메뉴 건너뛰기




Volumn 60, Issue 8, 2000, Pages 1171-1178

Signaling angiogenesis via p42/p44 MAP kinase and hypoxia

Author keywords

Angiogenesis; Apoptosis; HIF 1; Hypoxia; p42 p44 MAP kinases; VEGF promoter

Indexed keywords

ESTRADIOL; HYPOXIA INDUCIBLE FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

EID: 0034668187     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00423-8     Document Type: Article
Times cited : (184)

References (58)
  • 1
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst. 82:1990;4-6.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 4-6
    • Folkman, J.1
  • 2
    • 0026639806 scopus 로고
    • Angiogenesis
    • Folkman J., Shing Y. Angiogenesis. J Biol Chem. 267:1992;10931-10934.
    • (1992) J Biol Chem , vol.267 , pp. 10931-10934
    • Folkman, J.1    Shing, Y.2
  • 3
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1:1995;27-31.
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 4
    • 0028939826 scopus 로고
    • Clinical importance of the determination of tumor angiogenesis in breast carcinoma: Much more than a new prognostic tool
    • Gasparini G., Harris A.L. Clinical importance of the determination of tumor angiogenesis in breast carcinoma Much more than a new prognostic tool. J Clin Oncol. 13:1995;765-782.
    • (1995) J Clin Oncol , vol.13 , pp. 765-782
    • Gasparini, G.1    Harris, A.L.2
  • 5
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung D.W., Cachianes G., Kuang W.J., Goeddel D.V., Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 246:1989;1306-1309.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 6
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W. Mechanisms of angiogenesis. Nature. 386:1997;671-674.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 7
    • 0025999033 scopus 로고
    • The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon Sp1icing
    • Tischer E., Mitchell R., Hartman T., Silva M., Gospodarowicz D., Fiddes J.C., Abraham J.A. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon Sp1icing. J Biol Chem. 266:1991;11947-11954.
    • (1991) J Biol Chem , vol.266 , pp. 11947-11954
    • Tischer, E.1    Mitchell, R.2    Hartman, T.3    Silva, M.4    Gospodarowicz, D.5    Fiddes, J.C.6    Abraham, J.A.7
  • 8
    • 0027104066 scopus 로고
    • Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors
    • Berse B., Brown L.F., Van de Water L., Dvorak H.F., Senger D.R. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol Biol Cell. 3:1992;211-220.
    • (1992) Mol Biol Cell , vol.3 , pp. 211-220
    • Berse, B.1    Brown, L.F.2    Van De Water, L.3    Dvorak, H.F.4    Senger, D.R.5
  • 12
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong G.H., Rossant J., Gertsenstein M., Breitman M.L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature. 376:1995;66-70.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 13
    • 0029043582 scopus 로고
    • How MAP kinases are regulated
    • Cobb M.H., Goldsmith E.J. How MAP kinases are regulated. J Biol Chem. 270:1995;14843-14846.
    • (1995) J Biol Chem , vol.270 , pp. 14843-14846
    • Cobb, M.H.1    Goldsmith, E.J.2
  • 14
    • 0028825531 scopus 로고
    • Ras target proteins in eukaryotic cells
    • Marshall M.S. Ras target proteins in eukaryotic cells. FASEB J. 9:1995;1311-1318.
    • (1995) FASEB J , vol.9 , pp. 1311-1318
    • Marshall, M.S.1
  • 15
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • Seger R., Krebs E.G. The MAPK signaling cascade. FASEB J. 9:1995;726-735.
    • (1995) FASEB J , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 16
    • 0032981328 scopus 로고    scopus 로고
    • Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo
    • Waskiewicz A.J., Johnson J.C., Penn B., Mahalingam M., Kimball S.R., Cooper J.A. Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Mol Cell Biol. 19:1999;1871-1880.
    • (1999) Mol Cell Biol , vol.19 , pp. 1871-1880
    • Waskiewicz, A.J.1    Johnson, J.C.2    Penn, B.3    Mahalingam, M.4    Kimball, S.R.5    Cooper, J.A.6
  • 17
    • 0033521535 scopus 로고    scopus 로고
    • Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E
    • Pyronnet S., Imataka H., Gingras A.C., Fukunaga R., Hunter T., Sonenberg N. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J. 18:1999;270-279.
    • (1999) EMBO J , vol.18 , pp. 270-279
    • Pyronnet, S.1    Imataka, H.2    Gingras, A.C.3    Fukunaga, R.4    Hunter, T.5    Sonenberg, N.6
  • 20
    • 0027385030 scopus 로고
    • Conditional transformation of cells and rapid activation of the mitogen- activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase
    • Samuels M.L., Weber M.J., Bishop J.M., McMahon M. Conditional transformation of cells and rapid activation of the mitogen- activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase. Mol Cell Biol. 13:1993;6241-6252.
    • (1993) Mol Cell Biol , vol.13 , pp. 6241-6252
    • Samuels, M.L.1    Weber, M.J.2    Bishop, J.M.3    McMahon, M.4
  • 21
    • 0028109683 scopus 로고
    • Inhibition of platelet-derived growth factor- And epidermal growth factor-mediated mitogenesis and signaling in 3T3 cells expressing delta Raf-1:ER, an estradiol-regulated form of Raf-1
    • Samuels M.L., McMahon M. Inhibition of platelet-derived growth factor- and epidermal growth factor-mediated mitogenesis and signaling in 3T3 cells expressing delta Raf-1:ER, an estradiol-regulated form of Raf-1. Mol Cell Biol. 14:1994;7855-7866.
    • (1994) Mol Cell Biol , vol.14 , pp. 7855-7866
    • Samuels, M.L.1    McMahon, M.2
  • 22
    • 0029906339 scopus 로고    scopus 로고
    • Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway
    • Lenormand P., McMahon M., Pouysségur J. Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway. J Biol Chem. 271:1996;15762-15768.
    • (1996) J Biol Chem , vol.271 , pp. 15762-15768
    • Lenormand, P.1    McMahon, M.2    Pouysségur, J.3
  • 23
    • 0027408685 scopus 로고
    • Interference with endogenous ras function inhibits cellular responses to wounding
    • Sosnowski R.G., Feldman S., Feramisco J.R. Interference with endogenous ras function inhibits cellular responses to wounding. J Cell Biol. 121:1993;113-119.
    • (1993) J Cell Biol , vol.121 , pp. 113-119
    • Sosnowski, R.G.1    Feldman, S.2    Feramisco, J.R.3
  • 24
    • 0031466232 scopus 로고    scopus 로고
    • The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells
    • Kroll J., Waltenberger J. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem. 272:1997;32521-32527.
    • (1997) J Biol Chem , vol.272 , pp. 32521-32527
    • Kroll, J.1    Waltenberger, J.2
  • 25
    • 0030734010 scopus 로고    scopus 로고
    • P38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
    • Rousseau S., Houle F., Landry J., Huot J. p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells. Oncogene. 15:1997;2169-2177.
    • (1997) Oncogene , vol.15 , pp. 2169-2177
    • Rousseau, S.1    Houle, F.2    Landry, J.3    Huot, J.4
  • 26
    • 0031041463 scopus 로고    scopus 로고
    • Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells
    • Sexl V., Mancusi G., Holler C., Gloria-Maercker E., Schutz W., Freissmuth M. Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells. J Biol Chem. 272:1997;5792-5799.
    • (1997) J Biol Chem , vol.272 , pp. 5792-5799
    • Sexl, V.1    Mancusi, G.2    Holler, C.3    Gloria-Maercker, E.4    Schutz, W.5    Freissmuth, M.6
  • 27
    • 0032512822 scopus 로고    scopus 로고
    • Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium
    • Parenti A., Morbidelli L., Cui X.L., Douglas J.G., Hood J.D., Granger H.J., Ledda F., Ziche M. Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium. J Biol Chem. 273:1998;4220-4226.
    • (1998) J Biol Chem , vol.273 , pp. 4220-4226
    • Parenti, A.1    Morbidelli, L.2    Cui, X.L.3    Douglas, J.G.4    Hood, J.D.5    Granger, H.J.6    Ledda, F.7    Ziche, M.8
  • 28
    • 0039917633 scopus 로고    scopus 로고
    • Confluence of vascular endothelial cells induces cell cycle exit by inhibiting p42/p44 mitogen-activated protein kinase activity
    • Vinals F., Pouysségur J. Confluence of vascular endothelial cells induces cell cycle exit by inhibiting p42/p44 mitogen-activated protein kinase activity. Mol Cell Biol. 19:1999;2763-2772.
    • (1999) Mol Cell Biol , vol.19 , pp. 2763-2772
    • Vinals, F.1    Pouysségur, J.2
  • 29
    • 0028221238 scopus 로고
    • Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells
    • Pertovaara L., Kaipainen A., Mustonen T., Orpana A., Ferrara N., Saksela O., Alitalo K. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. J Biol Chem. 269:1994;6271-6274.
    • (1994) J Biol Chem , vol.269 , pp. 6271-6274
    • Pertovaara, L.1    Kaipainen, A.2    Mustonen, T.3    Orpana, A.4    Ferrara, N.5    Saksela, O.6    Alitalo, K.7
  • 30
    • 0029045246 scopus 로고
    • Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing
    • Frank S., Hubner G., Breier G., Longaker M.T., Greenhalgh D.G., Werner S. Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. J Biol Chem. 270:1995;12607-12613.
    • (1995) J Biol Chem , vol.270 , pp. 12607-12613
    • Frank, S.1    Hubner, G.2    Breier, G.3    Longaker, M.T.4    Greenhalgh, D.G.5    Werner, S.6
  • 31
    • 0028834638 scopus 로고
    • Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells
    • Grugel S., Finkenzeller G., Weindel K., Barleon B., Marme D. Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells. J Biol Chem. 270:1995;25915-25919.
    • (1995) J Biol Chem , vol.270 , pp. 25915-25919
    • Grugel, S.1    Finkenzeller, G.2    Weindel, K.3    Barleon, B.4    Marme, D.5
  • 33
    • 0031039923 scopus 로고    scopus 로고
    • Transforming growth factor-alpha-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation
    • Gille J., Swerlick R.A., Caughman S.W. Transforming growth factor-alpha-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation. EMBO J. 16:1997;750-759.
    • (1997) EMBO J , vol.16 , pp. 750-759
    • Gille, J.1    Swerlick, R.A.2    Caughman, S.W.3
  • 34
    • 0029681850 scopus 로고    scopus 로고
    • Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression
    • Mazure N.M., Chen E.Y., Yeh P., Laderoute K.R., Giaccia A.J. Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res. 56:1996;3436-3440.
    • (1996) Cancer Res , vol.56 , pp. 3436-3440
    • Mazure, N.M.1    Chen, E.Y.2    Yeh, P.3    Laderoute, K.R.4    Giaccia, A.J.5
  • 35
    • 0030869787 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element
    • Mazure N.M., Chen E.Y., Laderoute K.R., Giaccia A.J. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood. 90:1997;3322-3331.
    • (1997) Blood , vol.90 , pp. 3322-3331
    • Mazure, N.M.1    Chen, E.Y.2    Laderoute, K.R.3    Giaccia, A.J.4
  • 36
    • 0034650744 scopus 로고    scopus 로고
    • Oncogenes and tumor angiogenesis: Differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts
    • Rak J., Mitsuhashi Y., Sheehan C., Tamir A., Viloria-Petit A., Filmus J., Mansour S.J., Ahn N.G., Kerbel R.S. Oncogenes and tumor angiogenesis Differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts. Cancer Res. 60:2000;490-498.
    • (2000) Cancer Res , vol.60 , pp. 490-498
    • Rak, J.1    Mitsuhashi, Y.2    Sheehan, C.3    Tamir, A.4    Viloria-Petit, A.5    Filmus, J.6    Mansour, S.J.7    Ahn, N.G.8    Kerbel, R.S.9
  • 37
    • 0032541029 scopus 로고    scopus 로고
    • P42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts
    • Milanini J., Vinals F., Pouysségur J., Pagès G. p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts. J Biol Chem. 273:1998;18165-18172.
    • (1998) J Biol Chem , vol.273 , pp. 18165-18172
    • Milanini, J.1    Vinals, F.2    Pouysségur, J.3    Pagès, G.4
  • 38
    • 0029039195 scopus 로고
    • Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
    • Levy A.P., Levy N.S., Wegner S., Goldberg M.A. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem. 270:1995;13333-13340.
    • (1995) J Biol Chem , vol.270 , pp. 13333-13340
    • Levy, A.P.1    Levy, N.S.2    Wegner, S.3    Goldberg, M.A.4
  • 39
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe J.A., Jiang B.H., Iyer N.V., Agani F., Leung S.W., Koos R.D., Semenza G.L. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 16:1996;4604-4613.
    • (1996) Mol Cell Biol , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3    Agani, F.4    Leung, S.W.5    Koos, R.D.6    Semenza, G.L.7
  • 40
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang G.L., Semenza G.L. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem. 270:1995;1230-1237.
    • (1995) J Biol Chem , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 41
    • 0030963616 scopus 로고    scopus 로고
    • The hypoxic response: Huffing and HIFing
    • Guillemin K., Krasnow M.A. The hypoxic response Huffing and HIFing. Cell. 89:1997;9-12.
    • (1997) Cell , vol.89 , pp. 9-12
    • Guillemin, K.1    Krasnow, M.A.2
  • 42
    • 0029753008 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
    • Huang L.E., Arany Z., Livingston D.M., Bunn H.F. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem. 271:1996;32253-32259.
    • (1996) J Biol Chem , vol.271 , pp. 32253-32259
    • Huang, L.E.1    Arany, Z.2    Livingston, D.M.3    Bunn, H.F.4
  • 43
    • 0029789568 scopus 로고    scopus 로고
    • Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of the Arnt transcription factor
    • Gradin K., McGuire J., Wenger R.H., Kvietikova I., Fhitelaw M.L., Toftgard R., Tora L., Gassmann M., Poellinger L. Functional interference between hypoxia and dioxin signal transduction pathways Competition for recruitment of the Arnt transcription factor. Mol Cell Biol. 16:1996;5221-5231.
    • (1996) Mol Cell Biol , vol.16 , pp. 5221-5231
    • Gradin, K.1    McGuire, J.2    Wenger, R.H.3    Kvietikova, I.4    Fhitelaw, M.L.5    Toftgard, R.6    Tora, L.7    Gassmann, M.8    Poellinger, L.9
  • 44
    • 0030914648 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor 1alpha: Posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor
    • Kallio P.J., Pongratz I., Gradin K., McGuire J., Poellinger L. Activation of hypoxia-inducible factor 1alpha Posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor. Proc Natl Acad Sci USA. 94:1997;5667-5672.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 5667-5672
    • Kallio, P.J.1    Pongratz, I.2    Gradin, K.3    McGuire, J.4    Poellinger, L.5
  • 45
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian H., McKnight S.L., Russell D.W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11:1997;72-82.
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 47
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
    • Salceda S., Caro J. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem. 272:1997;22642-22647.
    • (1997) J Biol Chem , vol.272 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 48
    • 0032493368 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1 alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
    • Huang L.E., Gu J., Schau M., Bunn H.F. Regulation of hypoxia-inducible factor 1 alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA. 95:1998;7987-7992.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7987-7992
    • Huang, L.E.1    Gu, J.2    Schau, M.3    Bunn, H.F.4
  • 49
    • 0033525830 scopus 로고    scopus 로고
    • Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
    • Kallio P.J., Wilson W.J., O'Brien S., Makino Y., Poellinger L. Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway. J Biol Chem. 274:1999;6519-6525.
    • (1999) J Biol Chem , vol.274 , pp. 6519-6525
    • Kallio, P.J.1    Wilson, W.J.2    O'Brien, S.3    Makino, Y.4    Poellinger, L.5
  • 51
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner M., Werness B.A., Huibregtse J.M., Levine A.J., Howley P.M. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell. 63:1990;1129-1136.
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 52
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y., Maya R., Kazaz A., Oren M. Mdm2 promotes the rapid degradation of p53. Nature. 387:1997;296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 53
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • Kubbutat M.H., Jones S.N., Vousden K.H. Regulation of p53 stability by Mdm2. Nature. 387:1997;299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.1    Jones, S.N.2    Vousden, K.H.3
  • 56
    • 0032725554 scopus 로고    scopus 로고
    • P42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
    • Richard D.E., Berra E., Gothié E., Roux D., Pouysségur J. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. J Biol Chem. 274:1999;32631-32637.
    • (1999) J Biol Chem , vol.274 , pp. 32631-32637
    • Richard, D.E.1    Berra, E.2    Gothié, E.3    Roux, D.4    Pouysségur, J.5
  • 57
    • 0028785860 scopus 로고
    • Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1
    • Wang G.L., Jiang B.H., Semenza G.L. Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. Biochem Biophys Res Commun. 216:1995;669-675.
    • (1995) Biochem Biophys Res Commun , vol.216 , pp. 669-675
    • Wang, G.L.1    Jiang, B.H.2    Semenza, G.L.3
  • 58
    • 0032190614 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Master regulator of O2 homeostasis
    • Semenza G.L. Hypoxia-inducible factor 1 Master regulator of O2 homeostasis. Curr Opin Genet Dev. 8:1998;588-594.
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 588-594
    • Semenza, G.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.