Thornton, P. Lane, R.C. Borghaei, E.A. Pease, J. Caro, and E. Mochan Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts Biochem. J. 350 2000 307 312
107. K.B. Sandau, J. Zhou, T. Kietzmann, and B. Brune Regulation of the hypoxia-inducible factor 1α by the inflammatory mediators nitric oxide and tumor necrosis factor-α in contrast to desferroxamine and phenylarsine oxide J. Biol. Chem. 276 2001 39805 39811
108. J.J. Haddad, and S.C. Land A non-hypoxic, ROS-sensitive pathway mediates TNF-α-dependent regulation of HIF-1α FEBS Lett. 505 2001 269 274
109. D.A. Elson, G. Thurston, L.E. Huang, D.G. Ginzinger, D.M. McDonald, and R.S. Johnson Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α Genes Dev. 15 2001 2520 2532
110. J.E. Albina, B. Mastrofrancesco, J.A. Vessella, C.A. Louis, W.L. Henry Jr., and J.S. Reichner HIF-1 expression in healing wounds: HIF-1α induction in primary inflammatory cells by TNF-α Am. J. Physiol. Cell Physiol. 281 2001 C1971 C1977
111. K.I. Mecklenburgh, S.R. Walmsley, A.S. Cowburn, M. Wiesener, B.J. Reed, and P.D. Upton Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis Blood 100 2002 3008 3016
112. T. Cramer, Y. Yamanishi, B.E. Clausen, I. Forster, R. Pawlinski, and N. Mackman HIF-1α is essential for myeloid cell-mediated inflammation Cell 112 2003 645 657
113. C.C. Blouin, E.L. Page, G.M. Soucy, and D.E. Richard Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1α Blood 103 2004 1124 1130
114. C.K. Mukhopadhyay, B. Mazumder, and P.L. Fox Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency J. Biol. Chem. 275 2000 21048 21054
115. K.B. Sandau, H.G. Faus, and B. Brune Induction of hypoxia-inducible- factor 1 by nitric oxide is mediated via the PI 3K pathway Biochem. Biophys. Res. Commun. 278 2000 263 267
116. K.B. Sandau, J. Fandrey, and B. Brune Accumulation of HIF-1α under the influence of nitric oxide Blood 97 2001 1009 1015
117. C. Hierholzer, and T.R. Billiar Molecular mechanisms in the early phase of hemorrhagic shock Langenbecks Arch. Surg. 386 2001 302 308
118. J. Qian, K. Ramroop, A. McLeod, P. Bandari, D.H. Livingston, and J.S. Harrison Induction of hypoxia-inducible factor-1α and activation of caspase-3 in hypoxia-reoxygenated bone marrow stroma is negatively regulated by the delayed production of substance P J. Immunol. 167 2001 4600 4608
119. D. Lukashev, C. Caldwell, A. Ohta, P. Chen, and M. Sitkovsky Differential regulation of two alternatively spliced isoforms of hypoxia-inducible factor-1α in activated T lymphocytes J. Biol. Chem. 276 2001 48754 48763
120. Y. Makino, H. Nakamura, E. Ikeda, K. Ohnuma, K. Yamauchi, and Y. Yabe Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells J. Immunol. 171 2003 6534 6540
121. J.D. Vogel, G.A. West, S. Danese, C. De La Motte, M.H. Phillips, and S.A. Strong CD40-mediated immune-nonimmune cell interactions induce mucosal fibroblast chemokines leading to T-cell transmigration Gastroenterology 126 2004 63 80
122. G. Melillo HIF-1: a target for cancer, ischemia and inflammation-too good to be true? Cell Cycle 3 2004 154 155
123. N.G. Bazan, and W.J. Lukiw Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1β and amyloid β 42 peptide is potentiated by hypoxia in primary human neural cells J. Biol. Chem. 277 2002 30359 30367
124. C.L. Peters, C.J. Morris, P.I. Mapp, D.R. Blake, C.E. Lewis, and V.R. Winrow The transcription factors hypoxia-inducible factor 1α and Ets-1 colocalize in the hypoxic synovium of inflamed joints in adjuvant-induced arthritis Arthritis Rheum. 50 2004 291 296
125. S.W. French The role of hypoxia in the pathogenesis of alcoholic liver disease Hepatol. Res. 29 2004 69 74
126. P. Hofman Molecular regulation of neutrophil apoptosis and potential targets for therapeutic strategy against the inflammatory process Curr. Drug Targets Inflamm. Allergy 3 2004 1 9
127. N.A. Maianski, A.N. Maianski, T.W. Kuijpers, and D. Roos Apoptosis of neutrophils Acta Haematol. 111 2004 56 66
128. M. Yamakawa, L.X. Liu, T. Date, A.J. Belanger, K.A. Vincent, and G.Y. Akita Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors Circ. Res. 93 2003 664 673
129. B. El Awad, B. Kreft, E.M. Wolber, T. Hellwig-Burgel, E. Metzen, and J. Fandrey Hypoxia and interleukin-1β stimulate vascular endothelial growth factor production in human proximal tubular cells Kidney Int. 58 2000 43 50
130. D.P. Stiehl, W. Jelkmann, R.H. Wenger, and T. Hellwig-Burgel Normoxic induction of the hypoxia-inducible factor 1α by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway FEBS Lett. 512 2002 157 162
131. J.J. Haddad Recombinant human interleukin (IL)-1β-mediated regulation of hypoxia-inducible factor-1α (HIF-1α) stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism Eur. Cytokine Netw. 13 2002 250 260
132. D. Qian, H.Y. Lin, H.M. Wang, X. Zhang, D.L. Liu, and Q.L. Li Normoxic induction of the hypoxic-inducible factor-1α by interleukin-1β involves the extracellular signal-regulated kinase 1/2 pathway in normal human cytotrophoblast cells Biol. Reprod. 70 2004 1822 1827
133. K. Amano, M. Okigaki, Y. Adachi, S. Fujiyama, Y. Mori, and A. Kosaki Mechanism for IL-1β-mediated neovascularization unmasked by IL-1β knock-out mice J. Mol. Cell. Cardiol. 36 2004 469 480
134. C.C. Caldwell, H. Kojima, D. Lukashev, J. Armstrong, M. Farber, and S.G. Apasov Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions J. Immunol. 167 2001 6140 6149
135. J.A. Sosman Targeting of the VHL-hypoxia-inducible factor-hypoxia-induced gene pathway for renal cell carcinoma therapy J. Am. Soc. Nephrol. 14 2003 2695 2702
136. G. Ruiz-Deya, S.C. Sikka, R. Thomas, and A.B. Abdel-Mageed Potential role for the nuclear transcription factor NF-κB in the pathogenesis of ureteropelvic junction obstruction J. Endourol. 16 2002 611 615
137. H.J. Jeong, H.S. Chung, B.R. Lee, S.J. Kim, S.J. Yoo, and S.H. Hong Expression of proinflammatory cytokines via HIF-1α and NF-κB activation on desferrioxamine-stimulated HMC-1 cells Biochem. Biophys. Res. Commun. 306 2003 805 811
138. N. Hirani, F. Antonicelli, R.M. Strieter, M.S. Wiesener, P.J. Ratcliffe, and C. Haslett The regulation of interleukin-8 by hypoxia in human macrophages: a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS) Mol. Med. 7 2001 685 697
139. A.P. Berger, K. Kofler, J. Bektic, H. Rogatsch, H. Steiner, and G. Bartsch Increased growth factor production in a human prostatic stromal cell culture model caused by hypoxia Prostate 57 2003 57 65
140. M. Fishman, J. Seigne, and S. Antonia Novel therapies for renal cell carcinoma Expert. Opin. Investig. Drugs 10 2001 1033 1044
141. H. Kuniyasu, Y. Chihara, and H. Kondo A role of histone H4 hypoacetylation in vascular endothelial growth factor expression in colon mucosa adjacent to implanted cancer in athymic mice cecum Pathobiology 70 2002-2003 348 352
142. E. Ohga, and T. Matsuse The relationship between adhesion molecules and hypoxia Nippon Rinsho 58 2000 1587 1591
143. J.L. Hall, X. Wang, V. Adamson, Y. Zhao, and G.H. Gibbons Overexpression of Ref-1 inhibits hypoxia and tumor necrosis factor-induced endothelial cell apoptosis through nuclear factor-κB-independent and -dependent pathways Circ. Res. 88 2001 1247 1253
144. T. Hehlgans, C. Seitz, C. Lewis, and D.N. Mannel Hypoxic upregulation of TNF receptor type 2 expression involves NF-IL-6 and is independent of HIF-1 or HIF-2 J. Interferon Cytokine Res. 21 2001 757 762
145. C. Akgul, and S.W. Edwards Regulation of neutrophil apoptosis via death receptors Cell. Mol. Life Sci. 60 2003 2402 2408
146. P.S. Patel, S. Yang, A. Li, M.L. Varney, and R.K. Singh Capsaicin regulates vascular endothelial cell growth factor expression by modulation of hypoxia inducing factor-1α in human malignant melanoma cells J. Cancer Res. Clin. Oncol. 128 2002 461 468
147. J. Zhou, T. Schmid, and B. Brune Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1α through a nuclear factor-κB-dependent pathway Mol. Biol. Cell 14 2003 2216 2225
148. J.J. Haddad, N.E. Saadé, and B. Safieh-Garabedian Interleukin-10 and the regulation of mitogen-activated protein kinases: are these signalling modules targets for the anti-inflammatory action of this cytokine? Cell. Signal. 15 2003 255 267
149. J.J. Haddad Mitogen-activated protein kinases and the evolution of Alzheimer's: a revolutionary neurogenetic axis for therapeutic intervention? Prog. Neurobiol. 73 2004 359 377
150. P.P. Roux, and J. Blenis ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions Microbiol. Mol. Biol. Rev. 68 2004 320 344
151. S. Boldt, and W. Kolch Targeting MAPK signalling: Prometheus' fire or Pandora's box? Curr. Pharm. Des. 10 2004 1885 1905
152. C. Waters, S. Pyne, and N.J. Pyne The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction Semin. Cell Dev. Biol. 15 2004 309 323
153. T. Wada, and J.M. Penninger Mitogen-activated protein kinases in apoptosis regulation Oncogene 23 2004 2838 2849
154. S. Ory, and D.K. Morrison Signal transduction: implications for Ras-dependent ERK signaling Curr. Biol. 14 2004 R277 R278
155. M.A. Bogoyevitch, I. Boehm, A. Oakley, A.J. Ketterman, and R.K. Barr Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential Biochim. Biophys. Acta 1697 2004 89 101
156. S.V. Kyosseva Mitogen-activated protein kinase signaling Int. Rev. Neurobiol. 59 2004 201 220
157. H. Rubinfeld, and R. Seger The ERK cascade as a prototype of MAPK signaling pathways Methods Mol. Biol. 250 2004 1 28
158. E. Minet, G. Michel, D. Mottet, M. Raes, and C. Michiels Transduction pathways involved in hypoxia-inducible factor-1 phosphorylation and activation Free Radic. Biol. Med. 31 2001 847 855
159. A. Sodhi, S. Montaner, V. Patel, M. Zohar, C. Bais, and E.A. Mesri The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1α Cancer Res. 60 2000 4873 4880
160. L. Tacchini, P. Dansi, E. Matteucci, and M.A. Desiderio Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells Carcinogenesis 22 2001 1363 1371
161. V. Poulaki, W. Qin, A.M. Joussen, P. Hurlbut, S.J. Wiegand, and J. Rudge Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1α and VEGF J. Clin. Invest. 109 2002 805 815
162. E.A. Sheta, H. Trout, J.J. Gildea, M.A. Harding, and D. Theodorescu Cell density mediated pericellular hypoxia leads to induction of HIF-1α via nitric oxide and Ras/MAP kinase mediated signaling pathways Oncogene 20 2001 7624 7634
163. B. Shemirani, and D.L. Crowe Hypoxic induction of HIF-1α and VEGF expression in head and neck squamous cell carcinoma lines is mediated by stress activated protein kinases Oral. Oncol. 38 2002 251 257
164. N. Gao, B.H. Jiang, S.S. Leonard, L. Corum, Z. Zhang, and J.R. Roberts p38 Signaling-mediated hypoxia-inducible factor 1α and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cells J. Biol. Chem. 277 2002 45041 45048
165. M.C. Duyndam, S.T. Hulscher, E. van der Wall, H.M. Pinedo, and E. Boven Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite J. Biol. Chem. 278 2003 6885 6895
166. C. Gomez-Manzano, J. Fueyo, H. Jiang, T.L. Glass, H.Y. Lee, and M. Hu Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis Ann. Neurol. 53 2003 109 117
167. T. Kietzmann, K. Jungermann, and A. Gorlach Regulation of the hypoxia-dependent plasminogen activator inhibitor 1 expression by MAP kinases Thromb. Haemost. 89 2003 666 673
168. C. Liu, Y. Shi, Z. Han, Y. Pan, N. Liu, and S. Han Suppression of the dual-specificity phosphatase MKP-1 enhances HIF-1 trans-activation and increases expression of EPO Biochem. Biophys. Res. Commun. 312 2003 780 786
169. K. Furuichi, T. Wada, H. Yokoyama, and K.I. Kobayashi Role of cytokines and chemokines in renal ischemia-reperfusion injury Drug News Perspect. 15 2002 477 482
170. J.D. Vogel, G.A. West, S. Danese, C. De La Motte, M.H. Phillips, and S.A. Strong CD40-mediated immune-nonimmune cell interactions induce mucosal fibroblast chemokines leading to T-cell transmigration Gastroenterology 126 2004 63 80
171. D.E. Richard, E. Berra, E. Gothie, D. Roux, and J. Pouyssegur p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1 J. Biol. Chem. 274 1999 32631 32637
172. G. Pages, J. Milanini, D.E. Richard, E. Berra, E. Gothie, and F. Vinals Signaling angiogenesis via p42/p44 MAP kinase cascade Ann. N. Y. Acad. Sci. 902 2000 187 200
173. E. Berra, J. Milanini, D.E. Richard, M. Le Gall, F. Vinals, and E. Gothie Signaling angiogenesis via p42/p44 MAP kinase and hypoxia Biochem. Pharmacol. 60 2000 1171 1178
174. E. Berra, G. Pages, and J. Pouyssegur MAP kinases and hypoxia in the control of VEGF expression Cancer Metastasis Rev. 19 2000 139 145
175. E. Berra, D.E. Richard, E. Gothie, and J. Pouyssegur HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1α degradation FEBS Lett. 491 2001 85 90
176. E. Hur, K.Y. Chang, E. Lee, S.K. Lee, and H. Park Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1α Mol. Pharmacol. 59 2001 1216 1224
177. V. Volmat, M. Camps, S. Arkinstall, J. Pouyssegur, and P. Lenormand The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases J. Cell Sci. 114 2001 3433 3443
178. E. Lee, S. Yim, S.K. Lee, and H. Park Two transactivation domains of hypoxia-inducible factor-1α regulated by the MEK-1/p42/p44 MAPK pathway Mol. Cells 14 2002 9 15
179. Y.G. Yoo, S.H. Oh, E.S. Park, H. Cho, N. Lee, and H. Park Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1α through activation of mitogen-activated protein kinase pathway J. Biol. Chem. 278 2003 39076 39084
180. X. Liu, X. Wu, L. Cai, C. Tang, and J. Su Hypoxic preconditioning of cardiomyocytes and cardioprotection: phosphorylation of HIF-1α induced by p42/p44 mitogen-activated protein kinases is involved Pathophysiology 9 2003 201 205
181. A. Alfranca, M.D. Gutierrez, A. Vara, J. Aragones, F. Vidal, and M.O. Landazuri c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription Mol. Cell. Biol. 22 2002 12 22
182. R.S. Bandyopadhyay, M. Phelan, and D.V. Faller Hypoxia induces AP-1-regulated genes and AP-1 transcription factor binding in human endothelial and other cell types Biochim. Biophys. Acta 1264 1995 72 78
183. C. Michiels, E. Minet, G. Michel, D. Mottet, J.P. Piret, and M. Raes HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases IUBMB Life 52 2001 49 53
184. V. Poulaki, C.S. Mitsiades, C. McMullan, D. Sykoutri, G. Fanourakis, and V. Kotoula Regulation of vascular endothelial growth factor expression by insulin-like growth factor I in thyroid carcinomas J. Clin. Endocrinol. Metab. 88 2003 5392 5398
185. K.R. Laderoute, J.M. Calaoagan, M. Knapp, and R.S. Johnson Glucose utilization is essential for hypoxia-inducible factor 1α-dependent phosphorylation of c-Jun Mol. Cell. Biol. 24 2004 4128 4137
186. V. Poulaki, A.M. Joussen, N. Mitsiades, C.S. Mitsiades, E.F. Iliaki, and A.P. Adamis Insulin-like growth factor-I plays a pathogenetic role in diabetic retinopathy Am. J. Pathol. 165 2004 457 469
187. A. Sodhi, S. Montaner, H. Miyazaki, and J.S. Gutkind MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1α in rasV12 upregulation of VEGF Biochem. Biophys. Res. Commun. 287 2001 292 300
188. C. Treins, S. Giorgetti-Peraldi, J. Murdaca, G.L. Semenza, and E. Van Obberghen Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway J. Biol. Chem. 277 2002 27975 27981
189. 2 induces hypoxia-inducible factor-1α stabilization and nuclear localization in a human prostate cancer cell line J. Biol. Chem. 277 2002 50081 50086
190. J.I. Bardos, and M. Ashcroft Hypoxia-inducible factor-1 and oncogenic signalling Bioessays 26 2004 262 269
191. Y.H. Shi, and W.G. Fang Hypoxia-inducible factor-1 in tumour angiogenesis World J. Gastroenterol. 10 2004 1082 1087
192. A.O. Fedele, M.L. Whitelaw, and D.J. Peet Regulation of gene expression by the hypoxia-inducible factors Mol. Interv. 2 2002 229 243